Abstract:
:The dystrophin glycoprotein complex (DGC) is a specialization of cardiac and skeletal muscle membrane. This large multicomponent complex has both mechanical stabilizing and signaling roles in mediating interactions between the cytoskeleton, membrane, and extracellular matrix. Dystrophin, the protein product of the Duchenne and X-linked dilated cardiomyopathy locus, links cytoskeletal and membrane elements. Mutations in additional DGC genes, the sarcoglycans, also lead to cardiomyopathy and muscular dystrophy. Animal models of DGC mutants have shown that destabilization of the DGC leads to membrane fragility and loss of membrane integrity, resulting in degeneration of skeletal muscle and cardiomyocytes. Vascular reactivity is altered in response to primary degeneration in striated myocytes and arises from a vascular smooth muscle cell-extrinsic mechanism.
journal_name
Circ Resjournal_title
Circulation researchauthors
Lapidos KA,Kakkar R,McNally EMdoi
10.1161/01.RES.0000126574.61061.25subject
Has Abstractpub_date
2004-04-30 00:00:00pages
1023-31issue
8eissn
0009-7330issn
1524-4571pii
94/8/1023journal_volume
94pub_type
杂志文章,评审abstract::We designed this study to test the hypothesis that in acute mitral regurgitation the mitral regurgitant area (MRA) is a dynamic quantity which varies with the time variation of ventricular volume. Mitral insufficiency was created in five open-chest dogs in which a portion of the anterior leaflet was excised. Phasic ao...
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更新日期:2005-02-04 00:00:00
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pub_type: 杂志文章
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更新日期:1996-11-01 00:00:00