Gap junctional conductance in ventricular myocyte pairs isolated from postischemic rabbit myocardium.

abstract：:Among the factors that might influence collateral arterial growth after arterial occlusion, the capacity to deliver blood flow in relation to metabolic need and work performance are obvious candidates. In this study in rats after superficial femoral artery ligation, we assessed collateral arterial growth (by arteriogr...

journal_title：Circulation research

authors： Paskins-Hurlburt AJ,Hollenberg NK

更新日期：1992-03-01 00:00:00

abstract：RATIONALE:Although PSA (prostate-specific antigen)-a tumor marker for prostate cancer-has been reported to be associated with cardiovascular disease (CVD) risk factors, studies on the association of PSA with subclinical and clinical CVD remain limited. OBJECTIVE:We examined the association of total serum PSA within th...

journal_title：Circulation research

authors： Chang Y,Kim JH,Noh JW,Cho YS,Park HJ,Joo KJ,Ryu S

更新日期：2019-05-10 00:00:00

abstract：:In the present study, we established an injury model of the mouse carotid artery. Complete removal of the endothelium was achieved with a flexible wire. A platelet monolayer covered the denuded surface, and damage to underlying medial smooth muscle cells (SMCs) was detected. Injection of [3H]thymidine was used to dete...

journal_title：Circulation research

authors： Lindner V,Fingerle J,Reidy MA

更新日期：1993-11-01 00:00:00

abstract：:The deposition of microspheres in small tissue regions is not strictly flow dependent. In comparison with the soluble flow marker 2-iododesmethylimipramine (IDMI), deposition of 16.5-microns microspheres was mildly but systematically biased into high flow regions of rabbit hearts (Bassingthwaighte JB, Malone MA, Moffe...

journal_title：Circulation research

authors： Bassingthwaighte JB,Malone MA,Moffett TC,King RB,Chan IS,Link JM,Krohn KA

更新日期：1990-05-01 00:00:00

abstract：:The role of the central nervous system in the mechanism(s) involved in acute carotid baroreflex resetting was studied in six conscious, chronically instrumented, aortic-denervated dogs. Dogs were prepared for reversible vascular isolation of the carotid sinuses. Acute baroreflex resetting was induced by holding the le...

journal_title：Circulation research

authors： Tan W,Panzenbeck MJ,Hajdu MA,Zucker IH

更新日期：1989-07-01 00:00:00

abstract：:It is believed that inotropic agents exert their effects in cardiac muscle via a modulation of Ca2+ cycling; however, the involvement of phospholipase activation and the biochemical pathways participating in inotropic responsiveness remain unclear. The aim of the current study was to determine whether arachidonic acid...

journal_title：Circulation research

authors： Damron DS,Bond M

更新日期：1993-02-01 00:00:00

abstract：RATIONALE:One goal of cardiac tissue engineering is the generation of a living, human pump in vitro that could replace animal models and eventually serve as an in vivo therapeutic. Models that replicate the geometrically complex structure of the heart, harboring chambers and large vessels with soft biomaterials, can be...

journal_title：Circulation research

authors： Kupfer ME,Lin WH,Ravikumar V,Qiu K,Wang L,Gao L,Bhuiyan DB,Lenz M,Ai J,Mahutga RR,Townsend D,Zhang J,McAlpine MC,Tolkacheva EG,Ogle BM

更新日期：2020-07-03 00:00:00

abstract：:Congenital heart defects affect almost 1% of human newborns. Recently, mutations in Notch ligands and receptors have been found to cause a variety of heart defects in rodents and humans. However, the molecular effects downstream of Notch are still poorly understood. Here we report that combined inactivation of Hey1 an...

journal_title：Circulation research

authors： Fischer A,Steidl C,Wagner TU,Lang E,Jakob PM,Friedl P,Knobeloch KP,Gessler M

更新日期：2007-03-30 00:00:00

abstract：:Vascular endothelial cells respond to laminar shear stress by aligning in the direction of flow, a process which may contribute to atheroprotection. Here we report that localized alpha4 integrin phosphorylation is a mechanism for establishing the directionality of shear stress-induced alignment in microvascular endoth...

journal_title：Circulation research

authors： Goldfinger LE,Tzima E,Stockton R,Kiosses WB,Kinbara K,Tkachenko E,Gutierrez E,Groisman A,Nguyen P,Chien S,Ginsberg MH

更新日期：2008-07-18 00:00:00

abstract：:Collagens are abundant within the atherosclerotic plaque, where they contribute to lesion volume and mechanical stability and influence cell signaling. The discoidin domain receptor 1 (DDR1), a receptor tyrosine kinase that binds to collagen, is expressed in blood vessels, but evidence for a functional role during ath...

journal_title：Circulation research

authors： Franco C,Hou G,Ahmad PJ,Fu EY,Koh L,Vogel WF,Bendeck MP

更新日期：2008-05-23 00:00:00

abstract：:Increasing evidence indicates that the control of cell proliferation and apoptosis are linked. The c-myc proto-oncogene is induced early after cell-cycle entry in vascular smooth muscle cells (VSMCs) in vitro and after arterial injury and regulates both cell proliferation and apoptosis. Although both proliferation and...

journal_title：Circulation research

authors： Macdonald K,Bennett MR

更新日期：1999-04-16 00:00:00

abstract：:Recent evidence suggests that dopamine may alter kidney function by actions not only in the renal vasculature but also at the glomerular-mesangial level. We studied this phenomenon by examining the ability of dopamine to antagonize the contractile properties of angiotensin II in isolated rat glomeruli and cultured mes...

journal_title：Circulation research

authors： Barnett R,Singhal PC,Scharschmidt LA,Schlondorff D

更新日期：1986-11-01 00:00:00

abstract：RATIONALE:Postconditioning at the time of primary percutaneous coronary intervention (PCI) for ST-segment-elevation myocardial infarction may reduce infarct size and improve myocardial salvage. However, clinical trials have shown inconsistent benefit. OBJECTIVE:We performed the first National Heart, Lung, and Blood In...

journal_title：Circulation research

authors： Traverse JH,Swingen CM,Henry TD,Fox J,Wang YL,Chavez IJ,Lips DL,Lesser JR,Pedersen WR,Burke NM,Pai A,Lindberg JL,Garberich RF

更新日期：2019-03-01 00:00:00

abstract：:The goal of this study was to test the hypothesis that the cardioprotective effects of the late phase of ischemic preconditioning (PC) can be mimicked by treatment with NO donors. In phase I (studies of myocardial stunning), conscious rabbits underwent a sequence of six 4-minute coronary occlusion/4-minute reperfusion...

journal_title：Circulation research

authors： Takano H,Tang XL,Qiu Y,Guo Y,French BA,Bolli R

更新日期：1998-07-13 00:00:00

abstract：:Some statistical techniques for analyzing the kinds of studies typically reported in Circulation Research are described. Particular emphasis is given to the comparison of means from more than two populations, the joint effect of several experimentally controlled variables, and the analysis of studies with repeated mea...

journal_title：Circulation research

authors： Wallenstein S,Zucker CL,Fleiss JL

更新日期：1980-07-01 00:00:00

abstract：:Contraction and relaxation of vascular smooth muscle and cardiac myocytes are key physiological events in the cardiovascular system. These events are regulated by second messengers, cAMP and cGMP, in response to extracellular stimulants. The strength of signal transduction is controlled by intracellular cyclic nucleot...

journal_title：Circulation research

authors： Omori K,Kotera J

更新日期：2007-02-16 00:00:00

abstract：RATIONALE:We have previously demonstrated that the importance of endothelium-derived hyperpolarizing factor (EDHF) increases as the vessel size decreases and that endothelium-derived hydrogen peroxide (H(2)O(2)) is an EDHF in animals and humans, for which endothelial nitric oxide synthase (eNOS) is the major source. Re...

journal_title：Circulation research

authors： Nakajima S,Ohashi J,Sawada A,Noda K,Fukumoto Y,Shimokawa H

更新日期：2012-06-22 00:00:00

abstract：:We tested a number of hypotheses concerning the mechanism of K+-induced vasodilation of the coronary vascular bed. Blood flow in the circumflex artery was measured in pentobarbital-anesthetized, open-chest dogs. Intracircumflex artery bolus injections of 40 mumol of isomotic KCl produced decreases in coronary vascular...

journal_title：Circulation research

authors： Murray PA,Sparks HV

更新日期：1978-01-01 00:00:00

abstract：:Tyrosine kinase cascades may play a role in the hypoxic regulation of hypoxia-inducible factor (HIF)-1. We investigated the role of tyrosine kinase phosphorylation and of the Shc/Ras cascade on hypoxic HIF-1 stabilization. Exposure of human umbilical vein endothelial cells to hypoxia results in HIF protein stabilizati...

journal_title：Circulation research

authors： Jung F,Haendeler J,Hoffmann J,Reissner A,Dernbach E,Zeiher AM,Dimmeler S

更新日期：2002-07-12 00:00:00

abstract：:Magnesium modulates vascular smooth muscle cell (VSMC) function. However, molecular mechanisms regulating VSMC Mg2+ remain unknown. Using biochemical, pharmacological, and genetic tools, the role of transient receptor potential membrane melastatin 7 (TRPM7) cation channel in VSMC Mg2+ homeostasis was evaluated. Rat, m...

journal_title：Circulation research

authors： He Y,Yao G,Savoia C,Touyz RM

更新日期：2005-02-04 00:00:00

abstract：:Heterozygous familial hypercholesterolemia (FH) is a highly atherogenic genetic disorder leading to premature coronary heart disease (CHD), usually before 60 years of age. We studied an extended multigenerational kindred with FH linked to chromosome 1p32 in which atherosclerotic complications were either delayed or pr...

journal_title：Circulation research

authors： Canizales-Quinteros S,Aguilar-Salinas CA,Reyes-Rodríguez E,Riba L,Rodríguez-Torres M,Ramírez-Jiménez S,Huertas-Vázquez A,Fragoso-Ontiveros V,Zentella-Dehesa A,Ventura-Gallegos JL,Vega-Hernández G,López-Estrada A,Aurón-Gómez M,G

更新日期：2003-03-21 00:00:00

abstract：:The purpose of this study was to develop an isolated tissue model in which arrhythmic activity could be generated in response to conditions encountered in ischemia followed by reperfusion, and in which intracellular recordings could be used to identify and study arrhythmogenic mechanisms. Isolated canine Purkinje fibe...

journal_title：Circulation research

authors： Ferrier GR,Moffat MP,Lukas A

更新日期：1985-02-01 00:00:00

abstract：:Postischemic endothelial dysfunction may occur as a result of the effects of endogenous oxidants like hydrogen peroxide. Since endothelium-dependent vasodilator function may be affected by pHi, the effect of hydrogen peroxide on endothelial pHi was examined. Hydrogen peroxide (100 micromol/L for 10 minutes) decreased ...

journal_title：Circulation research

authors： Hu Q,Xia Y,Corda S,Zweier JL,Ziegelstein RC

更新日期：1998-09-21 00:00:00

abstract：:Diadenosine triphosphate is present in platelet-dense granules and released quantitatively on platelet aggregation. We have found that intact porcine aortic endothelial cells can efficiently hydrolyze extracellular diadenosine triphosphate. The products of diadenosine triphosphate hydrolysis are adenosine monophosphat...

journal_title：Circulation research

authors： Goldman SJ,Gordon EL,Slakey LL

更新日期：1986-09-01 00:00:00

abstract：:The influence of inhibition of the Na+ pump, with secondary stimulation of Na+-Ca++ exchange, on cellular Ca++ distribution is examined using the on-line scintillation disk technique and cultured neonatal rat myocardial cells. Under control conditions, La+++ displaced 78.1 +/- 1.13% (SEM) of the total cell associated ...

journal_title：Circulation research

authors： Burt JM,Langer GA

更新日期：1982-11-01 00:00:00

abstract：RATIONALE:Microparticles are cell-derived membrane vesicles, relevant to a range of biological responses and known to be elevated in cardiovascular disease. OBJECTIVE:To investigate microparticle release during cardiac stress and how this response differs in those with vascular disease. METHODS AND RESULTS:We measure...

journal_title：Circulation research

authors： Augustine D,Ayers LV,Lima E,Newton L,Lewandowski AJ,Davis EF,Ferry B,Leeson P

更新日期：2014-01-03 00:00:00

abstract：:Ventricular/vascular coupling dynamics and regional hemodynamics of five hypertensive baboons with concentric left ventricular (LV) hypertrophy (mean arterial pressure +/- SD, 148 +/- 16 mm Hg; LV mass/body weight ratio 3.42 +/- 0.8) were compared with five normotensive controls (mean arterial pressure 89 +/- 3 mm Hg;...

journal_title：Circulation research

authors： Latham RD,Rubal BJ,Sipkema P,Westerhof N,Virmani R,Robinowitz M,Walsh RA

更新日期：1988-10-01 00:00:00

abstract：RATIONALE:Circulating progenitor cells (CPCs) mobilize in response to ischemic injury, but their predictive value remains unknown in acute coronary syndrome (ACS). OBJECTIVE:We aimed to investigate the number of CPCs in ACS compared with those with stable coronary artery disease (CAD), relationship between bone marrow...

journal_title：Circulation research

authors： Samman Tahhan A,Hammadah M,Raad M,Almuwaqqat Z,Alkhoder A,Sandesara PB,Mohamed-Kelli H,Hayek SS,Kim JH,O'Neal WT,Topel ML,Grant AJ,Sabbak N,Heinl RE,Gafeer MM,Obideen M,Kaseer B,Abdelhadi N,Ko YA,Liu C,Hesaroieh I

更新日期：2018-05-25 00:00:00

abstract：:The present study investigated the effect of adrenomedullin, a novel vasorelaxant peptide, on the migration of cultured rat vascular smooth muscle cells (SMCs) by using the Boyden-chamber method. Fetal calf serum (FCS) and platelet-derived growth factor (PDGF)-BB strongly stimulated SMC migration. Adrenomedullin clear...

journal_title：Circulation research

authors： Horio T,Kohno M,Kano H,Ikeda M,Yasunari K,Yokokawa K,Minami M,Takeda T

更新日期：1995-10-01 00:00:00

abstract：:Atherosclerotic lesion development seems to be inflammatory in nature and involves the recruitment of monocytes to the vessel wall. In this study, we investigated the role of vascular cell adhesion molecule-1 (VCAM-1) and fibronectin (FN) connecting segment-1 containing the amino acid sequence ILDV as functional ligan...

journal_title：Circulation research

authors： Huo Y,Hafezi-Moghadam A,Ley K

更新日期：2000-07-21 00:00:00