A phosphorus-31 nuclear magnetic resonance study of the metabolic, contractile, and ionic consequences of induced calcium alterations in the isovolumic rat heart.

abstract：:Our previous studies suggested that enhanced fibronectin mRNA translation in ductus arteriosus compared with aortic smooth muscle cells is related to increased expression of light chain 3 (LC3) of microtubule-associated protein 1, which binds an AU-rich element in the 3' untranslated region of fibronectin mRNA. We the...

journal_title：Circulation research

authors： Zhou B,Rabinovitch M

更新日期：1998-09-07 00:00:00

abstract：RATIONALE:Thioredoxin (Trx)1 inhibits pathological cardiac hypertrophy. MicroRNAs (miRNAs) are small noncoding RNAs that downregulate posttranscriptional expression of target molecules. OBJECTIVES:We investigated the role of miRNAs in mediating the antihypertrophic effect of Trx1 on angiotensin II (Ang II)-induced car...

journal_title：Circulation research

authors： Yang Y,Ago T,Zhai P,Abdellatif M,Sadoshima J

更新日期：2011-02-04 00:00:00

abstract：:Two NO synthase (NOS) isoforms have been described in vessels, an endothelial constitutive NOS (eNOS) and an inducible NOS (iNOS). The purpose of the present study was to examine the endothelium-dependent and endothelium-independent hypotensive response in aging rats, analyzing the ability of their vessels to produce ...

journal_title：Circulation research

authors： Cernadas MR,Sánchez de Miguel L,García-Durán M,González-Fernández F,Millás I,Montón M,Rodrigo J,Rico L,Fernández P,de Frutos T,Rodríguez-Feo JA,Guerra J,Caramelo C,Casado S,López-Farré

更新日期：1998-08-10 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) activity in the guinea pig fetal-placental unit was assessed at the different oxygen tensions found in utero, during labor, and at birth. To determine fetal-placental ACE activity, we separately perfused in situ term guinea pig fetuses and their placentas via the umbilical vessels u...

journal_title：Circulation research

authors： Davidson D,Stalcup SA,Mellins RB

更新日期：1981-02-01 00:00:00

abstract：:Heme oxygenase (HO)-1 is a protective antioxidant enzyme that prevents cardiomyocyte apoptosis, for instance, during progressive cardiomyopathy. Here we identify a fundamental aspect of the HO-1 protection mechanism by demonstrating that HO-1 activity in mouse heart stimulates the bigenomic mitochondrial biogenesis pr...

journal_title：Circulation research

authors： Piantadosi CA,Carraway MS,Babiker A,Suliman HB

更新日期：2008-11-21 00:00:00

abstract：:In our morphometric study of the effects of exercise on the heart, male Wistar-Kyoto rats at 5 weeks of age were subjected daily to a moderate treadmill running program that lasted for 7 weeks. The heart responded to physical conditioning by different magnitudes of tissue growth of the right (22%) and left (7%) ventri...

journal_title：Circulation research

authors： Anversa P,Levicky V,Beghi C,McDonald SL,Kikkawa Y

更新日期：1983-01-01 00:00:00

abstract：:-The vascular endothelial growth factor receptor Flk-1/KDR is highly expressed during development and almost disappears in adult tissues. Despite its biological relevance, little is known about the molecular mechanisms controlling its expression. In the present work, it is shown that cAMP response element binding prot...

journal_title：Circulation research

authors： Illi B,Puri P,Morgante L,Capogrossi MC,Gaetano C

更新日期：2000-06-23 00:00:00

abstract：:A large body of data gathered over the past couple of years has identified the peroxisome proliferator-activated receptors (PPAR) alpha, gamma, and beta/delta as transcription factors exerting modulatory actions in vascular cells. PPARs, which belong to the nuclear receptor family of ligand-activated transcription fac...

journal_title：Circulation research

authors： Marx N,Duez H,Fruchart JC,Staels B

更新日期：2004-05-14 00:00:00

abstract：RATIONALE:Uncoupling protein (UCP)2 is a mitochondrial inner membrane protein that is expressed in mammalian myocardium under normal conditions and upregulated in pathological states such as heart failure. UCP2 is thought to protect cardiomyocytes against oxidative stress by dissipating the mitochondrial proton gradien...

journal_title：Circulation research

authors： Turner JD,Gaspers LD,Wang G,Thomas AP

更新日期：2010-03-05 00:00:00

abstract：RATIONALE:Cryptogenic strokes, those of unknown cause, have been estimated as high as 30% to 40% of strokes. Inflammation has been suggested as a critical etiologic factor. However, there is lack of experimental evidence. OBJECTIVE:In this study, we investigated inflammation-associated stroke using a mouse model that ...

journal_title：Circulation research

authors： Hollander MC,Latour LL,Yang D,Ishii H,Xiao Z,Min Y,Ray-Choudhury A,Munasinghe J,Merchant AS,Lin PC,Hallenbeck J,Boehm M,Yang L

更新日期：2017-12-08 00:00:00

abstract：:The present study was performed to examine the mechanism by which cyclooxygenase blockade produces vasoconstriction in well-developed coronary collateral vessels. Eight dogs were studied 4 to 6 months after occlusion of the left anterior descending coronary artery (LAD) had been performed to stimulate collateral vesse...

journal_title：Circulation research

authors： Altman JD,Bache RJ

更新日期：1994-02-01 00:00:00

abstract：:Troponin is essential for the regulation of cardiac contraction. Troponin is a sarcomeric molecular switch, directly regulating the contractile event in concert with intracellular calcium signals. Troponin isoform switching, missense mutations, proteolytic cleavage, and posttranslational modifications are known to dir...

journal_title：Circulation research

authors： Metzger JM,Westfall MV

更新日期：2004-02-06 00:00:00

abstract：:To determine if intestinal microvascular growth is impaired in diabetic juvenile animals, a segment of the terminal ileum was marked and the microvasculature of this segment observed at the age of 5 weeks and again at the age of 10-11 weeks in normal and diabetic Sprague Dawley rats. Diabetes was induced by streptozot...

journal_title：Circulation research

authors： Unthank JL,Bohlen HG

更新日期：1988-08-01 00:00:00

abstract：:Vascular endothelial growth factors (VEGFs) and their receptors have emerged as central regulators of the angiogenic process. However, involvement of VEGF-B, one of these factors, in angiogenesis remains obscure. Mice received subcutaneous injection of Matrigel alone or Matrigel with human recombinant protein rhVEGF-B...

journal_title：Circulation research

authors： Silvestre JS,Tamarat R,Ebrahimian TG,Le-Roux A,Clergue M,Emmanuel F,Duriez M,Schwartz B,Branellec D,Lévy BI

更新日期：2003-07-25 00:00:00

abstract：:Loss-of-function mutations in the human ERG1 potassium channel (hERG1) frequently underlie the long QT2 (LQT2) syndrome. The role of the ERG potassium channel in cardiac development was elaborated in an in vivo model of a homozygous, loss-of-function LQT2 syndrome mutation. The hERG N629D mutation was introduced into ...

journal_title：Circulation research

authors： Teng GQ,Zhao X,Lees-Miller JP,Quinn FR,Li P,Rancourt DE,London B,Cross JC,Duff HJ

更新日期：2008-12-05 00:00:00

abstract：:Although functional coupling between protein kinase Cepsilon (PKCepsilon) and mitochondria has been implicated in the genesis of cardioprotection, the signal transduction mechanisms that enable this link and the identities of the mitochondrial proteins modulated by PKCepsilon remain unknown. Based on recent evidence t...

journal_title：Circulation research

authors： Baines CP,Song CX,Zheng YT,Wang GW,Zhang J,Wang OL,Guo Y,Bolli R,Cardwell EM,Ping P

更新日期：2003-05-02 00:00:00

abstract：:The pulmonary vein is sleeved by myocardium, which is a major source of atrial fibrillation and is involved in congenital sinus venosus defects. Little is known about the cellular origin and mechanism of formation of the pulmonary myocardium. We observed a biphasic process of pulmonary myocardium formation in mice. Fi...

journal_title：Circulation research

authors： Mommersteeg MT,Brown NA,Prall OW,de Gier-de Vries C,Harvey RP,Moorman AF,Christoffels VM

更新日期：2007-10-26 00:00:00

abstract：:The influence that the pressure-sensitive receptors in the cardiovascular system have on renal nerve activity and on heart rate was compared in normotensive rats (NTR) and spontaneously hypertensive rats (SHR). The cardiovascular receptors were stimulated by raising the blood pressure (BP) with intravenous phenylephri...

journal_title：Circulation research

authors： Coote JH,Sato Y

更新日期：1977-06-01 00:00:00

abstract：:High sodium intake (HNa) increases brain ouabainlike activity (OLA) in rats. In spontaneously hypertensive rats (SHR), HNa exaggerates development of hypertension and pressor and sympathoexcitatory responses to stress. To investigate whether dietary sodium-induced changes in brain OLA play a functional role, responses...

journal_title：Circulation research

authors： Huang BS,Leenen FH

更新日期：1992-02-01 00:00:00

abstract：:Human peripheral blood leukocytes, activated by phorbol myristate acetate, disrupt canine sarcoplasmic reticulum calcium transport, in vitro, by an oxygen-derived free radical mechanism. Activated leukocytes significantly depress Ca++ uptake activity and Ca++ -stimulated, Mg++ -dependent ATPase activity. The depressio...

journal_title：Circulation research

authors： Rowe GT,Manson NH,Caplan M,Hess ML

更新日期：1983-11-01 00:00:00

abstract：:Inwardly rectifying K+ (Kir) channels are responsible for maintaining endothelial membrane potential and play a key role in endothelium-dependent vasorelaxation. In this study, we show that endothelial Kir channels are suppressed by hypercholesterolemic levels of lipoproteins in vitro and by serum hypercholesterolemia...

journal_title：Circulation research

authors： Fang Y,Mohler ER 3rd,Hsieh E,Osman H,Hashemi SM,Davies PF,Rothblat GH,Wilensky RL,Levitan I

更新日期：2006-04-28 00:00:00

abstract：:Cyclic nucleotide phosphodiesterases regulate cAMP-mediated signaling by controlling intracellular cAMP content. The cAMP-hydrolyzing activity of several families of cyclic nucleotide phosphodiesterases found in human heart is regulated by cGMP. In the case of PDE2, this regulation primarily involves the allosteric st...

journal_title：Circulation research

authors： Zaccolo M,Movsesian MA

更新日期：2007-06-08 00:00:00

abstract：:The fat-derived hormone adiponectin has been shown to have a protective role in macrovascular disorders. However, nothing is known about the function of adiponectin in retinal microvessel disease. Here, we investigated the causal role of adiponectin in retinal vessel formation and inflammation under conditions of hypo...

journal_title：Circulation research

authors： Higuchi A,Ohashi K,Kihara S,Walsh K,Ouchi N

更新日期：2009-05-08 00:00:00

abstract：:Mechanoreceptors and chemoreceptors have been identified inside the kidney, but their functional role is still largely unclear. The aim of this study was to investigate whether changes in urine output could modify the discharge rate of renal afferent fibers. Experiments were performed in anesthetized cats in which aff...

journal_title：Circulation research

authors： Genovesi S,Pieruzzi F,Wijnmaalen P,Centonza L,Golin R,Zanchetti A,Stella A

更新日期：1993-11-01 00:00:00

abstract：:Elevated plasma levels of plasminogen activator inhibitor type I (PAI-1), a significant risk factor of ischemic heart disease, are associated with insulin resistance in which insulin and transforming growth factor (TGF)-beta play a pivotal role in regulating PAI-1 production. Forkhead transcription factor FOXC2 is an ...

journal_title：Circulation research

authors： Fujita H,Kang M,Eren M,Gleaves LA,Vaughan DE,Kume T

更新日期：2006-03-17 00:00:00

abstract：:Electrical responses induced by perivasascular nerve stimulation were recorded intracellularly from the smooth muscle of dog middle cerebral artery. With nerve stimulation, the muscle membrane produced excitatory junction potential and then a slow hyperpolarization. The excitatory junction potential showed facilitatio...

journal_title：Circulation research

authors： Suzuki H,Fujiwara S

更新日期：1982-12-01 00:00:00

abstract：:Osteopontin (OPN) is a multifunctional cytokine that is strongly expressed in healing wounds and fibrotic lesions, both of which are characterized by the formation of myofibroblasts. We examined the role of OPN in myofibroblast differentiation induced by the profibrotic cytokine transforming growth factor-beta1. In cu...

journal_title：Circulation research

authors： Lenga Y,Koh A,Perera AS,McCulloch CA,Sodek J,Zohar R

更新日期：2008-02-15 00:00:00

abstract：:The phorbol ester 12-O-tetradecanoyl phorbol-13-acetate was used to probe the role of protein kinase-C in the modulation of alpha-adrenergic receptor-coupled calcium efflux in cultured vascular smooth muscle cells derived from rabbit aorta. Exposure of cells to 12-O-tetradecanoyl phorbol-13-acetate for 6 minutes cause...

journal_title：Circulation research

authors： Colucci WS,Gimbrone MA Jr,Alexander RW

更新日期：1986-03-01 00:00:00

abstract：:Changes in cardiac filling pressure (central venous pressure) were measured following carotid occlusion and infusions of catecholamines in awake dogs while cardiac output was held constant. After carotid occlusion in dogs with vagi blocked, central venous pressure increased about 0.8 mm Hg (an estimated decrease in va...

journal_title：Circulation research

authors： Bennett TD,Wyss CR,Scher AM

更新日期：1984-10-01 00:00:00

abstract：:The signaling pathways involved in the long-term metabolic effects of angiotensin II (Ang II) in vascular smooth muscle cells are incompletely understood but include the generation of molecules likely to affect oxidase activity. We examined the ability of Ang II to stimulate superoxide anion formation and investigated...

journal_title：Circulation research

authors： Griendling KK,Minieri CA,Ollerenshaw JD,Alexander RW

更新日期：1994-06-01 00:00:00