Receptor-Mediated Mechanism Controlling Tissue Levels of Bioactive Lipid Oxidation Products.

abstract：:Platelet hyperactivity associated with hyperlipidemia may contribute to development of a prothrombotic state. We previously showed that oxidized low-density lipoprotein (oxLDL) formed in the setting of hyperlipidemia and atherosclerosis activated platelets in a CD36-dependent manner. We now show that mitogen-activated...

journal_title：Circulation research

authors： Chen K,Febbraio M,Li W,Silverstein RL

更新日期：2008-06-20 00:00:00

abstract：:Vascular remodeling, rather than vasoconstriction, is believed to account for high vascular resistance in severe pulmonary arterial hypertension (PAH). We have found previously that acute Rho kinase inhibition nearly normalizes PAH in chronically hypoxic rats that have no occlusive neointimal lesions. Here we examined...

journal_title：Circulation research

authors： Oka M,Homma N,Taraseviciene-Stewart L,Morris KG,Kraskauskas D,Burns N,Voelkel NF,McMurtry IF

更新日期：2007-03-30 00:00:00

abstract：RATIONALE:One goal of cardiac tissue engineering is the generation of a living, human pump in vitro that could replace animal models and eventually serve as an in vivo therapeutic. Models that replicate the geometrically complex structure of the heart, harboring chambers and large vessels with soft biomaterials, can be...

journal_title：Circulation research

authors： Kupfer ME,Lin WH,Ravikumar V,Qiu K,Wang L,Gao L,Bhuiyan DB,Lenz M,Ai J,Mahutga RR,Townsend D,Zhang J,McAlpine MC,Tolkacheva EG,Ogle BM

更新日期：2020-07-03 00:00:00

abstract：:Proteases of the plasminogen activator (PA) and matrix metalloproteinase (MMP) system play an important role in smooth muscle cell (SMC) migration and neointima formation after vascular injury. Inhibition of either PAs or MMPs has previously been shown to result in decreased neointima formation in vivo. To inhibit bot...

journal_title：Circulation research

authors： Lamfers ML,Grimbergen JM,Aalders MC,Havenga MJ,de Vries MR,Huisman LG,van Hinsbergh VW,Quax PH

更新日期：2002-11-15 00:00:00

abstract：:The role of the Na+-Ca2+ exchanger as a major determinant of cell Ca2+ is well defined in cardiac tissue, and there has been much effort to develop specific inhibitors of the exchanger. We use a novel system to test the specificity of two putative specific inhibitors, KB-R7943 and SEA0400. The drugs are applied to ele...

journal_title：Circulation research

authors： Reuter H,Henderson SA,Han T,Matsuda T,Baba A,Ross RS,Goldhaber JI,Philipson KD

更新日期：2002-07-26 00:00:00

abstract：:Baroreceptor reflexes can be demonstrated during fetal life, but whether baroreceptors normally regulate fetal arterial pressure is unknown. This problem was addressed directly by measuring arterial pressure and analyzing its variation in eight unanesthetized fetal lambs throughout the last third of gestation, and com...

journal_title：Circulation research

authors： Yardley RW,Bowes G,Wilkinson M,Cannata JP,Maloney JE,Ritchie BC,Walker AM

更新日期：1983-05-01 00:00:00

abstract：:Endothelial cells release nitric oxide (NO) more potently in response to increased shear stress than to agonists which elevate intracellular free calcium concentration ([Ca2+]i). To determine mechanistic differences in the regulation of endothelial constitutive NO synthase (ecNOS), we measured NO production by bovine ...

journal_title：Circulation research

authors： Corson MA,James NL,Latta SE,Nerem RM,Berk BC,Harrison DG

更新日期：1996-11-01 00:00:00

abstract：:The realization of regenerative cardiac medicine depends on the availability of cardiomyocytes in sufficient numbers for transplantation of cardiac tissue and the accompanying blood vessels. Embryonic stem (ES) cells, bone marrow (BM) stem cells, and tissue-derived stem cells are all potential cell sources. Although E...

journal_title：Circulation research

authors： Fukuda K,Yuasa S

更新日期：2006-04-28 00:00:00

abstract：:alpha-Adrenergic receptor stimulation regulates the activity of a number of different cardiac ion channels, including those underlying one or more distinct Cl- conductances. The whole-cell patch-clamp technique was used in the present study to investigate the effects of alpha-adrenergic stimulation on the beta-adrener...

journal_title：Circulation research

authors： Oleksa LM,Hool LC,Harvey RD

更新日期：1996-06-01 00:00:00

abstract：RATIONALE:The mutation A341V in the S6 transmembrane segment of KCNQ1, the α-subunit of the slowly activating delayed-rectifier K(+) (I(Ks)) channel, predisposes to a severe long-QT1 syndrome with sympathetic-triggered ventricular tachyarrhythmias and sudden cardiac death. OBJECTIVE:Several genetic risk modifiers have...

journal_title：Circulation research

authors： Heijman J,Spätjens RL,Seyen SR,Lentink V,Kuijpers HJ,Boulet IR,de Windt LJ,David M,Volders PG

更新日期：2012-01-20 00:00:00

abstract：:To study the effects of stretch on the function of rat left atrium, we recorded contraction force, calcium transients, and intracellular action potentials (APs) during stretch manipulations. The stretch of the atrium was controlled by intra-atrial pressure. The Frank-Starling behavior of the atrium was manifested as a...

journal_title：Circulation research

authors： Tavi P,Han C,Weckström M

更新日期：1998-11-30 00:00:00

abstract：:The dystrophin glycoprotein complex (DGC) is a specialization of cardiac and skeletal muscle membrane. This large multicomponent complex has both mechanical stabilizing and signaling roles in mediating interactions between the cytoskeleton, membrane, and extracellular matrix. Dystrophin, the protein product of the Duc...

journal_title：Circulation research

authors： Lapidos KA,Kakkar R,McNally EM

更新日期：2004-04-30 00:00:00

abstract：:Inherited restrictive cardiomyopathy (RCM) is a debilitating disease characterized by a stiff heart with impaired ventricular relaxation. Mutations in cardiac troponin I (cTnI) were identified as causal for RCM. Acute genetic engineering of adult cardiac myocytes was used to identify primary structure/function effects...

journal_title：Circulation research

authors： Davis J,Wen H,Edwards T,Metzger JM

更新日期：2007-05-25 00:00:00

abstract：:Propagation in cardiac muscle is faster in the longitudinal than in the transverse axis of the cells. Yet, as a result of the larger upstroke velocity of action potentials propagating transversely, it has been suggested that longitudinal propagation is more vulnerable to block. To study the relation between conduction...

journal_title：Circulation research

authors： Delmar M,Michaels DC,Johnson T,Jalife J

更新日期：1987-05-01 00:00:00

abstract：:Cyclosporine A (CsA)-induced hypertension appears to be caused in part by neurogenic vasoconstriction, but the mechanism by which CsA activates the sympathetic nervous system is unknown. In T lymphocytes, the cellular target of CsA and the macrolide immunosuppressant FK506 (as complexes with their endogenous cytoplasm...

journal_title：Circulation research

authors： Lyson T,Ermel LD,Belshaw PJ,Alberg DG,Schreiber SL,Victor RG

更新日期：1993-09-01 00:00:00

abstract：:RNA splicing represents a post-transcriptional mechanism to generate multiple functional RNAs or proteins from a single transcript. The evolution of RNA splicing is a prime example of the Darwinian function follows form concept. A mutation that leads to a new mRNA (form) that encodes for a new functional protein (func...

journal_title：Circulation research

authors： van den Hoogenhof MM,Pinto YM,Creemers EE

更新日期：2016-02-05 00:00:00

abstract：:3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) can exert beneficial effects independently of serum cholesterol reduction by increasing the bioavailability of nitric oxide. However, it is unclear whether statins can exert such effects directly on cardiac myocytes and whether mitochondria...

journal_title：Circulation research

authors： Jones SP,Teshima Y,Akao M,Marbán E

更新日期：2003-10-17 00:00:00

abstract：RATIONALE:Overexpression of muscle atrophy F-box (MAFbx/atrogin-1), an E3 ubiquitin ligase, induces proteasomal degradation in cardiomyocytes. The role of endogenous MAFbx in regulating cardiac hypertrophy and failure remains unclear. OBJECTIVE:We investigated the role of MAFbx in regulating cardiac hypertrophy and fu...

journal_title：Circulation research

authors： Usui S,Maejima Y,Pain J,Hong C,Cho J,Park JY,Zablocki D,Tian B,Glass DJ,Sadoshima J

更新日期：2011-07-08 00:00:00

abstract：:Extracellular ATP plays an important role in the regulation of prostacyclin and nitric oxide release from vascular endothelial cells. These cellular responses to ATP are generally attributed to the stimulation of the P2y subtype of P2 purinergic receptors. However, it has recently been suggested that two types of ATP ...

journal_title：Circulation research

authors： Motte S,Pirotton S,Boeynaems JM

更新日期：1993-03-01 00:00:00

abstract：:The role of the central nervous system in the mechanism(s) involved in acute carotid baroreflex resetting was studied in six conscious, chronically instrumented, aortic-denervated dogs. Dogs were prepared for reversible vascular isolation of the carotid sinuses. Acute baroreflex resetting was induced by holding the le...

journal_title：Circulation research

authors： Tan W,Panzenbeck MJ,Hajdu MA,Zucker IH

更新日期：1989-07-01 00:00:00

abstract：:Angiotensin II (Ang II) plays an important role in post-myocardial infarction (MI) remodeling. Most Ang II effects related to remodeling involve activation of the type 1 receptor (AT(1)). Although the AT(1) receptor is upregulated on cardiac fibroblasts post-MI, little is known about the mechanisms involved in the pro...

journal_title：Circulation research

authors： Gurantz D,Cowling RT,Villarreal FJ,Greenberg BH

更新日期：1999-08-06 00:00:00

abstract：:Oxidation converts low-density lipoprotein (LDL) into a cytotoxin in vitro. Oxidized LDL exists in vivo in atherosclerotic lesions and possibly in plasma. Many cell functions are altered in vitro by oxidized LDL, but few have been examined in vivo. To test whether oxidized LDL could injure endothelial cells and alter ...

journal_title：Circulation research

authors： Rangaswamy S,Penn MS,Saidel GM,Chisolm GM

更新日期：1997-01-01 00:00:00

abstract：:This study aimed to characterize the interaction between nitric oxide (NO)- and cAMP-related pathways in the control of renal blood flow. Using the isolated perfused rat kidney model, we determined the effects of inhibition of NO formation by Nomega-nitro-L-arginine methyl ester (L-NAME; 1 mmol/L) and of NO administra...

journal_title：Circulation research

authors： Sandner P,Kornfeld M,Ruan X,Arendshorst WJ,Kurtz A

更新日期：1999-02-05 00:00:00

abstract：:High affinity binding sites of angiotensin II (A II) have been characterized in rabbit renomedullary interstitial cells in tissue culture. Binding was rapid, specific, and saturable. Scatchard analysis of steady state saturation binding data at 22 degrees C indicated a single binding site with an equilibrium dissociat...

journal_title：Circulation research

authors： Brown CA,Zusman RM,Haber E

更新日期：1980-06-01 00:00:00

abstract：:Myocardial responses to acute ischemia/reperfusion and to chronic ischemic conditions have been studied extensively at all levels of organization. These include subcellular (eg, mitochondria in vitro); intact, large animal models (eg, swine with chronic coronary stenosis); as well as human subjects. Investigations in ...

journal_title：Circulation research

authors： Gewirtz H,Dilsizian V

更新日期：2017-03-31 00:00:00

abstract：RATIONALE:Remote ischemic conditioning (RIC) or ischemic postconditioning (PostC) may protect the myocardium from ischemia-reperfusion injury in patients with ST-segment-elevation myocardial infarction. OBJECTIVE:To determine whether combined intrahospital RIC and PostC or PostC alone in addition to primary percutaneo...

journal_title：Circulation research

authors： Stiermaier T,Jensen JO,Rommel KP,de Waha-Thiele S,Fuernau G,Desch S,Thiele H,Eitel I

更新日期：2019-05-10 00:00:00

abstract：:Structure/function analysis shows that the carboxyl terminal (CT) domain of connexin43 (Cx43) is essential for the chemical regulation of cell-cell communication. Of particular interest is the region between amino acids 260 and 300. Structural preservation of this region is essential for acidification-induced uncoupli...

journal_title：Circulation research

authors： Calero G,Kanemitsu M,Taffet SM,Lau AF,Delmar M

更新日期：1998-05-18 00:00:00

abstract：:Angiotensin (Ang) II is present inside vascular smooth muscle cells (VSMCs); however, its intracellular functions, if any, are unknown. We tested the hypothesis that intracellular Ang II exerts effects on cytosolic Ca2+ ([Ca2+]i) in VSMCs. Ang II was administered via microinjection. Intracellular Ang II localization w...

journal_title：Circulation research

authors： Haller H,Lindschau C,Erdmann B,Quass P,Luft FC

更新日期：1996-10-01 00:00:00

abstract：RATIONALE:Inactivating mutations in the Forkhead Box transcription factor F1 (FOXF1) gene locus are frequently found in patients with alveolar capillary dysplasia with misalignment of pulmonary veins, a lethal congenital disorder, which is characterized by severe abnormalities in the respiratory, cardiovascular, and ga...

journal_title：Circulation research

authors： Ren X,Ustiyan V,Pradhan A,Cai Y,Havrilak JA,Bolte CS,Shannon JM,Kalin TV,Kalinichenko VV

更新日期：2014-09-26 00:00:00

abstract：:Direct binding of apolipoprotein (apo)B-containing lipoproteins to proteoglycans is the initiating event in atherosclerosis, but the processes involved at later stages of development are unclear. Here, we investigated the importance of the apoB-proteoglycan interaction in the development of atherosclerosis over time a...

journal_title：Circulation research

authors： Gustafsson M,Levin M,Skålén K,Perman J,Fridén V,Jirholt P,Olofsson SO,Fazio S,Linton MF,Semenkovich CF,Olivecrona G,Borén J

更新日期：2007-10-12 00:00:00