Vascular smooth muscle LRP6 limits arteriosclerotic calcification in diabetic LDLR-/- mice by restraining noncanonical Wnt signals.

abstract：:Genome-wide association studies have provided a rich collection of ≈ 58 coronary artery disease (CAD) loci that suggest the existence of previously unsuspected new biology relevant to atherosclerosis. However, these studies only identify genomic loci associated with CAD, and many questions remain even after a genomic ...

journal_title：Circulation research

authors： Nurnberg ST,Zhang H,Hand NJ,Bauer RC,Saleheen D,Reilly MP,Rader DJ

更新日期：2016-02-19 00:00:00

abstract：RATIONALE:Proteasomal degradation is altered in many disease phenotypes including cardiac hypertrophy, a prevalent condition leading to heart failure. Our recent investigations identified heterogeneous subpopulations of proteasome complexes in the heart and implicated multiple mechanisms for their regulation. OBJECTIV...

journal_title：Circulation research

authors： Drews O,Tsukamoto O,Liem D,Streicher J,Wang Y,Ping P

更新日期：2010-10-29 00:00:00

abstract：:Phospholamban is a key regulatory protein that defines diastolic function. Proinflammatory cytokines interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) can depress contractility and intracellular Ca2+ currents and transients. An alteration in phospholamban expression is a possible pathway by wh...

journal_title：Circulation research

authors： McTiernan CF,Lemster BH,Frye C,Brooks S,Combes A,Feldman AM

更新日期：1997-10-01 00:00:00

abstract：:Isolated adult rat hearts perfused in an isovolumic mode were used to study the effects of sodium-potassium pump inhibition and sodium-calcium exchange alterations on the tissue content of adenosine triphosphate, phosphocreatine, inorganic phosphate, and intracellular pH, all measured by phosphorus-31 nuclear magnetic...

journal_title：Circulation research

authors： Hoerter JA,Miceli MV,Renlund DG,Jacobus WE,Gerstenblith G,Lakatta EG

更新日期：1986-04-01 00:00:00

abstract：:Desmosomes and gap junctions are distinct structural components of the cardiac intercalated disc. Here, we asked whether the presence of plakophilin (PKP)2, a component of the desmosome, is essential for the proper function and distribution of the gap junction protein connexin (Cx)43. We used RNA silencing technology ...

journal_title：Circulation research

authors： Oxford EM,Musa H,Maass K,Coombs W,Taffet SM,Delmar M

更新日期：2007-09-28 00:00:00

abstract：:We tested the hypothesis that impairment of flow-dependent dilator mechanisms of skeletal muscle arterioles is one of the underlying reasons for the increased peripheral resistance in hypertension. Isolated, cannulated arterioles (approximately 55 microns) of gracilis muscle of 12-week-old spontaneously hypertensive (...

journal_title：Circulation research

authors： Koller A,Huang A

更新日期：1994-03-01 00:00:00

abstract：RATIONALE:Vascular calcification is highly associated with cardiovascular morbidity and mortality, especially in patients with chronic kidney disease. The nuclear receptor farnesoid X receptor (FXR) has been implicated in the control of lipid, carbohydrate and bile acid metabolism in several cell types. Although recent...

journal_title：Circulation research

authors： Miyazaki-Anzai S,Levi M,Kratzer A,Ting TC,Lewis LB,Miyazaki M

更新日期：2010-06-25 00:00:00

abstract：:An increase in plasma renin activity was demonstrated in plasma from normal subjects and most patients with essential hypertension after prolonged storage of the plasma at -20 degrees C. No change in renin substrate concentration was observed after storage for 12 months, and the rate of angiotensin generation during i...

journal_title：Circulation research

authors： Sealey JE,Laragh JH

更新日期：1975-06-01 00:00:00

abstract：RATIONALE:Nuclear factor of activated T-cells (NFAT) is importantly implicated in pathological cardiac remodeling and vascular lesion formation. NFAT functionality is mainly regulated by calcineurin, a Ca(2+)-dependent multi-effector phosphatase. Calcineurin inhibitors such as cyclosporine A (CsA) were shown to be effe...

journal_title：Circulation research

authors： Yu H,Bot I,Sliedregt K,Xu X,Bot M,van Heiningen SH,van der Marel GA,Bennett MR,Overkleeft H,van Berkel TJ,Biessen EA

更新日期：2012-01-20 00:00:00

abstract：:We have measured the apparent Ca2+ sensitivities of force development in skinned cardiac trabeculae at different sarcome lengths together with shifts in troponin (Tn) T subunits on specimens from the same hearts and drawn insights into the pathogenesis of myocardial dysfunction in the diabetic rat. The Ca(2+)-force re...

journal_title：Circulation research

authors： Akella AB,Ding XL,Cheng R,Gulati J

更新日期：1995-04-01 00:00:00

abstract：:Radiolabeled triiodothyronine (T3) binding to isolated nuclei was measured to compare the binding characteristics of the nuclear receptors in rabbit ventricular and atrial muscle cells. Scatchard analysis of the binding data yielded a maximum binding capacity of 170 +/- 20 fmol per mg DNA and apparent dissociation con...

journal_title：Circulation research

authors： Banerjee SK,Ulrich JM,Kaldor GJ

更新日期：1988-07-01 00:00:00

abstract：:In response to hypoxia and reoxygenation, mammalian cells are known to express a variety of genes to adapt to these external stresses or lead to further cell damage. We investigated the intracellular signaling cascades in cultured rat cardiac myocytes subjected to hypoxia followed by reoxygenation (hypoxia/reoxygenati...

journal_title：Circulation research

authors： Seko Y,Tobe K,Ueki K,Kadowaki T,Yazaki Y

更新日期：1996-01-01 00:00:00

abstract：:The hypothesis that neurally mediated coronary vasodilation occurs as part of the carotid baroreceptor reflex was investigated. The left main coronary artery was cannulated and perfused at constant pressure (100 mm Hg) in closed-chest, chloralose-anesthetized dogs. The heart was paced at a constant rate between 60 and...

journal_title：Circulation research

authors： Ito BR,Feigl EO

更新日期：1985-04-01 00:00:00

abstract：:Spatial and temporal organization of signal transduction is coordinated through the segregation of signaling enzymes in selected cellular compartments. This highly evolved regulatory mechanism ensures the activation of selected enzymes only in the vicinity of their target proteins. In this context, cAMP-responsive tri...

journal_title：Circulation research

authors： Perino A,Ghigo A,Scott JD,Hirsch E

更新日期：2012-08-03 00:00:00

abstract：:Sympathetic activation appears to accelerate the development of atherosclerosis, an effect that may be inhibited by beta-receptor blockade. It is unclear, however, which mechanisms mediate this effect. In view of the significance attached to endothelial injury in the initial phases of atherogenesis, we decided to test...

journal_title：Circulation research

authors： Pettersson K,Bejne B,Björk H,Strawn WB,Bondjers G

更新日期：1990-10-01 00:00:00

abstract：RATIONALE:Molecular imaging is useful for longitudinal assessment of engraftment. However, it is not known which factors, other than cell number, can influence the molecular imaging signal obtained from reporter genes. OBJECTIVE:The effects of cell dissociation/suspension on cellular bioenergetics and the signal obtai...

journal_title：Circulation research

authors： Chang C,Chan A,Lin X,Higuchi T,Terrovitis J,Afzal JM,Rittenbach A,Sun D,Vakrou S,Woldemichael K,O'Rourke B,Wahl R,Pomper M,Tsui B,Abraham MR

更新日期：2013-02-01 00:00:00

abstract：RATIONALE:Anti-inflammatory and vascular protective actions of adiponectin are well recognized. However, many fundamental questions remain unanswered. OBJECTIVE:The current study attempted to identify the adiponectin receptor subtype responsible for adiponectin's vascular protective action and investigate the role of ...

journal_title：Circulation research

authors： Wang Y,Wang X,Lau WB,Yuan Y,Booth D,Li JJ,Scalia R,Preston K,Gao E,Koch W,Ma XL

更新日期：2014-02-28 00:00:00

abstract：:Understanding molecular mechanisms regulating angiogenesis may lead to novel therapies for ischemic disorders. Hypoxia-inducible factor 1 (HIF-1) activates vascular endothelial growth factor (VEGF) gene expression in hypoxic/ischemic tissue. In this study we demonstrate that exposure of primary cultures of cardiac and...

journal_title：Circulation research

authors： Kelly BD,Hackett SF,Hirota K,Oshima Y,Cai Z,Berg-Dixon S,Rowan A,Yan Z,Campochiaro PA,Semenza GL

更新日期：2003-11-28 00:00:00

abstract：:The lung parenchyma as a tissue has a rather unusual stress-strain relationship. A theoretical derivation of this relationship is presented which connects the surface tension and the tissue elastic stress in the alveolar septa with the alveolar geometry. The mathematical expression contains a few meaningful physical c...

journal_title：Circulation research

authors： Fung YC

更新日期：1975-10-01 00:00:00

abstract：:Leukocyte rolling along the endothelium in inflammation is caused by continuous formation and breakage of bonds between selectin adhesion molecules and their ligands. We investigated trauma-induced leukocyte rolling in venules (diameter, 23 to 58 microns; wall shear stress, 1.2 to 35 dyne/cm2) of the exteriorized rat ...

journal_title：Circulation research

authors： Damiano ER,Westheider J,Tözeren A,Ley K

更新日期：1996-12-01 00:00:00

abstract：:Subthreshold potentials are thought to be mediated by time-independent, "passive" background currents. In this study, we show that the background current-voltage (I-V) relation of guinea pig ventricular myocytes is changed significantly by repetitive stimulation, in such a way that cell excitability becomes enhanced. ...

journal_title：Circulation research

authors： Delmar M,Ibarra J,Davidenko J,Lorente P,Jalife J

更新日期：1991-11-01 00:00:00

abstract：:We investigated whether the heart, like other mammalian organs, possesses internal clocks, and, if so, whether pressure overload-induced hypertrophy alters the clock mechanism. Clock genes are intrinsically maintained, as shown by rhythmic changes even in single cells. Clocks are believed to confer a selective advanta...

journal_title：Circulation research

authors： Young ME,Razeghi P,Taegtmeyer H

更新日期：2001-06-08 00:00:00

abstract：:Sixty-eight blood pressure (BP)-lowering randomized controlled trials (defined as randomized controlled trials comparing active treatment with placebo, or less active treatment, achieving a BP difference, performed between 1966 and end 2013 in cohorts with ≥ 40% hypertensive patients, and exclusive of trials in acute ...

journal_title：Circulation research

authors： Zanchetti A,Thomopoulos C,Parati G

更新日期：2015-03-13 00:00:00

abstract：:Vascular disease in diabetics could arise in part from altered vessel wall catebolism. Specific activities of hydrolases in aortic smooth muscle cells from rats with streptozotocin-induced diabetes were measured. Enyzmes included: neutral alpha-glucosidase, alpha-mannosidase, and lysosomal N-acetyl beta-glucosaminidas...

journal_title：Circulation research

authors： Wolinsky H,Goldfischer S,Capron L,Capron F,Coltoff-Schiller B,Kasak L

更新日期：1978-06-01 00:00:00

abstract：RATIONALE:Mechanisms underlying diastolic dysfunction need to be better understood. OBJECTIVE:To study the role of titin in diastolic dysfunction using a mouse model of experimental heart failure induced by transverse aortic constriction. METHODS AND RESULTS:Eight weeks after transverse aortic constriction surgery, m...

journal_title：Circulation research

authors： Hudson B,Hidalgo C,Saripalli C,Granzier H

更新日期：2011-09-30 00:00:00

abstract：:Picrotoxin, an antagonist of gamma-aminobutyric acid, produces an increase in coronary vascular resistance, S-T segment elevation, and ventricular arrhythmias after an intravenous injection of 2 mg/kg in chloralose-anesthetized cats. To determine whether these responses were due to blockade of central nervous system G...

journal_title：Circulation research

authors： Segal SA,Jacob T,Gillis RA

更新日期：1984-09-01 00:00:00

abstract：:The extracellular pH (pHo) and intracellular pH (pHi) were simultaneously measured with H(+)-sensitive microelectrodes in the rabbit papillary muscle during normal arterial perfusion and no-flow ischemia. The preparation was kept in an artificial gaseous atmosphere (N2 and CO2 during ischemia) without a surrounding fl...

journal_title：Circulation research

authors： Yan GX,Kléber AG

更新日期：1992-08-01 00:00:00

abstract：:alpha-Adrenergic receptor stimulation regulates the activity of a number of different cardiac ion channels, including those underlying one or more distinct Cl- conductances. The whole-cell patch-clamp technique was used in the present study to investigate the effects of alpha-adrenergic stimulation on the beta-adrener...

journal_title：Circulation research

authors： Oleksa LM,Hool LC,Harvey RD

更新日期：1996-06-01 00:00:00

abstract：:We have recently demonstrated that endogenous erythropoietin (Epo)/Epo receptor (EpoR) system plays an important protective role in hypoxia-induced pulmonary hypertension. However, it remains to be examined whether vascular EpoR system contributes to angiogenesis in response to ischemia. We examined angiogenesis in Ep...

journal_title：Circulation research

authors： Nakano M,Satoh K,Fukumoto Y,Ito Y,Kagaya Y,Ishii N,Sugamura K,Shimokawa H

更新日期：2007-03-16 00:00:00

abstract：:A number of scavengers of reactive oxygen metabolites reduce myocardial injury when given before ischemia and reperfusion, but few, if any, have proven to be effective when given near the onset of reperfusion. This is particularly true when infarct size is measured after at least 48 hours of reperfusion, when the full...

journal_title：Circulation research

authors： Carrea FP,Lesnefsky EJ,Repine JE,Shikes RH,Horwitz LD

更新日期：1991-06-01 00:00:00