Novel biological functions of high-density lipoprotein cholesterol.

abstract：:Genetically hypertensive (GH) rats of the New Zealand strain and normotensive (N) rats were sympathectomized from birth with 6-hydroxydopamine (100 mg/kg,s.c, on alternate days, seven treatments). In adult treated rats from each strain (GHTr and NTr), blood pressure was lower than normal. Functional tests and electron...

journal_title：Circulation research

authors： Clark DW,Jones DR,Phelan EL,Devine CE

更新日期：1978-08-01 00:00:00

abstract：:Activity was recorded from physiologically identified baroreceptor or chemoreceptor fibers in carotid sinus nerves of urethane-anesthetized spontaneously breathing rabbits. A carotid sinus area was vascularly isolated so that carotid sinus pressure and perfusion medium (Locke's solution or rabbit blood) could be contr...

journal_title：Circulation research

authors： Qu L,Stuesse SL

更新日期：1991-12-01 00:00:00

abstract：:Adipose tissue (AT) plays a central role in both metabolic health and pathophysiology. Its expansion in obesity results in increased mortality and morbidity, with contributions to cardiovascular disease, diabetes mellitus, fatty liver disease, and cancer. Obesity prevalence is at an all-time high and is projected to b...

journal_title：Circulation research

authors： Weinstock A,Moura Silva H,Moore KJ,Schmidt AM,Fisher EA

更新日期：2020-05-22 00:00:00

abstract：RATIONALE:Although PSA (prostate-specific antigen)-a tumor marker for prostate cancer-has been reported to be associated with cardiovascular disease (CVD) risk factors, studies on the association of PSA with subclinical and clinical CVD remain limited. OBJECTIVE:We examined the association of total serum PSA within th...

journal_title：Circulation research

authors： Chang Y,Kim JH,Noh JW,Cho YS,Park HJ,Joo KJ,Ryu S

更新日期：2019-05-10 00:00:00

abstract：RATIONALE:ASK1-interacting protein-1 (AIP1), a Ras GTPase-activating protein family member, is highly expressed in endothelial cells and vascular smooth musccells (VSMCs). The role of AIP1 in VSMCs and VSMC proliferative disease is not known. OBJECTIVE:We used mouse graft arteriosclerosis models characterized by VSMC ...

journal_title：Circulation research

authors： Yu L,Qin L,Zhang H,He Y,Chen H,Pober JS,Tellides G,Min W

更新日期：2011-08-05 00:00:00

abstract：:Vascular remodeling, rather than vasoconstriction, is believed to account for high vascular resistance in severe pulmonary arterial hypertension (PAH). We have found previously that acute Rho kinase inhibition nearly normalizes PAH in chronically hypoxic rats that have no occlusive neointimal lesions. Here we examined...

journal_title：Circulation research

authors： Oka M,Homma N,Taraseviciene-Stewart L,Morris KG,Kraskauskas D,Burns N,Voelkel NF,McMurtry IF

更新日期：2007-03-30 00:00:00

abstract：:The effects of Bay K 8644 on the high-threshold calcium channel was investigated by means of the whole-cell patch-clamp technique in single guinea pig ventricular myocytes. The goal of the experiments was to characterize the inhibitory effects of Bay K 8644 on the calcium channel, and identify the factors that influen...

journal_title：Circulation research

authors： Hadley RW,Hume JR

更新日期：1988-01-01 00:00:00

abstract：:Ventricular arrhythmias that accompany myocardial infarction in dogs may be secondary to the altered electrophysiological properties of the subendocardial Purkinje fibers that survive 24 hours after the coronary occlusion. To better understand the ionic mechanisms that underlie the altered electrical activity of these...

journal_title：Circulation research

authors： Boyden PA,Albala A,Dresdner KP Jr

更新日期：1989-10-01 00:00:00

abstract：:Clonidine and related drugs cause a specific pattern of cardiovascular depression by an agonistic effect on alpha-adrenoceptors within the central nervous system (CNS). For further characterization of the central adrenoceptors, the actions of three substances of the "clonidine-type" derived from two different chemical...

journal_title：Circulation research

authors： Kobinger W,Lillie C,Pichler L

更新日期：1980-06-01 00:00:00

abstract：:We determined age-related differences in automaticity and responsiveness of cardiac Purkinje fibers from adult and neonatal dogs to graded concentrations of epinephrine, isoproterenol, and phenylephrine. Purkinje fibers were studied with standard microelectrode techniques during superfusion with Tyrode's solution at 3...

journal_title：Circulation research

authors： Rosen MR,Hordof AJ,Ilvento JP,Danilo P Jr

更新日期：1977-04-01 00:00:00

abstract：:By making use of immunoblotting and immunocytochemical analysis, we explored whether stimulation of adenosine A1 receptors would promote the activation of delta-protein kinase C (delta-PKC) immunolabeled with a polyclonal antibody. Immunoblot analysis of Triton X-100-soluble cell membrane and cytosolic fractions revea...

journal_title：Circulation research

authors： Henry P,Demolombe S,Pucéat M,Escande D

更新日期：1996-01-01 00:00:00

abstract：:Ca2+ influx through the L-type calcium channel (LTCC) induces Ca2+ release from the sarcoplasmic reticulum (SR) and maintains SR Ca2+ loading. Alterations in LTCC properties, their contribution to the blunted adrenergic responsiveness in failing hearts and their recovery after support with LV assist devices (LVAD) wer...

journal_title：Circulation research

authors： Chen X,Piacentino V 3rd,Furukawa S,Goldman B,Margulies KB,Houser SR

更新日期：2002-09-20 00:00:00

abstract：RATIONALE:Innate and adaptive immune responses alter numerous homeostatic processes that are controlled by nuclear hormone receptors. NR4A1 is a nuclear receptor that is induced in vascular pathologies, where it mediates protection. OBJECTIVE:The underlying mechanisms that regulate the activity of NR4A1 during vascula...

journal_title：Circulation research

authors： Papac-Milicevic N,Breuss JM,Zaujec J,Ryban L,Plyushch T,Wagner GA,Fenzl S,Dremsek P,Cabaravdic M,Steiner M,Glass CK,Binder CJ,Uhrin P,Binder BR

更新日期：2012-04-13 00:00:00

abstract：:We created knock-in mice in which a deletion of 3 base pairs coding for K210 in cardiac troponin (cTn)T found in familial dilated cardiomyopathy patients was introduced into endogenous genes. Membrane-permeabilized cardiac muscle fibers from mutant mice showed significantly lower Ca(2+) sensitivity in force generation...

journal_title：Circulation research

authors： Du CK,Morimoto S,Nishii K,Minakami R,Ohta M,Tadano N,Lu QW,Wang YY,Zhan DY,Mochizuki M,Kita S,Miwa Y,Takahashi-Yanaga F,Iwamoto T,Ohtsuki I,Sasaguri T

更新日期：2007-07-20 00:00:00

abstract：:Fetal ventricular performance has been considered limited because ventricular output does not increase with rapid volume expansion above mean left atrial pressures (mLAPs) of 5-7 mm Hg. To explore relations between preload, afterload, and stroke volume (SV) in the fetal left ventricle, we instrumented 126-129 days ges...

journal_title：Circulation research

authors： Hawkins J,Van Hare GF,Schmidt KG,Rudolph AM

更新日期：1989-07-01 00:00:00

abstract：RATIONALE:One goal of cardiac tissue engineering is the generation of a living, human pump in vitro that could replace animal models and eventually serve as an in vivo therapeutic. Models that replicate the geometrically complex structure of the heart, harboring chambers and large vessels with soft biomaterials, can be...

journal_title：Circulation research

authors： Kupfer ME,Lin WH,Ravikumar V,Qiu K,Wang L,Gao L,Bhuiyan DB,Lenz M,Ai J,Mahutga RR,Townsend D,Zhang J,McAlpine MC,Tolkacheva EG,Ogle BM

更新日期：2020-07-03 00:00:00

abstract：:The mechanism(s) by which mutations in sarcomeric proteins cause hypertrophic cardiomyopathy (HCM) remains unknown. A leading hypothesis proposes that mutant sarcomeric proteins impair cardiac myocyte contractility, providing an impetus for compensatory hypertrophy. To test this hypothesis, we determined the impact of...

journal_title：Circulation research

authors： Marian AJ,Zhao G,Seta Y,Roberts R,Yu QT

更新日期：1997-07-01 00:00:00

abstract：RATIONALE:Accurate knowledge of the cellular composition of the heart is essential to fully understand the changes that occur during pathogenesis and to devise strategies for tissue engineering and regeneration. OBJECTIVE:To examine the relative frequency of cardiac endothelial cells, hematopoietic-derived cells, and ...

journal_title：Circulation research

authors： Pinto AR,Ilinykh A,Ivey MJ,Kuwabara JT,D'Antoni ML,Debuque R,Chandran A,Wang L,Arora K,Rosenthal NA,Tallquist MD

更新日期：2016-02-05 00:00:00

abstract：:Calcineurin, a calcium/calmodulin-regulated protein phosphatase, modulates gene expression in cardiac and skeletal muscles during development and in remodeling responses such as cardiac hypertrophy that are evoked by environmental stresses or disease. Recently, we identified two genes encoding proteins (MCIP1 and MCIP...

journal_title：Circulation research

authors： Yang J,Rothermel B,Vega RB,Frey N,McKinsey TA,Olson EN,Bassel-Duby R,Williams RS

更新日期：2000-12-08 00:00:00

abstract：:True propagation coefficients of pulse wave harmonics in an artery can be determined in vivo by measuring pulsatile blood pressure and flow at each of two points along the length of the vessel. These coefficients, which are complex numbers that describe the attenuation and the phase shift imposed on a traveling wave, ...

journal_title：Circulation research

authors： Milnor WR,Nichols WW

更新日期：1975-05-01 00:00:00

abstract：:Connexin40 (Cx40) is a major gap junction protein that is expressed in the His-Purkinje system and thought to be a critical determinant of cell-to-cell communication and conduction of electrical impulses. Video maps of the ventricular epicardium and the proximal segment of the right bundle branch (RBB) were obtained u...

journal_title：Circulation research

authors： Tamaddon HS,Vaidya D,Simon AM,Paul DL,Jalife J,Morley GE

更新日期：2000-11-10 00:00:00

abstract：:Sixteen years ago, mutations in cardiac troponin (Tn)T and α-tropomyosin were linked to familial hypertrophic cardiomyopathy, thus transforming the disorder from a disease of the β-myosin heavy chain to a disease of the cardiac sarcomere. From the outset, studies suggested that mutations in the regulatory thin filamen...

journal_title：Circulation research

authors： Tardiff JC

更新日期：2011-03-18 00:00:00

abstract：:We tested a number of hypotheses concerning the mechanism of K+-induced vasodilation of the coronary vascular bed. Blood flow in the circumflex artery was measured in pentobarbital-anesthetized, open-chest dogs. Intracircumflex artery bolus injections of 40 mumol of isomotic KCl produced decreases in coronary vascular...

journal_title：Circulation research

authors： Murray PA,Sparks HV

更新日期：1978-01-01 00:00:00

abstract：:Experiments were performed to investigate whether balloon injury induces nitric oxide synthase activity in the blood vessel wall. Contractions to phenylephrine were compared in left carotid arteries of the rat, previously injured by balloon catheterization and excised either immediately (t = 0), 6, or 24 hours after t...

journal_title：Circulation research

authors： Joly GA,Schini VB,Vanhoutte PM

更新日期：1992-08-01 00:00:00

abstract：:Endothelins exert potent excitatory cardiac effects by acting on specific receptors on myocytes. In this study, we have examined the signal transduction mechanism for the chronotropic effect of endothelins in guinea pig atria. A competition binding of [125I]endothelin 1 ([125I]ET-1) using the recently developed ETA re...

journal_title：Circulation research

authors： Ono K,Eto K,Sakamoto A,Masaki T,Shibata K,Sada T,Hashimoto K,Tsujimoto G

更新日期：1995-02-01 00:00:00

abstract：:Deepak Srivastava’s group at the Gladstone Institute of Cardiovascular Disease, University of California San Francisco, reported in the August 6 issue of the journal Cell that to make heart muscle cells, all you need are three factors and some fibroblasts. But is it really that easy? ...

journal_title：Circulation research

authors： Williams R

更新日期：2010-10-29 00:00:00

abstract：:Angiotensin (Ang) II is present inside vascular smooth muscle cells (VSMCs); however, its intracellular functions, if any, are unknown. We tested the hypothesis that intracellular Ang II exerts effects on cytosolic Ca2+ ([Ca2+]i) in VSMCs. Ang II was administered via microinjection. Intracellular Ang II localization w...

journal_title：Circulation research

authors： Haller H,Lindschau C,Erdmann B,Quass P,Luft FC

更新日期：1996-10-01 00:00:00

abstract：:In 36 normolipemic pigs randomized to a 4-week feeding with regular pig chow (n = 18, control group) or chow supplemented with cod liver oil (1 ml/kg per day) (n = 18, treated group), treatment with cod liver oil produced a significant decrease in serum cholesterol, low density lipoprotein cholesterol, and triglycerid...

journal_title：Circulation research

authors： Lam JY,Badimon JJ,Ellefson RD,Fuster V,Chesebro JH

更新日期：1992-10-01 00:00:00

abstract：:A large body of data gathered over the past couple of years has identified the peroxisome proliferator-activated receptors (PPAR) alpha, gamma, and beta/delta as transcription factors exerting modulatory actions in vascular cells. PPARs, which belong to the nuclear receptor family of ligand-activated transcription fac...

journal_title：Circulation research

authors： Marx N,Duez H,Fruchart JC,Staels B

更新日期：2004-05-14 00:00:00

abstract：RATIONALE:We have shown recently that particulate (pGC) and soluble guanylyl (sGC) cyclases synthesize cGMP in different compartments in adult rat ventricular myocytes (ARVMs). OBJECTIVE:We hypothesized that cGMP-dependent protein kinase (PKG) exerts a feedback control on cGMP concentration contributing to its intrace...

journal_title：Circulation research

authors： Castro LR,Schittl J,Fischmeister R

更新日期：2010-11-12 00:00:00