Atrial natriuretic peptide in chronic heart failure in the rat: a correlation with ventricular dysfunction.

abstract：:Recovery of postischemic function may be limited by energy synthesis by mitochondria, energy transfer via the creatine kinase reaction, or energy utilization at myofibrils. To identify the limiting step, we defined the relations among oxygen consumption, creatine kinase reaction velocity and cardiac performance in myo...

journal_title：Circulation research

authors： Neubauer S,Hamman BL,Perry SB,Bittl JA,Ingwall JS

更新日期：1988-07-01 00:00:00

abstract：:Atherosclerotic plaque rupture is the main cause of coronary thrombosis and myocardial infarcts. Currently, there is no animal model of plaque disruption. We have developed a rabbit model in which an atherosclerotic plaque can be ruptured at will after an inflatable balloon becomes embedded into the plaque. Furthermor...

journal_title：Circulation research

authors： Rekhter MD,Hicks GW,Brammer DW,Work CW,Kim JS,Gordon D,Keiser JA,Ryan MJ

更新日期：1998-10-05 00:00:00

abstract：RATIONALE:Human clinical trials using type 1 angiotensin (AT(1)) receptor antagonists indicate that angiotensin II is a critical mediator of cardiovascular and renal disease. However, recent studies have suggested that individual tissue pools of AT(1) receptors may have divergent effects on target organ damage in hyper...

journal_title：Circulation research

authors： Zhang JD,Patel MB,Song YS,Griffiths R,Burchette J,Ruiz P,Sparks MA,Yan M,Howell DN,Gomez JA,Spurney RF,Coffman TM,Crowley SD

更新日期：2012-06-08 00:00:00

abstract：RATIONALE:Clinical studies have shown that Sirt3 (Sirtuin 3) expression declines by 40% by 65 years of age paralleling the increased incidence of hypertension and metabolic conditions further inactivate Sirt3 because of increased NADH (nicotinamide adenine dinucleotide, reduced form) and acetyl-CoA levels. Sirt3 impair...

journal_title：Circulation research

authors： Dikalova AE,Itani HA,Nazarewicz RR,McMaster WG,Flynn CR,Uzhachenko R,Fessel JP,Gamboa JL,Harrison DG,Dikalov SI

更新日期：2017-08-18 00:00:00

abstract：:Changes in cardiac filling pressure (central venous pressure) were measured following carotid occlusion and infusions of catecholamines in awake dogs while cardiac output was held constant. After carotid occlusion in dogs with vagi blocked, central venous pressure increased about 0.8 mm Hg (an estimated decrease in va...

journal_title：Circulation research

authors： Bennett TD,Wyss CR,Scher AM

更新日期：1984-10-01 00:00:00

abstract：:A number of neurotransmitters modulate cardiac dihydropyridine-sensitive L-type Ca2+ channels through several homologous G protein-coupled receptors. Previous studies that have examined receptor-Ca2+ channel interactions have suffered because of the coexpression of various receptor subtypes in native cells. To study t...

journal_title：Circulation research

authors： Yatani A,Wakamori M,Niidome T,Yamamoto S,Tanaka I,Mori Y,Katayama K,Green S

更新日期：1995-03-01 00:00:00

abstract：RATIONALE:Remodeling of the vessel wall and the formation of vascular networks are dynamic processes that occur during mammalian embryonic development and in adulthood. Plaque development and excessive neointima formation are hallmarks of atherosclerosis and vascular injury. As our understanding of these complex proces...

journal_title：Circulation research

authors： Becher T,Riascos-Bernal DF,Kramer DJ,Almonte VM,Chi J,Tong T,Oliveira-Paula GH,Koleilat I,Chen W,Cohen P,Sibinga NES

更新日期：2020-02-28 00:00:00

abstract：:Sarcolemmal and microsomal membranes prepared from adult canine cardiac myocytes (sarcolemmal Na+, K+-ATPase = 71.8 mumol/mg per hr and microsomal rotenone-insensitive NADH cytochrome c reductase = 114 mumol/mg per hr) were each preincubated at 37 degrees C in the presence of a free radical generating system consistin...

journal_title：Circulation research

authors： Kramer JH,Mak IT,Weglicki WB

更新日期：1984-07-01 00:00:00

abstract：:A large body of data gathered over the past couple of years has identified the peroxisome proliferator-activated receptors (PPAR) alpha, gamma, and beta/delta as transcription factors exerting modulatory actions in vascular cells. PPARs, which belong to the nuclear receptor family of ligand-activated transcription fac...

journal_title：Circulation research

authors： Marx N,Duez H,Fruchart JC,Staels B

更新日期：2004-05-14 00:00:00

abstract：:The sphingolipid metabolites, sphingosine (SPH), SPH 1-phosphate (S1P), and sphingosylphosphorylcholine (SPC), can act as intracellular as well as extracellular signaling molecules. These compounds have been implicated in the regulation of cell growth, differentiation, and programmed cell death in nonmyocytes, but the...

journal_title：Circulation research

authors： Sekiguchi K,Yokoyama T,Kurabayashi M,Okajima F,Nagai R

更新日期：1999-11-26 00:00:00

abstract：:Pinacidil belongs to a novel group of compounds that enhance the potassium permeability of vascular smooth muscle. Evidence also exists that this drug enhances the potassium permeability of cardiac tissue. The purpose of the present investigation was to determine if pinacidil alters potassium-channel activity in heart...

journal_title：Circulation research

authors： Arena JP,Kass RS

更新日期：1989-08-01 00:00:00

abstract：RATIONALE:Proteasomal degradation is altered in many disease phenotypes including cardiac hypertrophy, a prevalent condition leading to heart failure. Our recent investigations identified heterogeneous subpopulations of proteasome complexes in the heart and implicated multiple mechanisms for their regulation. OBJECTIV...

journal_title：Circulation research

authors： Drews O,Tsukamoto O,Liem D,Streicher J,Wang Y,Ping P

更新日期：2010-10-29 00:00:00

abstract：:Choline acetyltransferase activity, which is rate limiting in acetylcholine biosynthesis, was measured in the four heart chambers of guinea pigs subjected to (1) sham surgery, (2) constriction of the ascending aorta, (3) constriction of the descending thoracic aorta, and (4) constriction of the pulmonary artery. After...

journal_title：Circulation research

authors： Roskoski R Jr,Schmid PG,Mayer HE,Abboud FM

更新日期：1975-04-01 00:00:00

abstract：RATIONALE:Abnormal phenotypic switch of vascular smooth muscle cell (VSMC) is a hallmark of vascular disorders such as atherosclerosis and restenosis after angioplasty. MicroRNAs (miRNAs) have emerged as important regulators for VSMC function, and we recently identified miR-663 as critical for controlling human aortic ...

journal_title：Circulation research

authors： Li P,Zhu N,Yi B,Wang N,Chen M,You X,Zhao X,Solomides CC,Qin Y,Sun J

更新日期：2013-10-25 00:00:00

abstract：:Protein kinase A (PKA)-mediated enhancement of L-type calcium currents (I(Ca,L)) is essential for sympathetic regulation of the heartbeat and is the classic example of channel regulation by phosphorylation, and its loss is a common hallmark of heart failure. Mechanistic understanding of how distinct Ca(V) channel subu...

journal_title：Circulation research

authors： Miriyala J,Nguyen T,Yue DT,Colecraft HM

更新日期：2008-04-11 00:00:00

abstract：:Spatial and temporal organization of signal transduction is coordinated through the segregation of signaling enzymes in selected cellular compartments. This highly evolved regulatory mechanism ensures the activation of selected enzymes only in the vicinity of their target proteins. In this context, cAMP-responsive tri...

journal_title：Circulation research

authors： Perino A,Ghigo A,Scott JD,Hirsch E

更新日期：2012-08-03 00:00:00

abstract：:Intracellular potassium activity in guinea pig left atria was measured using potassium ion-selective microelectrodes and conventional microelectrodes. The effects of extracellular potassium concentration and acetylcholine on both intracellular potassium activity and the relationship between the resting membrane potent...

journal_title：Circulation research

authors： Baumgarten CM,Singer DH,Fozzard HA

更新日期：1984-01-01 00:00:00

abstract：:We studied the mechanisms underlying the increase in automaticity induced by alpha 1-adrenergic stimulation of normal and "ischemic" canine Purkinje fibers. Fibers were superfused with a control Tyrode's solution, followed by an ischemic superfusate that included 10 mM KCl, 5 mM NaHCO3, Po2 of 10-25 mm Hg, and pH 6.7....

journal_title：Circulation research

authors： Anyukhovsky EP,Rybin VO,Nikashin AV,Budanova OP,Rosen MR

更新日期：1992-09-01 00:00:00

abstract：:Several time- and voltage-dependent ionic currents have been identified in cardiac pacemaker cells, including Na(+) current, L- and T-type Ca(2+) currents, hyperpolarization-activated cation current, and various types of delayed rectifier K(+) currents. Mathematical models have demonstrated that spontaneous action pot...

journal_title：Circulation research

authors： Mitsuiye T,Shinagawa Y,Noma A

更新日期：2000-07-21 00:00:00

abstract：:Given the essential role played by gap junctions in the coordination of cardiac muscle contraction, it is plausible that down-regulation of gap junctional conduction is in part responsible for the contractile dysfunction observed in hypertrophied and failing hearts. In the present study, we analyzed the expression and...

journal_title：Circulation research

authors： Toyofuku T,Yabuki M,Otsu K,Kuzuya T,Tada M,Hori M

更新日期：1999-10-15 00:00:00

abstract：:We studied the time-dependent changes in the response of heart rate (sinus cycle length) to 30-second trains of vagal stimulation (8 Hz), repeated every 2 minutes, in canine neonates aged 7.1 +/- 2.5 (mean +/- SD) days. The first vagal train prolonged the sinus cycle length by 58 +/- 35%, but the response was attenuat...

journal_title：Circulation research

authors： Yamasaki S,Stolfi A,Mas MS,Fox LS,Pickoff AS

更新日期：1991-08-01 00:00:00

abstract：:Brugada syndrome has been linked to mutations in SCN5A. Agents that dissociate slowly from the sodium channel such as flecainide and ajmaline unmask the Brugada syndrome electrocardiogram and precipitate ventricular tachycardia/fibrillation. Lidocaine, an agent with rapid dissociation kinetics, has previously been sho...

journal_title：Circulation research

authors： Barajas-Martínez HM,Hu D,Cordeiro JM,Wu Y,Kovacs RJ,Meltser H,Kui H,Elena B,Brugada R,Antzelevitch C,Dumaine R

更新日期：2008-08-15 00:00:00

abstract：:Cytokine activation of vascular endothelial cells renders the hyperadhesiveness for neutrophils. During the processes of inflammation and atherosclerosis, the production of reactive oxygen species by neutrophils contributes to endothelial cell (EC) damage and injury. However, the precise mechanisms for neutrophil acti...

journal_title：Circulation research

authors： Takahashi T,Hato F,Yamane T,Fukumasu H,Suzuki K,Ogita S,Nishizawa Y,Kitagawa S

更新日期：2001-03-02 00:00:00

abstract：RATIONALE:autophagy, a bulk degradation process of cytosolic proteins and organelles, is protective during nutrient starvation in cardiomyocytes (CMs). However, the underlying signaling mechanism mediating autophagy is not well understood. OBJECTIVE:we investigated the role of FoxOs and its posttranslational modificat...

journal_title：Circulation research

authors： Hariharan N,Maejima Y,Nakae J,Paik J,Depinho RA,Sadoshima J

更新日期：2010-12-10 00:00:00

abstract：:By using excised postmortem hearts obtained from 15 mongrel dogs with the pericardium intact, we investigated mechanical interactions between the four heart chambers from the standpoint of ventricular pressure-volume relationships. The interactions investigated were those between (1) the atrium and the ventricle, (2) ...

journal_title：Circulation research

authors： Maruyama Y,Ashikawa K,Isoyama S,Kanatsuka H,Ino-Oka E,Takishima T

更新日期：1982-01-01 00:00:00

abstract：:Quinidine is the most commonly used drug for the chronic treatment of ventricular arrhythmias, but it may be arrhythmogenic. Much information exists concerning quinidine's effects on active properties in cardiac tissues, but virtually nothing is known of its effects on passive properties. We studied the effects of qui...

journal_title：Circulation research

authors： Arnsdorf MF,Sawicki GJ

更新日期：1987-08-01 00:00:00

abstract：:Transforming growth factor (TGF)-beta plays a major role in the development of vascular diseases. Despite the pleiotropic effects of TGF-ss on vascular smooth muscle cells (VSMCs), only a few genes have been characterized as direct targets of TGF-beta in VSMCs. Cardiac ankyrin repeat protein (CARP) has been thought to...

journal_title：Circulation research

authors： Kanai H,Tanaka T,Aihara Y,Takeda S,Kawabata M,Miyazono K,Nagai R,Kurabayashi M

更新日期：2001-01-19 00:00:00

abstract：:We studied the individual and combined effects of extracellular acidosis and increases in extracellular potassium on action potential characteristics and conduction in order to gain a better understanding of the effects of acute ischemia. At each level of potassium between 2.7 and 17 mm, acidosis induced by increasing...

journal_title：Circulation research

authors： Kagiyama Y,Hill JL,Gettes LS

更新日期：1982-11-01 00:00:00

abstract：:An extensive investigation of the cardiac actions of phorbol esters and the potential role of the Na(+)-H+ exchanger in those actions was carried out using isolated rat hearts. Sixty minutes of perfusion with 10(-9) M phorbol 12-myristate 13-acetate (PMA) or 10(-8) M phorbol 12,13-dibutyrate (PDBu) produced marked car...

journal_title：Circulation research

authors： Watson JE,Karmazyn M

更新日期：1991-10-01 00:00:00

abstract：:The action potential model presented in our accompanying article in this journal is used to investigate phenomena that involve dynamic changes of [Ca2+]i, as described below. Delayed afterdepolarizations (DADs) are induced by spontaneous Ca2+ release from the sarcoplasmic reticulum (SR), which, in turn, activates both...

journal_title：Circulation research

authors： Luo CH,Rudy Y

更新日期：1994-06-01 00:00:00