A retinoic acid-induced clonal cell line derived from multipotential P19 embryonal carcinoma cells expresses smooth muscle characteristics.

abstract：:Previous studies have postulated an important role for the inwardly rectifying potassium current (I(K1)) in controlling the dynamics of electrophysiological spiral waves responsible for ventricular tachycardia and fibrillation. In this study, we developed a novel tissue model of cultured neonatal rat ventricular myocy...

journal_title：Circulation research

authors： Sekar RB,Kizana E,Cho HC,Molitoris JM,Hesketh GG,Eaton BP,Marbán E,Tung L

更新日期：2009-02-13 00:00:00

abstract：:The extracellular and intracellular potassium (K+) activities of isolated superfused rabbit atrial muscle were measured using K+-sensitive liquid ion exchanger microelectrodes. When the pH of the bathing medium was decreased from 7.5 to 6.8, intracellular K+ activity fell and extracellular K+ activity rose from a mean...

journal_title：Circulation research

authors： Skinner RB Jr,Kunze DL

更新日期：1976-11-01 00:00:00

abstract：RATIONALE:Several studies have demonstrated links between infectious diseases and cardiovascular conditions. Malaria and hypertension are widespread in many low- and middle-income countries, but the possible link between them has not been considered. OBJECTIVE:In this article, we outline the basis for a possible link ...

journal_title：Circulation research

authors： Etyang AO,Smeeth L,Cruickshank JK,Scott JA

更新日期：2016-06-24 00:00:00

abstract：:Of 145 patients with borderline hypertension, 30% had increased resting cardiac index (QI), whereas the remainder had normal values. The specific aim of this study was to investigate cardiac regulation in patients who had normal resting QI. Eighty-five control subjects were used for comparison. At rest, patients with ...

journal_title：Circulation research

authors： Julius S,Randall OS,Esler MD,Kashima T,Ellis C,Bennett J

更新日期：1975-06-01 00:00:00

abstract：:The role of the central nervous system in the mechanism(s) involved in acute carotid baroreflex resetting was studied in six conscious, chronically instrumented, aortic-denervated dogs. Dogs were prepared for reversible vascular isolation of the carotid sinuses. Acute baroreflex resetting was induced by holding the le...

journal_title：Circulation research

authors： Tan W,Panzenbeck MJ,Hajdu MA,Zucker IH

更新日期：1989-07-01 00:00:00

abstract：:Isolated adult rat hearts perfused in an isovolumic mode were used to study the effects of sodium-potassium pump inhibition and sodium-calcium exchange alterations on the tissue content of adenosine triphosphate, phosphocreatine, inorganic phosphate, and intracellular pH, all measured by phosphorus-31 nuclear magnetic...

journal_title：Circulation research

authors： Hoerter JA,Miceli MV,Renlund DG,Jacobus WE,Gerstenblith G,Lakatta EG

更新日期：1986-04-01 00:00:00

abstract：:To investigate the spread of contraction in the rabbit ear artery, changes in segment diameter were measured after local stimulation. No spread of contraction was produced by direct current or local application of norepinephrine (NE). Repetitive electrical stimulation caused contraction which spread far from the point...

journal_title：Circulation research

authors： Vonderlage M

更新日期：1981-09-01 00:00:00

abstract：:Large-conductance Ca2+-dependent K+ channels (KCa), which are abundant on the sarcolemma of vascular myocytes, provide negative feedback via membrane hyperpolarization that limits Ca2+ entry through L-type Ca2+ channels (ICaL). We hypothesize that local accumulation of subsarcolemmal Ca2+ during ICaL openings amplifie...

journal_title：Circulation research

authors： Guia A,Wan X,Courtemanche M,Leblanc N

更新日期：1999-05-14 00:00:00

abstract：:After myocardial infarction (MI), the noninfarcted myocardium undergoes significant hypertrophy as part of the post-MI structural remodeling. Electrophysiological changes associated with the hypertrophied remodeled myocardium may play a key role in arrhythmia generation in the post-MI heart. We investigated the cellul...

journal_title：Circulation research

authors： Qin D,Zhang ZH,Caref EB,Boutjdir M,Jain P,el-Sherif N

更新日期：1996-09-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) proliferation is a critical event in the development and progression of vascular diseases, including atherosclerosis. We investigated whether the activation of adenosine monophosphate-activated protein kinase (AMPK) could suppress VSMC proliferation and inhibit cell cycle progression...

journal_title：Circulation research

authors： Igata M,Motoshima H,Tsuruzoe K,Kojima K,Matsumura T,Kondo T,Taguchi T,Nakamaru K,Yano M,Kukidome D,Matsumoto K,Toyonaga T,Asano T,Nishikawa T,Araki E

更新日期：2005-10-14 00:00:00

abstract：:Cell-cell communication has proven to be even more complex than previously thought since the discovery that extracellular vesicles serve as containers of biological information on various pathophysiological settings. Extracellular vesicles are classified into exosomes, microvesicles/microparticles, or apoptotic bodies...

journal_title：Circulation research

authors： Loyer X,Vion AC,Tedgui A,Boulanger CM

更新日期：2014-01-17 00:00:00

abstract：:Over the last 4 decades, heart transplantation (HTx) has evolved as a mainstream therapy for heart failure. Approximately half of patients needing HTx have organ failure consequent to atherosclerosis. Despite advances in immunosuppressive drugs, long-term success of HTx is limited by the development of a particular ty...

journal_title：Circulation research

authors： Rahmani M,Cruz RP,Granville DJ,McManus BM

更新日期：2006-10-13 00:00:00

abstract：:Vascular endothelial growth factors (VEGFs) and their receptors have emerged as central regulators of the angiogenic process. However, involvement of VEGF-B, one of these factors, in angiogenesis remains obscure. Mice received subcutaneous injection of Matrigel alone or Matrigel with human recombinant protein rhVEGF-B...

journal_title：Circulation research

authors： Silvestre JS,Tamarat R,Ebrahimian TG,Le-Roux A,Clergue M,Emmanuel F,Duriez M,Schwartz B,Branellec D,Lévy BI

更新日期：2003-07-25 00:00:00

abstract：:The major goal of this study was to determine the interactions of VLDL surface and core lipids with the artery wall. We first demonstrated in vitro that surface lipid in VLDL could be traced using the phospholipid-like fluorescent probe 1,1'-dioctadecyl-3,3, 3',3'-tetramethyl-indocarbocyanine (DiI). The core of VLDL p...

journal_title：Circulation research

authors： Rutledge JC,Mullick AE,Gardner G,Goldberg IJ

更新日期：2000-04-14 00:00:00

abstract：:Matrix metalloproteinases (MMPs) include most major constituents of the arterial wall as substrates. A common promotor polymorphism (5A/6A) is associated with differences in MMP-3 (stromelysin-1) activity, and associations with certain forms of vascular disease have been shown. This study investigated whether the MMP-...

journal_title：Circulation research

authors： Medley TL,Kingwell BA,Gatzka CD,Pillay P,Cole TJ

更新日期：2003-06-13 00:00:00

abstract：:Mast cells in rat hearts were studied quantitatively during normal postnatal growth and in two types of cardiac hypertrophy. Normally, cardiac mast cell density in 11-12-day-old animals is very low, but increases markedly in the following 2-3 weeks to its highest values, with a subsequent decline toward adult values. ...

journal_title：Circulation research

authors： Rakusan K,Sarkar K,Turek Z,Wicker P

更新日期：1990-02-01 00:00:00

abstract：:To determine whether or not salt loading restricted to the brain would elevate blood pressure, chronically implanted osmotic minipumps were used to infuse hypertonic sodium chloride solutions made in artificial cerebrospinal fluid into a jugular vein intravenously or the third cerebral ventricle, intracerebroventricul...

journal_title：Circulation research

authors： Miyajima E,Buñag RD

更新日期：1984-05-01 00:00:00

abstract：:A mathematical model for the regulation of mechanical activity in cardiac muscle has been developed based on a three-element rheological model of this muscle. The contractile element has been modeled taking into account the results of extensive mechanical tests that involved the recording of length-force and force-vel...

journal_title：Circulation research

authors： Izakov VYa,Katsnelson LB,Blyakhman FA,Markhasin VS,Shklyar TF

更新日期：1991-11-01 00:00:00

abstract：:Available data demonstrate that oxygen free radicals and derived reactive species of oxygen are produced during myocardial ischemia as well as upon reperfusion of the ischemic tissue. The present study was designed to determine if polyethylene glycol-conjugated superoxide dismutase (PEG-SOD), with its extended plasma ...

journal_title：Circulation research

authors： Chi LG,Tamura Y,Hoff PT,Macha M,Gallagher KP,Schork MA,Lucchesi BR

更新日期：1989-04-01 00:00:00

abstract：:We have recently demonstrated that endogenous erythropoietin (Epo)/Epo receptor (EpoR) system plays an important protective role in hypoxia-induced pulmonary hypertension. However, it remains to be examined whether vascular EpoR system contributes to angiogenesis in response to ischemia. We examined angiogenesis in Ep...

journal_title：Circulation research

authors： Nakano M,Satoh K,Fukumoto Y,Ito Y,Kagaya Y,Ishii N,Sugamura K,Shimokawa H

更新日期：2007-03-16 00:00:00

abstract：:If the control of infectious diseases was the public health success story of the first half of the 20th century, then the decline in mortality from coronary heart disease and stroke has been the success story of the century's past 4 decades. The early phase of this decline in coronary heart disease and stroke was unex...

journal_title：Circulation research

authors： Mensah GA,Wei GS,Sorlie PD,Fine LJ,Rosenberg Y,Kaufmann PG,Mussolino ME,Hsu LL,Addou E,Engelgau MM,Gordon D

更新日期：2017-01-20 00:00:00

abstract：:Volume densities of mitochondria, myofibrils, and unspecified cytoplasm were measured by ultrastructural morphometry in myocardium from dogs, rats, hamsters, mice, and in biopsied tissue from human hearts. Human myocardium was composed of 23% mitochondria, 59% myofibrils, and 18% cytoplasm. Volume densities for mitoch...

journal_title：Circulation research

authors： Schaper J,Meiser E,Stämmler G

更新日期：1985-03-01 00:00:00

abstract：:Human peripheral blood leukocytes, activated by phorbol myristate acetate, disrupt canine sarcoplasmic reticulum calcium transport, in vitro, by an oxygen-derived free radical mechanism. Activated leukocytes significantly depress Ca++ uptake activity and Ca++ -stimulated, Mg++ -dependent ATPase activity. The depressio...

journal_title：Circulation research

authors： Rowe GT,Manson NH,Caplan M,Hess ML

更新日期：1983-11-01 00:00:00

abstract：:The purpose of this study was to determine the coronary microvascular sites of autoregulation. The epimyocardial coronary microcirculation was observed through an intravital microscope by stroboscopic epi-illumination in anesthetized open-chest dogs (n = 20). Aortic pressure and heart rate were held constant by an aor...

journal_title：Circulation research

authors： Kanatsuka H,Lamping KG,Eastham CL,Marcus ML

更新日期：1990-02-01 00:00:00

abstract：RATIONALE:Endothelial colony forming cells (ECFCs) or late blood outgrowth endothelial cells can be isolated from human cord or peripheral blood, display properties of endothelial progenitors, home into ischemic tissues and support neovascularization in ischemic disease models. OBJECTIVE:To assess the functions of CYT...

journal_title：Circulation research

authors： Schneller D,Hofer-Warbinek R,Sturtzel C,Lipnik K,Gencelli B,Seltenhammer M,Wen M,Testori J,Bilban M,Borowski A,Windwarder M,Kapel SS,Besemfelder E,Cejka P,Habertheuer A,Schlechta B,Majdic O,Altmann F,Kocher A,August

更新日期：2019-01-18 00:00:00

abstract：:We evaluated the contribution of intramural electrical events in initiation and maintenance of ventricular tachycardia in 15 dogs 3-8 days after either permanent (n = 2) or transient (n = 13) coronary artery occlusion. Seven of the dogs (47%) demonstrated eight distinct monomorphic ventricular tachycardia patterns whi...

journal_title：Circulation research

authors： Kramer JB,Saffitz JE,Witkowski FX,Corr PB

更新日期：1985-05-01 00:00:00

abstract：:The proteoglycan versican is implicated in several atherogenic events, including stimulation of vascular smooth muscle cell (VSMC) growth and migration, retention of lipoproteins, and promotion of thrombogenesis. A high content of intimal versican also correlates with a low content of elastin, suggesting an inhibitory...

journal_title：Circulation research

authors： Huang R,Merrilees MJ,Braun K,Beaumont B,Lemire J,Clowes AW,Hinek A,Wight TN

更新日期：2006-02-17 00:00:00

abstract：:Multiple voltage-gated K+ channels contribute to the repolarization phases of the cardiac action potential and are targets of several antiarrhythmic drugs. The Kv1.5 K+ channel gene is expressed in the heart, and heterologous expression of this gene generates a slowly inactivating K+ current. Previously, we found that...

journal_title：Circulation research

authors： Takimoto K,Levitan ES

更新日期：1994-12-01 00:00:00

abstract：:Hyperhomocysteinemia, a risk factor for cardiovascular disease, is caused by nutritional or genetic disturbances in homocysteine metabolism. A polymorphism in methylenetetrahydrofolate reductase (MTHFR) is the most common genetic cause of mild hyperhomocysteinemia. To examine mechanisms by which an elevation in plasma...

journal_title：Circulation research

authors： Mikael LG,Genest J Jr,Rozen R

更新日期：2006-03-03 00:00:00

abstract：:The abundance of membrane cholesterol is an important determinant of the functional properties of biomembranes. To determine whether arterial smooth muscle acquires altered contractile properties in a high cholesterol environment, isolated canine coronary arteries were exposed to cholesterol in stable aqueous solution...

journal_title：Circulation research

authors： Yokoyama M,Henry PD

更新日期：1979-10-01 00:00:00