Central cardiovascular alpha-adrenoceptors. Relation to peripheral receptors.

abstract：:Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited disease characterized by life threatening arrhythmias and mutations in the gene encoding the ryanodine receptor (RyR2). Disagreement exists on whether (1) RyR2 mutations induce abnormal calcium transients in the absence of adrenergic stimulat...

journal_title：Circulation research

authors： Liu N,Colombi B,Memmi M,Zissimopoulos S,Rizzi N,Negri S,Imbriani M,Napolitano C,Lai FA,Priori SG

更新日期：2006-08-04 00:00:00

abstract：:The kinetic attributes of the afferent arteriole myogenic response were investigated using the in vitro perfused hydronephrotic rat kidney. Equations describing the time course for pressure-dependent vasoconstriction and vasodilation, and steady-state changes in diameter were combined to develop a mathematical model o...

journal_title：Circulation research

authors： Loutzenhiser R,Bidani A,Chilton L

更新日期：2002-06-28 00:00:00

abstract：:It is believed that inotropic agents exert their effects in cardiac muscle via a modulation of Ca2+ cycling; however, the involvement of phospholipase activation and the biochemical pathways participating in inotropic responsiveness remain unclear. The aim of the current study was to determine whether arachidonic acid...

journal_title：Circulation research

authors： Damron DS,Bond M

更新日期：1993-02-01 00:00:00

abstract：:The average lifespan of humans is increasing, and with it the percentage of people entering the 65 and older age group is growing rapidly and will continue to do so in the next 20 years. Within this age group, cardiovascular disease will remain the leading cause of death, and the cost associated with treatment will co...

journal_title：Circulation research

authors： North BJ,Sinclair DA

更新日期：2012-04-13 00:00:00

abstract：:To determine the effects of aging on the human myocardium, 67 hearts were obtained from individuals who died from causes other than cardiovascular disease. The age interval examined was 17-90 years. Regression analysis demonstrated that the aging process was characterized by a loss of 38 million and 14 million myocyte...

journal_title：Circulation research

authors： Olivetti G,Melissari M,Capasso JM,Anversa P

更新日期：1991-06-01 00:00:00

abstract：:The structure-function relationships of the sarcomeric proteins in the mammalian cardiac compartment remain ill-defined because of the lack of a suitable model in which they can be readily manipulated or exchanged in vivo. To establish the validity of the transgenic paradigm for remodeling the mammalian heart, the mur...

journal_title：Circulation research

authors： Palermo J,Gulick J,Colbert M,Fewell J,Robbins J

更新日期：1996-03-01 00:00:00

abstract：:Cardiac hypertrophy induced by thyrotoxic stress leads to an increase in the rate of force development, velocity of shortening, tension-dependent heat generation, and myosin ATPase activity. We did studies to see whether alterations in covalent phosphorylation of myofibrillar proteins correlate with these changes. The...

journal_title：Circulation research

authors： Litten RZ 3rd,Martin BJ,Howe ER,Alpert NR,Solaro RJ

更新日期：1981-04-01 00:00:00

abstract：:The past 2 decades have witnessed a >40% improvement in mortality for patients with heart failure and left ventricular systolic dysfunction. 1 This success has coincided with the stepwise availability of drugs that target neurohormonal activation: β-adrenergic receptor blockers (β-blockers), ACE (angiotensin-convertin...

journal_title：Circulation research

authors： Zelt JGE,Chaudhary KR,Cadete VJ,Mielniczuk LM,Stewart DJ

更新日期：2019-05-24 00:00:00

abstract：:T-wave alternans (TWA), an ABAB oscillation, has been postulated as the initial pattern in a stepwise progression to higher-order oscillations, culminating in sudden arrhythmic death. The present study is the first to provide experimental evidence to support this intriguing concept. Epicardial and endocardial ECGs fro...

journal_title：Circulation research

authors： Nearing BD,Verrier RL

更新日期：2002-10-18 00:00:00

abstract：RATIONALE:Angiotensin-converting enzyme (ACE)2 opposes the actions of angiotensin (Ang) II by degrading it to Ang 1-7. OBJECTIVE:Given the important role of Ang II/Ang 1-7 in atherogenesis, we investigated the impact of ACE2 deficiency on the development of atherosclerosis. METHODS AND RESULTS:C57Bl6, Ace2 knockout (...

journal_title：Circulation research

authors： Thomas MC,Pickering RJ,Tsorotes D,Koitka A,Sheehy K,Bernardi S,Toffoli B,Nguyen-Huu TP,Head GA,Fu Y,Chin-Dusting J,Cooper ME,Tikellis C

更新日期：2010-10-01 00:00:00

abstract：:Glycerophosphate and carnitine as competing acyl acceptors and the oxidation of different long chain acylcarnitines in isolated mitochondria have been investigated. In the presence of low concentrations of palmitate, glycerophosphate is the preferred acyl acceptor in isolated liver mitochondria, indicating that the gl...

journal_title：Circulation research

authors： Borrebaek B,Christiansen R,Christophersen BO,Bremer J

更新日期：1976-05-01 00:00:00

abstract：:To investigate the regulation of the actomyosin crossbridge cycle in cardiac muscles, the effects of ATP, ADP, Pi, and creatine phosphate (CP) on the rate of force redevelopment (ktr) were measured. We report that CP is a primary determinant in controlling the actomyosin crossbridge cycling kinetics of cardiac muscles...

journal_title：Circulation research

authors： Ogut O,Brozovich FV

更新日期：2003-07-11 00:00:00

abstract：:Isolated cardiac conduction disease is an autosomal dominant defect that includes various combinations of bundle branch or fascicular blocks. These defects can cause sudden death due to a complete heart block. We used a genome-wide screening approach with polymorphic (CA)n repeat markers to determine the chromosomal p...

journal_title：Circulation research

authors： de Meeus A,Stephan E,Debrus S,Jean MK,Loiselet J,Weissenbach J,Demaille J,Bouvagnet P

更新日期：1995-10-01 00:00:00

abstract：:The extracellular pH (pHo) and intracellular pH (pHi) were simultaneously measured with H(+)-sensitive microelectrodes in the rabbit papillary muscle during normal arterial perfusion and no-flow ischemia. The preparation was kept in an artificial gaseous atmosphere (N2 and CO2 during ischemia) without a surrounding fl...

journal_title：Circulation research

authors： Yan GX,Kléber AG

更新日期：1992-08-01 00:00:00

abstract：:Increased glomerular capillary hydrostatic pressure (PGC) is an important hemodynamic determinant of glomerular injury, but the molecular events responsible for this association are poorly understood. PGC is normal in spontaneously hypertensive rats (SHR), but uninephrectomy leads to an increase in PGC and accelerated...

journal_title：Circulation research

authors： Shankland SJ,Ly H,Thai K,Scholey JW

更新日期：1994-11-01 00:00:00

abstract：:This review reflects and expands on the contents of my presentation at the Thomas W. Smith Memorial Lecture at American Heart Association Scientific Sessions, 2011. "Decoding the cardiac message" refers to accumulating results from ongoing microRNA research that is altering longstanding concepts of the mechanisms for,...

journal_title：Circulation research

authors： Dorn GW 2nd

更新日期：2012-03-02 00:00:00

abstract：:Electrical activity of enzymatically isolated, smooth muscle cells from hog carotid arteries was recorded under current clamp and voltage clamp. Under the experimental conditions, membrane potential usually was not stable, and spontaneous hyperpolarizing transients of approximately 100-msec duration were recorded. The...

journal_title：Circulation research

authors： Désilets M,Driska SP,Baumgarten CM

更新日期：1989-09-01 00:00:00

abstract：:This study was designed to determine if opioids were detectable in cerebrospinal fluid (CSF) and if these concentrations were altered by hemorrhagic hypotension. This study was further designed to determine the effects of topically administered opioids on pial arteriolar diameter during normotension and hypotension. C...

journal_title：Circulation research

authors： Armstead WM,Mirro R,Busija DW,Desiderio DM,Leffler CW

更新日期：1991-04-01 00:00:00

abstract：:Effects of concentrations of intracellular calcium, [Ca2+]i, on the voltage-dependent Ca2+ current (ICa) recorded from dispersed single smooth muscle cells of the rabbit portal vein were studied, using a whole cell voltage clamp method combined with an intracellular perfusion technique. Outward currents were minimized...

journal_title：Circulation research

authors： Ohya Y,Kitamura K,Kuriyama H

更新日期：1988-02-01 00:00:00

abstract：:The effects of acute hypoxemia and hypercapnic acidosis were examined in five unanesthetized dogs in which sodium intake was controlled at 80 mEq/24 hours for 4 days prior to study. Each animal was studied during combined acute hypoxemia and hypercapnic acidosis (Pao2 = 36 +/- 1 mm Hg, Paco2 = 52 +/- 1 mm Hg, pH = 7.1...

journal_title：Circulation research

authors： Rose CE Jr,Kimmel DP,Godine RL Jr,Kaiser DL,Carey RM

更新日期：1983-08-01 00:00:00

abstract：:Previous studies have demonstrated that in adult rats with chronic hyponatremia, both symptoms of encephalopathy and mortality largely depend upon the gender of the animal and the presence of elevated plasma levels of vasopressin (AVP). Since effects of AVP on blood vessels may be gender dependent, the present study w...

journal_title：Circulation research

authors： Kozniewska E,Roberts TP,Vexler ZS,Oseka M,Kucharczyk J,Arieff AI

更新日期：1995-04-01 00:00:00

abstract：:Nitric oxide (NO), generated by platelets through stimulation of nitric oxide synthase (NOS), limits platelet adhesion and aggregation after a prothrombotic stimulus. Platelet beta-adrenoceptors (betaARs) mediate inhibition of aggregation, but no direct link has been shown between these receptors and platelet adhesion...

journal_title：Circulation research

authors： Queen LR,Xu B,Horinouchi K,Fisher I,Ferro A

更新日期：2000-07-07 00:00:00

abstract：:Elastance-resistance [E(t)-R] representations of the left ventricle (LV) were evaluated for their ability to reproduce instantaneous pressure [P(t)] and outflow [Q(t)]. Experiments were performed in open-chest rats. P(t) and Q(t) were measured during steady-state ejecting beats and during a beat in which the aorta was...

journal_title：Circulation research

authors： Campbell KB,Kirkpatrick RD,Knowlen GG,Ringo JA

更新日期：1990-01-01 00:00:00

abstract：:The paraoxonase (PON) gene cluster consists of the PON1, PON2, and PON3 genes, each of which can individually inhibit atherogenesis. To analyze the functions of the PON gene cluster (PC) in atherogenesis and plaque stability, human PC transgenic (Tg) mice were generated using bacterial artificial chromosome. The high-...

journal_title：Circulation research

authors： She ZG,Zheng W,Wei YS,Chen HZ,Wang AB,Li HL,Liu G,Zhang R,Liu JJ,Stallcup WB,Zhou Z,Liu DP,Liang CC

更新日期：2009-05-22 00:00:00

abstract：:Picrotoxin, an antagonist of gamma-aminobutyric acid, produces an increase in coronary vascular resistance, S-T segment elevation, and ventricular arrhythmias after an intravenous injection of 2 mg/kg in chloralose-anesthetized cats. To determine whether these responses were due to blockade of central nervous system G...

journal_title：Circulation research

authors： Segal SA,Jacob T,Gillis RA

更新日期：1984-09-01 00:00:00

abstract：:Alterations in voltage-dependent Ca2+ channels in the arterial smooth muscle cells of spontaneously hypertensive rats (SHR) were investigated using the whole-cell voltage clamp and compared with Wistar-Kyoto (WKY) rats. Single cells were freshly isolated from resistance mesenteric arteries from 4- to 5-week-old (young...

journal_title：Circulation research

authors： Ohya Y,Abe I,Fujii K,Takata Y,Fujishima M

更新日期：1993-12-01 00:00:00

abstract：:The purpose of this study was to examine by freeze-fracture the ultrastructure of intercellular junctions between mouse pulmonary endothelial and epithelial cells, and to relate this fine structure to that deduced from previous physiological and ultrastructural studies using tracer techniques. Junctions between capill...

journal_title：Circulation research

authors： Schneeberger EE,Karnovsky MJ

更新日期：1976-05-01 00:00:00

abstract：RATIONALE:Upregulation of endothelial vascular cell adhesion molecule (VCAM)-1 and the subsequent increase in monocyte recruitment constitute critical events in atherogenesis. We have recently shown that in human coronary artery endothelial cells (HCAECs) regulated expression of VCAM-1 depends, to a significant extent,...

journal_title：Circulation research

authors： Smedlund K,Tano JY,Vazquez G

更新日期：2010-05-14 00:00:00

abstract：RATIONALE:PCSKs (Proprotein convertase subtilisins/kexins) are a protease family with unknown functions in vasculature. Previously, we demonstrated PCSK6 upregulation in human atherosclerotic plaques associated with smooth muscle cells (SMCs), inflammation, extracellular matrix remodeling, and mitogens. OBJECTIVE:Here...

journal_title：Circulation research

authors： Rykaczewska U,Suur BE,Röhl S,Razuvaev A,Lengquist M,Sabater-Lleal M,van der Laan SW,Miller CL,Wirka RC,Kronqvist M,Gonzalez Diez M,Vesterlund M,Gillgren P,Odeberg J,Lindeman JH,Veglia F,Humphries SE,de Faire U,Baldass

更新日期：2020-02-28 00:00:00

abstract：:Sympathetic activation appears to accelerate the development of atherosclerosis, an effect that may be inhibited by beta-receptor blockade. It is unclear, however, which mechanisms mediate this effect. In view of the significance attached to endothelial injury in the initial phases of atherogenesis, we decided to test...

journal_title：Circulation research

authors： Pettersson K,Bejne B,Björk H,Strawn WB,Bondjers G

更新日期：1990-10-01 00:00:00