Abstract:
:The purpose of this study was to investigate the nature of the serotonin-induced coronary chemoreflex in the conscious monkey. Ten chronically prepared and four acute monkeys were used in this study. Five chronically prepared animals had catheters in the left atrium, ascending aorta, descending aorta, and, bilaterally, in the common carotid arteries. In addition, Silastic catheters were placed next to both vagi to permit vagal block with 2% lidocaine. Serotonin was injected (12-200 micrograms/kg) into the left atrium, ascending aorta, descending aorta, or, bilaterally, into the carotid arteries while blood pressure, heart rate, and respiratory movements were recorded. Injections of serotonin were associated with hypertension and bradycardia followed by tachycardia, all of which were preceded by a cough response. Atropine blocked the bradycardia, whereas atropine and phentolamine eliminated the cardiovascular components of the reflex. Vagal blockade eliminated the bradycardia but otherwise did not alter the response to left atrial serotonin. Three monkeys were prepared with aortic and left atrial catheters. Subsequently, they were subjected to sinoaortic deafferentation. Serotonin injected into these animals did not alter blood pressure or respiration. The results of this study show that serotonin injected into the left atrium of the conscious monkey produces respiratory and cardiovascular alterations by its effect on aortic and carotid chemoreceptors, and that there is no coronary chemoreflex in the conscious monkey.
journal_name
Circ Resjournal_title
Circulation researchauthors
Cornish KG,Zucker IHdoi
10.1161/01.res.52.3.312subject
Has Abstractpub_date
1983-03-01 00:00:00pages
312-8issue
3eissn
0009-7330issn
1524-4571journal_volume
52pub_type
杂志文章abstract:RATIONALE:Circumstantial evidence links the development of heart failure to posttranslational modifications of mitochondrial proteins, including lysine acetylation (Kac). Nonetheless, direct evidence that Kac compromises mitochondrial performance remains sparse. OBJECTIVE:This study sought to explore the premise that ...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.120.317293
更新日期:2020-09-25 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.115.307298
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pub_type: 杂志文章
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更新日期:2014-02-28 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1161/01.res.75.4.637
更新日期:1994-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.77.6.1166
更新日期:1995-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.72.3.504
更新日期:1993-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.108.176321
更新日期:2008-07-03 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:2005-01-07 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.84.1.9
更新日期:1999-01-08 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.0000019580.64013.31
更新日期:2002-05-31 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.57.1.182
更新日期:1985-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.47.1.1
更新日期:1980-07-01 00:00:00
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pub_type: 临床试验,杂志文章
doi:10.1161/CIRCRESAHA.115.304458
更新日期:2014-10-24 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.60.6.871
更新日期:1987-06-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.51.5.543
更新日期:1982-11-01 00:00:00
abstract::To investigate the functional consequences of a tropomyosin (TM) mutation associated with familial hypertrophic cardiomyopathy (FHC), we generated transgenic mice that express mutant alpha-TM in the adult heart. The missense mutation, which results in the substitution of asparagine for aspartic acid at amino acid posi...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.85.1.47
更新日期:1999-07-09 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1999-02-19 00:00:00
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更新日期:2004-03-19 00:00:00
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pub_type: 杂志文章
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更新日期:2009-12-04 00:00:00
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更新日期:2009-09-11 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,评审
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更新日期:2004-03-19 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.71.3.657
更新日期:1992-09-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:
更新日期:2000-06-23 00:00:00
abstract::The accumulation of inositol 1,4,5-trisphosphate (IP3) after hormonal stimulation has a physiological role, possibly by alteration of Ca2+ levels in cardiac myocyte. However, this accumulation has not been studied under pathophysiological conditions. In this report, we examine phosphatidylinositol metabolism during ce...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.72.5.966
更新日期:1993-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-08-08 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:2005-09-02 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.84.6.722
更新日期:1999-04-02 00:00:00