Abstract:
:The arterial pressure of rabbits with chronic one-kidney hypertension can be lowered to normotensive levels by direct immunization with preparations made from the cortex of hog kidneys. Hypertensive rabbits that are immunized with large amounts of renin may develop high plasma antirenin titers without affecting their blood pressure. Removal of renin by chromatography on columns of immobilized antirenin yields preparations with little or no renin. Such preparations may be effective in lowering blood pressure although they do not elicit the formation of plasma antirenin and the rabbits remain sensitive to challenging doses of rabbit renin. The evidence suggests that an unknown substance is responsible for the development of a cross-reacting antibody that neutralizes an unknown factor that is essential for the maintence of an elevated blood pressure level in rabbits with chronic one-kidney hypertension.
journal_name
Circ Resjournal_title
Circulation researchauthors
Skeggs LT,Kahn JR,Levine M,Dorer FE,Lentz KEdoi
10.1161/01.res.39.3.400subject
Has Abstractpub_date
1976-09-01 00:00:00pages
400-6issue
3eissn
0009-7330issn
1524-4571journal_volume
39pub_type
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