Experimental sympathetic activation causes endothelial injury in the rabbit thoracic aorta via beta 1-adrenoceptor activation.

abstract：:Acetylcholine (ACh) evokes the conduction of vasodilation along resistance microvessels. However, it is not known which cell layer (endothelium or smooth muscle) serves as the conduction pathway. In isolated, cannulated feed arteries ( approximately 70 microm in diameter at 75 mm Hg; length approximately 4 mm) of the ...

journal_title：Circulation research

authors： Emerson GG,Segal SS

更新日期：2000-01-07 00:00:00

abstract：:Given the essential role played by gap junctions in the coordination of cardiac muscle contraction, it is plausible that down-regulation of gap junctional conduction is in part responsible for the contractile dysfunction observed in hypertrophied and failing hearts. In the present study, we analyzed the expression and...

journal_title：Circulation research

authors： Toyofuku T,Yabuki M,Otsu K,Kuzuya T,Tada M,Hori M

更新日期：1999-10-15 00:00:00

abstract：:Morphometric data from stable (nonedematous) isolated dog lungs, perfused with nearly cell-free perfusates, were compared to similar stereological evaluations of isolated dog lungs after induction of severe acute hydrostatic edema. In the edematous lungs, capillary surface and volume densities were substantially incre...

journal_title：Circulation research

authors： DeFouw DO,Berendsen PB

更新日期：1978-07-01 00:00:00

abstract：:We have recently demonstrated that endogenous erythropoietin (Epo)/Epo receptor (EpoR) system plays an important protective role in hypoxia-induced pulmonary hypertension. However, it remains to be examined whether vascular EpoR system contributes to angiogenesis in response to ischemia. We examined angiogenesis in Ep...

journal_title：Circulation research

authors： Nakano M,Satoh K,Fukumoto Y,Ito Y,Kagaya Y,Ishii N,Sugamura K,Shimokawa H

更新日期：2007-03-16 00:00:00

abstract：:We have shown that the cellular contractile dysfunction characteristic of pressure-overload cardiac hypertrophy results not from an abnormality intrinsic to the myofilament portion of the cardiocyte cytoskeleton but rather from an increased density of the microtubule component of the extramyofilament portion of the ca...

journal_title：Circulation research

authors： Tagawa H,Wang N,Narishige T,Ingber DE,Zile MR,Cooper G 4th

更新日期：1997-02-01 00:00:00

abstract：:Targeted expression of genetic material within the vascular endothelium is potentially a powerful tool for the investigation of endothelial cell (EC) biology. We developed, optimized, and characterized an efficient somatic transgenic model of EC-specific gene transfer. Rat carotid arteries were infused with adenovirus...

journal_title：Circulation research

authors： Schulick AH,Dong G,Newman KD,Virmani R,Dichek DA

更新日期：1995-09-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) expression is upregulated by hypoxia-inducible factor-1 (HIF-1) in ischemic tissues and growing tumors. Normally, HIF-1 activity depends on the amount of HIF-1alpha subunit, which is tightly regulated by the oxygen tension. In the myocardium, VEGF expression has been shown to ...

journal_title：Circulation research

authors： Kim CH,Cho YS,Chun YS,Park JW,Kim MS

更新日期：2002-02-08 00:00:00

abstract：:Previously we have shown that AIP1 (apoptosis signal-regulating kinase [ASK]1-interacting protein 1), a novel member of the Ras-GAP protein family, facilitates dephosphorylation of ASK1 at pSer967 and subsequently 14-3-3 release from ASK1, leading to enhanced ASK1-JNK signaling. However, the phosphatase(s) responsible...

journal_title：Circulation research

authors： Min W,Lin Y,Tang S,Yu L,Zhang H,Wan T,Luhn T,Fu H,Chen H

更新日期：2008-04-11 00:00:00

abstract：:To investigate the spread of contraction in the rabbit ear artery, changes in segment diameter were measured after local stimulation. No spread of contraction was produced by direct current or local application of norepinephrine (NE). Repetitive electrical stimulation caused contraction which spread far from the point...

journal_title：Circulation research

authors： Vonderlage M

更新日期：1981-09-01 00:00:00

abstract：:Long QT syndrome (LQTS) type 3 (LQT3), typified by the DeltaKPQ mutation (LQT3 mutation in which amino acid residues 1505 to 1507 [KPQ] are deleted), is caused by increased sodium entry during the action potential plateau resulting from mutation-altered inactivation of the Na(v)1.5 channel. Although rare, LQT3 is the ...

journal_title：Circulation research

authors： Fredj S,Lindegger N,Sampson KJ,Carmeliet P,Kass RS

更新日期：2006-11-24 00:00:00

abstract：:The present study was designed to test the ability of regenerated endothelium to evoke endothelium-dependent hyperpolarizations. Hyperpolarizations induced by serotonin and bradykinin were compared in isolated porcine coronary arteries with native or regenerated endothelium, 4 weeks after balloon endothelial denudatio...

journal_title：Circulation research

authors： Thollon C,Bidouard JP,Cambarrat C,Delescluse I,Villeneuve N,Vanhoutte PM,Vilaine JP

更新日期：1999-03-05 00:00:00

abstract：:We have used tryptic digestion to determine whether Ca(2+) can regulate cardiac ryanodine receptor (RyR) channel gating from within the lumen of the sarcoplasmic reticulum (SR) or whether Ca(2+) must first flow through the channel and act via cytosolically located binding sites. Cardiac RyRs were incorporated into bil...

journal_title：Circulation research

authors： Ching LL,Williams AJ,Sitsapesan R

更新日期：2000-08-04 00:00:00

abstract：:The hypothesis that availability of functional Ca2+ channels in vascular smooth muscle is augmented in hypertension was tested in basilar artery cells from Wistar rats exhibiting stable systolic blood pressure (BPsys) for 2 to 11 weeks after partial renal artery ligation (Goldblatt 2-kidney 1-clip [2K1C] model). Cells...

journal_title：Circulation research

authors： Simard JM,Li X,Tewari K

更新日期：1998-06-29 00:00:00

abstract：:Compelling evidence continues to emerge suggesting that the glycocalyx surface layer on vascular endothelial cells plays a determining role in numerous physiological processes including inflammation, microvascular permeability, and endothelial mechanotransduction. Previous research has shown that enzymes degrade the g...

journal_title：Circulation research

authors： Potter DR,Jiang J,Damiano ER

更新日期：2009-06-05 00:00:00

abstract：:Spatial and temporal organization of signal transduction is coordinated through the segregation of signaling enzymes in selected cellular compartments. This highly evolved regulatory mechanism ensures the activation of selected enzymes only in the vicinity of their target proteins. In this context, cAMP-responsive tri...

journal_title：Circulation research

authors： Perino A,Ghigo A,Scott JD,Hirsch E

更新日期：2012-08-03 00:00:00

abstract：RATIONALE:Clinical benefits of reperfusion after myocardial infarction are offset by maladaptive innate immune cell function, and therapeutic interventions are lacking. OBJECTIVE:We sought to test the significance of phagocytic clearance by resident and recruited phagocytes after myocardial ischemia reperfusion. METH...

journal_title：Circulation research

authors： DeBerge M,Yeap XY,Dehn S,Zhang S,Grigoryeva L,Misener S,Procissi D,Zhou X,Lee DC,Muller WA,Luo X,Rothlin C,Tabas I,Thorp EB

更新日期：2017-09-29 00:00:00

abstract：:On endothelial cells, thrombin binds to thrombomodulin (TM), an integral membrane-bound glycoprotein, and to protease-activated receptors (PARs). Thrombin binding to TM modulates endothelial cell and smooth muscle cell proliferation mediated through PAR1. We studied the phosphorylation and nuclear translocation of ext...

journal_title：Circulation research

authors： Olivot JM,Estebanell E,Lafay M,Brohard B,Aiach M,Rendu F

更新日期：2001-04-13 00:00:00

abstract：:Leptin, a protein encoded by the obese gene, is produced by adipocytes and released into the bloodstream. In obese humans, serum leptin levels are increased and correlate with the individual's body mass index and blood pressure. Elevated serum concentrations of endothelin-1 (ET-1), a potent vasoconstrictor and mitogen...

journal_title：Circulation research

authors： Quehenberger P,Exner M,Sunder-Plassmann R,Ruzicka K,Bieglmayer C,Endler G,Muellner C,Speiser W,Wagner O

更新日期：2002-04-05 00:00:00

abstract：:The realization of regenerative cardiac medicine depends on the availability of cardiomyocytes in sufficient numbers for transplantation of cardiac tissue and the accompanying blood vessels. Embryonic stem (ES) cells, bone marrow (BM) stem cells, and tissue-derived stem cells are all potential cell sources. Although E...

journal_title：Circulation research

authors： Fukuda K,Yuasa S

更新日期：2006-04-28 00:00:00

abstract：:Catecholamines have been implicated in the phenomenon of ischemic preconditioning. We have previously demonstrated that ischemic preconditioning against postischemic mechanical dysfunction in the isolated rat heart is mediated by the alpha 1-adrenergic receptor. The purpose of this study was to delineate the signal tr...

journal_title：Circulation research

authors： Mitchell MB,Meng X,Ao L,Brown JM,Harken AH,Banerjee A

更新日期：1995-01-01 00:00:00

abstract：:We tested the hypothesis that activation of transient receptor potential vanilloid type-1 (TRPV1) by capsaicin prevents adipogenesis. TRPV1 channels in 3T3-L1-preadipocytes and visceral adipose tissue from mice and humans were detected by immunoblotting and quantitative real-time RT-PCR. The effect of TRPV1 on cytosol...

journal_title：Circulation research

authors： Zhang LL,Yan Liu D,Ma LQ,Luo ZD,Cao TB,Zhong J,Yan ZC,Wang LJ,Zhao ZG,Zhu SJ,Schrader M,Thilo F,Zhu ZM,Tepel M

更新日期：2007-04-13 00:00:00

abstract：:The hypothesis that neurally mediated coronary vasodilation occurs as part of the carotid baroreceptor reflex was investigated. The left main coronary artery was cannulated and perfused at constant pressure (100 mm Hg) in closed-chest, chloralose-anesthetized dogs. The heart was paced at a constant rate between 60 and...

journal_title：Circulation research

authors： Ito BR,Feigl EO

更新日期：1985-04-01 00:00:00

abstract：:This study aimed at identifying the type and functional significance of potassium channels and voltage-dependent calcium channels (Ca(v)) in single rat JG cells using whole-cell patch clamp. Single JG cells displayed outward rectification at positive membrane potentials and limited net currents between -60 and -10 mV....

journal_title：Circulation research

authors： Friis UG,Jørgensen F,Andreasen D,Jensen BL,Skøtt O

更新日期：2003-08-08 00:00:00

abstract：:We studied the effect of histamine and H1 or H2 blockers on the diameter of pial arteries (39-227 micron) using microapplication into the perivascular space. Concentration-response curves for histamine showed dilations which started at 10(-7) M and were maximal at 10(-5) and 10(-4) M. The H2 blocker, cimetidine, induc...

journal_title：Circulation research

authors： Wahl M,Kuschinsky W

更新日期：1979-02-01 00:00:00

abstract：:Isovolumic relaxation abnormalities have been noted in the ischemic left ventricle, but altered end-diastolic distensibility, as well as the role of right ventricular distention, is debated. Accordingly, left ventricular end-diastolic pressure and myocardial segment length were studied in the open-chest dogs with crit...

journal_title：Circulation research

authors： Momomura S,Bradley AB,Grossman W

更新日期：1984-08-01 00:00:00

abstract：RATIONALE:Atherosclerosis proceeds through a multistep reaction that begins with endothelial injury caused by a host of stress signals, among which oxidized low-density lipoprotein (oxLDL) plays a critical role. OxLDL disrupts normal functionality of the endothelium by upregulating adhesion molecules (eg, ICAM-1) and c...

journal_title：Circulation research

authors： Fang F,Yang Y,Yuan Z,Gao Y,Zhou J,Chen Q,Xu Y

更新日期：2011-04-01 00:00:00

abstract：:Alternans in heart is important as pulsus alternans in cardiac failure and electrophysiological alternans in myocardial ischemia. The explanation of this phenomenon is still unclear. We attempted to investigate the cellular mechanisms of alternans by measuring intracellular free calcium concentration [( Ca2+]i) with t...

journal_title：Circulation research

authors： Lab MJ,Lee JA

更新日期：1990-03-01 00:00:00

abstract：:The tyrosine phosphorylated protein Crk-associated substrate (CAS) has previously been shown to participate in the cellular processes regulating dynamic changes in the actin architecture and arterial constriction. In the present study, treatment of rat mesenteric arteries with phenylephrine (PE) led to the increase in...

journal_title：Circulation research

authors： Anfinogenova Y,Wang R,Li QF,Spinelli AM,Tang DD

更新日期：2007-08-17 00:00:00

abstract：:F2-Isoprostanes are novel bioactive prostaglandin F2-like compounds produced by nonenzymatic free radical-catalyzed peroxidation of arachidonic acid. F2-Isoprostanes are initially formed in situ on phospholipids and subsequently released. Quantification of the F2-isoprostanes has been found to represent a valuable and...

journal_title：Circulation research

authors： Moore KP,Darley-Usmar V,Morrow J,Roberts LJ 2nd

更新日期：1995-08-01 00:00:00

abstract：:Oxidation converts low-density lipoprotein (LDL) into a cytotoxin in vitro. Oxidized LDL exists in vivo in atherosclerotic lesions and possibly in plasma. Many cell functions are altered in vitro by oxidized LDL, but few have been examined in vivo. To test whether oxidized LDL could injure endothelial cells and alter ...

journal_title：Circulation research

authors： Rangaswamy S,Penn MS,Saidel GM,Chisolm GM

更新日期：1997-01-01 00:00:00