In vivo microscopy of the cerebral microcirculation using neonatal allografts in hamsters.

Abstract:

:Studies were performed to characterize the morphology and vascular reactivity of the allografted cerebral microcirculation. Cerebral cortical tissue was allografted into the cheek pouch of the hamster so that cerebral parenchymal vessels could be studied. The vascular morphology was characterized by a large number of looping vessels. The ultrastructural examination indicated viable cerebral tissue containing typical vessels, that is, "tight" junctions, not like those of the cheek pouch. Also, the microvasculature was impermeable to 150, 70, and 20 kDa fluorescein isothiocyanate dextrans. Angiotensin II and norepinephrine caused constriction of the cerebral vessels whereas adenosine caused dilation. Isoproterenol did not affect cerebral arterioles; however, it dilated cheek pouch arterioles. Thus, this preparation provides a satisfactory model for studying the living cerebral microcirculation.

journal_name

Circ Res

journal_title

Circulation research

authors

Joyner WL,Young R,Blank D,Eccleston-Joyner CA,Gilmore JP

doi

10.1161/01.res.63.4.758

subject

Has Abstract

pub_date

1988-10-01 00:00:00

pages

758-66

issue

4

eissn

0009-7330

issn

1524-4571

journal_volume

63

pub_type

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