Changes in extracellular potassium activity in response to decreased pH in rabbit atrial muscle.

abstract：:We recently established a new transgenic mouse model with brain-restricted overexpression of angiotensin II (Ang II) type 1a receptors (NSE-AT(1a)) to unmask the role of the brain renin-angiotensin system in hypertension. To test the hypothesis that these mice would exhibit an early exacerbation of renovascular hypert...

journal_title：Circulation research

authors： Lazartigues E,Lawrence AJ,Lamb FS,Davisson RL

更新日期：2004-09-03 00:00:00

abstract：:Our goal in this review is to discuss the pathophysiology, diagnosis, and treatment of stroke caused by atherosclerosis of the major intracranial arteries. References for the review were identified by searching PubMed for related studies published from 1955 to June 2016 using search terms intracranial stenosis and int...

journal_title：Circulation research

authors： Banerjee C,Chimowitz MI

更新日期：2017-02-03 00:00:00

abstract：:The programmed onset of myocardial dysfunction and its progression to congestive heart failure in the cardiomyopathic Syrian hamster is hallmarked by alterations in myocellular calcium regulation. To determine whether calcium channel blockade is effective in halting the progressive depression of myocardial contractile...

journal_title：Circulation research

authors： Capasso JM,Sonnenblick EH,Anversa P

更新日期：1990-12-01 00:00:00

abstract：RATIONALE:Pulmonary arterial hypertension (PAH) remains a progressive and eventually lethal disease characterized by increased pulmonary vascular resistance because of loss of functional lung microvasculature, primarily at the distal (intracinar) arteriolar level. Cell-based therapies offer the potential to repair and ...

journal_title：Circulation research

authors： Granton J,Langleben D,Kutryk MB,Camack N,Galipeau J,Courtman DW,Stewart DJ

更新日期：2015-09-11 00:00:00

abstract：:We studied a Syrian family with 3 children who had low-density lipoprotein cholesterol (LDL) concentrations of 13.3, 12.2, and 8.6 mmol/L, respectively. Three other siblings and the parents all had LDL values <4.52 mmol/L, suggesting an autosomal-recessive mode of inheritance. The extended pedigree had 66 additional p...

journal_title：Circulation research

authors： Al-Kateb H,Bähring S,Hoffmann K,Strauch K,Busjahn A,Nürnberg G,Jouma M,Bautz EK,Dresel HA,Luft FC

更新日期：2002-05-17 00:00:00

abstract：:A potent transcriptional enhancer was previously identified upstream of the mouse renin gene. Within the enhancer is a TGACCT direct-repeat motif, required for enhancer activity, that is the consensus sequence recognized by members of the thyroid hormone subfamily of steroid hormone receptors. We previously reported t...

journal_title：Circulation research

authors： Liu X,Huang X,Sigmund CD

更新日期：2003-05-16 00:00:00

abstract：:Atrial fibrillation (AF) may result from stationary reentry in the left atrium (LA), with fibrillatory conduction toward the right atrium (RA). We hypothesize that periodic input to the RA at an exceedingly high frequency results in disorganized wave propagation, compatible with fibrillatory conduction. Simultaneous e...

journal_title：Circulation research

authors： Berenfeld O,Zaitsev AV,Mironov SF,Pertsov AM,Jalife J

更新日期：2002-06-14 00:00:00

abstract：:Elastance-resistance [E(t)-R] representations of the left ventricle (LV) were evaluated for their ability to reproduce instantaneous pressure [P(t)] and outflow [Q(t)]. Experiments were performed in open-chest rats. P(t) and Q(t) were measured during steady-state ejecting beats and during a beat in which the aorta was...

journal_title：Circulation research

authors： Campbell KB,Kirkpatrick RD,Knowlen GG,Ringo JA

更新日期：1990-01-01 00:00:00

abstract：:Calcific aortic valve sclerosis involves inflammatory processes and occurs preferentially on the aortic side of endothelialized valve leaflets. Although the endothelium is recognized to play critical roles in focal vascular sclerosis, the contributions of valvular endothelial phenotypes to aortic valve sclerosis and s...

journal_title：Circulation research

authors： Simmons CA,Grant GR,Manduchi E,Davies PF

更新日期：2005-04-15 00:00:00

abstract：RATIONALE:Innate and adaptive immune responses alter numerous homeostatic processes that are controlled by nuclear hormone receptors. NR4A1 is a nuclear receptor that is induced in vascular pathologies, where it mediates protection. OBJECTIVE:The underlying mechanisms that regulate the activity of NR4A1 during vascula...

journal_title：Circulation research

authors： Papac-Milicevic N,Breuss JM,Zaujec J,Ryban L,Plyushch T,Wagner GA,Fenzl S,Dremsek P,Cabaravdic M,Steiner M,Glass CK,Binder CJ,Uhrin P,Binder BR

更新日期：2012-04-13 00:00:00

abstract：:Transmural heterogeneity of myocardial metabolism and function are present in the left ventricle under normal and ischemic conditions. To determine if endocardial versus epicardial differences of [Ca2+]i are also present, perfused rat heart studies using indo-1 fluorescence as an index of [Ca2+]i were performed in the...

journal_title：Circulation research

authors： Figueredo VM,Brandes R,Weiner MW,Massie BM,Camacho SA

更新日期：1993-05-01 00:00:00

abstract：:Nitric oxide (NO), generated by platelets through stimulation of nitric oxide synthase (NOS), limits platelet adhesion and aggregation after a prothrombotic stimulus. Platelet beta-adrenoceptors (betaARs) mediate inhibition of aggregation, but no direct link has been shown between these receptors and platelet adhesion...

journal_title：Circulation research

authors： Queen LR,Xu B,Horinouchi K,Fisher I,Ferro A

更新日期：2000-07-07 00:00:00

abstract：:Although clinical studies suggest that chronic hypercapnic acidosis may be associated with renal sodium retention, little information is available on the effect of acute hypercapnic acidosis on renal sodium excretion. We, therefore, increased PCO2 from 23 to 74 mm Hg in anesthetized dogs and observed a marked antinatr...

journal_title：Circulation research

authors： Anderson RJ,Henrich WL,Gross PA,Dillingham MA

更新日期：1982-02-01 00:00:00

abstract：:We previously reported that hyperhomocysteinemia (HHcy), an independent risk factor of coronary artery disease (CAD), is associated with increased atherosclerosis and decreased plasma high-density lipoprotein cholesterol (HDL-C) in cystathionine beta-synthase-/apolipoprotein E-deficient (CBS(-/-)/apoE(-/-)) mice. We o...

journal_title：Circulation research

authors： Liao D,Tan H,Hui R,Li Z,Jiang X,Gaubatz J,Yang F,Durante W,Chan L,Schafer AI,Pownall HJ,Yang X,Wang H

更新日期：2006-09-15 00:00:00

abstract：:The realization of regenerative cardiac medicine depends on the availability of cardiomyocytes in sufficient numbers for transplantation of cardiac tissue and the accompanying blood vessels. Embryonic stem (ES) cells, bone marrow (BM) stem cells, and tissue-derived stem cells are all potential cell sources. Although E...

journal_title：Circulation research

authors： Fukuda K,Yuasa S

更新日期：2006-04-28 00:00:00

abstract：:We tested the hypothesis that TNF-alpha induces early-onset endothelial adhesivity toward PMN by activating the constitutive endothelial cell surface ICAM-1, the beta2-integrin (CD11/CD18) counter-receptor. Stimulation of human pulmonary artery endothelial cells with TNF-alpha resulted in phosphorylation of ICAM-1 wit...

journal_title：Circulation research

authors： Javaid K,Rahman A,Anwar KN,Frey RS,Minshall RD,Malik AB

更新日期：2003-05-30 00:00:00

abstract：RATIONALE:Myocardial infarction (MI) results in loss of cardiac myocytes in the ischemic zone of the heart, followed by fibrosis and scar formation, which diminish cardiac contractility and impede angiogenesis and repair. Myofibroblasts, a specialized cell type that switches from a fibroblast-like state to a contractil...

journal_title：Circulation research

authors： Small EM,Thatcher JE,Sutherland LB,Kinoshita H,Gerard RD,Richardson JA,Dimaio JM,Sadek H,Kuwahara K,Olson EN

更新日期：2010-07-23 00:00:00

abstract：:Growing evidence exists that ATP-sensitive mitochondrial potassium channels (MitoKATP channel) are a major contributor to the cardiac protection against ischemia. Given the importance of mitochondria in the cardiac cell, we tested whether the potent and specific opener of the MitoKATP channel diazoxide attenuates the ...

journal_title：Circulation research

authors： Wang Y,Ashraf M

更新日期：1999-05-28 00:00:00

abstract：:Changes in angiotensin-converting enzyme were measured in the lungs of fetal rabbits isolated and perfused in situ at varying ages from 22 days gestation to 7 days of age under controlled conditions of flow, pH, and temperature. Enzyme activity was assessed by infusing bradykinin or angiotensin I in Krebs-Henseleit so...

journal_title：Circulation research

authors： Stalcup SA,Pang LM,Lipset JS,Odya CE,Goodfriend TL,Mellins RB

更新日期：1978-11-01 00:00:00

abstract：:To determine whether calcium channel agonists and antagonists bind to distinct pharmacologically active sites, the binding of dihydropyridine calcium channel agonists and antagonists was related to calcium flux and contractile state in primary monolayer cultures of spontaneously contracting chick embryo ventricular ce...

journal_title：Circulation research

authors： Lee RT,Smith TW,Marsh JD

更新日期：1987-05-01 00:00:00

abstract：:Studies were performed to determine whether an alteration in coronary vascular resistance and a reduction in the reflow phenomenon occurred in the blood-perfused, heparinized canine heart after various periods of myocaridal ischemia. Regional myocardial blood flow was measured with radioactive microspheres. Proximal l...

journal_title：Circulation research

authors： Willerson JT,Watson JT,Hutton I,Templeton GH,Fixler DE

更新日期：1975-06-01 00:00:00

abstract：:To investigate the kinetic parameters of the crossbridge cycle that regulate force and shortening in cardiac muscle, we compared the mechanical properties of cardiac trabeculae with either ATP or 2-deoxy-ATP (dATP) as the substrate for contraction. Comparisons were made in trabeculae from untreated rats (predominantly...

journal_title：Circulation research

authors： Regnier M,Rivera AJ,Chen Y,Chase PB

更新日期：2000-06-23 00:00:00

abstract：:The dystrophin glycoprotein complex (DGC) is a specialization of cardiac and skeletal muscle membrane. This large multicomponent complex has both mechanical stabilizing and signaling roles in mediating interactions between the cytoskeleton, membrane, and extracellular matrix. Dystrophin, the protein product of the Duc...

journal_title：Circulation research

authors： Lapidos KA,Kakkar R,McNally EM

更新日期：2004-04-30 00:00:00

abstract：:Body surface electrocardiograms and electrograms recorded from the surfaces of the heart are the basis for diagnosis and treatment of cardiac electrophysiological disorders and arrhythmias. Given recent advances in understanding the molecular mechanisms of arrhythmia, it is important to relate these electrocardiograph...

journal_title：Circulation research

authors： Gima K,Rudy Y

更新日期：2002-05-03 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) proliferation is a critical event in the development and progression of vascular diseases, including atherosclerosis. We investigated whether the activation of adenosine monophosphate-activated protein kinase (AMPK) could suppress VSMC proliferation and inhibit cell cycle progression...

journal_title：Circulation research

authors： Igata M,Motoshima H,Tsuruzoe K,Kojima K,Matsumura T,Kondo T,Taguchi T,Nakamaru K,Yano M,Kukidome D,Matsumoto K,Toyonaga T,Asano T,Nishikawa T,Araki E

更新日期：2005-10-14 00:00:00

abstract：RATIONALE:We previously discovered several phosphorylations to the beta subunit of the mitochondrial F(1)F(o) ATP synthase complex in isolated rabbit myocytes on adenosine treatment, an agent that induces cardioprotection. The role of these phosphorylations is unknown. OBJECTIVE:The present study focuses on the functi...

journal_title：Circulation research

authors： Kane LA,Youngman MJ,Jensen RE,Van Eyk JE

更新日期：2010-02-19 00:00:00

abstract：:Abnormal mechanical forces can trigger aberrant proliferation of endothelial and smooth muscle cells, as observed in the progression of vascular diseases such as atherosclerosis. It has been previously shown that cells can sense physical forces such as stretch through adhesions to the extracellular matrix. Here, we se...

journal_title：Circulation research

authors： Liu WF,Nelson CM,Tan JL,Chen CS

更新日期：2007-08-31 00:00:00

abstract：RATIONALE:Unlike conventional dendritic cells, plasmacytoid DCs (PDC) are poor in antigen presentation and critical for type I interferon response. Though proposed to be present in human atherosclerotic lesions, their role in atherosclerosis remains elusive. OBJECTIVE:To investigate the role of PDC in atherosclerosis....

journal_title：Circulation research

authors： Daissormont IT,Christ A,Temmerman L,Sampedro Millares S,Seijkens T,Manca M,Rousch M,Poggi M,Boon L,van der Loos C,Daemen M,Lutgens E,Halvorsen B,Aukrust P,Janssen E,Biessen EA

更新日期：2011-12-09 00:00:00

abstract：:Isolated, cultured arterial endothelial cells express an acetylcholine (ACh)-activated K+ current in addition to an inward rectifier current whose conductance is unaffected by ACh. The cholinergic K+ current is specifically blocked by atropine (1 microM) and shows single saturation kinetics with ACh (half-maximal stim...

journal_title：Circulation research

authors： Olesen SP,Davies PF,Clapham DE

更新日期：1988-06-01 00:00:00

abstract：:Radiolabeled triiodothyronine (T3) binding to isolated nuclei was measured to compare the binding characteristics of the nuclear receptors in rabbit ventricular and atrial muscle cells. Scatchard analysis of the binding data yielded a maximum binding capacity of 170 +/- 20 fmol per mg DNA and apparent dissociation con...

journal_title：Circulation research

authors： Banerjee SK,Ulrich JM,Kaldor GJ

更新日期：1988-07-01 00:00:00