Coronary arteriolar myogenic response is independent of endothelium.

abstract：:Telomeres-the specialized DNA-protein structures at the ends of eukaryotic chromosomes-are essential for maintaining genome stability and integrity and for extended proliferative life span in both cultured cells and in the whole organism. Telomerase and additional telomere-associated proteins are necessary for preserv...

journal_title：Circulation research

authors： Serrano AL,Andrés V

更新日期：2004-03-19 00:00:00

abstract：:Hemodynamic shear stress elicits a rise in endothelial [Ca2+]i, which may serve as a key second messenger to regulate many flow-associated physiological and biochemical processes. In the present study, we used Mn2+ quenching of fluorescent dye Fluo3 as an assay to investigate the Ca2+ influx of rat aortic endothelial ...

journal_title：Circulation research

authors： Kwan HY,Leung PC,Huang Y,Yao X

更新日期：2003-02-21 00:00:00

abstract：:Previous studies have shown that cardiac endothelial cells release substances that influence myocardial contraction. Since PO2 is an important stimulus that modulates endothelial function, we investigated the effects of acute moderate hypoxia and reoxygenation on the release of cardioactive factors by endothelial cell...

journal_title：Circulation research

authors： Shah AM,Mebazaa A,Yang ZK,Cuda G,Lankford EB,Pepper CB,Sollott SJ,Sellers JR,Robotham JL,Lakatta EG

更新日期：1997-05-01 00:00:00

abstract：:In vitro and in vivo evidence indicates that hemodynamic wall shear stress evokes a diversity of biological responses in vascular endothelial cells, ranging from cell shape changes to alterations in low density lipoprotein receptor expression. The signal transduction mechanisms by which the level of fluid mechanical s...

journal_title：Circulation research

authors： Prasad AR,Logan SA,Nerem RM,Schwartz CJ,Sprague EA

更新日期：1993-04-01 00:00:00

abstract：:The purpose of this study was to evaluate the limitations of the double sucrose gap voltage clamp technique in the determination of tension-voltage relationships for frog atrial muscle. Tension-voltage relationships were determined under two conditions. In one case we determined both the tension response and slow inwa...

journal_title：Circulation research

authors： Tarr M,Trank JW

更新日期：1976-07-01 00:00:00

abstract：:We created knock-in mice in which a deletion of 3 base pairs coding for K210 in cardiac troponin (cTn)T found in familial dilated cardiomyopathy patients was introduced into endogenous genes. Membrane-permeabilized cardiac muscle fibers from mutant mice showed significantly lower Ca(2+) sensitivity in force generation...

journal_title：Circulation research

authors： Du CK,Morimoto S,Nishii K,Minakami R,Ohta M,Tadano N,Lu QW,Wang YY,Zhan DY,Mochizuki M,Kita S,Miwa Y,Takahashi-Yanaga F,Iwamoto T,Ohtsuki I,Sasaguri T

更新日期：2007-07-20 00:00:00

abstract：:Genetically hypertensive (GH) rats of the New Zealand strain and normotensive (N) rats were sympathectomized from birth with 6-hydroxydopamine (100 mg/kg,s.c, on alternate days, seven treatments). In adult treated rats from each strain (GHTr and NTr), blood pressure was lower than normal. Functional tests and electron...

journal_title：Circulation research

authors： Clark DW,Jones DR,Phelan EL,Devine CE

更新日期：1978-08-01 00:00:00

abstract：:Activity was recorded from physiologically identified baroreceptor or chemoreceptor fibers in carotid sinus nerves of urethane-anesthetized spontaneously breathing rabbits. A carotid sinus area was vascularly isolated so that carotid sinus pressure and perfusion medium (Locke's solution or rabbit blood) could be contr...

journal_title：Circulation research

authors： Qu L,Stuesse SL

更新日期：1991-12-01 00:00:00

abstract：:We have recently shown that adult canine ventricular myocytes express three distinct gap junction channel proteins, connexin40 (Cx40), connexin43 (Cx43), and connexin45 (Cx45). These proteins have unique cytoplasmic domains that likely confer connexin-specific physiological properties. To determine whether the three d...

journal_title：Circulation research

authors： Kanter HL,Laing JG,Beyer EC,Green KG,Saffitz JE

更新日期：1993-08-01 00:00:00

abstract：:Tissue factor (TF) is a low-molecular-weight glycoprotein that initiates the extrinsic clotting cascade and is considered a major regulator of arterial thrombogenicity. TF pathway inhibitor (TFPI) is a major physiological inhibitor of TF-initiated coagulation. The aim of this study was to define the complex interplay ...

journal_title：Circulation research

authors： Singh R,Pan S,Mueske CS,Witt T,Kleppe LS,Peterson TE,Slobodova A,Chang JY,Caplice NM,Simari RD

更新日期：2001-07-06 00:00:00

abstract：RATIONALE:Pulmonary hypertensive remodeling is characterized by excessive proliferation, migration, and proinflammatory activation of adventitial fibroblasts. In culture, fibroblasts maintain a similar activated phenotype. The mechanisms responsible for generation/maintenance of this phenotype remain unknown. OBJECTIV...

journal_title：Circulation research

authors： Wang D,Zhang H,Li M,Frid MG,Flockton AR,McKeon BA,Yeager ME,Fini MA,Morrell NW,Pullamsetti SS,Velegala S,Seeger W,McKinsey TA,Sucharov CC,Stenmark KR

更新日期：2014-01-03 00:00:00

abstract：:The objective of this study was to elucidate the mechanisms associated with the reciprocal relation between magnesium and calcium on vascular smooth muscle tone in bovine pulmonary artery and vein. Rapid removal of magnesium from Krebs-bicarbonate medium used to bathe isolated rings of precontracted artery or vein cau...

journal_title：Circulation research

authors： Gold ME,Buga GM,Wood KS,Byrns RE,Chaudhuri G,Ignarro LJ

更新日期：1990-02-01 00:00:00

abstract：:cAMP-dependent protein kinase is anchored to discrete cellular compartments by a family of proteins, the A-kinase anchor proteins (AKAPs). We have investigated in vivo and in vitro the biological effects of the expression of a prototypic member of the family, AKAP75, on smooth muscle cells. In vitro expression of AKAP...

journal_title：Circulation research

authors： Indolfi C,Stabile E,Coppola C,Gallo A,Perrino C,Allevato G,Cavuto L,Torella D,Di Lorenzo E,Troncone G,Feliciello A,Avvedimento E,Chiariello M

更新日期：2001-02-16 00:00:00

abstract：:Hypertrophied cardiac myocytes exhibit prolonged action potentials and decreased transient outward potassium current (I(to)). Because Kv4.3 is a major contributor to I:(to), we studied regulation of its expression in neonatal rat cardiac myocytes in response to the known stimulators of cardiac myocyte hypertrophy, ang...

journal_title：Circulation research

authors： Zhang TT,Takimoto K,Stewart AF,Zhu C,Levitan ES

更新日期：2001-03-16 00:00:00

abstract：:Although urinary sodium excretion is positively influenced by acute changes in renal perfusion pressure, micropuncture studies show highly conflicting results concerning the response of superficial proximal tubule sodium reabsorption to changes in renal perfusion pressure. In the present study, the changes of superfic...

journal_title：Circulation research

authors： Kinoshita Y,Knox FG

更新日期：1990-05-01 00:00:00

abstract：:Hibernating myocardium, characterized by reductions in flow and function at rest, has limited contractile reserve in response to increases in external workload. We hypothesized that this attenuation of function reflects an adaptive downregulation that prevents the development of metabolic evidence of ischemia during s...

journal_title：Circulation research

authors： Fallavollita JA,Malm BJ,Canty JM Jr

更新日期：2003-01-10 00:00:00

abstract：:Aging of the vasculature plays a central role in morbidity and mortality of older people. To develop novel treatments for amelioration of unsuccessful vascular aging and prevention of age-related vascular pathologies, it is essential to understand the cellular and functional changes that occur in the vasculature durin...

journal_title：Circulation research

authors： Ungvari Z,Tarantini S,Donato AJ,Galvan V,Csiszar A

更新日期：2018-09-14 00:00:00

abstract：:The bioactivity of nitric oxide (.NO) depends, in part, on its interaction with superoxide. Usually, superoxide dismutase (SOD) preserves .NO bioactivity by limiting the availability of superoxide. Ascorbic acid also effectively scavenges superoxide, but the extent to which this interaction is necessary for intact .NO...

journal_title：Circulation research

authors： Jackson TS,Xu A,Vita JA,Keaney JF Jr

更新日期：1998-11-02 00:00:00

abstract：:Alternans in heart is important as pulsus alternans in cardiac failure and electrophysiological alternans in myocardial ischemia. The explanation of this phenomenon is still unclear. We attempted to investigate the cellular mechanisms of alternans by measuring intracellular free calcium concentration [( Ca2+]i) with t...

journal_title：Circulation research

authors： Lab MJ,Lee JA

更新日期：1990-03-01 00:00:00

abstract：:Radiolabeled triiodothyronine (T3) binding to isolated nuclei was measured to compare the binding characteristics of the nuclear receptors in rabbit ventricular and atrial muscle cells. Scatchard analysis of the binding data yielded a maximum binding capacity of 170 +/- 20 fmol per mg DNA and apparent dissociation con...

journal_title：Circulation research

authors： Banerjee SK,Ulrich JM,Kaldor GJ

更新日期：1988-07-01 00:00:00

abstract：RATIONALE:Individuals with naturally occurring loss-of-function proprotein convertase subtilisin/kexin type 9 (PCSK9) mutations experience reduced low-density lipoprotein cholesterol levels and protection against cardiovascular disease. OBJECTIVE:The goal of this study was to assess whether genome editing using a clus...

journal_title：Circulation research

authors： Ding Q,Strong A,Patel KM,Ng SL,Gosis BS,Regan SN,Cowan CA,Rader DJ,Musunuru K

更新日期：2014-08-15 00:00:00

abstract：:We previously have shown that alpha-adrenergic stimulation of canine Purkinje fibers and rat ventricle decreases automaticity. Experiments on rat ventricular myocytes in tissue culture have suggested that the decrease in automaticity induced by alpha-adrenergic stimulation depends on the development of sympathetic inn...

journal_title：Circulation research

authors： Rosen MR,Steinberg SF,Chow YK,Bilezikian JP,Danilo P Jr

更新日期：1988-02-01 00:00:00

abstract：:A large body of data gathered over the past couple of years has identified the peroxisome proliferator-activated receptors (PPAR) alpha, gamma, and beta/delta as transcription factors exerting modulatory actions in vascular cells. PPARs, which belong to the nuclear receptor family of ligand-activated transcription fac...

journal_title：Circulation research

authors： Marx N,Duez H,Fruchart JC,Staels B

更新日期：2004-05-14 00:00:00

abstract：:Cold-induced vasoconstriction in cutaneous blood vessels is mediated in part by increased activity of vascular smooth muscle alpha2-adrenoceptors (VSM alpha2-ARs). In mouse cutaneous arteries, alpha2C-ARs are normally silent at 37 degrees C but mediate cold-induced augmentation of alpha2-AR responsiveness. In transfec...

journal_title：Circulation research

authors： Bailey SR,Eid AH,Mitra S,Flavahan S,Flavahan NA

更新日期：2004-05-28 00:00:00

abstract：:A number of scavengers of reactive oxygen metabolites reduce myocardial injury when given before ischemia and reperfusion, but few, if any, have proven to be effective when given near the onset of reperfusion. This is particularly true when infarct size is measured after at least 48 hours of reperfusion, when the full...

journal_title：Circulation research

authors： Carrea FP,Lesnefsky EJ,Repine JE,Shikes RH,Horwitz LD

更新日期：1991-06-01 00:00:00

abstract：:Isovolumic relaxation abnormalities have been noted in the ischemic left ventricle, but altered end-diastolic distensibility, as well as the role of right ventricular distention, is debated. Accordingly, left ventricular end-diastolic pressure and myocardial segment length were studied in the open-chest dogs with crit...

journal_title：Circulation research

authors： Momomura S,Bradley AB,Grossman W

更新日期：1984-08-01 00:00:00

abstract：:Volume expansion has been shown to increase plasma atrial natriuretic peptide (ANP) levels, but the precise role of paracrine and autocrine factors in stretch-induced cardiac hormone release is not clear. In the present study, we report the effects of endothelin (ET) and angiotensin receptor (AT receptor) antagonists ...

journal_title：Circulation research

authors： Leskinen H,Vuolteenaho O,Ruskoaho H

更新日期：1997-01-01 00:00:00

abstract：:Inducible nitric oxide synthase (iNOS) protein is expressed in cardiac myocytes of patients and experimental animals with congestive heart failure (CHF). Here we show that iNOS expression plays a role in pressure overload-induced myocardial chamber dilation and hypertrophy. In wild-type mice, chronic transverse aortic...

journal_title：Circulation research

authors： Zhang P,Xu X,Hu X,van Deel ED,Zhu G,Chen Y

更新日期：2007-04-13 00:00:00

abstract：:The expression of angiotensin II type 2 (AT(2)) receptor is closely associated with cell growth, differentiation, and/or injury. We examined the effect of interferon (IFN)-gamma on AT(2) receptor expression in mouse fibroblast R3T3 cells and demonstrated that IFN-gamma treatment increased the expression of AT(2) recep...

journal_title：Circulation research

authors： Horiuchi M,Hayashida W,Akishita M,Yamada S,Lehtonen JY,Tamura K,Daviet L,Chen YE,Hamai M,Cui TX,Iwai M,Minokoshi Y

更新日期：2000-02-04 00:00:00

abstract：RATIONALE:Smooth muscle precursor cells have previously been reported to reside in bone marrow and in the circulation, but little is currently known regarding the proximate stimuli for smooth muscle cell differentiation of these putative progenitors. OBJECTIVE:Because local thrombin generation occurs as an initial res...

journal_title：Circulation research

authors： Martin K,Weiss S,Metharom P,Schmeckpeper J,Hynes B,O'Sullivan J,Caplice N

更新日期：2009-07-31 00:00:00