Morphometry of exercise-induced right ventricular hypertrophy in the rat.

abstract：:It is known that branching strands of cardiac tissue can form a substrate for very slow conduction. The branches slow conduction by acting as current loads drawing depolarizing current from the main strand ("pull" effect). It has been suggested that, upon depolarization of the branches, they become current sources rei...

journal_title：Circulation research

authors： Kucera JP,Rudy Y

更新日期：2001-10-26 00:00:00

abstract：:Recent evidence shows that circulating granulocytes play an important role in capillary stasis and tissue injury. We investigated two aspects of the problem in a Wiggers hemorrhagic shock model of the rat: the survival rate and the microvascular no-reflow phenomenon. A conventional group of rats with normal blood cell...

journal_title：Circulation research

authors： Barroso-Aranda J,Schmid-Schönbein GW,Zweifach BW,Engler RL

更新日期：1988-08-01 00:00:00

abstract：:Bone morphogenetic protein receptor 2 (BMPR2) mutations have been linked to familial pulmonary arterial hypertension (PAH), but the molecular pathways leading to this severe pathology remain poorly characterized. We report that hypoxia, a paramount stimulus for the development of pulmonary hypertension, suppresses the...

journal_title：Circulation research

authors： Wu X,Chang MS,Mitsialis SA,Kourembanas S

更新日期：2006-08-04 00:00:00

abstract：RATIONALE:We previously reported that vascular endothelial growth factor (VEGF)-induced binding of VEGF receptor 2 (VEGFR2) to epsins 1 and 2 triggers VEGFR2 degradation and attenuates VEGF signaling. The epsin ubiquitin interacting motif (UIM) was shown to be required for the interaction with VEGFR2. However, the mole...

journal_title：Circulation research

authors： Rahman HNA,Wu H,Dong Y,Pasula S,Wen A,Sun Y,Brophy ML,Tessneer KL,Cai X,McManus J,Chang B,Kwak S,Rahman NS,Xu W,Fernandes C,Mcdaniel JM,Xia L,Smith L,Srinivasan RS,Chen H

更新日期：2016-03-18 00:00:00

abstract：RATIONALE:Increased sympathetic nerve activity has been linked to the pathogenesis of hypertension in humans and animal models. Enhanced peripheral chemoreceptor sensitivity which increases sympathetic nerve activity has been observed in established hypertension but has not been identified as a possible mechanism for i...

journal_title：Circulation research

authors： Tan ZY,Lu Y,Whiteis CA,Simms AE,Paton JF,Chapleau MW,Abboud FM

更新日期：2010-02-19 00:00:00

abstract：:Left ventricular (LV) remodeling after experimental myocardial infarction (MI) is associated with hypertrophy of noninfarcted myocardium and electrophysiological alterations. We have recently shown that post-MI hypertrophied LV myocytes have prolonged action potential duration (APD) and generate triggered activity fro...

journal_title：Circulation research

authors： Gidh-Jain M,Huang B,Jain P,el-Sherif N

更新日期：1996-10-01 00:00:00

abstract：:Vascular disease in diabetics could arise in part from altered vessel wall catebolism. Specific activities of hydrolases in aortic smooth muscle cells from rats with streptozotocin-induced diabetes were measured. Enyzmes included: neutral alpha-glucosidase, alpha-mannosidase, and lysosomal N-acetyl beta-glucosaminidas...

journal_title：Circulation research

authors： Wolinsky H,Goldfischer S,Capron L,Capron F,Coltoff-Schiller B,Kasak L

更新日期：1978-06-01 00:00:00

abstract：:Over the last 4 decades, heart transplantation (HTx) has evolved as a mainstream therapy for heart failure. Approximately half of patients needing HTx have organ failure consequent to atherosclerosis. Despite advances in immunosuppressive drugs, long-term success of HTx is limited by the development of a particular ty...

journal_title：Circulation research

authors： Rahmani M,Cruz RP,Granville DJ,McManus BM

更新日期：2006-10-13 00:00:00

abstract：:Although the molecular effectors of apoptotic cell death have been largely annotated over the past 30 years, leading to a strong biological understanding of this process and its importance in cell biology, cell death through necrosis has only recently been accepted as a similarly regulated process with definable molec...

journal_title：Circulation research

authors： Karch J,Molkentin JD

更新日期：2015-05-22 00:00:00

abstract：:RNA splicing represents a post-transcriptional mechanism to generate multiple functional RNAs or proteins from a single transcript. The evolution of RNA splicing is a prime example of the Darwinian function follows form concept. A mutation that leads to a new mRNA (form) that encodes for a new functional protein (func...

journal_title：Circulation research

authors： van den Hoogenhof MM,Pinto YM,Creemers EE

更新日期：2016-02-05 00:00:00

abstract：:The aim of this study is to quantify the porcine coronary arterial branching pattern and to use this quantification for the interpretation of flow heterogeneity. Two casts of the coronary arterial tree were made at diastolic arrest and maximal dilation. The relation between length and diameter of arterial segments was...

journal_title：Circulation research

authors： VanBavel E,Spaan JA

更新日期：1992-11-01 00:00:00

abstract：:Previous studies have shown that integrin activation and fluid shear stress can modulate the activity of sterol regulatory element binding proteins (SREBPs) in vascular endothelial cells. We investigated the role of small GTPase Rho-mediated signal transduction pathway in this mode of SREBP activation. Fluid shear str...

journal_title：Circulation research

authors： Lin T,Zeng L,Liu Y,DeFea K,Schwartz MA,Chien S,Shyy JY

更新日期：2003-06-27 00:00:00

abstract：:This study examines the cellular basis and specificity of the effects of adenosine on early afterdepolarizations (EADs), delayed afterdepolarizations (DADs), and triggered activity (TA) induced by various drugs with different mechanisms of action. Membrane potential and currents were measured in isolated guinea pig ve...

journal_title：Circulation research

authors： Song Y,Thedford S,Lerman BB,Belardinelli L

更新日期：1992-04-01 00:00:00

abstract：:The relationship of P-wave polarity and morphology in leads II, III, and aVF to the sequence of atrial activation was studied in the canine heart when the atria were paced from the region of the sinus node or the posterior-inferior left atrium and when retrograde activation of the atria occurred with right ventricular...

journal_title：Circulation research

authors： Waldo AL,Vitikainen KJ,Hoffman BF

更新日期：1975-08-01 00:00:00

abstract：:Thrombin stimulates synthesis and secretion of endothelin-1 (ET-1), a vasoactive peptide that triggers responses in the vascular endothelium and smooth muscle. We investigated the signal transduction pathways by which thrombin stimulates preproET-1 gene expression and ET-1 peptide secretion in macrovascular cells (hum...

journal_title：Circulation research

authors： Marsen TA,Simonson MS,Dunn MJ

更新日期：1995-06-01 00:00:00

abstract：:Pinacidil belongs to a novel group of compounds that enhance the potassium permeability of vascular smooth muscle. Evidence also exists that this drug enhances the potassium permeability of cardiac tissue. The purpose of the present investigation was to determine if pinacidil alters potassium-channel activity in heart...

journal_title：Circulation research

authors： Arena JP,Kass RS

更新日期：1989-08-01 00:00:00

abstract：RATIONALE:Patients with chronic kidney disease (CKD) develop hyperhomocysteinemia and have a higher cardiovascular mortality than those without hyperhomocysteinemia by 10-fold. OBJECTIVE:We investigated monocyte differentiation in human CKD and cardiovascular disease (CVD). METHODS AND RESULTS:We identified CD40 as a...

journal_title：Circulation research

authors： Yang J,Fang P,Yu D,Zhang L,Zhang D,Jiang X,Yang WY,Bottiglieri T,Kunapuli SP,Yu J,Choi ET,Ji Y,Yang X,Wang H

更新日期：2016-11-11 00:00:00

abstract：:By making use of immunoblotting and immunocytochemical analysis, we explored whether stimulation of adenosine A1 receptors would promote the activation of delta-protein kinase C (delta-PKC) immunolabeled with a polyclonal antibody. Immunoblot analysis of Triton X-100-soluble cell membrane and cytosolic fractions revea...

journal_title：Circulation research

authors： Henry P,Demolombe S,Pucéat M,Escande D

更新日期：1996-01-01 00:00:00

abstract：RATIONALE:Cell therapy is a promising option for the treatment of acute or chronic myocardial ischemia. The intracoronary infusion of cells imposes the potential risk of cell clotting, which may be prevented by the addition of anticoagulants. However, a comprehensive analysis of the effects of anticoagulants on the fun...

journal_title：Circulation research

authors： Seeger FH,Rasper T,Fischer A,Muhly-Reinholz M,Hergenreider E,Leistner DM,Sommer K,Manavski Y,Henschler R,Chavakis E,Assmus B,Zeiher AM,Dimmeler S

更新日期：2012-09-14 00:00:00

abstract：:The contractile response of the aged adult heart to beta-adrenergic stimulation is known to be reduced compared with the young adult heart. Since endogenous adenosine exerts an antiadrenergic action in the heart, this study was undertaken to determine if the basal endogenous level of myocardial adenosine increases wit...

journal_title：Circulation research

authors： Dobson JG Jr,Fenton RA,Romano FD

更新日期：1990-05-01 00:00:00

abstract：:Although it has been established that myocyte enhancer factor 2 (MEF2) plays pivotal roles in the development of the cardiovascular system as well as skeletal muscle cells, little is known of its role in vascular inflammatory diseases such as atherosclerosis and restenosis after angioplasty. To investigate the role of...

journal_title：Circulation research

authors： Suzuki E,Satonaka H,Nishimatsu H,Oba S,Takeda R,Omata M,Fujita T,Nagai R,Hirata Y

更新日期：2004-07-09 00:00:00

abstract：:An extensive investigation of the cardiac actions of phorbol esters and the potential role of the Na(+)-H+ exchanger in those actions was carried out using isolated rat hearts. Sixty minutes of perfusion with 10(-9) M phorbol 12-myristate 13-acetate (PMA) or 10(-8) M phorbol 12,13-dibutyrate (PDBu) produced marked car...

journal_title：Circulation research

authors： Watson JE,Karmazyn M

更新日期：1991-10-01 00:00:00

abstract：:In the mammalian myocardium, potassium (K(+)) channels control resting potentials, action potential waveforms, automaticity, and refractory periods and, in most cardiac cells, multiple types of K(+) channels that subserve these functions are expressed. Molecular cloning has revealed the presence of a large number of K...

journal_title：Circulation research

authors： Nerbonne JM,Nichols CG,Schwarz TL,Escande D

更新日期：2001-11-23 00:00:00

abstract：:The mechanism of adenosine-induced inhibition of Ca2+ currents was studied by recording single-channel Ca2+ currents from cell-attached patches on isolated guinea pig ventricular cells with pipettes containing 50 or 100 mM Ba2+. Numerous 100-msec depolarization steps were applied repetitively at 2 Hz from the resting ...

journal_title：Circulation research

authors： Kato M,Yamaguchi H,Ochi R

更新日期：1990-11-01 00:00:00

abstract：:The enzyme heme oxygenase, which exists in inducible (HO-1) and constitutive (HO-2) isoforms, catalyzes the degradation of heme to biliverdin and CO in mammalian tissues. CO has been implicated in the control of vascular tone in a manner similar to that for NO. In the present study, we investigated the contribution of...

journal_title：Circulation research

authors： Motterlini R,Gonzales A,Foresti R,Clark JE,Green CJ,Winslow RM

更新日期：1998-09-07 00:00:00

abstract：:The purpose of this study was to explore the changes in fetal blood volume that occur after fetal hemorrhage. Fifteen unanesthetized, chronically catheterized fetal sheep averaging 130 +/- 3 (SD) days gestation were studied 4 to 6 (average 5) days after catheter implantation. The fetuses were hemorrhaged by continuous...

journal_title：Circulation research

authors： Brace RA

更新日期：1983-06-01 00:00:00

abstract：:The cellular basis of reactive oxygen intermediate-induced arrhythmias was investigated in isolated rabbit ventricular cells using the whole-cell voltage- and current-clamp techniques. Singlet oxygen and superoxide were generated by the photoactivation of rose bengal. Single ventricular cells exposed to rose bengal (1...

journal_title：Circulation research

authors： Matsuura H,Shattock MJ

更新日期：1991-02-01 00:00:00

abstract：:Leukocyte rolling along the endothelium in inflammation is caused by continuous formation and breakage of bonds between selectin adhesion molecules and their ligands. We investigated trauma-induced leukocyte rolling in venules (diameter, 23 to 58 microns; wall shear stress, 1.2 to 35 dyne/cm2) of the exteriorized rat ...

journal_title：Circulation research

authors： Damiano ER,Westheider J,Tözeren A,Ley K

更新日期：1996-12-01 00:00:00

abstract：:We determined the effects of changing the spatial dispersion of acetylcholine release on the phase-dependent chronotropic responses to vagal stimulation in anesthetized dogs. We stimulated the vagus nerves with one brief burst of electrical pulses each cardiac cycle, and we changed the timing of the stimulus by a smal...

journal_title：Circulation research

authors： Yang TE,Cheng J,Levy MN

更新日期：1990-10-01 00:00:00

abstract：:alpha-Adrenergic receptor stimulation regulates the activity of a number of different cardiac ion channels, including those underlying one or more distinct Cl- conductances. The whole-cell patch-clamp technique was used in the present study to investigate the effects of alpha-adrenergic stimulation on the beta-adrener...

journal_title：Circulation research

authors： Oleksa LM,Hool LC,Harvey RD

更新日期：1996-06-01 00:00:00