Functional roles of a Ca2+-activated K+ channel in atrioventricular nodes.

abstract：:After myocardial infarction (MI), the noninfarcted myocardium undergoes significant hypertrophy as part of the post-MI structural remodeling. Electrophysiological changes associated with the hypertrophied remodeled myocardium may play a key role in arrhythmia generation in the post-MI heart. We investigated the cellul...

journal_title：Circulation research

authors： Qin D,Zhang ZH,Caref EB,Boutjdir M,Jain P,el-Sherif N

更新日期：1996-09-01 00:00:00

abstract：:To determine whether the attenuation in the growth capacity of myocytes in the overloaded aging heart is associated with an impairment in the activation of insulin-like growth factor-1 (IGF-1) and its receptor (IGF-1R) in the stressed cells, large myocardial infarcts were produced in Fischer 344 rats at 4 and 16 month...

journal_title：Circulation research

authors： Cheng W,Reiss K,Li P,Chun MJ,Kajstura J,Olivetti G,Anversa P

更新日期：1996-04-01 00:00:00

abstract：:The transcriptional regulation of cardiovascular development requires precise spatiotemporal control of gene expression, and heterozygous mutations of transcription factors have frequently been implicated in human cardiovascular malformations. A novel mechanism involving posttranscriptional regulation by small, noncod...

journal_title：Circulation research

authors： Cordes KR,Srivastava D

更新日期：2009-03-27 00:00:00

abstract：:We have recently demonstrated that endogenous erythropoietin (Epo)/Epo receptor (EpoR) system plays an important protective role in hypoxia-induced pulmonary hypertension. However, it remains to be examined whether vascular EpoR system contributes to angiogenesis in response to ischemia. We examined angiogenesis in Ep...

journal_title：Circulation research

authors： Nakano M,Satoh K,Fukumoto Y,Ito Y,Kagaya Y,Ishii N,Sugamura K,Shimokawa H

更新日期：2007-03-16 00:00:00

abstract：:To determine whether the vasoconstriction evoked by A1-adenosine receptor stimulation in the skin circulation caused the release of other substances or whether A1 stimulation modulated the vasoconstriction evoked by other compounds, a potent A1-selective, synthetic agonist, cyclohexyladenosine (CHA), was topically app...

journal_title：Circulation research

authors： Proctor KG,Stojanov I

更新日期：1991-03-01 00:00:00

abstract：:The spatial and dynamic properties of ventricular fibrillation (VF) may be random or related to cellular electrical properties of the normal heart. Local activation intervals (AIs) in VF may depend on the local refractory period (RP), and sustained VF may require a steep action potential (AP) restitution curve. In gui...

journal_title：Circulation research

authors： Choi BR,Liu T,Salama G

更新日期：2001-03-16 00:00:00

abstract：:Our goal in this review is to discuss the pathophysiology, diagnosis, and treatment of stroke caused by atherosclerosis of the major intracranial arteries. References for the review were identified by searching PubMed for related studies published from 1955 to June 2016 using search terms intracranial stenosis and int...

journal_title：Circulation research

authors： Banerjee C,Chimowitz MI

更新日期：2017-02-03 00:00:00

abstract：:Although atrial fibrillation is the most common serious cardiac arrhythmia, the fundamental molecular pathways remain undefined. Mutations in KCNQ1, one component of a sympathetically activated cardiac potassium channel complex, cause familial atrial fibrillation, although the mechanisms in vivo are unknown. We show h...

journal_title：Circulation research

authors： Temple J,Frias P,Rottman J,Yang T,Wu Y,Verheijck EE,Zhang W,Siprachanh C,Kanki H,Atkinson JB,King P,Anderson ME,Kupershmidt S,Roden DM

更新日期：2005-07-08 00:00:00

abstract：:Electrical uncoupling at gap junctions during acute myocardial ischemia contributes to conduction abnormalities and reentrant arrhythmias. Increased levels of intracellular Ca(2+) and H(+) and accumulation of amphipathic lipid metabolites during ischemia promote uncoupling, but other mechanisms may play a role. We tes...

journal_title：Circulation research

authors： Beardslee MA,Lerner DL,Tadros PN,Laing JG,Beyer EC,Yamada KA,Kléber AG,Schuessler RB,Saffitz JE

更新日期：2000-10-13 00:00:00

abstract：:Thrombin stimulates synthesis and secretion of endothelin-1 (ET-1), a vasoactive peptide that triggers responses in the vascular endothelium and smooth muscle. We investigated the signal transduction pathways by which thrombin stimulates preproET-1 gene expression and ET-1 peptide secretion in macrovascular cells (hum...

journal_title：Circulation research

authors： Marsen TA,Simonson MS,Dunn MJ

更新日期：1995-06-01 00:00:00

abstract：:The myocardium contains collagen matrix that is a major determinant of its architecture, structural integrity, and mechanical properties. This fibrillar matrix consists primarily of type I and type III collagens having epimysial, perimysial, and endomysial components. The present study shows the alteration of collagen...

journal_title：Circulation research

authors： Mukherjee D,Sen S

更新日期：1990-12-01 00:00:00

abstract：:Although clinical trials of cell-based approaches to cardiovascular disease have yielded some promising results, no cell-based therapy has achieved regulatory approval for a cardiovascular indication. To broadly assess the challenges to regulatory approval and identify strategies to facilitate this goal, the Cardiac S...

journal_title：Circulation research

authors： Fanaroff AC,Morrow V,Krucoff MW,Seltzer JH,Perin EC,Taylor DA,Miller LW,Zeiher AM,Fernández-Avilés F,Losordo DW,Henry TD,Povsic TJ

更新日期：2018-08-03 00:00:00

abstract：:A variety of delivery systems have been used to genetically modify vascular endothelial cells and smooth muscle cells (SMCs), but currently available systems suffer from either inefficient in vivo gene transfer, transient episomal vector expression, or significant immune responses and inflammation. In the present stud...

journal_title：Circulation research

authors： Lynch CM,Hara PS,Leonard JC,Williams JK,Dean RH,Geary RL

更新日期：1997-04-01 00:00:00

abstract：:To see how serotonin affects filtration from lung vessels, we measured vascular pressures, lung lymph flow, lung lymph and blood plasma protein concentrations, arterial blood gases, cardiac output, and lung water content in unanesthetized sheep before and during intravenous serotonin infusions and compared serotonin e...

journal_title：Circulation research

authors： Brigham KL,Owen PJ

更新日期：1975-06-01 00:00:00

abstract：:Disturbances in cardiac metabolism underlie most cardiovascular diseases. Metabolomics, one of the newer omics technologies, has emerged as a powerful tool for defining changes in both global and cardiac-specific metabolism that occur across a spectrum of cardiovascular disease states. Findings from metabolomics studi...

journal_title：Circulation research

authors： McGarrah RW,Crown SB,Zhang GF,Shah SH,Newgard CB

更新日期：2018-04-27 00:00:00

abstract：:RhoA and Rac1 regulate formation of stress fibers and intercellular junctions, thus modulating endothelial monolayer permeability. Posttranslational modifications of RhoA and Rac1 regulate enzyme activity and subcellular localization, resulting in altered cellular function. The role of RhoA and Rac1 carboxyl methylati...

journal_title：Circulation research

authors： Lu Q,Harrington EO,Hai CM,Newton J,Garber M,Hirase T,Rounds S

更新日期：2004-02-20 00:00:00

abstract：:Structural remodeling of the ventricular wall is a key determinant of clinical outcome in heart disease. Such remodeling involves the production and destruction of extracellular matrix proteins, cell proliferation and migration, and apoptotic and necrotic cell death. Cardiac fibroblasts are crucially involved in these...

journal_title：Circulation research

authors： Manabe I,Shindo T,Nagai R

更新日期：2002-12-13 00:00:00

abstract：:Although peroxisome proliferator-activated receptor gamma (PPARgamma) ligands have an antihypertensive effect in vivo, the precise mechanism has not been fully elucidated. We examined their effects on Rho/Rho kinase pathway, a key regulator of vascular tone. In cultured rat aortic smooth muscle cells (RASMC), Rho kina...

journal_title：Circulation research

authors： Wakino S,Hayashi K,Kanda T,Tatematsu S,Homma K,Yoshioka K,Takamatsu I,Saruta T

更新日期：2004-09-03 00:00:00

abstract：:When exposed to an increasing transmural pressure, middle cerebral arteries of the cat exhibit reduction of internal diameter which is mediated by vascular muscle cell depolarization. This laboratory has recently demonstrated that this "pressure-induced" activation is dependent upon the presence of an intact endotheli...

journal_title：Circulation research

authors： Harder DR,Sanchez-Ferrer C,Kauser K,Stekiel WJ,Rubanyi GM

更新日期：1989-07-01 00:00:00

abstract：:The extracellular epicardial potential fields produced by simple depolarization waves in the in situ canine left ventricular myocardium were analyzed. A mathematical model that included tissue anisotrophy was developed to explain the observed fields. Values of intracellular (i), extracellular (o), longitudinal (l), an...

journal_title：Circulation research

authors： Roberts DE,Scher AM

更新日期：1982-03-01 00:00:00

abstract：:The introduction of statins ≈ 30 years ago ushered in the era of lipid lowering as the most effective way to reduce risk of atherosclerotic cardiovascular disease. Nonetheless, residual risk remains high, and statin intolerance is frequently encountered in clinical practice. After a long dry period, the field of thera...

journal_title：Circulation research

authors： Shapiro MD,Fazio S

更新日期：2016-02-19 00:00:00

abstract：:The potential for heparin to enhance the training-induced increase in collateral-dependent blood flow to the distal hind-limb muscles was evaluated after bilateral femoral artery ligation in adult male rats (approximately 350 g). Rats received either saline (n = 34) or heparin (n = 36) injections and were kept sedenta...

journal_title：Circulation research

authors： Yang HT,Ogilvie RW,Terjung RL

更新日期：1995-03-01 00:00:00

abstract：:We tested the hypothesis that a parenchymally derived mediator is required for arterioles to exhibit oxygen sensitivity. To that end, the parenchyma was dissected and removed from around hamster cheek pouch arterioles, and the oxygen sensitivity of these "aparenchymal arteriolar segments" was studied, either in vitro,...

journal_title：Circulation research

authors： Jackson WF,Duling BR

更新日期：1983-10-01 00:00:00

abstract：:Vascular disease in diabetics could arise in part from altered vessel wall catebolism. Specific activities of hydrolases in aortic smooth muscle cells from rats with streptozotocin-induced diabetes were measured. Enyzmes included: neutral alpha-glucosidase, alpha-mannosidase, and lysosomal N-acetyl beta-glucosaminidas...

journal_title：Circulation research

authors： Wolinsky H,Goldfischer S,Capron L,Capron F,Coltoff-Schiller B,Kasak L

更新日期：1978-06-01 00:00:00

abstract：:Calcium uptake was measured in homogenates and microsomal preparations enriched in sarcoplasmic reticulum vesicles isolated from hearts of hypertrophic (BIO 14.6) and dilated (BIO 53.58) cardiomyopathic as well as control (F1B) Syrian hamsters at 3, 7, 9, and 11 months of age. Calcium uptake studies were done using th...

journal_title：Circulation research

authors： Whitmer JT,Kumar P,Solaro RJ

更新日期：1988-01-01 00:00:00

abstract：:Although it has been established that myocyte enhancer factor 2 (MEF2) plays pivotal roles in the development of the cardiovascular system as well as skeletal muscle cells, little is known of its role in vascular inflammatory diseases such as atherosclerosis and restenosis after angioplasty. To investigate the role of...

journal_title：Circulation research

authors： Suzuki E,Satonaka H,Nishimatsu H,Oba S,Takeda R,Omata M,Fujita T,Nagai R,Hirata Y

更新日期：2004-07-09 00:00:00

abstract：:The programmed onset of myocardial dysfunction and its progression to congestive heart failure in the cardiomyopathic Syrian hamster is hallmarked by alterations in myocellular calcium regulation. To determine whether calcium channel blockade is effective in halting the progressive depression of myocardial contractile...

journal_title：Circulation research

authors： Capasso JM,Sonnenblick EH,Anversa P

更新日期：1990-12-01 00:00:00

abstract：:Previous studies have demonstrated that in adult rats with chronic hyponatremia, both symptoms of encephalopathy and mortality largely depend upon the gender of the animal and the presence of elevated plasma levels of vasopressin (AVP). Since effects of AVP on blood vessels may be gender dependent, the present study w...

journal_title：Circulation research

authors： Kozniewska E,Roberts TP,Vexler ZS,Oseka M,Kucharczyk J,Arieff AI

更新日期：1995-04-01 00:00:00

abstract：:Previously, it was shown that the D enantiomer of isoidide dinitrate was 10-fold more potent than the L enantiomer and 10-fold less potent than glyceryl trinitrate for stimulating cyclic GMP accumulation and relaxation of isolated rat aorta. In the present study, these organic nitrates were tested for their ability to...

journal_title：Circulation research

authors： Bennett BM,Schröder H,Hayward LD,Waldman SA,Murad F

更新日期：1988-10-01 00:00:00

abstract：:The 2-amino-3-benzoylthiophene derivative PD 81,723 is an allosteric enhancer of agonist binding to brain A1 adenosine receptors. One aim of this study was to characterize and contrast the effects of PD 81,723 on the A1 receptor-mediated negative dromotropic and A2a receptor-mediated vasodilatory actions of adenosine ...

journal_title：Circulation research

authors： Kollias-Baker C,Ruble J,Dennis D,Bruns RF,Linden J,Belardinelli L

更新日期：1994-12-01 00:00:00