Antithrombotic Agents.

Abstract:

:Recent advances in our understanding of the contribution of thrombin generation to arterial thrombosis and the role of platelets in venous thrombosis have prompted new treatment paradigms. Nonetheless, bleeding remains the major side effect of such treatments spurring the quest for new antithrombotic regimens with better benefit-risk profiles and for safer anticoagulants for existing and new indications. The aims of this article are to review the results of recent trials aimed at enhancing the benefit-risk profile of antithrombotic therapy and explain how these findings are changing our approach to the management of arterial and venous thrombosis. Focusing on these 2 aspects of thrombosis management, this article discusses 4 advances: (1) the observation that in some indications, lowering the dose of some direct oral anticoagulants reduces the risk of bleeding without compromising efficacy, (2) the recognition that aspirin is not only effective for secondary prevention of atherothrombosis but also for prevention of venous thromboembolism, (3) the finding that dual pathway inhibition with the combination of low-dose rivaroxaban to attenuate thrombin generation plus aspirin to reduce thromboxane A2-mediated platelet activation is superior to aspirin or rivaroxaban alone for prevention of atherothrombosis in patients with coronary or peripheral artery disease, and (4) the development of inhibitors of factor XI or XII as potentially safer anticoagulants.

journal_name

Circ Res

journal_title

Circulation research

authors

Chan NC,Weitz JI

doi

10.1161/CIRCRESAHA.118.313155

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

426-436

issue

3

eissn

0009-7330

issn

1524-4571

journal_volume

124

pub_type

杂志文章,评审
  • Canine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase.

    abstract::Therapy directed against the toxic effects of reactive oxygen species may reduce the final extent of ischemic injury in otherwise viable tissue irreversibly injured by the abrupt reoxygenation of reperfusion. In four groups of dogs, superoxide dismutase plus catalase (groups I-III) or saline (controls) (group IV) was ...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.54.3.277

    authors: Jolly SR,Kane WJ,Bailie MB,Abrams GD,Lucchesi BR

    更新日期:1984-03-01 00:00:00

  • Dynamic changes in the canine mitral regurgitant orifice area during ventricular ejection.

    abstract::We designed this study to test the hypothesis that in acute mitral regurgitation the mitral regurgitant area (MRA) is a dynamic quantity which varies with the time variation of ventricular volume. Mitral insufficiency was created in five open-chest dogs in which a portion of the anterior leaflet was excised. Phasic ao...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.45.5.677

    authors: Yellin EL,Yoran C,Sonnenblick EH,Gabbay S,Frater RW

    更新日期:1979-11-01 00:00:00

  • Molecular cloning and characterization of the intermediate-conductance Ca(2+)-activated K(+) channel in vascular smooth muscle: relationship between K(Ca) channel diversity and smooth muscle cell function.

    abstract::Recent evidence suggests that functional diversity of vascular smooth muscle is produced in part by a differential expression of ion channels. The aim of the present study was to examine the role of Ca(2+)-activated K(+) channels (K(Ca) channels) in the expression of smooth muscle cell functional phenotype. We found t...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.85.9.e33

    authors: Neylon CB,Lang RJ,Fu Y,Bobik A,Reinhart PH

    更新日期:1999-10-29 00:00:00

  • Distribution and three-dimensional structure of intercellular junctions in canine myocardium.

    abstract::Electrotonic coupling of cardiac myocytes at gap junctions may influence patterns of conduction in myocardium. To delineate the three-dimensional structure and distribution of intercellular junctions, we analyzed serial ultrathin sections of canine myocardium with transmission electron microscopy and disaggregated myo...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.64.3.563

    authors: Hoyt RH,Cohen ML,Saffitz JE

    更新日期:1989-03-01 00:00:00

  • Signal transduction in atria and ventricles of mice with transient cardiac expression of activated G protein alpha(q).

    abstract::We recently showed that the transient expression of a hemagglutinin (HA) epitope-tagged, constitutively active mutant of the G protein alpha(q) subunit (HAalpha(q)*) in the hearts of transgenic mice is sufficient to induce cardiac hypertrophy and dilatation that continue to progress after HAalpha(q)* protein becomes u...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.85.11.1085

    authors: Mende U,Kagen A,Meister M,Neer EJ

    更新日期:1999-11-26 00:00:00

  • Duration of ischemia is vital for collateral development: repeated brief coronary artery occlusions in conscious dogs.

    abstract::The effects of two types of repeated transient coronary artery occlusions on collateral development were examined in chronically instrumented, conscious dogs. A 2-minute coronary occlusion at 32-minute intervals (group 1, n = 11) or a 15-second occlusion at 4-minute intervals (group 2, n = 7) were repeated day and nig...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.64.2.287

    authors: Mohri M,Tomoike H,Noma M,Inoue T,Hisano K,Nakamura M

    更新日期:1989-02-01 00:00:00

  • Oxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosis.

    abstract::The mitochondrial enzyme monoamine oxidase (MAO), its isoform MAO-A, plays a major role in reactive oxygen species-dependent cardiomyocyte apoptosis and postischemic cardiac damage. In the current study, we investigated whether sphingolipid metabolism can account for mediating MAO-A- and reactive oxygen species-depend...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.RES.0000253900.66640.34

    authors: Pchejetski D,Kunduzova O,Dayon A,Calise D,Seguelas MH,Leducq N,Seif I,Parini A,Cuvillier O

    更新日期:2007-01-05 00:00:00

  • Peroxisome proliferator-activated receptors and atherogenesis: regulators of gene expression in vascular cells.

    abstract::A large body of data gathered over the past couple of years has identified the peroxisome proliferator-activated receptors (PPAR) alpha, gamma, and beta/delta as transcription factors exerting modulatory actions in vascular cells. PPARs, which belong to the nuclear receptor family of ligand-activated transcription fac...

    journal_title:Circulation research

    pub_type: 杂志文章,评审

    doi:10.1161/01.RES.0000127122.22685.0A

    authors: Marx N,Duez H,Fruchart JC,Staels B

    更新日期:2004-05-14 00:00:00

  • High-resolution optical mapping of the right bundle branch in connexin40 knockout mice reveals slow conduction in the specialized conduction system.

    abstract::Connexin40 (Cx40) is a major gap junction protein that is expressed in the His-Purkinje system and thought to be a critical determinant of cell-to-cell communication and conduction of electrical impulses. Video maps of the ventricular epicardium and the proximal segment of the right bundle branch (RBB) were obtained u...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.87.10.929

    authors: Tamaddon HS,Vaidya D,Simon AM,Paul DL,Jalife J,Morley GE

    更新日期:2000-11-10 00:00:00

  • Ionic current basis of electrocardiographic waveforms: a model study.

    abstract::Body surface electrocardiograms and electrograms recorded from the surfaces of the heart are the basis for diagnosis and treatment of cardiac electrophysiological disorders and arrhythmias. Given recent advances in understanding the molecular mechanisms of arrhythmia, it is important to relate these electrocardiograph...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.0000016960.61087.86

    authors: Gima K,Rudy Y

    更新日期:2002-05-03 00:00:00

  • Use-dependence of ryanodine effects on postrest contraction in ferret cardiac muscle.

    abstract::During an investigation of the effect of ryanodine on contractions in cardiac muscle, it was found that long rest periods removed all or most of the drug's effect. Therefore, we studied the kinetics of block development and recovery from block produced by low concentrations of ryanodine (1-100 pM) on the postrest cont...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.60.4.560

    authors: Malecot CO,Katzung BG

    更新日期:1987-04-01 00:00:00

  • A TREK-1-like potassium channel in atrial cells inhibited by beta-adrenergic stimulation and activated by volatile anesthetics.

    abstract::Many members of the two-pore-domain potassium (K(+)) channel family have been detected in the mammalian heart but the endogenous correlates of these channels still have to be identified. We investigated whether I(KAA), a background K(+) current activated by negative pressure (stretch) and by arachidonic acid (AA) and ...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/hh1601.094979

    authors: Terrenoire C,Lauritzen I,Lesage F,Romey G,Lazdunski M

    更新日期:2001-08-17 00:00:00

  • Simvastatin attenuates oxidant-induced mitochondrial dysfunction in cardiac myocytes.

    abstract::3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) can exert beneficial effects independently of serum cholesterol reduction by increasing the bioavailability of nitric oxide. However, it is unclear whether statins can exert such effects directly on cardiac myocytes and whether mitochondria...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.RES.0000097262.21507.DF

    authors: Jones SP,Teshima Y,Akao M,Marbán E

    更新日期:2003-10-17 00:00:00

  • Cardiac-specific IGF-1 expression attenuates dilated cardiomyopathy in tropomodulin-overexpressing transgenic mice.

    abstract::To test the hypothesis that early interventional treatment with insulin-like growth factor-1 (IGF-1) alleviates subsequent development of dilated cardiomyopathy, cardiac-specific IGF-1 expression was introduced by selective cross-breeding into a transgenic mouse model of heart failure that displays phenotypic characte...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.0000013780.77774.75

    authors: Welch S,Plank D,Witt S,Glascock B,Schaefer E,Chimenti S,Andreoli AM,Limana F,Leri A,Kajstura J,Anversa P,Sussman MA

    更新日期:2002-04-05 00:00:00

  • Social Integration and Reduced Risk of Coronary Heart Disease in Women: The Role of Lifestyle Behaviors.

    abstract:RATIONALE:Higher social integration is associated with lower cardiovascular mortality; however, whether it is associated with incident coronary heart disease (CHD), especially in women, and whether associations differ by case fatality are unclear. OBJECTIVES:This study sought to examine the associations between social...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/CIRCRESAHA.116.309443

    authors: Chang SC,Glymour M,Cornelis M,Walter S,Rimm EB,Tchetgen Tchetgen E,Kawachi I,Kubzansky LD

    更新日期:2017-06-09 00:00:00

  • A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiation.

    abstract::The action potential model presented in our accompanying article in this journal is used to investigate phenomena that involve dynamic changes of [Ca2+]i, as described below. Delayed afterdepolarizations (DADs) are induced by spontaneous Ca2+ release from the sarcoplasmic reticulum (SR), which, in turn, activates both...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.74.6.1097

    authors: Luo CH,Rudy Y

    更新日期:1994-06-01 00:00:00

  • Mechanisms of TGF-beta1-induced intimal growth: plasminogen-independent activities of plasminogen activator inhibitor-1 and heterogeneous origin of intimal cells.

    abstract::Transforming growth factor (TGF)-beta(1) is a potent stimulator of intimal growth. We showed previously that TGF-beta(1) stimulates intimal growth through early upregulation of plasminogen activator inhibitor-1 (PAI-1) and, subsequently, PAI-1-dependent increases in cell migration and matrix accumulation. We also show...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.RES.0000266970.34017.8d

    authors: Otsuka G,Stempien-Otero A,Frutkin AD,Dichek DA

    更新日期:2007-05-11 00:00:00

  • miR33 inhibition overcomes deleterious effects of diabetes mellitus on atherosclerosis plaque regression in mice.

    abstract:RATIONALE:Diabetes mellitus increases cardiovascular disease risk in humans and remains elevated despite cholesterol-lowering therapy with statins. Consistent with this, in mouse models, diabetes mellitus impairs atherosclerosis plaque regression after aggressive cholesterol lowering. MicroRNA 33 (miR33) is a key negat...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/CIRCRESAHA.115.304164

    authors: Distel E,Barrett TJ,Chung K,Girgis NM,Parathath S,Essau CC,Murphy AJ,Moore KJ,Fisher EA

    更新日期:2014-10-10 00:00:00

  • Plasminogen activator inhibitor-1 regulates myoendothelial junction formation.

    abstract:RATIONALE:Plasminogen activator inhibitor-1 (PAI-1) is a biomarker for several vascular disease states; however, its target of action within the vessel wall is undefined. OBJECTIVE:Determine the ability of PAI-1 to regulate myoendothelial junction (MEJ) formation. METHODS AND RESULTS:MEJs are found throughout the vas...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/CIRCRESAHA.109.215723

    authors: Heberlein KR,Straub AC,Best AK,Greyson MA,Looft-Wilson RC,Sharma PR,Meher A,Leitinger N,Isakson BE

    更新日期:2010-04-02 00:00:00

  • Heart failure in rats causes changes in skeletal muscle morphology and gene expression that are not explained by reduced activity.

    abstract::In patients with congestive heart failure, skeletal muscle is characterized by a smaller proportion of slow-twitch oxidative fibers and reduced oxidative enzyme activity. However, whether these changes result from disuse or occur as a direct consequence of heart failure is unresolved. To address this issue, 18 rats wi...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.79.1.128

    authors: Simonini A,Long CS,Dudley GA,Yue P,McElhinny J,Massie BM

    更新日期:1996-07-01 00:00:00

  • Influence of prostaglandin E2, indomethacin, and reserpine on renal vascular responses to nerve stimulation, pressor and depressor hormones.

    abstract::The effects of prostaglandin E2 (PGE2) indomethacin, and reserpine were evaluated in the rabbit renal vascular bed in situ under conditions of controlled blood flow. Intrarenal infusion of PGE2, 0.03 and 0.3 microgram/min, decreased responses to renal nerve stimulation, intra-arterial norepinephrine, and angiotensin. ...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.41.2.172

    authors: Fink GD,Chapnick BM,Goldberg MR,Paustian PW,Kadowitz PJ

    更新日期:1977-08-01 00:00:00

  • Low-pressure-sensitive baroreceptor fibers recorded from rabbit carotid sinus nerves.

    abstract::Activity was recorded from physiologically identified baroreceptor or chemoreceptor fibers in carotid sinus nerves of urethane-anesthetized spontaneously breathing rabbits. A carotid sinus area was vascularly isolated so that carotid sinus pressure and perfusion medium (Locke's solution or rabbit blood) could be contr...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.69.6.1608

    authors: Qu L,Stuesse SL

    更新日期:1991-12-01 00:00:00

  • Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in Mice.

    abstract:RATIONALE:Aortic valve disease is a cell-mediated process without effective pharmacotherapy. CNP (C-type natriuretic peptide) inhibits myofibrogenesis and osteogenesis of cultured valve interstitial cells and is downregulated in stenotic aortic valves. However, it is unknown whether CNP signaling regulates aortic valve...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/CIRCRESAHA.117.311194

    authors: Blaser MC,Wei K,Adams RLE,Zhou YQ,Caruso LL,Mirzaei Z,Lam AY,Tam RKK,Zhang H,Heximer SP,Henkelman RM,Simmons CA

    更新日期:2018-02-02 00:00:00

  • Control of cardiac sarcolemmal adenylate cyclase and sodium, potassium-activated adenosinetriphosphatase activities.

    abstract::A plasma membrane preparation purified from guinea pig ventricles without the use of high concentrations of detergents or structure-disrupting salts was used to compare the mechanisms of controlling sodium, potassium-activated adenosinetriphosphatase (Na, K-ATPase) and adenylate cyclase activities. The basal ATPase ac...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.36.1.8

    authors: Tada M,Kirchberger MA,Iorio JM,Katz AM

    更新日期:1975-01-01 00:00:00

  • Gene expression profiling of the forming atrioventricular node using a novel tbx3-based node-specific transgenic reporter.

    abstract::The atrioventricular (AV) node is a recurrent source of potentially life-threatening arrhythmias. Nevertheless, limited data are available on its developmental control or molecular phenotype. We used a novel AV nodal myocardium-specific reporter mouse to gain insight into the gene programs determining the formation an...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/CIRCRESAHA.108.192443

    authors: Horsthuis T,Buermans HP,Brons JF,Verkerk AO,Bakker ML,Wakker V,Clout DE,Moorman AF,'t Hoen PA,Christoffels VM

    更新日期:2009-07-02 00:00:00

  • IK1 heterogeneity affects genesis and stability of spiral waves in cardiac myocyte monolayers.

    abstract::Previous studies have postulated an important role for the inwardly rectifying potassium current (I(K1)) in controlling the dynamics of electrophysiological spiral waves responsible for ventricular tachycardia and fibrillation. In this study, we developed a novel tissue model of cultured neonatal rat ventricular myocy...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/CIRCRESAHA.108.178335

    authors: Sekar RB,Kizana E,Cho HC,Molitoris JM,Hesketh GG,Eaton BP,Marbán E,Tung L

    更新日期:2009-02-13 00:00:00

  • Diverse origin and function of cells with endothelial phenotype obtained from adult human blood.

    abstract::Cells with endothelial phenotype generated from adult peripheral blood have emerging diagnostic and therapeutic potential. This study examined the lineage relationship between, and angiogenic function of, early endothelial progenitor cells (EPCs) and late outgrowth endothelial cells (OECs) in culture. Culture conditio...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.RES.0000105569.77539.21

    authors: Gulati R,Jevremovic D,Peterson TE,Chatterjee S,Shah V,Vile RG,Simari RD

    更新日期:2003-11-28 00:00:00

  • Myeloid cell-specific ABCA1 deletion protects mice from bacterial infection.

    abstract:RATIONALE:ATP-binding cassette transporter A1 (ABCA1) plays a critical role in eliminating excess free cholesterol from tissues by effluxing cellular free cholesterol and phospholipids to lipid-poor apolipoprotein AI. Macrophage ABCA1 also dampens proinflammatory myeloid differentiation primary-response protein 88-depe...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/CIRCRESAHA.112.269043

    authors: Zhu X,Westcott MM,Bi X,Liu M,Gowdy KM,Seo J,Cao Q,Gebre AK,Fessler MB,Hiltbold EM,Parks JS

    更新日期:2012-11-09 00:00:00

  • Diminished Ca2+ sensitivity of skinned cardiac muscle contractility coincident with troponin T-band shifts in the diabetic rat.

    abstract::We have measured the apparent Ca2+ sensitivities of force development in skinned cardiac trabeculae at different sarcome lengths together with shifts in troponin (Tn) T subunits on specimens from the same hearts and drawn insights into the pathogenesis of myocardial dysfunction in the diabetic rat. The Ca(2+)-force re...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/01.res.76.4.600

    authors: Akella AB,Ding XL,Cheng R,Gulati J

    更新日期:1995-04-01 00:00:00

  • Long noncoding RNAs in patients with acute myocardial infarction.

    abstract:RATIONALE:Long noncoding RNAs (lncRNAs) constitute a novel class of noncoding RNAs that regulate gene expression. Although recent data suggest that lncRNAs may be associated with cardiac disease, little is known about lncRNAs in the setting of myocardial ischemia. OBJECTIVE:To measure lncRNAs in patients with myocardi...

    journal_title:Circulation research

    pub_type: 杂志文章

    doi:10.1161/CIRCRESAHA.115.303836

    authors: Vausort M,Wagner DR,Devaux Y

    更新日期:2014-09-12 00:00:00