Preconditioning of isolated rat heart is mediated by protein kinase C.


:Catecholamines have been implicated in the phenomenon of ischemic preconditioning. We have previously demonstrated that ischemic preconditioning against postischemic mechanical dysfunction in the isolated rat heart is mediated by the alpha 1-adrenergic receptor. The purpose of this study was to delineate the signal transduction of preconditioning distal to the alpha 1-adrenergic receptor. Our results suggest that (1) transient ischemia and alpha 1-adrenergic receptor-induced preconditioning is inhibited by protein kinase C (PKC) antagonists, (2) functional protection against global ischemia/reperfusion injury can be induced by infusion of diacylglycerol, the second messenger of the alpha 1-adrenergic pathway, and (3) transient ischemia and alpha 1-adrenergic preconditioning are both characterized by similar translocation of PKC-delta to the sarcolemma of myocardium. These findings suggest that PKC is an effector of preconditioning in the isolated rat heart.


Circ Res


Circulation research


Mitchell MB,Meng X,Ao L,Brown JM,Harken AH,Banerjee A




Has Abstract


1995-01-01 00:00:00












  • Redundancy reduction for improved display and analysis of body surface potential maps. II. Temporal compression.

    abstract::This paper describes use of the Karhunen-Loeve expansion to identify and reduce temporal redundancy in electrocardiographic body surface potential maps (192 body surface leads recorded simultaneously at 1 kHz/channel for approximately 600 msec). Temporal data compression of about 20 to 1 was obtained with accurate rep...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Evans AK,Lux RL,Burgess MJ,Wyatt RF,Abildskov JA

    更新日期:1981-07-01 00:00:00

  • Lymphatic pumping in response to changes in transmural pressure is modulated by erythrolysate/hemoglobin.

    abstract::Red blood cells and lysate products (erythrolysate) are observed consistently in lymph draining acute and chronic inflammatory reactions and from tissues subjected to trauma or surgical procedures. Using hemoglobin as a marker for erythrolysate, we have measured hemoglobin in lymph up to the 10(-6) M range in a number...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Elias RM,Wandolo G,Ranadive NS,Eisenhoffer J,Johnston MG

    更新日期:1990-11-01 00:00:00

  • Sox2 transduction enhances cardiovascular repair capacity of blood-derived mesoangioblasts.

    abstract:RATIONALE:Complementation of pluripotency genes may improve adult stem cell functions. OBJECTIVES:Here we show that clonally expandable, telomerase expressing progenitor cells can be isolated from peripheral blood of children. The surface marker profile of the clonally expanded cells is distinct from hematopoietic or ...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Koyanagi M,Iwasaki M,Rupp S,Tedesco FS,Yoon CH,Boeckel JN,Trauth J,Schütz C,Ohtani K,Goetz R,Iekushi K,Bushoven P,Momma S,Mummery C,Passier R,Henschler R,Akintuerk H,Schranz D,Urbich C,Galvez BG,Cossu G,Zeiher A

    更新日期:2010-04-16 00:00:00

  • Mitogenic effect of angiotensin II on rat carotid arteries and type II or III mesenteric microvessels but not type I mesenteric microvessels is mediated by endogenous basic fibroblast growth factor.

    abstract::In this study, anti-basic fibroblast growth factor (anti-bFGF) antibody was used to determine whether the mitogenic effect of angiotensin II in vivo could be blocked by neutralizing bFGF in the vessel wall. Animals, divided into six experimental groups, were given (1) angiotensin II, (2) angiotensin II + anti-bFGF ant...

    journal_title:Circulation research

    pub_type: 杂志文章,评审


    authors: Su EJ,Lombardi DM,Wiener J,Daemen MJ,Reidy MA,Schwartz SM

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  • Decline in Cardiovascular Mortality: Possible Causes and Implications.

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    journal_title:Circulation research

    pub_type: 杂志文章,评审


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    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Seidel CL,LaRochelle J

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  • The Malaria-High Blood Pressure Hypothesis.

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    pub_type: 杂志文章,评审


    authors: Etyang AO,Smeeth L,Cruickshank JK,Scott JA

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    pub_type: 杂志文章


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    更新日期:1999-04-02 00:00:00

  • Heterogeneous behavior of the canine arterial and venous wall. Importance of the endothelium.

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    journal_title:Circulation research

    pub_type: 杂志文章


    authors: De Mey JG,Vanhoutte PM

    更新日期:1982-10-01 00:00:00

  • Current fluctuations and oscillations in smooth muscle cells from hog carotid artery. Role of the sarcoplasmic reticulum.

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    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Désilets M,Driska SP,Baumgarten CM

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  • Branching patterns in the porcine coronary arterial tree. Estimation of flow heterogeneity.

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    journal_title:Circulation research

    pub_type: 杂志文章


    authors: VanBavel E,Spaan JA

    更新日期:1992-11-01 00:00:00

  • Elevations in arterial pressure induce the formation of spontaneous action potentials and alter neurotransmission in canine ileum arteries.

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    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Smeda JS,Daniel EE

    更新日期:1988-06-01 00:00:00

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    pub_type: 杂志文章


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    journal_title:Circulation research

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    journal_title:Circulation research

    pub_type: 杂志文章


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    更新日期:1994-01-01 00:00:00

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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章


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    更新日期:1978-03-01 00:00:00

  • Contractile failure and high-energy phosphate turnover during hypoxia: 31P-NMR surface coil studies in living rat.

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Colucci WS

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    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Bing OH,Fishbein MC

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    journal_title:Circulation research

    pub_type: 杂志文章


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    journal_title:Circulation research

    pub_type: 杂志文章


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    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Advani SV,Geenen D,Malhotra A,Factor SM,Scheuer J

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    pub_type: 杂志文章


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    journal_title:Circulation research

    pub_type: 杂志文章


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    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Vassalle M,Mugelli A

    更新日期:1981-05-01 00:00:00