Chemoreceptor hypersensitivity, sympathetic excitation, and overexpression of ASIC and TASK channels before the onset of hypertension in SHR.

abstract：:Oxidative stress through the production of oxygen metabolites such as hydrogen peroxide (H2O2) increases vascular endothelial permeability. H2O2 stimulates ADP-ribose formation, which in turn opens transient receptor potential melastatin (TRPM)2 channels. Here, in endothelial cells, we demonstrate transcript and prote...

journal_title：Circulation research

authors： Hecquet CM,Ahmmed GU,Vogel SM,Malik AB

更新日期：2008-02-15 00:00:00

abstract：:Whereas numerous studies have investigated the role of prostacyclin and thromboxane A2 in the maintenance of coronary blood flow, most of these have focused on normal vessels. In the present investigation, we examined the prostaglandin- and thromboxane-synthesizing capacity of isolated coronary artery segments obtaine...

journal_title：Circulation research

authors： Schmitz JM,Apprill PG,Buja LM,Willerson JT,Campbell WB

更新日期：1985-08-01 00:00:00

abstract：:We studied the individual and combined effects of extracellular acidosis and increases in extracellular potassium on action potential characteristics and conduction in order to gain a better understanding of the effects of acute ischemia. At each level of potassium between 2.7 and 17 mm, acidosis induced by increasing...

journal_title：Circulation research

authors： Kagiyama Y,Hill JL,Gettes LS

更新日期：1982-11-01 00:00:00

abstract：RATIONALE:Proteasomal degradation is altered in many disease phenotypes including cardiac hypertrophy, a prevalent condition leading to heart failure. Our recent investigations identified heterogeneous subpopulations of proteasome complexes in the heart and implicated multiple mechanisms for their regulation. OBJECTIV...

journal_title：Circulation research

authors： Drews O,Tsukamoto O,Liem D,Streicher J,Wang Y,Ping P

更新日期：2010-10-29 00:00:00

abstract：:Pyridine nucleotides are abundant soluble coenzymes and they undergo reversible oxidation and reduction in several biological electron-transfer reactions. They are comprised of two mononucleotides, adenosine monophosphate and nicotinamide mononucleotide, and are present as oxidized and reduced nicotinamide adenine din...

journal_title：Circulation research

authors： Nakamura M,Bhatnagar A,Sadoshima J

更新日期：2012-08-17 00:00:00

abstract：:The structure of the mouse natriuretic peptide type-B (BNP) gene was determined by isolating and sequencing genomic clones. The mouse BNP gene was structurally similar to other natriuretic peptide genes and comprised three exons and two introns. Expression of the mouse BNP gene was found only in cardiac tissue as dete...

journal_title：Circulation research

authors： Steinhelper ME

更新日期：1993-05-01 00:00:00

abstract：:We previously have shown that alpha-adrenergic stimulation of canine Purkinje fibers and rat ventricle decreases automaticity. Experiments on rat ventricular myocytes in tissue culture have suggested that the decrease in automaticity induced by alpha-adrenergic stimulation depends on the development of sympathetic inn...

journal_title：Circulation research

authors： Rosen MR,Steinberg SF,Chow YK,Bilezikian JP,Danilo P Jr

更新日期：1988-02-01 00:00:00

abstract：:We sought to determine the ejection variables that are principally responsible for increases in isovolumic ventricular relaxation rate observed with increases in stroke volume. In nine isolated canine hearts, left ventricular ejection was controlled by patterns specially designed to isolate the ejection parameters mos...

journal_title：Circulation research

authors： Hori M,Kitakaze M,Ishida Y,Fukunami M,Kitabatake A,Inoue M,Kamada T,Yue DT

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:Inhibition of glycogen synthase kinase-3 (GSK-3) protects the heart during ischemia/reperfusion (I/R), yet the underlying mechanisms of cardioprotection afforded by beta isoform-specific inhibition GSK-3 remain to be elucidated. OBJECTIVE:We studied the molecular mechanism mediating the effect of GSK-3β acti...

journal_title：Circulation research

authors： Zhai P,Sciarretta S,Galeotti J,Volpe M,Sadoshima J

更新日期：2011-08-19 00:00:00

abstract：RATIONALE:The impact of severe cardiovascular disease and critical limb ischemia (CLI) on the bone marrow (BM) is largely unknown. OBJECTIVE:To investigate microvascular and neuropathic changes in BM of patients with CLI. METHODS AND RESULTS:BM biopsies were obtained from patients with CLI (n=33) included in the Reju...

journal_title：Circulation research

authors： Teraa M,Fledderus JO,Rozbeh RI,Leguit RJ,Verhaar MC,Juventas Study Group{dagger}.

更新日期：2014-01-17 00:00:00

abstract：:Acetylcholine (ACh) evokes the conduction of vasodilation along resistance microvessels. However, it is not known which cell layer (endothelium or smooth muscle) serves as the conduction pathway. In isolated, cannulated feed arteries ( approximately 70 microm in diameter at 75 mm Hg; length approximately 4 mm) of the ...

journal_title：Circulation research

authors： Emerson GG,Segal SS

更新日期：2000-01-07 00:00:00

abstract：:Congenital heart defects affect almost 1% of human newborns. Recently, mutations in Notch ligands and receptors have been found to cause a variety of heart defects in rodents and humans. However, the molecular effects downstream of Notch are still poorly understood. Here we report that combined inactivation of Hey1 an...

journal_title：Circulation research

authors： Fischer A,Steidl C,Wagner TU,Lang E,Jakob PM,Friedl P,Knobeloch KP,Gessler M

更新日期：2007-03-30 00:00:00

abstract：:To determine the mechanical factors affecting regional segmental motion after acute coronary occlusion, we studied seven conscious dogs, instrumented with sonomicrometers. Loading conditions were changed by the withdrawal of 500 ml of blood and the transfusion of 800 ml of blood. To express segmental motion, percent s...

journal_title：Circulation research

authors： Akaishi M,Weintraub WS,Schneider RM,Klein LW,Agarwal JB,Helfant RH

更新日期：1986-02-01 00:00:00

abstract：RATIONALE:Circumstantial evidence links the development of heart failure to posttranslational modifications of mitochondrial proteins, including lysine acetylation (Kac). Nonetheless, direct evidence that Kac compromises mitochondrial performance remains sparse. OBJECTIVE:This study sought to explore the premise that ...

journal_title：Circulation research

authors： Davidson MT,Grimsrud PA,Lai L,Draper JA,Fisher-Wellman KH,Narowski TM,Abraham DM,Koves TR,Kelly DP,Muoio DM

更新日期：2020-09-25 00:00:00

abstract：:Catecholamines and catecholamine-synthesizing enzymes have been examined in specific brain areas during the development of spontaneously (genetic) hypertensive (SH) rats. Changes in catecholamine metabolism were localized to regions of the brain implicated in the regulation of blood pressure. Norepinephrine levels and...

journal_title：Circulation research

authors： Saavedra JM,Grobecker H,Axelrod J

更新日期：1978-04-01 00:00:00

abstract：RATIONALE:One of the physiological mechanisms by which the heart adapts to a rise in blood pressure is by augmenting myocyte stretch-mediated intracellular calcium, with a subsequent increase in contractility. This slow force response was first described over a century ago and has long been considered compensatory, but...

journal_title：Circulation research

authors： Cingolani OH,Kirk JA,Seo K,Koitabashi N,Lee DI,Ramirez-Correa G,Bedja D,Barth AS,Moens AL,Kass DA

更新日期：2011-12-09 00:00:00

abstract：:Of 145 patients with borderline hypertension, 30% had increased resting cardiac index (QI), whereas the remainder had normal values. The specific aim of this study was to investigate cardiac regulation in patients who had normal resting QI. Eighty-five control subjects were used for comparison. At rest, patients with ...

journal_title：Circulation research

authors： Julius S,Randall OS,Esler MD,Kashima T,Ellis C,Bennett J

更新日期：1975-06-01 00:00:00

abstract：:Understanding molecular mechanisms regulating angiogenesis may lead to novel therapies for ischemic disorders. Hypoxia-inducible factor 1 (HIF-1) activates vascular endothelial growth factor (VEGF) gene expression in hypoxic/ischemic tissue. In this study we demonstrate that exposure of primary cultures of cardiac and...

journal_title：Circulation research

authors： Kelly BD,Hackett SF,Hirota K,Oshima Y,Cai Z,Berg-Dixon S,Rowan A,Yan Z,Campochiaro PA,Semenza GL

更新日期：2003-11-28 00:00:00

abstract：:The global prevalence of overweight and obesity has risen substantially over the past 4 decades and is accompanied by an increasing burden of cardiovascular risk factors such as hypertension. Metabolic surgery is the most effective method to treat obesity and may further improve associated conditions. Although most re...

journal_title：Circulation research

authors： Pareek M,Bhatt DL,Schiavon CA,Schauer PR

更新日期：2019-03-29 00:00:00

abstract：:In vivo studies of the rheological behavior of blood in the microcirculation were conducted by direct in situ measurements in cat mesentery. Upstream to downstream pressure drops were measured in unbranched arterioles, capillaries, and venules, with diameters from 7 to 58 micrometer. Simultaneous measurements of red c...

journal_title：Circulation research

authors： Lipowsky HH,Kovalcheck S,Zweifach BW

更新日期：1978-11-01 00:00:00

abstract：RATIONALE:Upregulation of endothelial vascular cell adhesion molecule (VCAM)-1 and the subsequent increase in monocyte recruitment constitute critical events in atherogenesis. We have recently shown that in human coronary artery endothelial cells (HCAECs) regulated expression of VCAM-1 depends, to a significant extent,...

journal_title：Circulation research

authors： Smedlund K,Tano JY,Vazquez G

更新日期：2010-05-14 00:00:00

abstract：:Cardiomyocyte hypertrophy is transcriptionally controlled and inhibited by glycogen synthase kinase 3beta (GSK3beta). Myocardin is a muscle-specific transcription factor with yet unknown relation to hypertrophy. Therefore, we investigated whether myocardin is sufficient to induce cardiomyocyte hypertrophy and whether ...

journal_title：Circulation research

authors： Badorff C,Seeger FH,Zeiher AM,Dimmeler S

更新日期：2005-09-30 00:00:00

abstract：:Choline acetyltransferase is the enzyme that catalyzes the biosynthesis of acetylcholine, the neurotransmitter of the pre- and postganglionic parasympathetic system. To assess the extent of parasympathetic innervation, enzyme activity was measured in specialized and contractile regions throughout the guinea pig heart....

journal_title：Circulation research

authors： Schmid PG,Greif BJ,Lund DD,Roskoski R Jr

更新日期：1978-05-01 00:00:00

abstract：:The regeneration of new myocardium by stem or progenitor cells is an important therapeutic option. Cellular or nuclear fusion is considered as an alternative to cell reprogramming by transdifferentiation. However, the generation of hybrid cells may also be a consequence of a transient transmembrane exchange of protein...

journal_title：Circulation research

authors： Koyanagi M,Brandes RP,Haendeler J,Zeiher AM,Dimmeler S

更新日期：2005-05-27 00:00:00

abstract：:Leukocyte-derived microparticles (LMPs) may originate from neutrophils, monocytes/macrophages, and lymphocytes. They express markers from their parental cells and harbor membrane and cytoplasmic proteins as well as bioactive lipids implicated in a variety of mechanisms, maintaining or disrupting vascular homeostasis. ...

journal_title：Circulation research

authors： Angelillo-Scherrer A

更新日期：2012-01-20 00:00:00

abstract：:Although estradiol (E(2)) has been recognized to exert several vasculoprotective effects in several species, its effects in mouse vasomotion are unknown, and consequently, so is the estrogen receptor subtype mediating these effects. We investigated the effect of E(2) (80 microg/kg/day for 15 days) on NO production in ...

journal_title：Circulation research

authors： Darblade B,Pendaries C,Krust A,Dupont S,Fouque MJ,Rami J,Chambon P,Bayard F,Arnal JF

更新日期：2002-03-08 00:00:00

abstract：:Fcγ receptors (FcγRs) classically modulate intracellular signaling on binding of the Fc region of IgG in immune response cells. How FcγR and their ligands affect cardiovascular health and disease has been interrogated recently in both preclinical and clinical studies. The stimulation of activating FcγR in endothelial ...

journal_title：Circulation research

authors： Tanigaki K,Sundgren N,Khera A,Vongpatanasin W,Mineo C,Shaul PW

更新日期：2015-01-16 00:00:00

abstract：:The role of the central nervous system in the mechanism(s) involved in acute carotid baroreflex resetting was studied in six conscious, chronically instrumented, aortic-denervated dogs. Dogs were prepared for reversible vascular isolation of the carotid sinuses. Acute baroreflex resetting was induced by holding the le...

journal_title：Circulation research

authors： Tan W,Panzenbeck MJ,Hajdu MA,Zucker IH

更新日期：1989-07-01 00:00:00

abstract：:The purpose of this study was to determine whether a quantitative relationship existed between a reduction in regional myocardial blood flow, measured by radiolabeled microspheres, and the degree and type of changes in myocardial activation recorded in bipolar left ventricular subepicardial and subendocardial electrog...

journal_title：Circulation research

authors： Ruffy R,Lovelace DE,Mueller TM,Knoebel SB,Zipes DP

更新日期：1979-12-01 00:00:00

abstract：:We hypothesized that a redox-sensitive transcription factor, redox factor-1 (Ref-1) (HAP1, APE, and APEX), was critical in the regulation of endothelial cell survival in response to hypoxia and cytokines, including tumor necrosis factor (TNF)-alpha. Hypoxia resulted in a significant decrease in Ref-1 protein expressio...

journal_title：Circulation research

authors： Hall JL,Wang X,Van Adamson,Zhao Y,Gibbons GH

更新日期：2001-06-22 00:00:00