Differential roles of GSK-3β during myocardial ischemia and ischemia/reperfusion.

abstract：:Two gap junction proteins, connexin43 (Cx43) and connexin45 (Cx45), are coexpressed in many cardiac and other cells. Homomeric channels formed by these proteins differ in unitary conductance, permeability, and regulation. We sought to determine the ability of Cx43 and Cx45 to oligomerize with each other to form hetero...

journal_title：Circulation research

authors： Martinez AD,Hayrapetyan V,Moreno AP,Beyer EC

更新日期：2002-05-31 00:00:00

abstract：RATIONALE:Cardiac remodeling and subsequent heart failure remain critical issues after myocardial infarction despite improved treatment and reperfusion strategies. Recently, cardiac regeneration has been demonstrated in fish and newborn mice after apex resection or cardiac infarctions. Two key issues remain to translat...

journal_title：Circulation research

authors： Haubner BJ,Schneider J,Schweigmann U,Schuetz T,Dichtl W,Velik-Salchner C,Stein JI,Penninger JM

更新日期：2016-01-22 00:00:00

abstract：:The isolated rat heart perfused with washed platelets was used as a model to examine platelet-vessel wall interactions. Release of prostacyclin and thromboxane A2 was measured, using a cascade of smooth muscle bioassay tissues or radioimmunoassays of the stable hydration products. In hearts perfused with rabbit or hum...

journal_title：Circulation research

authors： Purchase M,Dusting GJ,Li DM,Read MA

更新日期：1986-01-01 00:00:00

abstract：:Postischemic endothelial dysfunction may occur as a result of the effects of endogenous oxidants like hydrogen peroxide. Since endothelium-dependent vasodilator function may be affected by pHi, the effect of hydrogen peroxide on endothelial pHi was examined. Hydrogen peroxide (100 micromol/L for 10 minutes) decreased ...

journal_title：Circulation research

authors： Hu Q,Xia Y,Corda S,Zweier JL,Ziegelstein RC

更新日期：1998-09-21 00:00:00

abstract：:Blocking brain mineralocorticoid receptors (MRs) reduces the high circulating levels of tumor necrosis factor (TNF)-alpha in heart failure (HF) rats. TNF-alpha and other proinflammatory cytokines activate neurons in the paraventricular nucleus (PVN) of hypothalamus, including corticotropin-releasing hormone (CRH) neur...

journal_title：Circulation research

authors： Kang YM,Zhang ZH,Johnson RF,Yu Y,Beltz T,Johnson AK,Weiss RM,Felder RB

更新日期：2006-09-29 00:00:00

abstract：:Astrocyte signals can modulate arteriolar tone, contributing to regulation of cerebral blood flow, but specific intercellular communication mechanisms are unclear. Here we used isolated cerebral arteriole myocytes, astrocytes, and brain slices to investigate whether carbon monoxide (CO) generated by the enzyme heme ox...

journal_title：Circulation research

authors： Li A,Xi Q,Umstot ES,Bellner L,Schwartzman ML,Jaggar JH,Leffler CW

更新日期：2008-02-01 00:00:00

abstract：:Many forms of vascular disease are characterized by increased transforming growth factor (TGF)-beta1 expression and endothelial dysfunction. Smad proteins are a key step in TGF-beta-initiated signal transduction. We hypothesized that NO may regulate endothelial TGF-beta-dependent gene expression. We show that NO inhib...

journal_title：Circulation research

authors： Saura M,Zaragoza C,Herranz B,Griera M,Diez-Marqués L,Rodriguez-Puyol D,Rodriguez-Puyol M

更新日期：2005-11-25 00:00:00

abstract：RATIONALE:ATP-binding cassette transporter A1 (ABCA1) plays a critical role in eliminating excess free cholesterol from tissues by effluxing cellular free cholesterol and phospholipids to lipid-poor apolipoprotein AI. Macrophage ABCA1 also dampens proinflammatory myeloid differentiation primary-response protein 88-depe...

journal_title：Circulation research

authors： Zhu X,Westcott MM,Bi X,Liu M,Gowdy KM,Seo J,Cao Q,Gebre AK,Fessler MB,Hiltbold EM,Parks JS

更新日期：2012-11-09 00:00:00

abstract：:To investigate the spread of contraction in the rabbit ear artery, changes in segment diameter were measured after local stimulation. No spread of contraction was produced by direct current or local application of norepinephrine (NE). Repetitive electrical stimulation caused contraction which spread far from the point...

journal_title：Circulation research

authors： Vonderlage M

更新日期：1981-09-01 00:00:00

abstract：:Hypercholesterolemia induces atheroma formation, and the concentration of sphingomyelin is increased compared with that in the normal aortic intima-media. The aortic intima-media sphingomyelin concentration appears to increase exponentially with time on the cholesterol diet. Moreover, the entry rate of serum sphingomy...

journal_title：Circulation research

authors： Seth SK,Newman AI

更新日期：1975-02-01 00:00:00

abstract：RATIONALE:Transcatheter, intramyocardial injections of bone marrow-derived cell therapy produces reverse remodeling in large animal models of ischemic cardiomyopathy. OBJECTIVE:We used cardiac MRI (CMR) in patients with left ventricular (LV) dysfunction related to remote myocardial infarction (MI) to test the hypothes...

journal_title：Circulation research

authors： Williams AR,Trachtenberg B,Velazquez DL,McNiece I,Altman P,Rouy D,Mendizabal AM,Pattany PM,Lopera GA,Fishman J,Zambrano JP,Heldman AW,Hare JM

更新日期：2011-04-01 00:00:00

abstract：:Despite intense interest in understanding the differentiation of vascular smooth muscle, very little is known about the cellular and molecular mechanisms that control differentiation of this cell type. Progress in this field has been hampered by the lack of an inducible in vitro system for study of the early steps of ...

journal_title：Circulation research

authors： Blank RS,Swartz EA,Thompson MM,Olson EN,Owens GK

更新日期：1995-05-01 00:00:00

abstract：:The circulatory effects associated with lifelong plasma atrial natriuretic factor (ANF) elevation were examined by generating transgenic mice, which constitutively express a fusion gene consisting of the transthyretin promoter and the ANF structural gene. These mice have chronically elevated ANF levels as compared wit...

journal_title：Circulation research

authors： Barbee RW,Perry BD,Ré RN,Murgo JP,Field LJ

更新日期：1994-04-01 00:00:00

abstract：:Adipose tissue (AT) can accumulate macrophages and secrete several inflammatory mediators. Despite its pivotal role in the progression of chronic inflammatory processes such as atherosclerosis, the adaptive role of immunity in obesity remains poorly explored. Visceral AT of diet-induced obese C57BL/6 mice had higher n...

journal_title：Circulation research

authors： Rocha VZ,Folco EJ,Sukhova G,Shimizu K,Gotsman I,Vernon AH,Libby P

更新日期：2008-08-29 00:00:00

abstract：:Electrical responses induced by perivasascular nerve stimulation were recorded intracellularly from the smooth muscle of dog middle cerebral artery. With nerve stimulation, the muscle membrane produced excitatory junction potential and then a slow hyperpolarization. The excitatory junction potential showed facilitatio...

journal_title：Circulation research

authors： Suzuki H,Fujiwara S

更新日期：1982-12-01 00:00:00

abstract：:On endothelial cells, thrombin binds to thrombomodulin (TM), an integral membrane-bound glycoprotein, and to protease-activated receptors (PARs). Thrombin binding to TM modulates endothelial cell and smooth muscle cell proliferation mediated through PAR1. We studied the phosphorylation and nuclear translocation of ext...

journal_title：Circulation research

authors： Olivot JM,Estebanell E,Lafay M,Brohard B,Aiach M,Rendu F

更新日期：2001-04-13 00:00:00

abstract：:Heart failure is associated with death of cardiomyocytes leading to loss of contractility. Previous studies using membrane-targeted Akt (myristolated-Akt), an enzyme involved in antiapoptotic signaling, showed inhibition of cell death and prevention of pathogenesis induced by cardiomyopathic stimuli. However, recent s...

journal_title：Circulation research

authors： Shiraishi I,Melendez J,Ahn Y,Skavdahl M,Murphy E,Welch S,Schaefer E,Walsh K,Rosenzweig A,Torella D,Nurzynska D,Kajstura J,Leri A,Anversa P,Sussman MA

更新日期：2004-04-16 00:00:00

abstract：:A selective history of the pathophysiological, structural, and metabolic changes found during an episode of severe myocardial ischemia in the canine heart is presented. The changes that cause ischemic injury to become irreversible are discussed in detail because these changes are the target of any successful therapy d...

journal_title：Circulation research

authors： Jennings RB

更新日期：2013-08-02 00:00:00

abstract：:The purpose of this study was to determine whether increased sympathetic nervous system activity with proportionally greater stimulation to the kidney could result in sustained hypertension. This was simulated by continuous intrarenal norepinephrine infusion. Effects of chronic infusion of norepinephrine (0.285 micron...

journal_title：Circulation research

authors： Katholi RE,Carey RM,Ayers CR,Vaughan ED Jr,Yancey MR,Morton CL

更新日期：1977-05-01 00:00:00

abstract：:A distal transcriptional enhancer has been previously reported upstream of the mouse renin gene. A homologous sequence is also present upstream of the human renin gene, but the mouse and human renin enhancers differ markedly in their ability to activate transcription of a renin promoter. Although the 2 enhancers share...

journal_title：Circulation research

authors： Shi Q,Black TA,Gross KW,Sigmund CD

更新日期：1999-09-17 00:00:00

abstract：RATIONALE:Chronic inflammation in the myocardium is involved in the development of left ventricular (LV) remodeling and failure after myocardial infarction (MI). Invariant natural killer T (iNKT) cells have been shown to produce inflammatory cytokines and orchestrate tissue inflammation. However, no previous studies ha...

journal_title：Circulation research

authors： Sobirin MA,Kinugawa S,Takahashi M,Fukushima A,Homma T,Ono T,Hirabayashi K,Suga T,Azalia P,Takada S,Taniguchi M,Nakayama T,Ishimori N,Iwabuchi K,Tsutsui H

更新日期：2012-09-28 00:00:00

abstract：:Beta(1)- and beta(2)-adrenergic receptors (betaARs) are known to differentially regulate cardiomyocyte contraction and growth. We tested the hypothesis that these differences are attributable to spatial compartmentation of the second messenger cAMP. Using a fluorescent resonance energy transfer (FRET)-based approach, ...

journal_title：Circulation research

authors： Nikolaev VO,Bünemann M,Schmitteckert E,Lohse MJ,Engelhardt S

更新日期：2006-11-10 00:00:00

abstract：:Despite the absence of a systematic development plan, β-blockers have reached the top tier of medical therapies for chronic heart failure. The successful outcome was due to the many dedicated investigators who produced, over a 30-year period, increasing evidence that β-blocking agents should or actually did improve th...

journal_title：Circulation research

authors： Bristow MR

更新日期：2011-10-28 00:00:00

abstract：:Two characteristic features of the rapid component of the cardiac delayed rectifier current (IKr) are prominent inward rectification and an unexpected reduction in activating current with decreased [K+]o. Similar features are observed with heterologous expression of HERG, the gene thought to encode the channel carryin...

journal_title：Circulation research

authors： Yang T,Snyders DJ,Roden DM

更新日期：1997-06-01 00:00:00

abstract：:We have identified immunologically the protein kinase C (PKC) isoforms present in rat mesenteric small arteries, defined their distribution between particulate and soluble fractions, and studied their involvement in phorbol ester-induced contraction. Our analysis revealed the presence of the CA(2+)-dependent PKCs (alp...

journal_title：Circulation research

authors： Ohanian V,Ohanian J,Shaw L,Scarth S,Parker PJ,Heagerty AM

更新日期：1996-05-01 00:00:00

abstract：:The hallmark of most cardiac diseases is the progressive loss of cardiomyocytes. In the perinatal period, cardiomyocytes still proliferate, and the heart shows the capacity to regenerate upon injury. In the adult heart, however, the actual rate of cardiomyocyte renewal is too low to efficiently counteract substantial ...

journal_title：Circulation research

authors： Derks W,Bergmann O

更新日期：2020-02-14 00:00:00

abstract：:We report the cloning of cDNAs encoding two different human nonmuscle myosin heavy chains designated NMMHC-A and NMMHC-B. The mRNAs encoding NMMHC-A and NMMHC-B are both 7.5 kb in size but are shown to be the products of different genes, which are localized to chromosome 22q11.2 and chromosome 17q13, respectively. In ...

journal_title：Circulation research

authors： Simons M,Wang M,McBride OW,Kawamoto S,Yamakawa K,Gdula D,Adelstein RS,Weir L

更新日期：1991-08-01 00:00:00

abstract：:We investigated the effects of streptozotocin-induced diabetes on atrial natriuretic peptide (ANP) synthesis, hemodynamic parameters, blood volume, and histopathology, as well as the reversibility of such effects with insulin therapy in Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHRs). The biatrial A...

journal_title：Circulation research

authors： Matsubara H,Mori Y,Yamamoto J,Inada M

更新日期：1990-10-01 00:00:00

abstract：:The cardiovascular actions of the synthetic natriuretic peptide, atriopeptin II, were examined in conscious unrestrained spontaneously hypertensive rats and normotensive Wistar-Kyoto rats. The animals were chronically instrumented with miniaturized pulsed Doppler flow probes to allow measurement of regional blood flow...

journal_title：Circulation research

authors： Lappe RW,Smits JF,Todt JA,Debets JJ,Wendt RL

更新日期：1985-04-01 00:00:00

abstract：:Activin is a member of the transforming growth factor-beta superfamily, and it modulates the proliferation and differentiation of various target cells. In this study, we investigated the role of activin in the initiation and progression of human atherosclerosis. The expression of activin, its physiological inhibitor f...

journal_title：Circulation research

authors： Engelse MA,Neele JM,van Achterberg TA,van Aken BE,van Schaik RH,Pannekoek H,de Vries CJ

更新日期：1999-11-12 00:00:00