Abstract:
:Adipose tissue (AT) plays a central role in both metabolic health and pathophysiology. Its expansion in obesity results in increased mortality and morbidity, with contributions to cardiovascular disease, diabetes mellitus, fatty liver disease, and cancer. Obesity prevalence is at an all-time high and is projected to be 50% in the United States by 2030. AT is home to a large variety of immune cells, which are critical to maintain normal tissue functions. For example, γδ T cells are fundamental for AT innervation and thermogenesis, and macrophages are required for recycling of lipids released by adipocytes. The expansion of visceral white AT promotes dysregulation of its immune cell composition and likely promotes low-grade chronic inflammation, which has been proposed to be the underlying cause for the complications of obesity. Interestingly, weight loss after obesity alters the AT immune compartment, which may account for the decreased risk of developing these complications. Recent technological advancements that allow molecular investigation on a single-cell level have led to the discovery of previously unappreciated heterogeneity in many organs and tissues. In this review, we will explore the heterogeneity of immune cells within the visceral white AT and their contributions to homeostasis and pathology.
journal_name
Circ Resjournal_title
Circulation researchauthors
Weinstock A,Moura Silva H,Moore KJ,Schmidt AM,Fisher EAdoi
10.1161/CIRCRESAHA.120.316203subject
Has Abstractpub_date
2020-05-22 00:00:00pages
1590-1612issue
11eissn
0009-7330issn
1524-4571journal_volume
126pub_type
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pub_type: 杂志文章
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更新日期:2001-07-20 00:00:00
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doi:10.1161/CIRCRESAHA.118.312804
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pub_type: 杂志文章,meta分析,评审
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