The mechanism of K+-induced vasodilation of the coronary vascular bed of the dog.

abstract：:To investigate the contributions of humoral and hemodynamic factors to cardiac adaptations associated with chronic exercise, female Fischer 344 rats were subjected to chronic swimming, infrarenal cardiac transplantation, or both. Swimming resulted in hypertrophy (11-12%) of the in situ hearts in both the unoperated an...

journal_title：Circulation research

authors： Advani SV,Geenen D,Malhotra A,Factor SM,Scheuer J

更新日期：1990-09-01 00:00:00

abstract：:Remodeling of the uterine spiral arteries during pregnancy transforms them from high to low resistance vessels that lack vasoconstrictive properties. This process is essential to meet the demand for increased blood flow imposed by the growing fetus. Loss of endothelial and smooth muscle cells (SMC) is evident in remod...

journal_title：Circulation research

authors： Keogh RJ,Harris LK,Freeman A,Baker PN,Aplin JD,Whitley GS,Cartwright JE

更新日期：2007-03-30 00:00:00

abstract：RATIONALE:Although PSA (prostate-specific antigen)-a tumor marker for prostate cancer-has been reported to be associated with cardiovascular disease (CVD) risk factors, studies on the association of PSA with subclinical and clinical CVD remain limited. OBJECTIVE:We examined the association of total serum PSA within th...

journal_title：Circulation research

authors： Chang Y,Kim JH,Noh JW,Cho YS,Park HJ,Joo KJ,Ryu S

更新日期：2019-05-10 00:00:00

abstract：:Our objective was to test the hypotheses that 1) myoplasmic [Ca2+] is the primary determinant of crossbridge phosphorylation and that 2) phosphorylation is the primary determinant of crossbridge interactions with the thin filament in swine carotid arterial smooth muscle. We tested these hypotheses by evaluating the re...

journal_title：Circulation research

authors： Rembold CM,Murphy RA

更新日期：1988-09-01 00:00:00

abstract：RATIONALE:The recent discovery of meningeal lymphatics in mammals is reshaping our understanding of fluid homeostasis and cellular waste management in the brain, but visualization and experimental analysis of these vessels is challenging in mammals. Although the optical clarity and experimental advantages of zebrafish ...

journal_title：Circulation research

authors： Castranova D,Samasa B,Venero Galanternik M,Jung HM,Pham VN,Weinstein BM

更新日期：2021-01-08 00:00:00

abstract：:Adenosine, a vasodilator metabolite, is often produced in tissues where the demand for oxygen exceeds the supply. We have recently demonstrated in isolated cannulated arterioles that adenosine and its metabolite, inosine, can also cause vasoconstriction by stimulation of mast cells. Secondary release of histamine and ...

journal_title：Circulation research

authors： Shepherd RK,Linden J,Duling BR

更新日期：1996-04-01 00:00:00

abstract：:We have used tryptic digestion to determine whether Ca(2+) can regulate cardiac ryanodine receptor (RyR) channel gating from within the lumen of the sarcoplasmic reticulum (SR) or whether Ca(2+) must first flow through the channel and act via cytosolically located binding sites. Cardiac RyRs were incorporated into bil...

journal_title：Circulation research

authors： Ching LL,Williams AJ,Sitsapesan R

更新日期：2000-08-04 00:00:00

abstract：:We investigated the combined effectiveness of intra-aortic balloon counterpulsation and hyperosmotic mannitol (25%) on regional myocardial blood flow during acute coronary insufficiency. Cardiac output and paced heart rate were held constant in chloralose-anesthetized dogs during right heart bypass. Acute coronary ins...

journal_title：Circulation research

authors： Watson JT,Fixler DE,Platt MR,Nall BB,Jett GK,Willerson JT

更新日期：1976-06-01 00:00:00

abstract：:Reactive oxygen species and reactive nitrogen species are biological molecules that play important roles in cardiovascular physiology and contribute to disease initiation, progression, and severity. Because of their ephemeral nature and rapid reactivity, these species are difficult to measure directly with high accura...

journal_title：Circulation research

authors： Griendling KK,Touyz RM,Zweier JL,Dikalov S,Chilian W,Chen YR,Harrison DG,Bhatnagar A,American Heart Association Council on Basic Cardiovascular Sciences.

更新日期：2016-08-19 00:00:00

abstract：RATIONALE:Pulmonary hypertensive remodeling is characterized by excessive proliferation, migration, and proinflammatory activation of adventitial fibroblasts. In culture, fibroblasts maintain a similar activated phenotype. The mechanisms responsible for generation/maintenance of this phenotype remain unknown. OBJECTIV...

journal_title：Circulation research

authors： Wang D,Zhang H,Li M,Frid MG,Flockton AR,McKeon BA,Yeager ME,Fini MA,Morrell NW,Pullamsetti SS,Velegala S,Seeger W,McKinsey TA,Sucharov CC,Stenmark KR

更新日期：2014-01-03 00:00:00

abstract：:Whole-cell voltage-clamp experiments were performed on enzymatically dissociated single ventricular myocytes harvested from feline endocardial and epicardial surfaces. The studies were designed to test the hypothesis that the differences in the amplitude of transient outward current (Ito) contribute to the difference ...

journal_title：Circulation research

authors： Furukawa T,Myerburg RJ,Furukawa N,Bassett AL,Kimura S

更新日期：1990-11-01 00:00:00

abstract：:The purpose of this study was to evaluate the limitations of the double sucrose gap voltage clamp technique in the determination of tension-voltage relationships for frog atrial muscle. Tension-voltage relationships were determined under two conditions. In one case we determined both the tension response and slow inwa...

journal_title：Circulation research

authors： Tarr M,Trank JW

更新日期：1976-07-01 00:00:00

abstract：:It is believed that inotropic agents exert their effects in cardiac muscle via a modulation of Ca2+ cycling; however, the involvement of phospholipase activation and the biochemical pathways participating in inotropic responsiveness remain unclear. The aim of the current study was to determine whether arachidonic acid...

journal_title：Circulation research

authors： Damron DS,Bond M

更新日期：1993-02-01 00:00:00

abstract：:Endothelial hyperpermeability induced by inflammatory mediators is a hallmark of sepsis and adult respiratory distress syndrome. Increased levels of the regulatory peptide adrenomedullin (ADM) have been found in patients with systemic inflammatory response. We analyzed the effect of ADM on the permeability of cultured...

journal_title：Circulation research

authors： Hippenstiel S,Witzenrath M,Schmeck B,Hocke A,Krisp M,Krüll M,Seybold J,Seeger W,Rascher W,Schütte H,Suttorp N

更新日期：2002-10-04 00:00:00

abstract：:In the mammalian myocardium, potassium (K(+)) channels control resting potentials, action potential waveforms, automaticity, and refractory periods and, in most cardiac cells, multiple types of K(+) channels that subserve these functions are expressed. Molecular cloning has revealed the presence of a large number of K...

journal_title：Circulation research

authors： Nerbonne JM,Nichols CG,Schwarz TL,Escande D

更新日期：2001-11-23 00:00:00

abstract：:Electrotonic coupling of cardiac myocytes at gap junctions may influence patterns of conduction in myocardium. To delineate the three-dimensional structure and distribution of intercellular junctions, we analyzed serial ultrathin sections of canine myocardium with transmission electron microscopy and disaggregated myo...

journal_title：Circulation research

authors： Hoyt RH,Cohen ML,Saffitz JE

更新日期：1989-03-01 00:00:00

abstract：RATIONALE:Myogenic tone, an important regulator of vascular resistance, is dependent on vascular smooth muscle (VSM) depolarization, can be modulated by endothelial factors, and is increased in several models of hypertension. Intermittent hypoxia (IH) elevates blood pressure and causes endothelial dysfunction. Hydrogen...

journal_title：Circulation research

authors： Jackson-Weaver O,Paredes DA,Gonzalez Bosc LV,Walker BR,Kanagy NL

更新日期：2011-06-10 00:00:00

abstract：:Angiotensin II and its metabolites, [des-Asp-1]-angiotensin II (angiotensin III), [des-(Asp-1,Arg-2)]angiotensin II, and [des-(Asp-1,Arg-2,val-3)]angiotensin II, were measured in arterial and venous plasma from normal rats. Paper chromatography was used to separate the peptides which were measured with a radioimmunoas...

journal_title：Circulation research

authors： Semple PF,Morton JJ

更新日期：1976-06-01 00:00:00

abstract：RATIONALE:MicroRNAs (miRNAs) are short noncoding RNA species generated by the processing of longer precursors by the ribonucleases Drosha and Dicer. Platelets contain large amounts of miRNA that are altered by disease, in particular diabetes mellitus. OBJECTIVE:This study determined why platelet miRNA levels are atten...

journal_title：Circulation research

authors： Elgheznawy A,Shi L,Hu J,Wittig I,Laban H,Pircher J,Mann A,Provost P,Randriamboavonjy V,Fleming I

更新日期：2015-07-03 00:00:00

abstract：:The effects of endothelin on systemic and renal hemodynamics in anesthetized spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats were examined. Endothelin (500 ng i.v. +1,000 ng/hr per 300-g rat) elevated mean blood pressure by 13% (p less than 0.02) and decreased renal blood flow by 71% and glomerular filtrat...

journal_title：Circulation research

authors： Hirata Y,Matsuoka H,Kimura K,Fukui K,Hayakawa H,Suzuki E,Sugimoto T,Sugimoto T,Yanagisawa M,Masaki T

更新日期：1989-11-01 00:00:00

abstract：:Age-related diastolic dysfunction is a major factor in the epidemic of heart failure. In patients hospitalized with heart failure, HFpEF is now as common as heart failure with reduced ejection fraction. We now have many successful treatments for heart failure with reduced ejection fraction, while specific treatment op...

journal_title：Circulation research

authors： Loffredo FS,Nikolova AP,Pancoast JR,Lee RT

更新日期：2014-06-20 00:00:00

abstract：:Structural remodeling of the ventricular wall is a key determinant of clinical outcome in heart disease. Such remodeling involves the production and destruction of extracellular matrix proteins, cell proliferation and migration, and apoptotic and necrotic cell death. Cardiac fibroblasts are crucially involved in these...

journal_title：Circulation research

authors： Manabe I,Shindo T,Nagai R

更新日期：2002-12-13 00:00:00

abstract：:Cultured vascular endothelium displays profound morphological adaptations to shear stress that include planar cell polarity (PCP) that is directed downstream. Endothelial cells in blood vessels are also polarized; however, the direction of polarity is vessel specific, and shear-independent mechanisms have been inferre...

journal_title：Circulation research

authors： McCue S,Dajnowiec D,Xu F,Zhang M,Jackson MR,Langille BL

更新日期：2006-04-14 00:00:00

abstract：:We have cloned from cultured vascular smooth muscle cells a protein tyrosine phosphatase, rat density-enhanced phosphatase-1 (rDEP-1), which is a probable rat homologue of DEP-1/HPTP eta. rDEP-1 is encoded by an 8.7-kb transcript and is expressed as a 180- to 220-kD protein. The rDEP-1 gene is located on human chromos...

journal_title：Circulation research

authors： Borges LG,Seifert RA,Grant FJ,Hart CE,Disteche CM,Edelhoff S,Solca FF,Lieberman MA,Lindner V,Fischer EH,Lok S,Bowen-Pope DF

更新日期：1996-09-01 00:00:00

abstract：:Genetically hypertensive (GH) rats of the New Zealand strain and normotensive (N) rats were sympathectomized from birth with 6-hydroxydopamine (100 mg/kg,s.c, on alternate days, seven treatments). In adult treated rats from each strain (GHTr and NTr), blood pressure was lower than normal. Functional tests and electron...

journal_title：Circulation research

authors： Clark DW,Jones DR,Phelan EL,Devine CE

更新日期：1978-08-01 00:00:00

abstract：RATIONALE:Myocardial infarction causes irreversible tissue damage, leading to heart failure. We recently discovered that canonical Wnt signaling and the Wnt10b ligand are strongly induced in mouse hearts after infarction. Wnt10b regulates cell fate in various organs, but its role in the heart is unknown. OBJECTIVE:To ...

journal_title：Circulation research

authors： Paik DT,Rai M,Ryzhov S,Sanders LN,Aisagbonhi O,Funke MJ,Feoktistov I,Hatzopoulos AK

更新日期：2015-10-09 00:00:00

abstract：:We studied the effects of slow continuous hemorrhage (0.5 ml/kg per min) on measurements of arterial and left atrial pressures, and renal nerve activity in conscious dogs with all reflexes intact, or after sinoaortic baroreceptor denervation, cardiac denervation, or sinoaortic baroreceptor denervation plus vagal dener...

journal_title：Circulation research

authors： Morita H,Vatner SF

更新日期：1985-11-01 00:00:00

abstract：:The site of earliest extracellular electrical activation in the sinoatrial node (SAN) is known to shift in response to autonomic stimuli, but the mechanisms underlying this phenomenon and the determinants of the location of dominant pacemaker activity have not been elucidated. The present study was designed to charact...

journal_title：Circulation research

authors： Beau SL,Hand DE,Schuessler RB,Bromberg BI,Kwon B,Boineau JP,Saffitz JE

更新日期：1995-11-01 00:00:00

abstract：:The potential for exogenous infusion of basic fibroblast growth factor (bFGF) to increase collateral blood flow to dependent tissue was quantified in adult male rats with peripheral arterial insufficiency. Occlusion of the femoral artery at a proximal site did not infringe on resting blood flow to the distal hindlimb ...

journal_title：Circulation research

authors： Yang HT,Deschenes MR,Ogilvie RW,Terjung RL

更新日期：1996-07-01 00:00:00

abstract：RATIONALE:Microparticles are cell-derived membrane vesicles, relevant to a range of biological responses and known to be elevated in cardiovascular disease. OBJECTIVE:To investigate microparticle release during cardiac stress and how this response differs in those with vascular disease. METHODS AND RESULTS:We measure...

journal_title：Circulation research

authors： Augustine D,Ayers LV,Lima E,Newton L,Lewandowski AJ,Davis EF,Ferry B,Leeson P

更新日期：2014-01-03 00:00:00