cdc25A is necessary but not sufficient for optimal c-myc-induced apoptosis and cell proliferation of vascular smooth muscle cells.

abstract：:A narrow zone of block in isolated false tendon preparations was created by perfusion of the central compartment (gap) of a three-compartment tissue bath with either an isotonic sucrose solution or a solution designed to mimic the extracellular milieu in ischemic tissue. Driven responses on the proximal side of the ga...

journal_title：Circulation research

authors： Antzelevitch C,Moe GK

更新日期：1981-11-01 00:00:00

abstract：:Large-conductance Ca2+-dependent K+ channels (KCa), which are abundant on the sarcolemma of vascular myocytes, provide negative feedback via membrane hyperpolarization that limits Ca2+ entry through L-type Ca2+ channels (ICaL). We hypothesize that local accumulation of subsarcolemmal Ca2+ during ICaL openings amplifie...

journal_title：Circulation research

authors： Guia A,Wan X,Courtemanche M,Leblanc N

更新日期：1999-05-14 00:00:00

abstract：:Rat lungs were inflated and incubated in either anionic or cationic ferritin, and alveolar and capillary basement membranes were examined by electron microscopy. Cationic ferritin bound to heparan sulfate proteoglycans on the external surface of the alveolar basement membrane, whereas cationic ferritin bound to the la...

journal_title：Circulation research

authors： Brody JS,Vaccaro CA,Hill NS,Rounds S

更新日期：1984-08-01 00:00:00

abstract：:High sodium intake (HNa) increases brain ouabainlike activity (OLA) in rats. In spontaneously hypertensive rats (SHR), HNa exaggerates development of hypertension and pressor and sympathoexcitatory responses to stress. To investigate whether dietary sodium-induced changes in brain OLA play a functional role, responses...

journal_title：Circulation research

authors： Huang BS,Leenen FH

更新日期：1992-02-01 00:00:00

abstract：RATIONALE:Activation of the mitochondrial ATP-sensitive potassium channel (mitoK(ATP)) has been implicated in the mechanism of cardiac ischemic preconditioning, yet its molecular composition is unknown. OBJECTIVE:To use an unbiased proteomic analysis of the mitochondrial inner membrane to identify the mitochondrial K(...

journal_title：Circulation research

authors： Foster DB,Ho AS,Rucker J,Garlid AO,Chen L,Sidor A,Garlid KD,O'Rourke B

更新日期：2012-08-03 00:00:00

abstract：:Isolated, cultured arterial endothelial cells express an acetylcholine (ACh)-activated K+ current in addition to an inward rectifier current whose conductance is unaffected by ACh. The cholinergic K+ current is specifically blocked by atropine (1 microM) and shows single saturation kinetics with ACh (half-maximal stim...

journal_title：Circulation research

authors： Olesen SP,Davies PF,Clapham DE

更新日期：1988-06-01 00:00:00

abstract：:Cardiac hemodynamics, diameter, blood flow velocity, and volumic flow of the brachial artery were studied before and after diltiazem administration in 11 patients with sustained essential hypertension. The study was compared with the hemodynamic effects of dihydralazine. The caliber of the brachial artery was evaluate...

journal_title：Circulation research

authors： Safar ME,Simon AC,Levenson JA,Cazor JL

更新日期：1983-02-01 00:00:00

abstract：:Lipid rafts are discrete membrane subdomains rich in sphingolipids and cholesterol. In ventricular myocytes a function of caveolae, a type of lipid rafts, is to concentrate in close proximity several proteins of the beta-adrenergic transduction pathway. We have investigated the subcellular localization of HCN4 channel...

journal_title：Circulation research

authors： Barbuti A,Gravante B,Riolfo M,Milanesi R,Terragni B,DiFrancesco D

更新日期：2004-05-28 00:00:00

abstract：:Patients with peripheral artery disease (PAD) are at heightened risk of both systemic cardiovascular adverse events, as well as limb-related morbidity. The optimal management of patients with PAD requires a comprehensive treatment strategy incorporating both lifestyle changes, including smoking cessation and exercise,...

journal_title：Circulation research

authors： Bonaca MP,Creager MA

更新日期：2015-04-24 00:00:00

abstract：RATIONALE:The cardiac inwardly rectifying K(+) current (I(K1)) plays a critical role in modulating excitability by setting the resting membrane potential and shaping phase 3 of the cardiac action potential. OBJECTIVE:This study aims to analyze the effects of nitric oxide (NO) on human atrial I(K1) and on Kir2.1 channe...

journal_title：Circulation research

authors： Gómez R,Caballero R,Barana A,Amorós I,Calvo E,López JA,Klein H,Vaquero M,Osuna L,Atienza F,Almendral J,Pinto A,Tamargo J,Delpón E

更新日期：2009-08-14 00:00:00

abstract：:To determine whether calcium channel agonists and antagonists bind to distinct pharmacologically active sites, the binding of dihydropyridine calcium channel agonists and antagonists was related to calcium flux and contractile state in primary monolayer cultures of spontaneously contracting chick embryo ventricular ce...

journal_title：Circulation research

authors： Lee RT,Smith TW,Marsh JD

更新日期：1987-05-01 00:00:00

abstract：RATIONALE:Monocyte infiltration into the subintimal space and its intracellular lipid accumulation are the most prominent features of atherosclerosis. To understand the pathophysiology of atherosclerotic disease, we need to understand the characteristics of lipid-laden foamy macrophages in the subintimal space during a...

journal_title：Circulation research

authors： Kim K,Shim D,Lee JS,Zaitsev K,Williams JW,Kim KW,Jang MY,Seok Jang H,Yun TJ,Lee SH,Yoon WK,Prat A,Seidah NG,Choi J,Lee SP,Yoon SH,Nam JW,Seong JK,Oh GT,Randolph GJ,Artyomov MN,Cheong C,Choi JH

更新日期：2018-10-26 00:00:00

abstract：:Arterial segments (less than 250 micron o.d.) excised from canine ileum were mounted in a chamber that permitted arterial transmural pressure (TMP) to be altered and measured. Subsequently, the periarterial nerves were field stimulated with single pulses (0.1 msec, 70 V), and the resting membrane potential (Em) as wel...

journal_title：Circulation research

authors： Smeda JS,Daniel EE

更新日期：1988-06-01 00:00:00

abstract：:Inflammation is a condition that underscores many cardiovascular pathologies including endothelial dysfunction, but no link is yet established between the vascular pathology of the metabolic syndrome with a particular inflammatory cytokine. We hypothesized that impairments in coronary endothelial function in the obese...

journal_title：Circulation research

authors： Picchi A,Gao X,Belmadani S,Potter BJ,Focardi M,Chilian WM,Zhang C

更新日期：2006-07-07 00:00:00

abstract：:The identification of endothelium-derived relaxing factor as nitric oxide (NO) dramatically altered the course of vascular biology, as well as other biomedical disciplines. The ubiquity of this natural product of cell metabolism and the complexity of its biochemistry provide a rich source of molecular mediators of phe...

journal_title：Circulation research

authors： Loscalzo J

更新日期：2013-07-05 00:00:00

abstract：:Inherited mutations and a polymorphism in minK-related peptide 1 (MiRP1) have been linked to congenital or acquired long-QT syndrome, pointing to the importance of MiRP1 in maintaining the cardiac electrical stability. We tested whether MiRP1 could affect the function of Kv4.x (x=2 and 3), the major pore-forming (alph...

journal_title：Circulation research

authors： Zhang M,Jiang M,Tseng GN

更新日期：2001-05-25 00:00:00

abstract：RATIONALE:Gamma aminobutyric acid (GABA), a neurotransmitter of the central nervous system, is found in the systemic circulation of humans at a concentration between 0.5 and 3 μmol/L. However, the potential source of circulating GABA and its significance on the vascular system remains unknown. We hypothesized that endo...

journal_title：Circulation research

authors： Sen S,Roy S,Bandyopadhyay G,Scott B,Xiao D,Ramadoss S,Mahata SK,Chaudhuri G

更新日期：2016-08-19 00:00:00

abstract：:Rationale: The overuse of antibiotics has been an important clinical issue, and antibiotic exposure is linked to alterations in gut microbiota, which has been related to risks of various chronic diseases such as cardiovascular disease and cancer. Also, duration of antibiotic exposure may be a risk factor of premature ...

journal_title：Circulation research

authors： Heianza Y,Ma W,Li X,Cao Y,Chan AT,Rimm EB,Hu FB,Rexrode KM,Manson JE,Qi L

更新日期：2020-01-31 00:00:00

abstract：:The global prevalence of overweight and obesity has risen substantially over the past 4 decades and is accompanied by an increasing burden of cardiovascular risk factors such as hypertension. Metabolic surgery is the most effective method to treat obesity and may further improve associated conditions. Although most re...

journal_title：Circulation research

authors： Pareek M,Bhatt DL,Schiavon CA,Schauer PR

更新日期：2019-03-29 00:00:00

abstract：:The present experiments were performed to investigate whether neurogenic inflammation in rat trachea (with edema formation and protein extravasation when the circulation is intact) induced by electrical field stimulation of neuropeptide-containing C fibers in the vagal nerve is accompanied by increased negativity of i...

journal_title：Circulation research

authors： Woie K,Koller ME,Heyeraas KJ,Reed RK

更新日期：1993-11-01 00:00:00

abstract：:We determined the effects of indomethacin and meclofenamate, two inhibitors of prostaglandin synthesis, on renal vascular resistance and on renal responses to nerve stimulation, pressor and depressor hormones in the in situ feline kidney under conditions of controlled blood flow. Both inhibitors produced a gradual ris...

journal_title：Circulation research

authors： Chapnick BM,Paustian PW,Feigen LP,Joiner PD,Hyman AL,Kadowitz PJ

更新日期：1977-04-01 00:00:00

abstract：:The transverse tubular system (t-system) of cardiac muscle is a structure that allows rapid propagation of excitation into the cell interior. Using 2-photon molecular excitation microscopy and digital image-processing methods, we have obtained a comprehensive overview of the t-system of rat ventricular myocytes in liv...

journal_title：Circulation research

authors： Soeller C,Cannell MB

更新日期：1999-02-19 00:00:00

abstract：:Vascular disease often involves vessel hypertrophy with underlying cellular hypertrophy or hyperplasia. Experimental diabetes stimulates hypertrophy of the rat mesenteric vasculature, and we investigated the hypothesis that this hypertrophy is associated with activation of Na(+)-H(+) exchange (NHE) activity. We measur...

journal_title：Circulation research

authors： Jandeleit-Dahm K,Hannan KM,Farrelly CA,Allen TJ,Rumble JR,Gilbert RE,Cooper ME,Little PJ

更新日期：2000-12-08 00:00:00

abstract：RATIONALE:The heart contains abundant interstitial and perivascular fibroblasts. Traditional views suggest that, under conditions of mechanical stress, cytokines, growth factors, and neurohumoral mediators stimulate fibroblast activation, inducing ECM (extracellular matrix) protein synthesis and promoting fibrosis and ...

journal_title：Circulation research

authors： Russo I,Cavalera M,Huang S,Su Y,Hanna A,Chen B,Shinde AV,Conway SJ,Graff J,Frangogiannis NG

更新日期：2019-04-12 00:00:00

abstract：RATIONALE:Activin receptor-like kinase-1 (ALK1) is an endothelial transforming growth factor β receptor involved in angiogenesis. ALK1 expression is high in the embryo vasculature, becoming less detectable in the quiescent endothelium of adult stages. However, ALK1 expression becomes rapidly increased after angiogenic ...

journal_title：Circulation research

authors： Garrido-Martín EM,Blanco FJ,Roquè M,Novensà L,Tarocchi M,Lang UE,Suzuki T,Friedman SL,Botella LM,Bernabéu C

更新日期：2013-01-04 00:00:00

abstract：:We examined the late coronary vascular response to carotid chemoreceptor reflex activation in normal, conscious dogs instrumented for the measurement of right main and left circumflex coronary artery blood flows, arterial and right ventricular pressures, and arterial and coronary sinus blood gases and O2 contents. Wit...

journal_title：Circulation research

authors： Murray PA,Lavallee M,Vatner SF

更新日期：1984-01-01 00:00:00

abstract：:First-generation, E1-deleted adenoviral vectors (E1-AV) can transduce the vascular endothelium with high efficiency, but their use is limited by the resulting acute endothelial injury and the long-term development of intimal hyperplasia. To reduce the impact of viral proteins on the gene-modified cells, a second-gener...

journal_title：Circulation research

authors： Qian HS,Channon K,Neplioueva V,Wang Q,Finer M,Tsui L,George SE,McArthur J

更新日期：2001-05-11 00:00:00

abstract：:To understand the role of bone marrow mononuclear cells in the treatment of acute myocardial infarction, this overview offers a retrospective examination of strengths and limitations of 3 contemporaneous trials with attention to critical design features and provides an analysis of the combined data set and implication...

journal_title：Circulation research

authors： Simari RD,Pepine CJ,Traverse JH,Henry TD,Bolli R,Spoon DB,Yeh E,Hare JM,Schulman IH,Anderson RD,Lambert C,Sayre SL,Taylor DA,Ebert RF,Moyé LA

更新日期：2014-05-09 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) play important roles in cardiovascular development. However, how BMP-signaling pathways regulate cardiac gene expression is less clear. We have previously identified myocardin as a cardiac and smooth muscle-specific transcriptional cofactor for serum response factor (SRF). Myocardin ...

journal_title：Circulation research

authors： Callis TE,Cao D,Wang DZ

更新日期：2005-11-11 00:00:00

abstract：:Recent studies in isolated cardiac tissue preparations have demonstrated the applicability of a one-dimensional difference equation model describing the global behavior of a driven nonpacemaker cell to the understanding of rate-dependent cardiac excitation. As a first approximation to providing an ionic basis to compl...

journal_title：Circulation research

authors： Vinet A,Chialvo DR,Michaels DC,Jalife J

更新日期：1990-12-01 00:00:00