Preconditioning of isolated rat heart is mediated by protein kinase C.

Abstract:

:Catecholamines have been implicated in the phenomenon of ischemic preconditioning. We have previously demonstrated that ischemic preconditioning against postischemic mechanical dysfunction in the isolated rat heart is mediated by the alpha 1-adrenergic receptor. The purpose of this study was to delineate the signal transduction of preconditioning distal to the alpha 1-adrenergic receptor. Our results suggest that (1) transient ischemia and alpha 1-adrenergic receptor-induced preconditioning is inhibited by protein kinase C (PKC) antagonists, (2) functional protection against global ischemia/reperfusion injury can be induced by infusion of diacylglycerol, the second messenger of the alpha 1-adrenergic pathway, and (3) transient ischemia and alpha 1-adrenergic preconditioning are both characterized by similar translocation of PKC-delta to the sarcolemma of myocardium. These findings suggest that PKC is an effector of preconditioning in the isolated rat heart.

journal_name

Circ Res

journal_title

Circulation research

authors

Mitchell MB,Meng X,Ao L,Brown JM,Harken AH,Banerjee A

doi

10.1161/01.res.76.1.73

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

73-81

issue

1

eissn

0009-7330

issn

1524-4571

journal_volume

76

pub_type

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