Biphasic development of the mammalian ventricular conduction system.

abstract：:Some statistical techniques for analyzing the kinds of studies typically reported in Circulation Research are described. Particular emphasis is given to the comparison of means from more than two populations, the joint effect of several experimentally controlled variables, and the analysis of studies with repeated mea...

journal_title：Circulation research

authors： Wallenstein S,Zucker CL,Fleiss JL

更新日期：1980-07-01 00:00:00

abstract：:The purpose of this study was to determine whether a cyclic adenosine 3',5'-monophosphate-dependent process can be involved in the regulation of vascular smooth muscle alpha 1-adrenergic receptor responsiveness. Experiments were performed in cultured rabbit aortic smooth muscle cells which were characterized previousl...

journal_title：Circulation research

authors： Colucci WS

更新日期：1986-02-01 00:00:00

abstract：:The aim of this study was to examine the effect of exercise training on reflex control of vascular resistance in human males. Forearm vascular responses to lower body negative pressure (LBNP) at -10 and -40 mm Hg were compared between highly trained young athletes (21.5 +/- 0.5 years old, n = 14) and age-matched nonat...

journal_title：Circulation research

authors： Takeshita A,Jingu S,Imaizumi T,Kunihiko Y,Koyanagi S,Nakamura M

更新日期：1986-07-01 00:00:00

abstract：RATIONALE:Inhibition of glycogen synthase kinase-3 (GSK-3) protects the heart during ischemia/reperfusion (I/R), yet the underlying mechanisms of cardioprotection afforded by beta isoform-specific inhibition GSK-3 remain to be elucidated. OBJECTIVE:We studied the molecular mechanism mediating the effect of GSK-3β acti...

journal_title：Circulation research

authors： Zhai P,Sciarretta S,Galeotti J,Volpe M,Sadoshima J

更新日期：2011-08-19 00:00:00

abstract：:We investigated the effect of medium conditioned by bovine aortic endothelial cells on collagen accumulation and total protein formation by human embryonic fibroblasts or bovine smooth muscle cells in cultures. The conditioned medium at a 1:10 dilution induced a twofold increase in collagen and total protein accumulat...

journal_title：Circulation research

authors： Villanueva AG,Farber HW,Rounds S,Goldstein RH

更新日期：1991-07-01 00:00:00

abstract：:We have shown that the cellular contractile dysfunction characteristic of pressure-overload cardiac hypertrophy results not from an abnormality intrinsic to the myofilament portion of the cardiocyte cytoskeleton but rather from an increased density of the microtubule component of the extramyofilament portion of the ca...

journal_title：Circulation research

authors： Tagawa H,Wang N,Narishige T,Ingber DE,Zile MR,Cooper G 4th

更新日期：1997-02-01 00:00:00

abstract：:Oxidative stress through the production of oxygen metabolites such as hydrogen peroxide (H2O2) increases vascular endothelial permeability. H2O2 stimulates ADP-ribose formation, which in turn opens transient receptor potential melastatin (TRPM)2 channels. Here, in endothelial cells, we demonstrate transcript and prote...

journal_title：Circulation research

authors： Hecquet CM,Ahmmed GU,Vogel SM,Malik AB

更新日期：2008-02-15 00:00:00

abstract：:Heparin has growth inhibitory effects on pulmonary artery smooth muscle cell (PASMC) in vitro and in vivo. However, the mechanism has not been fully defined. In this study, we investigated the role of cyclin-dependent kinase inhibitors, p21(WAF1/cip1) (p21) and p27Kip1 (p27), in the inhibitory effect of heparin on PAS...

journal_title：Circulation research

authors： Yu L,Quinn DA,Garg HG,Hales CA

更新日期：2005-10-28 00:00:00

abstract：:E1A can evoke G1 exit in cardiac myocytes and other cell types by displacing E2F transcription factors from tumor suppressor "pocket" proteins and by a less well-characterized p300-dependent pathway. Bypassing pocket proteins (through overexpression of E2F-1) reproduces the effect of inactivating pocket proteins (thro...

journal_title：Circulation research

authors： Akli S,Zhan S,Abdellatif M,Schneider MD

更新日期：1999-08-20 00:00:00

abstract：:Angiotensin II and its metabolites, [des-Asp-1]-angiotensin II (angiotensin III), [des-(Asp-1,Arg-2)]angiotensin II, and [des-(Asp-1,Arg-2,val-3)]angiotensin II, were measured in arterial and venous plasma from normal rats. Paper chromatography was used to separate the peptides which were measured with a radioimmunoas...

journal_title：Circulation research

authors： Semple PF,Morton JJ

更新日期：1976-06-01 00:00:00

abstract：:Pinocytotic vesicles are one of several anatomic factors relevant to the permeability for macromolecules of capillary endothelia. We quantitified the number and distribution of pinocytotic vesicles present in the endothelium of pulmonary capillaries. Several similar studies have been reported in the past for endotheli...

journal_title：Circulation research

authors： Gil J,Silage DA

更新日期：1980-09-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a critical regulator of angiogenesis that stimulates proliferation, migration, and proteolytic activity of endothelial cells. Although the mitogenic activity of VEGF is endothelial cell specific, recent reports indicate VEGF is able to stimulate chemotaxis and tissue factor...

journal_title：Circulation research

authors： Wang H,Keiser JA

更新日期：1998-10-19 00:00:00

abstract：:Deepak Srivastava’s group at the Gladstone Institute of Cardiovascular Disease, University of California San Francisco, reported in the August 6 issue of the journal Cell that to make heart muscle cells, all you need are three factors and some fibroblasts. But is it really that easy? ...

journal_title：Circulation research

authors： Williams R

更新日期：2010-10-29 00:00:00

abstract：:To investigate the kinetic parameters of the crossbridge cycle that regulate force and shortening in cardiac muscle, we compared the mechanical properties of cardiac trabeculae with either ATP or 2-deoxy-ATP (dATP) as the substrate for contraction. Comparisons were made in trabeculae from untreated rats (predominantly...

journal_title：Circulation research

authors： Regnier M,Rivera AJ,Chen Y,Chase PB

更新日期：2000-06-23 00:00:00

abstract：:Platelet activation is markedly increased during coronary thrombolysis and limits the response to thrombolytic therapy. A possible mediator of platelet activation in this setting is thromboxane (TX) A2, a potent platelet agonist formed in greatly increased amounts during coronary thrombolysis in man. To address this h...

journal_title：Circulation research

authors： Fitzgerald DJ,Wright F,FitzGerald GA

更新日期：1989-07-01 00:00:00

abstract：:The present study was performed to examine the mechanism by which cyclooxygenase blockade produces vasoconstriction in well-developed coronary collateral vessels. Eight dogs were studied 4 to 6 months after occlusion of the left anterior descending coronary artery (LAD) had been performed to stimulate collateral vesse...

journal_title：Circulation research

authors： Altman JD,Bache RJ

更新日期：1994-02-01 00:00:00

abstract：:In the present study, we investigated the modulatory role of the epicardium in myocardial and coronary development. Epicardial cell tracing experiments have shown that epicardium-derived cells are the source of interstitial myocardial fibroblasts, cushion mesenchyme, and smooth muscle cells. Epicardial outgrowth inhib...

journal_title：Circulation research

authors： Gittenberger-de Groot AC,Vrancken Peeters MP,Bergwerff M,Mentink MM,Poelmann RE

更新日期：2000-11-24 00:00:00

abstract：RATIONALE:The high morbidity/mortality of atherosclerosis is typically precipitated by plaque rupture and consequent thrombosis. However, research on underlying mechanisms and therapeutic approaches is limited by the lack of animal models that reproduce plaque instability observed in humans. OBJECTIVE:Development and ...

journal_title：Circulation research

authors： Chen YC,Bui AV,Diesch J,Manasseh R,Hausding C,Rivera J,Haviv I,Agrotis A,Htun NM,Jowett J,Hagemeyer CE,Hannan RD,Bobik A,Peter K

更新日期：2013-07-19 00:00:00

abstract：:The present study was designed to test the ability of regenerated endothelium to evoke endothelium-dependent hyperpolarizations. Hyperpolarizations induced by serotonin and bradykinin were compared in isolated porcine coronary arteries with native or regenerated endothelium, 4 weeks after balloon endothelial denudatio...

journal_title：Circulation research

authors： Thollon C,Bidouard JP,Cambarrat C,Delescluse I,Villeneuve N,Vanhoutte PM,Vilaine JP

更新日期：1999-03-05 00:00:00

abstract：:Age-related diastolic dysfunction is a major factor in the epidemic of heart failure. In patients hospitalized with heart failure, HFpEF is now as common as heart failure with reduced ejection fraction. We now have many successful treatments for heart failure with reduced ejection fraction, while specific treatment op...

journal_title：Circulation research

authors： Loffredo FS,Nikolova AP,Pancoast JR,Lee RT

更新日期：2014-06-20 00:00:00

abstract：:The effects of synthetic human atrial 28-amino acid peptide (alpha-human atrial polypeptide) on systemic and renal hemodynamics were examined in two separate groups of Inactin-anesthetized rats. First, mean arterial pressure, heart rate, and cardiac output were measured before and during infusion of the peptide at rat...

journal_title：Circulation research

authors： Hirata Y,Ishii M,Sugimoto T,Matsuoka H,Sugimoto T,Kangawa K,Matsuo H

更新日期：1985-10-01 00:00:00

abstract：:To test the hypothesis that the capacity to develop left ventricular (LV) hypertrophy might diminish with advancing age, we examined the hypertrophic response to ascending aortic constriction in 3 groups of adult Fischer 344 rats (9 months, 18 months, and 22 months of age). Aortic constriction was created so that aort...

journal_title：Circulation research

authors： Isoyama S,Wei JY,Izumo S,Fort P,Schoen FJ,Grossman W

更新日期：1987-09-01 00:00:00

abstract：:Raising the hepatic venous pressure experimentally duplicates the type of hepatic congestion seen in many clinical situations including congestive heart failure. Venous pressure was controlled using a hepatic venous long circuit preparation and was raised by 6 cm blood (4.7 mm Hg) or 10 cm (7.8 mm Hg). Total splanchni...

journal_title：Circulation research

authors： Lautt WW

更新日期：1977-12-01 00:00:00

abstract：:To evaluate the degree and lateral extent of dysfunction in nonischemic myocardium adjacent to ischemic muscle, we measured systolic wall thickening with sonomicrometers during circumflex coronary occlusion in 12 anesthetized, open-chest dogs. The locations of the wall thickness measurements relative to the perfusion ...

journal_title：Circulation research

authors： Gallagher KP,Gerren RA,Stirling MC,Choy M,Dysko RC,McManimon SP,Dunham WR

更新日期：1986-04-01 00:00:00

abstract：:The solid angle theory has long been applied to the interpretation of the ECG; however, quantitative evaluation of its applicability has been minimal. We applied solid angle analysis to the interpretation of the TQ-ST deflection during acute ischemia. Five anesthetized pigs were studied 1--3 hours after coronary occlu...

journal_title：Circulation research

authors： Richeson JF,Akiyama T,Schenk E

更新日期：1978-12-01 00:00:00

abstract：:Sarcolemmal and microsomal membranes prepared from adult canine cardiac myocytes (sarcolemmal Na+, K+-ATPase = 71.8 mumol/mg per hr and microsomal rotenone-insensitive NADH cytochrome c reductase = 114 mumol/mg per hr) were each preincubated at 37 degrees C in the presence of a free radical generating system consistin...

journal_title：Circulation research

authors： Kramer JH,Mak IT,Weglicki WB

更新日期：1984-07-01 00:00:00

abstract：:We evaluated the contribution of intramural electrical events in initiation and maintenance of ventricular tachycardia in 15 dogs 3-8 days after either permanent (n = 2) or transient (n = 13) coronary artery occlusion. Seven of the dogs (47%) demonstrated eight distinct monomorphic ventricular tachycardia patterns whi...

journal_title：Circulation research

authors： Kramer JB,Saffitz JE,Witkowski FX,Corr PB

更新日期：1985-05-01 00:00:00

abstract：:The objective of this study was to elucidate the mechanisms associated with the reciprocal relation between magnesium and calcium on vascular smooth muscle tone in bovine pulmonary artery and vein. Rapid removal of magnesium from Krebs-bicarbonate medium used to bathe isolated rings of precontracted artery or vein cau...

journal_title：Circulation research

authors： Gold ME,Buga GM,Wood KS,Byrns RE,Chaudhuri G,Ignarro LJ

更新日期：1990-02-01 00:00:00

abstract：RATIONALE:Significant progress has revealed transcriptional inputs that underlie regulation of artery and vein endothelial cell fates. However, little is known concerning genome-wide regulation of this process. Therefore, such studies are warranted to address this gap. OBJECTIVE:To identify and characterize artery- an...

journal_title：Circulation research

authors： Sissaoui S,Yu J,Yan A,Li R,Yukselen O,Kucukural A,Zhu LJ,Lawson ND

更新日期：2020-03-27 00:00:00

abstract：:The cardiac troponin T (TnT) I79N mutation has been linked to familial hypertrophic cardiomyopathy and high incidence of sudden death, despite causing little or no cardiac hypertrophy in patients. Transgenic mice expressing mutant human TnT (I79N-Tg) have increased cardiac contractility, but no ventricular hypertrophy...

journal_title：Circulation research

authors： Knollmann BC,Kirchhof P,Sirenko SG,Degen H,Greene AE,Schober T,Mackow JC,Fabritz L,Potter JD,Morad M

更新日期：2003-03-07 00:00:00