"Tissue need" and limb collateral arterial growth. Skeletal contractile power and perfusion during collateral development in the rat.

abstract：:The relationship between cell swelling and plasma membrane disruption has been evaluated in thin myocardial slices incubated in oxygenated or anoxic Krebs-Ringer phosphate media. Electron microscopy and measurements of inulin-diffusible space were used to monitor plasma membrane integrity. Inulin is excluded from the ...

journal_title：Circulation research

authors： Steenbergen C,Hill ML,Jennings RB

更新日期：1985-12-01 00:00:00

abstract：:Existing evidence led us to hypothesize that increases in p85alpha, a regulatory subunit of PI3-kinase, in presympathetic brain areas contribute to hypertension. PI3-kinase p85alpha, p110alpha, and p110delta mRNA was 1.5- to 2-fold higher in the paraventricular nucleus (PVN) of spontaneously hypertensive rats (SHR) co...

journal_title：Circulation research

authors： Veerasingham SJ,Yamazato M,Berecek KH,Wyss JM,Raizada MK

更新日期：2005-02-18 00:00:00

abstract：:Aging of the vasculature plays a central role in morbidity and mortality of older people. To develop novel treatments for amelioration of unsuccessful vascular aging and prevention of age-related vascular pathologies, it is essential to understand the cellular and functional changes that occur in the vasculature durin...

journal_title：Circulation research

authors： Ungvari Z,Tarantini S,Donato AJ,Galvan V,Csiszar A

更新日期：2018-09-14 00:00:00

abstract：:Previous work has shown that neutrophils isolated from whole blood adhere to cardiac-myocytes via CD18 (beta 2 integrin) to cause injury to the heart cells. In vitro, we have found that upon endothelial transmigration, neutrophils can also express alpha 4 beta 1; however, whether this contributes to neutrophil adhesio...

journal_title：Circulation research

authors： Reinhardt PH,Ward CA,Giles WR,Kubes P

更新日期：1997-08-01 00:00:00

abstract：:We determined the effects of indomethacin and meclofenamate, two inhibitors of prostaglandin synthesis, on renal vascular resistance and on renal responses to nerve stimulation, pressor and depressor hormones in the in situ feline kidney under conditions of controlled blood flow. Both inhibitors produced a gradual ris...

journal_title：Circulation research

authors： Chapnick BM,Paustian PW,Feigen LP,Joiner PD,Hyman AL,Kadowitz PJ

更新日期：1977-04-01 00:00:00

abstract：:Hypercholesterolemia induces atheroma formation, and the concentration of sphingomyelin is increased compared with that in the normal aortic intima-media. The aortic intima-media sphingomyelin concentration appears to increase exponentially with time on the cholesterol diet. Moreover, the entry rate of serum sphingomy...

journal_title：Circulation research

authors： Seth SK,Newman AI

更新日期：1975-02-01 00:00:00

abstract：:The daily rate of cell replication in the aortic endothelium of the normal rat falls from a maximum of 13% at birth to 0.1-0.3% at age 5-6 months. This residual rate of replication largely represents the turnover rate of the endothelium in normal animals. After renal hypertension of 2-3 weeks duration, however, the ra...

journal_title：Circulation research

authors： Schwartz SM,Benditt EP

更新日期：1977-08-01 00:00:00

abstract：:Mitral regurgitation (MR) causes ventricular dilation, a blunted myocardial force-frequency relation, and increased crossbridge force-time integral (FTI). The mechanism of FTI increase was investigated using sinusoidal length perturbation analysis to compare crossbridge function in skinned left ventricular (LV) epicar...

journal_title：Circulation research

authors： Mulieri LA,Barnes W,Leavitt BJ,Ittleman FP,LeWinter MM,Alpert NR,Maughan DW

更新日期：2002-01-11 00:00:00

abstract：:We measured pressure-volume curves in nine excised dog ventricles and stress-strain curves in two to five muscle specimens from each ventricle to verify a derived formula that relates muscle stiffness to the ventricular pressure-volume curve. The assumptions underlying this formula are: (1) the ventricle is a uniform ...

journal_title：Circulation research

authors： Glantz SA,Kernoff RS

更新日期：1975-12-01 00:00:00

abstract：:Cultured quail myocytes were much more resistant to H2O2 toxicity than cultured mouse myocytes. The intracellular concentration of glutathione ([GSH]i) and the activity of gamma-glutamylcysteine synthetase (gamma-GCS) in quail heart cells were about five and three times higher, respectively, than in mouse heart cells,...

journal_title：Circulation research

authors： Nakamura TY,Yamamoto I,Kanno Y,Shiba Y,Goshima K

更新日期：1994-05-01 00:00:00

abstract：:Deepak Srivastava’s group at the Gladstone Institute of Cardiovascular Disease, University of California San Francisco, reported in the August 6 issue of the journal Cell that to make heart muscle cells, all you need are three factors and some fibroblasts. But is it really that easy? ...

journal_title：Circulation research

authors： Williams R

更新日期：2010-10-29 00:00:00

abstract：:Caspase-1 processes the interleukin (IL)-1beta and IL-18 inactive precursors to the biologically active cytokines that are known to have proatherogenic effects. The present study investigated the genetic variability of the CASP1 gene and plasma levels of caspase-1 in relation to cardiovascular risk. In Europeans, 3 ta...

journal_title：Circulation research

authors： Blankenberg S,Godefroy T,Poirier O,Rupprecht HJ,Barbaux S,Bickel C,Nicaud V,Schnabel R,Kee F,Morrison C,Evans A,Lackner KJ,Cambien F,Münzel T,Tiret L,AtheroGene Investigators.

更新日期：2006-07-07 00:00:00

abstract：:Osteopontin (OPN) is a cytokine upregulated in diabetic vascular disease. To better understand its role in vascular remodeling, we assessed how OPN controls metalloproteinase (MMP) activation in aortic adventitial myofibroblasts (AMFs) and A7r5 vascular smooth muscle cells (VSMCs). By zymography, OPN and tumor necrosi...

journal_title：Circulation research

authors： Lai CF,Seshadri V,Huang K,Shao JS,Cai J,Vattikuti R,Schumacher A,Loewy AP,Denhardt DT,Rittling SR,Towler DA

更新日期：2006-06-23 00:00:00

abstract：:The responses of cardiac mitochondria to anoxia may be evaluated in terms of the oxidation-reduction state of the electron carriers and the ability of the mitochondria to function in energy-linked reactions. The previous detailed evaluation of the oxygen requirements for electron transfer in mitochondria is here exten...

journal_title：Circulation research

authors： Chance B

更新日期：1976-05-01 00:00:00

abstract：:Herein, we show that the paired-related homeobox gene, Prx1, is required for lung vascularization. Initial studies revealed that Prx1 localizes to differentiating endothelial cells (ECs) within the fetal lung mesenchyme, and later within ECs forming vascular networks. To begin to determine whether Prx1 promotes EC dif...

journal_title：Circulation research

authors： Ihida-Stansbury K,McKean DM,Gebb SA,Martin JF,Stevens T,Nemenoff R,Akeson A,Vaughn J,Jones PL

更新日期：2004-06-11 00:00:00

abstract：:Since the first description of the anatomical atrioventricular nodes (AVNs), a large number of studies have provided insights into the heterogeneity of the structure as well as a repertoire of ion channel proteins that govern this complex conduction pathway between the atria and ventricles. These studies have revealed...

journal_title：Circulation research

authors： Zhang Q,Timofeyev V,Lu L,Li N,Singapuri A,Long MK,Bond CT,Adelman JP,Chiamvimonvat N

更新日期：2008-02-29 00:00:00

abstract：RATIONALE:Nuclear factor of activated T-cells (NFAT) is importantly implicated in pathological cardiac remodeling and vascular lesion formation. NFAT functionality is mainly regulated by calcineurin, a Ca(2+)-dependent multi-effector phosphatase. Calcineurin inhibitors such as cyclosporine A (CsA) were shown to be effe...

journal_title：Circulation research

authors： Yu H,Bot I,Sliedregt K,Xu X,Bot M,van Heiningen SH,van der Marel GA,Bennett MR,Overkleeft H,van Berkel TJ,Biessen EA

更新日期：2012-01-20 00:00:00

abstract：:Smooth muscle expresses the Ialpha and the Ibeta isoforms of cGMP-dependent protein kinase I (cGKI). Inactivation of the murine cGKI gene prkg1 leads to multiple phenotypes and premature death at approximately 6 weeks. We reconstituted mice with the cGKIalpha or -Ibeta isozyme to test which isozyme was needed to suppo...

journal_title：Circulation research

authors： Weber S,Bernhard D,Lukowski R,Weinmeister P,Wörner R,Wegener JW,Valtcheva N,Feil S,Schlossmann J,Hofmann F,Feil R

更新日期：2007-11-26 00:00:00

abstract：:The dystrophin-glycoprotein complex is a large complex of membrane-associated proteins linking the cytoskeleton to the extracellular matrix in muscle. Transmembrane heterodimeric (alphabeta) integrins serve also as cellular adhesion molecules and mechanotransducers. In the animal model for Duchenne muscular dystrophy,...

journal_title：Circulation research

authors： Elsherif L,Huang MS,Shai SY,Yang Y,Li RY,Chun J,Mekany MA,Chu AL,Kaufman SJ,Ross RS

更新日期：2008-05-09 00:00:00

abstract：:Myocardial responses to acute ischemia/reperfusion and to chronic ischemic conditions have been studied extensively at all levels of organization. These include subcellular (eg, mitochondria in vitro); intact, large animal models (eg, swine with chronic coronary stenosis); as well as human subjects. Investigations in ...

journal_title：Circulation research

authors： Gewirtz H,Dilsizian V

更新日期：2017-03-31 00:00:00

abstract：:We previously observed that stimulation of vascular smooth muscle cell (VSMC) proliferation with growth factors is associated with dismantling of cadherin junctions and nuclear translocation of beta-catenin. In this study we demonstrate directly that growth factors stimulate beta-catenin/T-cell factor (TCF) signaling ...

journal_title：Circulation research

authors： Quasnichka H,Slater SC,Beeching CA,Boehm M,Sala-Newby GB,George SJ

更新日期：2006-12-08 00:00:00

abstract：:Red blood cells and lysate products (erythrolysate) are observed consistently in lymph draining acute and chronic inflammatory reactions and from tissues subjected to trauma or surgical procedures. Using hemoglobin as a marker for erythrolysate, we have measured hemoglobin in lymph up to the 10(-6) M range in a number...

journal_title：Circulation research

authors： Elias RM,Wandolo G,Ranadive NS,Eisenhoffer J,Johnston MG

更新日期：1990-11-01 00:00:00

abstract：:Cardiovascular aging is associated with decreased endothelial vasoreactivity and prolonged diastolic relaxation. As diminished NO signaling contributes to age-associated endothelial dysfunction, we tested the hypothesis that impaired NO signaling or bioactivity also contributes to slowed ventricular relaxation with ag...

journal_title：Circulation research

authors： Zieman SJ,Gerstenblith G,Lakatta EG,Rosas GO,Vandegaer K,Ricker KM,Hare JM

更新日期：2001-01-19 00:00:00

abstract：:The ionic currents that cross the myocardial membrane during cardiac activation have a corresponding return path in the extracellular space. The transmembrane current (Im) during activation of cardiac cells in situ has previously been envisioned only in mathematical models. We have developed a remarkably simple in viv...

journal_title：Circulation research

authors： Witkowski FX,Kavanagh KM,Penkoske PA,Plonsey R

更新日期：1993-02-01 00:00:00

abstract：:To investigate the functional consequences of a tropomyosin (TM) mutation associated with familial hypertrophic cardiomyopathy (FHC), we generated transgenic mice that express mutant alpha-TM in the adult heart. The missense mutation, which results in the substitution of asparagine for aspartic acid at amino acid posi...

journal_title：Circulation research

authors： Muthuchamy M,Pieples K,Rethinasamy P,Hoit B,Grupp IL,Boivin GP,Wolska B,Evans C,Solaro RJ,Wieczorek DF

更新日期：1999-07-09 00:00:00

abstract：:The transcription factor nuclear factor-kappaB (NF-kappaB) plays a pivotal role in the coordinated transactivation of cytokine and adhesion molecule genes involved in endothelial activation. Although recent reports have documented the contribution of NF-kappaB to apoptosis, it is still controversial. Especially, the r...

journal_title：Circulation research

authors： Matsushita H,Morishita R,Nata T,Aoki M,Nakagami H,Taniyama Y,Yamamoto K,Higaki J,Yasufumi K,Ogihara T

更新日期：2000-05-12 00:00:00

abstract：:Calcium channel blockers (CCBs), which are used clinically for treatment of angina and hypertension, are known to inhibit calcium influx into arterial smooth muscle cells and thereby decrease smooth muscle cell contraction. In addition, they prevent cholesteryl ester (CE) accumulation, the hallmark of human atheroscle...

journal_title：Circulation research

authors： Etingin OR,Hajjar DP

更新日期：1990-01-01 00:00:00

abstract：:Congenital heart disease (CHD) is the most common congenital anomaly in newborn babies. Cardiac malformations have been produced in multiple experimental animal models, by perturbing selected molecules that function in the developmental pathways involved in myocyte specification, differentiation, or cardiac morphogene...

journal_title：Circulation research

authors： Fahed AC,Gelb BD,Seidman JG,Seidman CE

更新日期：2013-02-15 00:00:00

abstract：:Patients with peripheral artery disease (PAD) are at heightened risk of both systemic cardiovascular adverse events, as well as limb-related morbidity. The optimal management of patients with PAD requires a comprehensive treatment strategy incorporating both lifestyle changes, including smoking cessation and exercise,...

journal_title：Circulation research

authors： Bonaca MP,Creager MA

更新日期：2015-04-24 00:00:00

abstract：:Extracellular ATP plays an important role in the regulation of prostacyclin and nitric oxide release from vascular endothelial cells. These cellular responses to ATP are generally attributed to the stimulation of the P2y subtype of P2 purinergic receptors. However, it has recently been suggested that two types of ATP ...

journal_title：Circulation research

authors： Motte S,Pirotton S,Boeynaems JM

更新日期：1993-03-01 00:00:00