Abstract:
:Obesity results in marked alterations in cardiac energy metabolism, with a prominent effect being an increase in fatty acid uptake and oxidation by the heart. Obesity also results in dramatic changes in the release of adipokines, such as leptin and adiponectin, both of which have emerged as important regulators of cardiac energy metabolism. The link among obesity, cardiovascular disease, lipid metabolism, and adipokine signaling is complex and not well understood. However, optimizing cardiac energy metabolism in obese subjects may be one approach to preventing and treating cardiac dysfunction that can develop in this population. This review discusses what is presently known about the effects of obesity and the impact adipokines have on cardiac energy metabolism and insulin signaling. The clinical implications of obesity and energy metabolism on cardiac disease are also discussed.
journal_name
Circ Resjournal_title
Circulation researchauthors
Lopaschuk GD,Folmes CD,Stanley WCdoi
10.1161/CIRCRESAHA.107.150417subject
Has Abstractpub_date
2007-08-17 00:00:00pages
335-47issue
4eissn
0009-7330issn
1524-4571pii
101/4/335journal_volume
101pub_type
杂志文章,评审abstract::Angiotensin-converting enzyme inhibitor was used in dogs with uranyl nitrate-induced acute renal failure to evaluate (1) a possible protective effect of angiotensin blockade and (2)the role of angiotensin II in the generation of renal failure in this model. Angiotensin-converting enzyme inhibitor treatment attenuated ...
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pub_type: 杂志文章
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更新日期:2000-12-08 00:00:00
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更新日期:2003-08-22 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:
更新日期:1977-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/hh2201.100315
更新日期:2001-11-09 00:00:00
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pub_type: 杂志文章
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