Abstract:
:Recent studies in isolated cardiac tissue preparations have demonstrated the applicability of a one-dimensional difference equation model describing the global behavior of a driven nonpacemaker cell to the understanding of rate-dependent cardiac excitation. As a first approximation to providing an ionic basis to complex excitation patterns in cardiac cells, we have compared the predictions of the one-dimensional model with those of numerical simulations using a modified high-dimensional ionic model of the space-clamped myocyte. Stimulus-response ratios were recorded at various stimulus magnitudes, durations, and frequencies. Iteration of the difference equation model reproduced all important features of the ionic model results, including a wide spectrum of stimulus-response locking patterns, period doubling, and irregular (chaotic) dynamics. In addition, in the parameter plane, both models predict that the bifurcation structure of the cardiac cell must change as a function of stimulus duration, because stimulus duration modifies the type of supernormal excitability present at short diastolic interval. We conclude that, to a large extent, the bifurcation structure of the ionic model under repetitive stimulation can be understood by two functions: excitability and action potential duration. The characteristics of these functions depend on the stimulus duration.
journal_name
Circ Resjournal_title
Circulation researchauthors
Vinet A,Chialvo DR,Michaels DC,Jalife Jdoi
10.1161/01.res.67.6.1510subject
Has Abstractpub_date
1990-12-01 00:00:00pages
1510-24issue
6eissn
0009-7330issn
1524-4571journal_volume
67pub_type
杂志文章abstract::Although estradiol (E(2)) has been recognized to exert several vasculoprotective effects in several species, its effects in mouse vasomotion are unknown, and consequently, so is the estrogen receptor subtype mediating these effects. We investigated the effect of E(2) (80 microg/kg/day for 15 days) on NO production in ...
journal_title:Circulation research
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2004-05-14 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.75.4.751
更新日期:1994-10-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.116.308811
更新日期:2016-06-24 00:00:00
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更新日期:2003-08-08 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2002-12-13 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.76.4.551
更新日期:1995-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.108.177055
更新日期:2008-12-05 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2014-05-09 00:00:00
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pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.109.213165
更新日期:2010-04-16 00:00:00
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pub_type: 杂志文章
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更新日期:1992-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.82.7.803
更新日期:1998-04-20 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.73.2.379
更新日期:1993-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.115.306993
更新日期:2015-08-28 00:00:00
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更新日期:2020-02-28 00:00:00
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pub_type: 杂志文章
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更新日期:1984-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:1992-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1991-08-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-01-04 00:00:00
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pub_type: 杂志文章
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更新日期:1994-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.63.6.1020
更新日期:1988-12-01 00:00:00
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更新日期:1975-07-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:2014-09-26 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:2017-02-17 00:00:00
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pub_type: 杂志文章,评审
doi:10.1161/CIRCRESAHA.117.310450
更新日期:2017-02-17 00:00:00