IK1 heterogeneity affects genesis and stability of spiral waves in cardiac myocyte monolayers.

abstract：:Obesity results in marked alterations in cardiac energy metabolism, with a prominent effect being an increase in fatty acid uptake and oxidation by the heart. Obesity also results in dramatic changes in the release of adipokines, such as leptin and adiponectin, both of which have emerged as important regulators of car...

journal_title：Circulation research

authors： Lopaschuk GD,Folmes CD,Stanley WC

更新日期：2007-08-17 00:00:00

abstract：:The positive inotropic effect of the beta-adrenoceptor agonist isoproterenol is accompanied by inhibition of phosphatase type 1 activity in myocardium. Indirect assays suggest that this effect is due to activation of protein phosphatase inhibitor-1, which inhibits phosphatase activity only when phosphorylated. To test...

journal_title：Circulation research

authors： Neumann J,Gupta RC,Schmitz W,Scholz H,Nairn AC,Watanabe AM

更新日期：1991-12-01 00:00:00

abstract：:This report evaluates pulse wave propagation with respect to contributions by vascular wall elastic and geometric properties, vessel wall and blood viscosity, and nonlinearities in system parameters and in the equations of motion. Discrepancies in results obtained with different experimental methods and theory are dis...

journal_title：Circulation research

authors： Li JK,Melbin J,Riffle RA,Noordergraaf A

更新日期：1981-08-01 00:00:00

abstract：:The atrioventricular (AV) node is a recurrent source of potentially life-threatening arrhythmias. Nevertheless, limited data are available on its developmental control or molecular phenotype. We used a novel AV nodal myocardium-specific reporter mouse to gain insight into the gene programs determining the formation an...

journal_title：Circulation research

authors： Horsthuis T,Buermans HP,Brons JF,Verkerk AO,Bakker ML,Wakker V,Clout DE,Moorman AF,'t Hoen PA,Christoffels VM

更新日期：2009-07-02 00:00:00

abstract：:We determined whether local bradykinin production modulates cardiac adrenergic activity. Depolarization of guinea pig heart sympathetic nerve endings (synaptosomes) with 1 to 100 mmol/L K+ caused the release of endogenous norepinephrine (10% to 50% above basal level). This release was exocytotic, because it depended o...

journal_title：Circulation research

authors： Seyedi N,Win T,Lander HM,Levi R

更新日期：1997-11-01 00:00:00

abstract：:Nitric oxide (NO) decreases cellular oxygen (O(2)) consumption by competitively inhibiting cytochrome c oxidase. Here, we show that endogenously released endothelial NO, either basal or stimulated, can modulate O(2) consumption both throughout the thickness of conductance vessels and in the microcirculation. Furthermo...

journal_title：Circulation research

authors： Victor VM,Nuñez C,D'Ocón P,Taylor CT,Esplugues JV,Moncada S

更新日期：2009-05-22 00:00:00

abstract：:Given the essential role played by gap junctions in the coordination of cardiac muscle contraction, it is plausible that down-regulation of gap junctional conduction is in part responsible for the contractile dysfunction observed in hypertrophied and failing hearts. In the present study, we analyzed the expression and...

journal_title：Circulation research

authors： Toyofuku T,Yabuki M,Otsu K,Kuzuya T,Tada M,Hori M

更新日期：1999-10-15 00:00:00

abstract：:Angiotensin II and its metabolites, [des-Asp-1]-angiotensin II (angiotensin III), [des-(Asp-1,Arg-2)]angiotensin II, and [des-(Asp-1,Arg-2,val-3)]angiotensin II, were measured in arterial and venous plasma from normal rats. Paper chromatography was used to separate the peptides which were measured with a radioimmunoas...

journal_title：Circulation research

authors： Semple PF,Morton JJ

更新日期：1976-06-01 00:00:00

abstract：:Although Ca(2+) waves in cardiac myocytes are regarded as arrhythmogenic substrates, their properties in the heart in situ are poorly understood. On the hypothesis that Ca(2+) waves in the heart behave diversely and some of them influence the cardiac function, we analyzed their incidence, propagation velocity, and int...

journal_title：Circulation research

authors： Kaneko T,Tanaka H,Oyamada M,Kawata S,Takamatsu T

更新日期：2000-05-26 00:00:00

abstract：:Telomeres-the specialized DNA-protein structures at the ends of eukaryotic chromosomes-are essential for maintaining genome stability and integrity and for extended proliferative life span in both cultured cells and in the whole organism. Telomerase and additional telomere-associated proteins are necessary for preserv...

journal_title：Circulation research

authors： Serrano AL,Andrés V

更新日期：2004-03-19 00:00:00

abstract：:A series of new phenylethanolamines with 2-methoxy and/or 4-methyl, 4-chloro, or 4-bromo ring substituents and either N-isopropyl or N-tert butyl substituents have been synthesized and tested for beta 1- and beta 2-adrenoceptor blocking activity using isolated guinea pig atrial and tracheal preparations. Each of the d...

journal_title：Circulation research

authors： Letts LG,Temple DM,Williams LR

更新日期：1980-06-01 00:00:00

abstract：RATIONALE:Lipoprotein(a) [Lp(a)] is a highly atherogenic low-density lipoprotein-like particle characterized by the presence of apoprotein(a) [apo(a)] bound to apolipoprotein B. Proprotein convertase subtilisin/kexin type 9 (PCSK9) selectively binds low-density lipoprotein; we hypothesized that it can also be associate...

journal_title：Circulation research

authors： Tavori H,Christian D,Minnier J,Plubell D,Shapiro MD,Yeang C,Giunzioni I,Croyal M,Duell PB,Lambert G,Tsimikas S,Fazio S

更新日期：2016-06-24 00:00:00

abstract：:Cardiac allograft vasculopathy (CAV) continues to be a major cause of late graft failure after cardiac transplantation. We have demonstrated that Rho-kinase, an effector of the small GTPase Rho, plays an important role in the pathogenesis of arteriosclerosis. In this study, we examined whether the Rho-kinase-mediated ...

journal_title：Circulation research

authors： Hattori T,Shimokawa H,Higashi M,Hiroki J,Mukai Y,Kaibuchi K,Takeshita A

更新日期：2004-01-09 00:00:00

abstract：:Dimethylarginie dimethylaminohydrolase (DDAH) degrades asymmetric dimethylarginine (ADMA), an endogenous nitric oxide (NO) synthase inhibitor, and comprises 2 isoforms, DDAH1 and DDAH2. To investigate the in vivo role of DDAH2, we generated transgenic mice overexpressing DDAH2. The transgenic mice manifested reduction...

journal_title：Circulation research

authors： Hasegawa K,Wakino S,Tatematsu S,Yoshioka K,Homma K,Sugano N,Kimoto M,Hayashi K,Itoh H

更新日期：2007-07-20 00:00:00

abstract：RATIONALE:Mitochondrial dysfunction plays an important role in heart failure (HF). However, the molecular mechanisms regulating mitochondrial functions via selective mitochondrial autophagy (mitophagy) are poorly understood. OBJECTIVE:We sought to determine the role of AMPK (AMP-activated protein kinase) in selective ...

journal_title：Circulation research

authors： Wang B,Nie J,Wu L,Hu Y,Wen Z,Dong L,Zou MH,Chen C,Wang DW

更新日期：2018-03-02 00:00:00

abstract：:Hypercholesterolemia induces atheroma formation, and the concentration of sphingomyelin is increased compared with that in the normal aortic intima-media. The aortic intima-media sphingomyelin concentration appears to increase exponentially with time on the cholesterol diet. Moreover, the entry rate of serum sphingomy...

journal_title：Circulation research

authors： Seth SK,Newman AI

更新日期：1975-02-01 00:00:00

abstract：RATIONALE:B-1 cell-derived natural IgM antibodies against oxidation-specific epitopes on low-density lipoprotein are anti-inflammatory and atheroprotective. Bone marrow (BM) B-1a cells contribute abundantly to IgM production, yet the unique repertoire of IgM antibodies generated by BM B-1a and the factors maintaining t...

journal_title：Circulation research

authors： Upadhye A,Srikakulapu P,Gonen A,Hendrikx S,Perry HM,Nguyen A,McSkimming C,Marshall MA,Garmey JC,Taylor AM,Bender TP,Tsimikas S,Holodick NE,Rothstein TL,Witztum JL,McNamara CA

更新日期：2019-10-25 00:00:00

abstract：:The effects of synthetic human atrial 28-amino acid peptide (alpha-human atrial polypeptide) on systemic and renal hemodynamics were examined in two separate groups of Inactin-anesthetized rats. First, mean arterial pressure, heart rate, and cardiac output were measured before and during infusion of the peptide at rat...

journal_title：Circulation research

authors： Hirata Y,Ishii M,Sugimoto T,Matsuoka H,Sugimoto T,Kangawa K,Matsuo H

更新日期：1985-10-01 00:00:00

abstract：:Cardiovascular dysfunction as a result of sepsis is the leading cause of death in the critically ill. Cardiomyocytes respond to infectious pathogens with a Toll-like receptor-initiated proinflammatory response in conjunction with a decrease in contractility, although the downstream events linking Toll-like receptor ac...

journal_title：Circulation research

authors： Boyd JH,Kan B,Roberts H,Wang Y,Walley KR

更新日期：2008-05-23 00:00:00

abstract：:G-protein receptor kinase 2 (GRK2) is 1 of 7 mammalian GRKs that phosphorylate ligand-bound 7-transmembrane receptors, causing receptor uncoupling from G proteins and potentially activating non-G-protein signaling pathways. GRK2 is unique among members of the GRK family in that its genetic ablation causes embryonic le...

journal_title：Circulation research

authors： Matkovich SJ,Diwan A,Klanke JL,Hammer DJ,Marreez Y,Odley AM,Brunskill EW,Koch WJ,Schwartz RJ,Dorn GW 2nd

更新日期：2006-10-27 00:00:00

abstract：:3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) can exert beneficial effects independently of serum cholesterol reduction by increasing the bioavailability of nitric oxide. However, it is unclear whether statins can exert such effects directly on cardiac myocytes and whether mitochondria...

journal_title：Circulation research

authors： Jones SP,Teshima Y,Akao M,Marbán E

更新日期：2003-10-17 00:00:00

abstract：:The present experiments were performed to investigate whether neurogenic inflammation in rat trachea (with edema formation and protein extravasation when the circulation is intact) induced by electrical field stimulation of neuropeptide-containing C fibers in the vagal nerve is accompanied by increased negativity of i...

journal_title：Circulation research

authors： Woie K,Koller ME,Heyeraas KJ,Reed RK

更新日期：1993-11-01 00:00:00

abstract：:The microelectrode technique of intracellular constant current application and intracellular transmembrane voltage recording was used to study the effects of procaine amide (PA) on cardiac excitability. We measured the effect of PA in a concentration equivalent to clinically effective antiarrhythmic plasma levels (5 m...

journal_title：Circulation research

authors： Arnsdorf MF,Bigger JT Jr

更新日期：1976-02-01 00:00:00

abstract：:The role of prostaglandin production in the control of regenerative function of endothelial progenitor cells (EPCs) has not been studied. We hypothesized that activation of cyclooxygenase (COX) enzymatic activity and the subsequent production of prostacyclin (PGI(2)) is an important mechanism responsible for the regen...

journal_title：Circulation research

authors： He T,Lu T,d'Uscio LV,Lam CF,Lee HC,Katusic ZS

更新日期：2008-07-03 00:00:00

abstract：:The dystrophin-glycoprotein complex is a large complex of membrane-associated proteins linking the cytoskeleton to the extracellular matrix in muscle. Transmembrane heterodimeric (alphabeta) integrins serve also as cellular adhesion molecules and mechanotransducers. In the animal model for Duchenne muscular dystrophy,...

journal_title：Circulation research

authors： Elsherif L,Huang MS,Shai SY,Yang Y,Li RY,Chun J,Mekany MA,Chu AL,Kaufman SJ,Ross RS

更新日期：2008-05-09 00:00:00

abstract：RATIONALE:Although the health effects of beta carotene have been studied extensively, a systematic examination of serum concentrations and long-term mortality, including cardiovascular disease mortality, has not been reported. OBJECTIVE:Explore whether serum beta carotene is associated with overall and cause-specific ...

journal_title：Circulation research

authors： Huang J,Weinstein SJ,Yu K,Männistö S,Albanes D

更新日期：2018-12-07 00:00:00

abstract：:This article examines the role of innervation in regulating expression of acetylcholinesterase (AchE), butyrylcholinesterase (BuchE), and the muscarinic acetylcholine receptor (mAchR) in avian heart. Two distinct approaches are taken. The first approach examines the relation between the onsets of parasympathetic and s...

journal_title：Circulation research

authors： Jo SA,Higgins DM,Berman HA

更新日期：1992-04-01 00:00:00

abstract：RATIONALE:ATP-binding cassette transporter A1 (ABCA1) plays a critical role in eliminating excess free cholesterol from tissues by effluxing cellular free cholesterol and phospholipids to lipid-poor apolipoprotein AI. Macrophage ABCA1 also dampens proinflammatory myeloid differentiation primary-response protein 88-depe...

journal_title：Circulation research

authors： Zhu X,Westcott MM,Bi X,Liu M,Gowdy KM,Seo J,Cao Q,Gebre AK,Fessler MB,Hiltbold EM,Parks JS

更新日期：2012-11-09 00:00:00

abstract：:CD40 is a 48-kDa phosphorylated transmembrane glycoprotein belonging to the TNF receptor superfamily. CD40 has been demonstrated on a range of cell types, and it has an important role in adaptive immunity and inflammation. CD40 has recently been described on platelets but platelet activation by CD40 has not been descr...

journal_title：Circulation research

authors： Inwald DP,McDowall A,Peters MJ,Callard RE,Klein NJ

更新日期：2003-05-16 00:00:00

abstract：:The blood pressure of rabbits with chronic one-kidney hypertension can be lowered to normal by immunization with hog kidney cortex preparations that do not contain renin, thus providing evidence for a new factor essential for the maintenance of an elevated blood pressure. A search for the new factor has led to the dis...

journal_title：Circulation research

authors： Skeggs LT,Kahn JR,Levine M,Dorer FE,Lentz KE

更新日期：1977-02-01 00:00:00