Endothelium-specific in vivo gene transfer.

abstract：:The aims of the current study were to examine the efficacy of acetylcholine (ACh) to mimic ischemic preconditioning in dogs and to determine the role of nitric oxide (NO), muscarinic receptors, and ATP-sensitive K+ (KATP) channels in mediating its effects. Barbital-anesthetized open-chest dogs were subjected to 60 min...

journal_title：Circulation research

authors： Yao Z,Gross GJ

更新日期：1993-12-01 00:00:00

abstract：:The rate of renin secretion from renal juxtaglomerular (JG) cells is the major determinant of the activity of the renin-angiotensin system. However, the mechanisms involved in the excretion and turnover of secretory granules in the JG cells remain obscure. Therefore, in the present study, the whole-cell patch-clamp te...

journal_title：Circulation research

authors： Friis UG,Jensen BL,Aas JK,Skøtt O

更新日期：1999-04-30 00:00:00

abstract：:Despite intense interest in understanding the differentiation of vascular smooth muscle, very little is known about the cellular and molecular mechanisms that control differentiation of this cell type. Progress in this field has been hampered by the lack of an inducible in vitro system for study of the early steps of ...

journal_title：Circulation research

authors： Blank RS,Swartz EA,Thompson MM,Olson EN,Owens GK

更新日期：1995-05-01 00:00:00

abstract：:Phospholamban is a key regulatory protein that defines diastolic function. Proinflammatory cytokines interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) can depress contractility and intracellular Ca2+ currents and transients. An alteration in phospholamban expression is a possible pathway by wh...

journal_title：Circulation research

authors： McTiernan CF,Lemster BH,Frye C,Brooks S,Combes A,Feldman AM

更新日期：1997-10-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors controlling lipid and glucose metabolism as well as inflammation. PPARs are expressed in macrophages, cells that also generate reactive oxygen species (ROS). In this study, we investigated whether PPARs regulate ROS production in macrophages. Di...

journal_title：Circulation research

authors： Teissier E,Nohara A,Chinetti G,Paumelle R,Cariou B,Fruchart JC,Brandes RP,Shah A,Staels B

更新日期：2004-12-10 00:00:00

abstract：RATIONALE:The mechanisms driving atherothrombotic risk in individuals with JAK2 V617F ( Jak2 VF) positive clonal hematopoiesis or myeloproliferative neoplasms are poorly understood. OBJECTIVE:The goal of this study was to assess atherosclerosis and underlying mechanisms in hypercholesterolemic mice with hematopoietic ...

journal_title：Circulation research

authors： Wang W,Liu W,Fidler T,Wang Y,Tang Y,Woods B,Welch C,Cai B,Silvestre-Roig C,Ai D,Yang YG,Hidalgo A,Soehnlein O,Tabas I,Levine RL,Tall AR,Wang N

更新日期：2018-11-09 00:00:00

abstract：:C-reactive protein (CRP), a characteristic inflammatory marker, is a powerful predictor of cardiovascular events. Recent data suggest that CRP may also promote atherogenesis through inducing endothelial dysfunction. Lectin-like oxidized low-density lipoprotein (oxLDL) receptor-1 (LOX-1) is a newly identified endotheli...

journal_title：Circulation research

authors： Li L,Roumeliotis N,Sawamura T,Renier G

更新日期：2004-10-29 00:00:00

abstract：:Quinidine is the most commonly used drug for the chronic treatment of ventricular arrhythmias, but it may be arrhythmogenic. Much information exists concerning quinidine's effects on active properties in cardiac tissues, but virtually nothing is known of its effects on passive properties. We studied the effects of qui...

journal_title：Circulation research

authors： Arnsdorf MF,Sawicki GJ

更新日期：1987-08-01 00:00:00

abstract：:The possibility of an interaction between the cytoskeletal protein dystrophin and cell surface caveolae in the mammalian myocardium was investigated by several techniques. Caveolin (cav)-3-enriched, detergent-insoluble membranes isolated from purified ventricular sarcolemma by density-gradient fractionation were found...

journal_title：Circulation research

authors： Doyle DD,Goings G,Upshaw-Earley J,Ambler SK,Mondul A,Palfrey HC,Page E

更新日期：2000-09-15 00:00:00

abstract：:Aldosterone is associated with the pathogenesis and progression of left ventricular hypertrophy and heart failure, independent of its relation with arterial blood pressure. However, little information exists about the possible influence of this mineralocorticoisteroid on cardiomyocyte electrical activity. The present ...

journal_title：Circulation research

authors： Bénitah JP,Vassort G

更新日期：1999-12-03 00:00:00

abstract：:This review reflects and expands on the contents of my presentation at the Thomas W. Smith Memorial Lecture at American Heart Association Scientific Sessions, 2011. "Decoding the cardiac message" refers to accumulating results from ongoing microRNA research that is altering longstanding concepts of the mechanisms for,...

journal_title：Circulation research

authors： Dorn GW 2nd

更新日期：2012-03-02 00:00:00

abstract：:Although human atherosclerosis is associated with aging, direct evidence of cellular senescence and the mechanism of senescence in vascular smooth muscle cells (VSMCs) in atherosclerotic plaques is lacking. We examined normal vessels and plaques by histochemistry, Southern blotting, and fluorescence in situ hybridizat...

journal_title：Circulation research

authors： Matthews C,Gorenne I,Scott S,Figg N,Kirkpatrick P,Ritchie A,Goddard M,Bennett M

更新日期：2006-07-21 00:00:00

abstract：:Oxidized low-density lipoproteins increase arginase activity and reciprocally decrease endothelial NO in human aortic endothelial cells. Here, we demonstrate that vascular endothelial arginase activity is increased in atherogenic-prone apolipoprotein E-null (ApoE(-/-)) and wild-type mice fed a high cholesterol diet. I...

journal_title：Circulation research

authors： Ryoo S,Gupta G,Benjo A,Lim HK,Camara A,Sikka G,Lim HK,Sohi J,Santhanam L,Soucy K,Tuday E,Baraban E,Ilies M,Gerstenblith G,Nyhan D,Shoukas A,Christianson DW,Alp NJ,Champion HC,Huso D,Berkowitz DE

更新日期：2008-04-25 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) activity in the guinea pig fetal-placental unit was assessed at the different oxygen tensions found in utero, during labor, and at birth. To determine fetal-placental ACE activity, we separately perfused in situ term guinea pig fetuses and their placentas via the umbilical vessels u...

journal_title：Circulation research

authors： Davidson D,Stalcup SA,Mellins RB

更新日期：1981-02-01 00:00:00

abstract：RATIONALE:Depletion of medial smooth muscle cell (SMC) is a major pathological characteristic of abdominal aortic aneurysm (AAA), although the mechanism by which these cells are eliminated remains incompletely understood. We reasoned that necroptosis, a recently described form of necrosis mediated by receptor-interacti...

journal_title：Circulation research

authors： Wang Q,Liu Z,Ren J,Morgan S,Assa C,Liu B

更新日期：2015-02-13 00:00:00

abstract：RATIONALE:Complementation of pluripotency genes may improve adult stem cell functions. OBJECTIVES:Here we show that clonally expandable, telomerase expressing progenitor cells can be isolated from peripheral blood of children. The surface marker profile of the clonally expanded cells is distinct from hematopoietic or ...

journal_title：Circulation research

authors： Koyanagi M,Iwasaki M,Rupp S,Tedesco FS,Yoon CH,Boeckel JN,Trauth J,Schütz C,Ohtani K,Goetz R,Iekushi K,Bushoven P,Momma S,Mummery C,Passier R,Henschler R,Akintuerk H,Schranz D,Urbich C,Galvez BG,Cossu G,Zeiher A

更新日期：2010-04-16 00:00:00

abstract：:Although the molecular effectors of apoptotic cell death have been largely annotated over the past 30 years, leading to a strong biological understanding of this process and its importance in cell biology, cell death through necrosis has only recently been accepted as a similarly regulated process with definable molec...

journal_title：Circulation research

authors： Karch J,Molkentin JD

更新日期：2015-05-22 00:00:00

abstract：:The atrioventricular (AV) node is a recurrent source of potentially life-threatening arrhythmias. Nevertheless, limited data are available on its developmental control or molecular phenotype. We used a novel AV nodal myocardium-specific reporter mouse to gain insight into the gene programs determining the formation an...

journal_title：Circulation research

authors： Horsthuis T,Buermans HP,Brons JF,Verkerk AO,Bakker ML,Wakker V,Clout DE,Moorman AF,'t Hoen PA,Christoffels VM

更新日期：2009-07-02 00:00:00

abstract：RATIONALE:Necrosis is one of the main forms of cardiomyocyte death in heart disease. Recent studies have demonstrated that certain types of necrosis are regulated and programmed dependent on the activation of receptor-interacting serine/threonine-protein kinase (RIPK) 1 and 3 which may be negatively regulated by Fas-as...

journal_title：Circulation research

authors： Wang JX,Zhang XJ,Li Q,Wang K,Wang Y,Jiao JQ,Feng C,Teng S,Zhou LY,Gong Y,Zhou ZX,Liu J,Wang JL,Li PF

更新日期：2015-07-31 00:00:00

abstract：:[3H](+/-)Carazolol, a newly available beta-adrenergic receptor antagonist, can be used to characterize beta-adrenergic receptor subtypes present in membrane vesicles derived from canine ventricular myocardium and canine lung. [3H](+/-)Carazolol binding is saturable, of high affinity, and is displaceable by beta-adrene...

journal_title：Circulation research

authors： Manalan AS,Besch HR Jr,Watanabe AM

更新日期：1981-08-01 00:00:00

abstract：:To delineate more clearly the importance of altered monovalent cation transport rate in the mediation of the positive inotropic effects of cardiac glycosides, we studied changes in the contractile state and rate of uptake of K+ and Rb+ by monolayer cultures of chick embryo ventricular cells during exposure to and wash...

journal_title：Circulation research

authors： Barry WH,Biedert S,Miura DS,Smith TW

更新日期：1981-07-01 00:00:00

abstract：:The goal of this study was to test the hypothesis that the cardioprotective effects of the late phase of ischemic preconditioning (PC) can be mimicked by treatment with NO donors. In phase I (studies of myocardial stunning), conscious rabbits underwent a sequence of six 4-minute coronary occlusion/4-minute reperfusion...

journal_title：Circulation research

authors： Takano H,Tang XL,Qiu Y,Guo Y,French BA,Bolli R

更新日期：1998-07-13 00:00:00

abstract：:Heparin inhibits the development of intimal thickening after carotid injury in the rat; however, the specific cellular events responsible for this effect have not been defined. In this study, smooth muscle cell growth fraction and migration into the intima were quantitatively measured in heparin-treated animals. All r...

journal_title：Circulation research

authors： Clowes AW,Clowes MM

更新日期：1986-06-01 00:00:00

abstract：:Cyclic nucleotide phosphodiesterases regulate cAMP-mediated signaling by controlling intracellular cAMP content. The cAMP-hydrolyzing activity of several families of cyclic nucleotide phosphodiesterases found in human heart is regulated by cGMP. In the case of PDE2, this regulation primarily involves the allosteric st...

journal_title：Circulation research

authors： Zaccolo M,Movsesian MA

更新日期：2007-06-08 00:00:00

abstract：:The purpose of these studies was to evaluate cardiovascular structural and functional changes in a model of hypertension-induced myocardial hypertrophy in which vasodilator therapy decreased blood pressure to normal levels. Thus, we determined the separate contributions of hypertension and hypertrophy on myocardial an...

journal_title：Circulation research

authors： Anderson PG,Bishop SP,Digerness SB

更新日期：1989-06-01 00:00:00

abstract：RATIONALE:Activin receptor-like kinase-1 (ALK1) is an endothelial transforming growth factor β receptor involved in angiogenesis. ALK1 expression is high in the embryo vasculature, becoming less detectable in the quiescent endothelium of adult stages. However, ALK1 expression becomes rapidly increased after angiogenic ...

journal_title：Circulation research

authors： Garrido-Martín EM,Blanco FJ,Roquè M,Novensà L,Tarocchi M,Lang UE,Suzuki T,Friedman SL,Botella LM,Bernabéu C

更新日期：2013-01-04 00:00:00

abstract：:Complete knowledge of myocardial structure, metabolism, and function is crucial to understanding the response of the heart to injury such as ischemia. Increasingly, this type of knowledge is required at multiple levels, from that of the isolated myocyte to the functioning organism, to provide basic scientists and clin...

journal_title：Circulation research

authors： Wu KC,Lima JA

更新日期：2003-12-12 00:00:00

abstract：:Myocardial damage due to reperfusion of ischemic tissue is caused primarily by infiltrating neutrophils. Although leukocyte beta2 integrins (CD18) play a critical role, significant neutrophil emigration persists when CD18 is neutralized or absent. This study examined the role of leukocyte beta1 integrin (alpha4) and i...

journal_title：Circulation research

authors： Bowden RA,Ding ZM,Donnachie EM,Petersen TK,Michael LH,Ballantyne CM,Burns AR

更新日期：2002-03-22 00:00:00

abstract：:3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) can exert beneficial effects independently of serum cholesterol reduction by increasing the bioavailability of nitric oxide. However, it is unclear whether statins can exert such effects directly on cardiac myocytes and whether mitochondria...

journal_title：Circulation research

authors： Jones SP,Teshima Y,Akao M,Marbán E

更新日期：2003-10-17 00:00:00

abstract：:Vascular endothelial growth factors (VEGFs) and their receptors have emerged as central regulators of the angiogenic process. However, involvement of VEGF-B, one of these factors, in angiogenesis remains obscure. Mice received subcutaneous injection of Matrigel alone or Matrigel with human recombinant protein rhVEGF-B...

journal_title：Circulation research

authors： Silvestre JS,Tamarat R,Ebrahimian TG,Le-Roux A,Clergue M,Emmanuel F,Duriez M,Schwartz B,Branellec D,Lévy BI

更新日期：2003-07-25 00:00:00