Abstract:
:A central role for leukocytes in neointimal hyperplasia after arterial injury is suspected. However, the relative importance of neutrophils and monocytes in balloon or stent-induced injury are not well understood, and mechanistic targeting of leukocyte recruitment or function is crude. We determined the temporal and spatial distribution of different leukocytes after balloon and stent-induced injury in primate iliac arteries. Based on these data, we targeted neutrophil and monocyte recruitment selectively after angioplasty or stent implantation and demonstrated that monocyte-specific blockade achieved via blockade of the MCP-1 receptor CCR2, was effective at reducing neointimal hyperplasia after stenting. In contrast, combined neutrophil and monocyte blockade achieved by targeting the leukocyte beta(2)-integrin beta-subunit CD18 was required to reduce neointimal hyperplasia after balloon injury. Distinct patterns of leukocyte infiltration in balloon versus stent-injured arteries predict distinct mechanisms for antiinflammatory strategies targeting neutrophils or monocytes in primates and may assist design of effective clinical strategies for optimizing vascular interventions.
journal_name
Circ Resjournal_title
Circulation researchauthors
Horvath C,Welt FG,Nedelman M,Rao P,Rogers Cdoi
10.1161/hh0402.105956subject
Has Abstractpub_date
2002-03-08 00:00:00pages
488-94issue
4eissn
0009-7330issn
1524-4571journal_volume
90pub_type
杂志文章abstract:RATIONALE:Lymphatic vasculature constitutes a second vascular system essential for immune surveillance and tissue fluid homeostasis. Maturation of the hierarchical vascular structure, with a highly branched network of capillaries and ducts, is crucial for its function. Environmental cues mediate the remodeling process,...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.116.308825
更新日期:2017-04-14 00:00:00
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journal_title:Circulation research
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更新日期:2009-02-13 00:00:00
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journal_title:Circulation research
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journal_title:Circulation research
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更新日期:2000-02-04 00:00:00
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pub_type: 杂志文章
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更新日期:2003-11-28 00:00:00
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更新日期:1997-09-01 00:00:00
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journal_title:Circulation research
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更新日期:1997-04-01 00:00:00
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journal_title:Circulation research
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更新日期:1999-01-08 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:
更新日期:1997-03-01 00:00:00
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journal_title:Circulation research
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更新日期:2006-02-03 00:00:00
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更新日期:2002-03-08 00:00:00
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更新日期:1984-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1982-08-01 00:00:00
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更新日期:1991-04-01 00:00:00
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更新日期:2001-01-19 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1987-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:1995-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-09-29 00:00:00