Abstract:
:We designed this study to test the hypothesis that in acute mitral regurgitation the mitral regurgitant area (MRA) is a dynamic quantity which varies with the time variation of ventricular volume. Mitral insufficiency was created in five open-chest dogs in which a portion of the anterior leaflet was excised. Phasic aortic and mitral flows were measured electromagnetically, along with left atrial and ventricular pressures. Filling, regurgitant, and stroke volumes, and systolic pressure gradient were determined by digital methods. MRA was calculated from the fluid dynamic equation of motion to give the temporal mean and the instantaneous value at three instants of time and at the time of peak flow (when inertia is negligible). Mean regurgitant fraction was 42 +/- 12% with no indication of left ventricular failure due to volume overload. MRA decreased monotonically with time to 59% of its initial value and closely paralleled the decrease in ventricular volume during systole. In a control study using a tilting-disc prosthesis with a hole 5 mm in diameter in the occluder, the calculated MRA was time invariant and equal to the measured area for regurgitation. We conclude that in acute mitral regurgitation the MRA is a function of ventricular volume.
journal_name
Circ Resjournal_title
Circulation researchauthors
Yellin EL,Yoran C,Sonnenblick EH,Gabbay S,Frater RWdoi
10.1161/01.res.45.5.677subject
Has Abstractpub_date
1979-11-01 00:00:00pages
677-83issue
5eissn
0009-7330issn
1524-4571journal_volume
45pub_type
杂志文章abstract:RATIONALE:One goal of cardiac tissue engineering is the generation of a living, human pump in vitro that could replace animal models and eventually serve as an in vivo therapeutic. Models that replicate the geometrically complex structure of the heart, harboring chambers and large vessels with soft biomaterials, can be...
journal_title:Circulation research
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pub_type: 杂志文章
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更新日期:1991-09-01 00:00:00
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更新日期:2002-04-05 00:00:00
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更新日期:1986-02-01 00:00:00
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更新日期:1997-10-01 00:00:00
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更新日期:1990-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-06-08 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.87.12.e61
更新日期:2000-12-08 00:00:00
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doi:10.1161/01.res.73.2.344
更新日期:1993-08-01 00:00:00
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更新日期:2014-02-28 00:00:00
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更新日期:2009-11-20 00:00:00
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更新日期:1992-04-01 00:00:00
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更新日期:2012-09-28 00:00:00
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更新日期:1975-08-01 00:00:00
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更新日期:2015-07-03 00:00:00
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更新日期:2019-08-16 00:00:00
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更新日期:2010-10-15 00:00:00
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更新日期:2006-11-10 00:00:00
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更新日期:2013-03-15 00:00:00