Localization patterns of plasma apolipoproteins in human atherosclerotic lesions.

abstract：:Studies were performed to determine whether an alteration in coronary vascular resistance and a reduction in the reflow phenomenon occurred in the blood-perfused, heparinized canine heart after various periods of myocaridal ischemia. Regional myocardial blood flow was measured with radioactive microspheres. Proximal l...

journal_title：Circulation research

authors： Willerson JT,Watson JT,Hutton I,Templeton GH,Fixler DE

更新日期：1975-06-01 00:00:00

abstract：:The endothelial cell membrane glycoprotein thrombomodulin (TM) plays a critical role in the regulation of coagulation. TM is an essential cofactor in protein C activation by thrombin, and a direct inhibitor of thrombin-induced platelet activation and fibrinogen clotting. Protease nexin-1 (PN-1) is a serpin synthesized...

journal_title：Circulation research

authors： Bouton MC,Venisse L,Richard B,Pouzet C,Arocas V,Jandrot-Perrus M

更新日期：2007-04-27 00:00:00

abstract：:Activin is a member of the transforming growth factor-beta superfamily, and it modulates the proliferation and differentiation of various target cells. In this study, we investigated the role of activin in the initiation and progression of human atherosclerosis. The expression of activin, its physiological inhibitor f...

journal_title：Circulation research

authors： Engelse MA,Neele JM,van Achterberg TA,van Aken BE,van Schaik RH,Pannekoek H,de Vries CJ

更新日期：1999-11-12 00:00:00

abstract：:Previous studies have demonstrated that in adult rats with chronic hyponatremia, both symptoms of encephalopathy and mortality largely depend upon the gender of the animal and the presence of elevated plasma levels of vasopressin (AVP). Since effects of AVP on blood vessels may be gender dependent, the present study w...

journal_title：Circulation research

authors： Kozniewska E,Roberts TP,Vexler ZS,Oseka M,Kucharczyk J,Arieff AI

更新日期：1995-04-01 00:00:00

abstract：RATIONALE:Elevations in C-reactive protein (CRP) are associated with increased cardiovascular disease risk and endothelial dysfunction. CRP antagonizes endothelial nitric oxide synthase (eNOS) through processes mediated by the IgG receptor Fcγ receptor IIB (FcγRIIB), its immunoreceptor tyrosine-based inhibitory motif, ...

journal_title：Circulation research

authors： Sundgren NC,Zhu W,Yuhanna IS,Chambliss KL,Ahmed M,Tanigaki K,Umetani M,Mineo C,Shaul PW

更新日期：2011-10-28 00:00:00

abstract：:The functional disturbance of microvasculature is recognized as an initiating mechanism that underlies the development of various diabetic complications. Although a causal relationship between microvascular leakage and tissue damage has been well documented in diabetic kidneys and eyes, there is a lack of information ...

journal_title：Circulation research

authors： Yuan SY,Ustinova EE,Wu MH,Tinsley JH,Xu W,Korompai FL,Taulman AC

更新日期：2000-09-01 00:00:00

abstract：RATIONALE:The dramatic upregulation of αvβ3-integrin that occurs in the vasculature during tumor growth has long suggested that the endothelial expression of this molecule is an ideal target for antiangiogenic therapy to treat cancer. This discovery led to the development of small-molecule inhibitors directed against α...

journal_title：Circulation research

authors： Steri V,Ellison TS,Gontarczyk AM,Weilbaecher K,Schneider JG,Edwards D,Fruttiger M,Hodivala-Dilke KM,Robinson SD

更新日期：2014-01-03 00:00:00

abstract：:Angiotensin-converting enzyme inhibitor was used in dogs with uranyl nitrate-induced acute renal failure to evaluate (1) a possible protective effect of angiotensin blockade and (2)the role of angiotensin II in the generation of renal failure in this model. Angiotensin-converting enzyme inhibitor treatment attenuated ...

journal_title：Circulation research

authors： Lindner A,Cutler RE,Bell AJ

更新日期：1982-08-01 00:00:00

abstract：:The purpose of this study was to investigate the nature of the serotonin-induced coronary chemoreflex in the conscious monkey. Ten chronically prepared and four acute monkeys were used in this study. Five chronically prepared animals had catheters in the left atrium, ascending aorta, descending aorta, and, bilaterally...

journal_title：Circulation research

authors： Cornish KG,Zucker IH

更新日期：1983-03-01 00:00:00

abstract：:Vessel stabilization and the inhibition of side effects such as tissue edema are essential in angiogenic gene therapy. Thus, combination gene transfers stimulating both endothelial cell and pericyte proliferation have become of interest. However, there is currently little data to support combination gene transfer in l...

journal_title：Circulation research

authors： Korpisalo P,Karvinen H,Rissanen TT,Kilpijoki J,Marjomäki V,Baluk P,McDonald DM,Cao Y,Eriksson U,Alitalo K,Ylä-Herttuala S

更新日期：2008-11-07 00:00:00

abstract：RATIONALE:Mechanisms of angiogenesis in skeletal muscle remain poorly understood. Efforts to induce physiological angiogenesis hold promise for the treatment of diabetic microvascular disease and peripheral artery disease but are hindered by the complexity of physiological angiogenesis and by the poor angiogenic respon...

journal_title：Circulation research

authors： Rowe GC,Raghuram S,Jang C,Nagy JA,Patten IS,Goyal A,Chan MC,Liu LX,Jiang A,Spokes KC,Beeler D,Dvorak H,Aird WC,Arany Z

更新日期：2014-08-15 00:00:00

abstract：:The pathogenesis of atherosclerosis and abdominal aortic aneurysm involves substantial proteolysis of the arterial extracellular matrix. The lysosomal cysteine proteases can exert potent elastolytic and collagenolytic activity. Human atherosclerotic plaques have increased cysteine protease content and decreased levels...

journal_title：Circulation research

authors： Sukhova GK,Wang B,Libby P,Pan JH,Zhang Y,Grubb A,Fang K,Chapman HA,Shi GP

更新日期：2005-02-18 00:00:00

abstract：:Cardiac and arterial tissues of six male and six female adult baboons were examined for nuclear uptake of tritiated 5-alpha-dihydrotestosterone (3H-DHT) or tritiated estradiol-17 beta (3H-E2) by autoradiography. 3H-DHT uptake occurred in nuclei of most atrial and ventricular myocardial fibers, no cardiac interstitial ...

journal_title：Circulation research

authors： McGill HC Jr,Sheridan PJ

更新日期：1981-02-01 00:00:00

abstract：RATIONALE:Complementation of pluripotency genes may improve adult stem cell functions. OBJECTIVES:Here we show that clonally expandable, telomerase expressing progenitor cells can be isolated from peripheral blood of children. The surface marker profile of the clonally expanded cells is distinct from hematopoietic or ...

journal_title：Circulation research

authors： Koyanagi M,Iwasaki M,Rupp S,Tedesco FS,Yoon CH,Boeckel JN,Trauth J,Schütz C,Ohtani K,Goetz R,Iekushi K,Bushoven P,Momma S,Mummery C,Passier R,Henschler R,Akintuerk H,Schranz D,Urbich C,Galvez BG,Cossu G,Zeiher A

更新日期：2010-04-16 00:00:00

abstract：:Electrical propagation in the normal heart occurs via intercellular transfer of current at gap junctions. Alterations in intercellular coupling in the diseased heart are critical in the pathogenesis of reentrant ventricular arrhythmias. Until recently only a single gap junction protein was known to couple cardiac myoc...

journal_title：Circulation research

authors： Kanter HL,Saffitz JE,Beyer EC

更新日期：1992-02-01 00:00:00

abstract：:Calcium uptake was measured in homogenates and microsomal preparations enriched in sarcoplasmic reticulum vesicles isolated from hearts of hypertrophic (BIO 14.6) and dilated (BIO 53.58) cardiomyopathic as well as control (F1B) Syrian hamsters at 3, 7, 9, and 11 months of age. Calcium uptake studies were done using th...

journal_title：Circulation research

authors： Whitmer JT,Kumar P,Solaro RJ

更新日期：1988-01-01 00:00:00

abstract：:During sustained isometric exercise, central command has very little effect on muscle sympathetic nerve activity (MSNA). To determine if central command has a greater effect on MSNA during intermittent than during sustained contractions, MSNA was recorded with microelectrodes (peroneal nerve) during intermittent isome...

journal_title：Circulation research

authors： Victor RG,Secher NH,Lyson T,Mitchell JH

更新日期：1995-01-01 00:00:00

abstract：:Aldosterone is associated with the pathogenesis and progression of left ventricular hypertrophy and heart failure, independent of its relation with arterial blood pressure. However, little information exists about the possible influence of this mineralocorticoisteroid on cardiomyocyte electrical activity. The present ...

journal_title：Circulation research

authors： Bénitah JP,Vassort G

更新日期：1999-12-03 00:00:00

abstract：:Net cellular L-lactate efflux associated with accelerated anaerobic glycolysis has been implicated as a potential cause of the marked cellular K+ loss contributing to lethal cardiac arrhythmias in ischemic heart and to impaired function of fatigued skeletal muscle. To examine the mechanisms of transsarcolemmal L-lacta...

journal_title：Circulation research

authors： Shieh RC,Goldhaber JI,Stuart JS,Weiss JN

更新日期：1994-05-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a critical regulator of angiogenesis that stimulates proliferation, migration, and proteolytic activity of endothelial cells. Although the mitogenic activity of VEGF is endothelial cell specific, recent reports indicate VEGF is able to stimulate chemotaxis and tissue factor...

journal_title：Circulation research

authors： Wang H,Keiser JA

更新日期：1998-10-19 00:00:00

abstract：:The effects of two types of repeated transient coronary artery occlusions on collateral development were examined in chronically instrumented, conscious dogs. A 2-minute coronary occlusion at 32-minute intervals (group 1, n = 11) or a 15-second occlusion at 4-minute intervals (group 2, n = 7) were repeated day and nig...

journal_title：Circulation research

authors： Mohri M,Tomoike H,Noma M,Inoue T,Hisano K,Nakamura M

更新日期：1989-02-01 00:00:00

abstract：:The mTOR (mechanistic target of rapamycin) is a master regulator of several crucial cellular processes, including protein synthesis, cellular growth, proliferation, autophagy, lysosomal function, and cell metabolism. mTOR interacts with specific adaptor proteins to form 2 multiprotein complexes, called mTORC1 (mTOR co...

journal_title：Circulation research

authors： Sciarretta S,Forte M,Frati G,Sadoshima J

更新日期：2018-02-02 00:00:00

abstract：:Previous studies have demonstrated that low shear rates promote leukocyte adherence to microvascular endothelium in postcapillary venules. The objective of this study was to determine whether an accumulation of inflammatory mediators such as platelet activating factor and leukotriene B4 is responsible for shear rate-d...

journal_title：Circulation research

authors： Bienvenu K,Russell J,Granger DN

更新日期：1992-10-01 00:00:00

abstract：:To assess whether coronary spasm affects the progression of atherosclerosis and results in evolution of myocardial infarction, the role of coronary spasm on the fine structure of conduit coronary arteries was studied morphologically. Göttingen miniature pigs were fed a semisynthetic diet containing 2% cholesterol and ...

journal_title：Circulation research

authors： Nagasawa K,Tomoike H,Hayashi Y,Yamada A,Yamamoto T,Nakamura M

更新日期：1989-08-01 00:00:00

abstract：:Effects of concentrations of intracellular calcium, [Ca2+]i, on the voltage-dependent Ca2+ current (ICa) recorded from dispersed single smooth muscle cells of the rabbit portal vein were studied, using a whole cell voltage clamp method combined with an intracellular perfusion technique. Outward currents were minimized...

journal_title：Circulation research

authors： Ohya Y,Kitamura K,Kuriyama H

更新日期：1988-02-01 00:00:00

abstract：:Adenosine modulates a variety of cellular functions by interacting with specific cell surface G protein-coupled receptors (A1, A2A, A2B, and A3) and is a potential mediator of angiogenesis through the A2B receptor. The lack of a potent, selective A2B receptor inhibitor has hampered its characterization. Our goal was t...

journal_title：Circulation research

authors： Afzal A,Shaw LC,Caballero S,Spoerri PE,Lewin AS,Zeng D,Belardinelli L,Grant MB

更新日期：2003-09-19 00:00:00

abstract：:Understanding molecular mechanisms regulating angiogenesis may lead to novel therapies for ischemic disorders. Hypoxia-inducible factor 1 (HIF-1) activates vascular endothelial growth factor (VEGF) gene expression in hypoxic/ischemic tissue. In this study we demonstrate that exposure of primary cultures of cardiac and...

journal_title：Circulation research

authors： Kelly BD,Hackett SF,Hirota K,Oshima Y,Cai Z,Berg-Dixon S,Rowan A,Yan Z,Campochiaro PA,Semenza GL

更新日期：2003-11-28 00:00:00

abstract：:Red blood cells and lysate products (erythrolysate) are observed consistently in lymph draining acute and chronic inflammatory reactions and from tissues subjected to trauma or surgical procedures. Using hemoglobin as a marker for erythrolysate, we have measured hemoglobin in lymph up to the 10(-6) M range in a number...

journal_title：Circulation research

authors： Elias RM,Wandolo G,Ranadive NS,Eisenhoffer J,Johnston MG

更新日期：1990-11-01 00:00:00

abstract：:Angiotensin II (Ang II) increases renal sympathetic nerve activity in anesthetized mice before and after ganglionic blockade, suggesting that Ang II may directly activate postganglionic sympathetic neurons. The present study directly tested this hypothesis in vitro. Neurons were dissociated from aortic-renal and celia...

journal_title：Circulation research

authors： Ma X,Chapleau MW,Whiteis CA,Abboud FM,Bielefeldt K

更新日期：2001-04-27 00:00:00

abstract：:Electrical field stimulation (EFS) of phenylephrine-contracted bovine mesenteric arteries pretreated with guanethidine elicited a relaxation that amounted to roughly 40%. This relaxation was sensitive to tetrodotoxin pretreatment, suggesting a neurogenic origin. The EFS-induced relaxation was correlated to an increase...

journal_title：Circulation research

authors： Ahlner J,Ljusegren ME,Grundström N,Axelsson KL

更新日期：1991-03-01 00:00:00