Abstract:
:Catecholamines have been implicated in the phenomenon of ischemic preconditioning. We have previously demonstrated that ischemic preconditioning against postischemic mechanical dysfunction in the isolated rat heart is mediated by the alpha 1-adrenergic receptor. The purpose of this study was to delineate the signal transduction of preconditioning distal to the alpha 1-adrenergic receptor. Our results suggest that (1) transient ischemia and alpha 1-adrenergic receptor-induced preconditioning is inhibited by protein kinase C (PKC) antagonists, (2) functional protection against global ischemia/reperfusion injury can be induced by infusion of diacylglycerol, the second messenger of the alpha 1-adrenergic pathway, and (3) transient ischemia and alpha 1-adrenergic preconditioning are both characterized by similar translocation of PKC-delta to the sarcolemma of myocardium. These findings suggest that PKC is an effector of preconditioning in the isolated rat heart.
journal_name
Circ Resjournal_title
Circulation researchauthors
Mitchell MB,Meng X,Ao L,Brown JM,Harken AH,Banerjee Adoi
10.1161/01.res.76.1.73subject
Has Abstractpub_date
1995-01-01 00:00:00pages
73-81issue
1eissn
0009-7330issn
1524-4571journal_volume
76pub_type
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