Angiotensin selectively activates a subpopulation of postganglionic sympathetic neurons in mice.

abstract：:Studies of the stellate ganglion and middle cervical ganglion indicate that sympathetic efferent nerve activity can be modified by peripheral excitatory inputs and that these neural connections may function as pathways for a peripheral reflex at the level of the thoracic sympathetic ganglia. This excitatory synaptic i...

journal_title：Circulation research

authors： Bosnjak ZJ,Kampine JP

更新日期：1989-03-01 00:00:00

abstract：:To isolate specific markers of both differentiated and proliferating vascular smooth muscle cells (VSMCs), we used the technique of differential cDNA screening using RNA from cultured rat aortic VSMCs. The tissue specificity of expression of all of the cDNAs isolated was determined by Northern analysis. We isolated se...

journal_title：Circulation research

authors： Shanahan CM,Weissberg PL,Metcalfe JC

更新日期：1993-07-01 00:00:00

abstract：:Electrocardiogram (ECG) electrodes and carotid arterial and superior vena caval (SVC) catheters were placed in eight nonpregnant ewes and 11 fetuses (109-129 days gestation) to measure heart rate, arterial presssure, P-R interval, left ventricular pre-ejection period (PEP), and left ventricular ejection time (LVET), b...

journal_title：Circulation research

authors： Berman W Jr,Ravenscroft PJ,Sheiner LB,Heymann MA,Melmon KL,Rudolph AM

更新日期：1977-11-01 00:00:00

abstract：:Tropomyosin (TM) is an integral component of the thin filament in muscle fibers and is involved in regulating actin-myosin interactions. TM is encoded by a family of four alternatively spliced genes that display highly conserved nucleotide and amino acid sequences. To assess the functional and developmental significan...

journal_title：Circulation research

authors： Rethinasamy P,Muthuchamy M,Hewett T,Boivin G,Wolska BM,Evans C,Solaro RJ,Wieczorek DF

更新日期：1998-01-09 00:00:00

abstract：:By using excised postmortem hearts obtained from 15 mongrel dogs with the pericardium intact, we investigated mechanical interactions between the four heart chambers from the standpoint of ventricular pressure-volume relationships. The interactions investigated were those between (1) the atrium and the ventricle, (2) ...

journal_title：Circulation research

authors： Maruyama Y,Ashikawa K,Isoyama S,Kanatsuka H,Ino-Oka E,Takishima T

更新日期：1982-01-01 00:00:00

abstract：:The average lifespan of humans is increasing, and with it the percentage of people entering the 65 and older age group is growing rapidly and will continue to do so in the next 20 years. Within this age group, cardiovascular disease will remain the leading cause of death, and the cost associated with treatment will co...

journal_title：Circulation research

authors： North BJ,Sinclair DA

更新日期：2012-04-13 00:00:00

abstract：:Cells with endothelial phenotype generated from adult peripheral blood have emerging diagnostic and therapeutic potential. This study examined the lineage relationship between, and angiogenic function of, early endothelial progenitor cells (EPCs) and late outgrowth endothelial cells (OECs) in culture. Culture conditio...

journal_title：Circulation research

authors： Gulati R,Jevremovic D,Peterson TE,Chatterjee S,Shah V,Vile RG,Simari RD

更新日期：2003-11-28 00:00:00

abstract：:Many forms of vascular disease are characterized by increased transforming growth factor (TGF)-beta1 expression and endothelial dysfunction. Smad proteins are a key step in TGF-beta-initiated signal transduction. We hypothesized that NO may regulate endothelial TGF-beta-dependent gene expression. We show that NO inhib...

journal_title：Circulation research

authors： Saura M,Zaragoza C,Herranz B,Griera M,Diez-Marqués L,Rodriguez-Puyol D,Rodriguez-Puyol M

更新日期：2005-11-25 00:00:00

abstract：:Sixteen years ago, mutations in cardiac troponin (Tn)T and α-tropomyosin were linked to familial hypertrophic cardiomyopathy, thus transforming the disorder from a disease of the β-myosin heavy chain to a disease of the cardiac sarcomere. From the outset, studies suggested that mutations in the regulatory thin filamen...

journal_title：Circulation research

authors： Tardiff JC

更新日期：2011-03-18 00:00:00

abstract：:The effects of acute hypoxemia and hypercapnic acidosis were examined in five unanesthetized dogs in which sodium intake was controlled at 80 mEq/24 hours for 4 days prior to study. Each animal was studied during combined acute hypoxemia and hypercapnic acidosis (Pao2 = 36 +/- 1 mm Hg, Paco2 = 52 +/- 1 mm Hg, pH = 7.1...

journal_title：Circulation research

authors： Rose CE Jr,Kimmel DP,Godine RL Jr,Kaiser DL,Carey RM

更新日期：1983-08-01 00:00:00

abstract：RATIONALE:Our insights into physiological and pathophysiological cardiac excitation-contraction coupling has greatly benefited from significant advancement in optical technologies such as high-speed confocal microscopy. This has pushed pixel dwell times into the time domain of nanoseconds, resulting in low signal-to-no...

journal_title：Circulation research

authors： Tian Q,Kaestner L,Lipp P

更新日期：2012-06-22 00:00:00

abstract：:To investigate the relation of pressure and vascular wall thickening in hypertension, we coarcted the abdominal aorta upstream to the renal arteries in 14 rats. Sham-coarcted (n = 16) and two-kidney, one-clip (Goldblatt) hypertensive rats (n = 13) served as controls. Tail, femoral, and carotid arterial pressures rose ...

journal_title：Circulation research

authors： Liu JL,Bishop SP,Overbeck HW

更新日期：1988-05-01 00:00:00

abstract：RATIONALE:Molecular imaging is useful for longitudinal assessment of engraftment. However, it is not known which factors, other than cell number, can influence the molecular imaging signal obtained from reporter genes. OBJECTIVE:The effects of cell dissociation/suspension on cellular bioenergetics and the signal obtai...

journal_title：Circulation research

authors： Chang C,Chan A,Lin X,Higuchi T,Terrovitis J,Afzal JM,Rittenbach A,Sun D,Vakrou S,Woldemichael K,O'Rourke B,Wahl R,Pomper M,Tsui B,Abraham MR

更新日期：2013-02-01 00:00:00

abstract：:We performed morphological studies of myocardial contracture to define its nature and relationship to mechanical changes occurring during metabolic blockade. Isolated rat papillary and trabecular muscles were stretched to the apices of their length-tension curves and stimulated to contract isometrically 12 times a min...

journal_title：Circulation research

authors： Bing OH,Fishbein MC

更新日期：1979-08-01 00:00:00

abstract：:We used two experimental techniques to study the effect of lidocaine hydrochloride on the early inward transient (sodium) current as it is reflected by the maximum rate of change of action potential phase 0 (Vmax). We assessed the effect of lidocaine on Vmax as Purkinje fibers were slowly depolarized by increasing the...

journal_title：Circulation research

authors： Weld FM,Bigger JT Jr

更新日期：1975-11-01 00:00:00

abstract：:Although enhanced growth of the vascular myocyte is believed to play a role in hypertensive cardiovascular disease, the cellular basis of altered growth regulation is not completely understood. The present study demonstrates that in the presence of 10% fetal calf serum, the logarithmic growth rate of cultured mesenter...

journal_title：Circulation research

authors： Bukoski RD,DeWan P,Bo J

更新日期：1991-09-01 00:00:00

abstract：RATIONALE:Pulmonary arterial hypertension (PAH) remains a progressive and eventually lethal disease characterized by increased pulmonary vascular resistance because of loss of functional lung microvasculature, primarily at the distal (intracinar) arteriolar level. Cell-based therapies offer the potential to repair and ...

journal_title：Circulation research

authors： Granton J,Langleben D,Kutryk MB,Camack N,Galipeau J,Courtman DW,Stewart DJ

更新日期：2015-09-11 00:00:00

abstract：:Many members of the two-pore-domain potassium (K(+)) channel family have been detected in the mammalian heart but the endogenous correlates of these channels still have to be identified. We investigated whether I(KAA), a background K(+) current activated by negative pressure (stretch) and by arachidonic acid (AA) and ...

journal_title：Circulation research

authors： Terrenoire C,Lauritzen I,Lesage F,Romey G,Lazdunski M

更新日期：2001-08-17 00:00:00

abstract：:Platelet hyperactivity associated with hyperlipidemia may contribute to development of a prothrombotic state. We previously showed that oxidized low-density lipoprotein (oxLDL) formed in the setting of hyperlipidemia and atherosclerosis activated platelets in a CD36-dependent manner. We now show that mitogen-activated...

journal_title：Circulation research

authors： Chen K,Febbraio M,Li W,Silverstein RL

更新日期：2008-06-20 00:00:00

abstract：:Although it has been established that myocyte enhancer factor 2 (MEF2) plays pivotal roles in the development of the cardiovascular system as well as skeletal muscle cells, little is known of its role in vascular inflammatory diseases such as atherosclerosis and restenosis after angioplasty. To investigate the role of...

journal_title：Circulation research

authors： Suzuki E,Satonaka H,Nishimatsu H,Oba S,Takeda R,Omata M,Fujita T,Nagai R,Hirata Y

更新日期：2004-07-09 00:00:00

abstract：:In clinical trials, aldosterone antagonists decrease cardiovascular mortality and ischemia by unknown mechanisms. The steroid hormone aldosterone acts by binding to the mineralocorticoid receptor (MR), a ligand-activated transcription factor. In humans, aldosterone causes MR-dependent endothelial cell (EC) dysfunction...

journal_title：Circulation research

authors： Caprio M,Newfell BG,la Sala A,Baur W,Fabbri A,Rosano G,Mendelsohn ME,Jaffe IZ

更新日期：2008-06-06 00:00:00

abstract：:Magnesium modulates vascular smooth muscle cell (VSMC) function. However, molecular mechanisms regulating VSMC Mg2+ remain unknown. Using biochemical, pharmacological, and genetic tools, the role of transient receptor potential membrane melastatin 7 (TRPM7) cation channel in VSMC Mg2+ homeostasis was evaluated. Rat, m...

journal_title：Circulation research

authors： He Y,Yao G,Savoia C,Touyz RM

更新日期：2005-02-04 00:00:00

abstract：:Hypoxia is a potent coronary-vasodilating signal; its mechanisms are still controversial. We have assessed the possible role of nitric oxide (NO) in hypoxic coronary vasodilatation (HCVD) in isolated guinea pig hearts perfused at constant pressure. HCVD was elicited by a 1-minute 100% N2 exposure; coronary flow double...

journal_title：Circulation research

authors： Park KH,Rubin LE,Gross SS,Levi R

更新日期：1992-10-01 00:00:00

abstract：:In vitro and in vivo evidence indicates that hemodynamic wall shear stress evokes a diversity of biological responses in vascular endothelial cells, ranging from cell shape changes to alterations in low density lipoprotein receptor expression. The signal transduction mechanisms by which the level of fluid mechanical s...

journal_title：Circulation research

authors： Prasad AR,Logan SA,Nerem RM,Schwartz CJ,Sprague EA

更新日期：1993-04-01 00:00:00

abstract：RATIONALE:Inhibition of glycogen synthase kinase-3 (GSK-3) protects the heart during ischemia/reperfusion (I/R), yet the underlying mechanisms of cardioprotection afforded by beta isoform-specific inhibition GSK-3 remain to be elucidated. OBJECTIVE:We studied the molecular mechanism mediating the effect of GSK-3β acti...

journal_title：Circulation research

authors： Zhai P,Sciarretta S,Galeotti J,Volpe M,Sadoshima J

更新日期：2011-08-19 00:00:00

abstract：:The arterial pressure of rabbits with chronic one-kidney hypertension can be lowered to normotensive levels by direct immunization with preparations made from the cortex of hog kidneys. Hypertensive rabbits that are immunized with large amounts of renin may develop high plasma antirenin titers without affecting their ...

journal_title：Circulation research

authors： Skeggs LT,Kahn JR,Levine M,Dorer FE,Lentz KE

更新日期：1976-09-01 00:00:00

abstract：RATIONALE:Gq signaling in cardiac myocytes is classically considered toxic. Targeting Gq directly to test this is problematic, because cardiac myocytes have many Gq-coupled receptors. OBJECTIVE:Test whether Gq coupling is required for the cardioprotective effects of an alpha-1A-AR (adrenergic receptor) agonist. METHO...

journal_title：Circulation research

authors： Myagmar BE,Ismaili T,Swigart PM,Raghunathan A,Baker AJ,Sahdeo S,Blevitt JM,Milla ME,Simpson PC

更新日期：2019-09-13 00:00:00

abstract：:Telomeres-the specialized DNA-protein structures at the ends of eukaryotic chromosomes-are essential for maintaining genome stability and integrity and for extended proliferative life span in both cultured cells and in the whole organism. Telomerase and additional telomere-associated proteins are necessary for preserv...

journal_title：Circulation research

authors： Serrano AL,Andrés V

更新日期：2004-03-19 00:00:00

abstract：:A plasma membrane preparation purified from guinea pig ventricles without the use of high concentrations of detergents or structure-disrupting salts was used to compare the mechanisms of controlling sodium, potassium-activated adenosinetriphosphatase (Na, K-ATPase) and adenylate cyclase activities. The basal ATPase ac...

journal_title：Circulation research

authors： Tada M,Kirchberger MA,Iorio JM,Katz AM

更新日期：1975-01-01 00:00:00

abstract：:Abnormal mechanical forces can trigger aberrant proliferation of endothelial and smooth muscle cells, as observed in the progression of vascular diseases such as atherosclerosis. It has been previously shown that cells can sense physical forces such as stretch through adhesions to the extracellular matrix. Here, we se...

journal_title：Circulation research

authors： Liu WF,Nelson CM,Tan JL,Chen CS

更新日期：2007-08-31 00:00:00