The mechanism of coronary collateral vasoconstriction in response to cyclooxygenase blockade.

abstract：:Mitral regurgitation (MR) causes ventricular dilation, a blunted myocardial force-frequency relation, and increased crossbridge force-time integral (FTI). The mechanism of FTI increase was investigated using sinusoidal length perturbation analysis to compare crossbridge function in skinned left ventricular (LV) epicar...

journal_title：Circulation research

authors： Mulieri LA,Barnes W,Leavitt BJ,Ittleman FP,LeWinter MM,Alpert NR,Maughan DW

更新日期：2002-01-11 00:00:00

abstract：:We determined the effects of changing the spatial dispersion of acetylcholine release on the phase-dependent chronotropic responses to vagal stimulation in anesthetized dogs. We stimulated the vagus nerves with one brief burst of electrical pulses each cardiac cycle, and we changed the timing of the stimulus by a smal...

journal_title：Circulation research

authors： Yang TE,Cheng J,Levy MN

更新日期：1990-10-01 00:00:00

abstract：RATIONALE:Depletion of medial smooth muscle cell (SMC) is a major pathological characteristic of abdominal aortic aneurysm (AAA), although the mechanism by which these cells are eliminated remains incompletely understood. We reasoned that necroptosis, a recently described form of necrosis mediated by receptor-interacti...

journal_title：Circulation research

authors： Wang Q,Liu Z,Ren J,Morgan S,Assa C,Liu B

更新日期：2015-02-13 00:00:00

abstract：:Baroreceptor reflexes can be demonstrated during fetal life, but whether baroreceptors normally regulate fetal arterial pressure is unknown. This problem was addressed directly by measuring arterial pressure and analyzing its variation in eight unanesthetized fetal lambs throughout the last third of gestation, and com...

journal_title：Circulation research

authors： Yardley RW,Bowes G,Wilkinson M,Cannata JP,Maloney JE,Ritchie BC,Walker AM

更新日期：1983-05-01 00:00:00

abstract：:Atherosclerosis causes clinical disease through luminal narrowing or by precipitating thrombi that obstruct blood flow to the heart (coronary heart disease), brain (ischemic stroke), or lower extremities (peripheral vascular disease). The most common of these manifestations is coronary heart disease, including stable ...

journal_title：Circulation research

authors： Bentzon JF,Otsuka F,Virmani R,Falk E

更新日期：2014-06-06 00:00:00

abstract：:Intussusceptive angiogenesis is a novel mode of blood vessel formation and remodeling, which occurs by internal division of the preexisting capillary plexus without sprouting. In this study, the process is demonstrated in developing chicken eye vasculature and in the chorioallantoic membrane by methylmethacrylate (Mer...

journal_title：Circulation research

authors： Djonov V,Schmid M,Tschanz SA,Burri PH

更新日期：2000-02-18 00:00:00

abstract：:We previously reported that hyperhomocysteinemia (HHcy), an independent risk factor of coronary artery disease (CAD), is associated with increased atherosclerosis and decreased plasma high-density lipoprotein cholesterol (HDL-C) in cystathionine beta-synthase-/apolipoprotein E-deficient (CBS(-/-)/apoE(-/-)) mice. We o...

journal_title：Circulation research

authors： Liao D,Tan H,Hui R,Li Z,Jiang X,Gaubatz J,Yang F,Durante W,Chan L,Schafer AI,Pownall HJ,Yang X,Wang H

更新日期：2006-09-15 00:00:00

abstract：:Endothelial hyperpermeability induced by inflammatory mediators is a hallmark of sepsis and adult respiratory distress syndrome. Increased levels of the regulatory peptide adrenomedullin (ADM) have been found in patients with systemic inflammatory response. We analyzed the effect of ADM on the permeability of cultured...

journal_title：Circulation research

authors： Hippenstiel S,Witzenrath M,Schmeck B,Hocke A,Krisp M,Krüll M,Seybold J,Seeger W,Rascher W,Schütte H,Suttorp N

更新日期：2002-10-04 00:00:00

abstract：:Recent evidence shows that circulating granulocytes play an important role in capillary stasis and tissue injury. We investigated two aspects of the problem in a Wiggers hemorrhagic shock model of the rat: the survival rate and the microvascular no-reflow phenomenon. A conventional group of rats with normal blood cell...

journal_title：Circulation research

authors： Barroso-Aranda J,Schmid-Schönbein GW,Zweifach BW,Engler RL

更新日期：1988-08-01 00:00:00

abstract：:In a freshly isolated endothelial cell preparation from rabbit aorta, the regulation of the acetylcholine (ACh)-sensitive intracellular Ca2+ store and the effects of the Ca(2+)-induced Ca2+ release agonists ryanodine and caffeine were studied using fura 2 imaging fluorescence microscopy. ACh (10 mumol/L) caused a tran...

journal_title：Circulation research

authors： Wang X,Lau F,Li L,Yoshikawa A,van Breemen C

更新日期：1995-07-01 00:00:00

abstract：:The sarcolemmal Na+-Ca2+ exchanger (NCX) is the main Ca2+ extrusion mechanism in cardiac myocytes and is thus essential for the regulation of Ca2+ homeostasis and contractile function. A cytosolic region (f-loop) of the protein mediates regulation of NCX function by intracellular factors including inhibition by exchan...

journal_title：Circulation research

authors： Maack C,Ganesan A,Sidor A,O'Rourke B

更新日期：2005-01-07 00:00:00

abstract：:Postnatal development of the mammalian heart is associated with changes in the population of isoforms of the thin filament proteins. We correlated the change in thin filament proteins, which occur in rabbit hearts between 5 days and 22 days of age, with changes in Ca2+ dependence of myofibrillar ATPase activity, force...

journal_title：Circulation research

authors： McAuliffe JJ,Gao LZ,Solaro RJ

更新日期：1990-05-01 00:00:00

abstract：:Rho regulates various cell functions, including cell morphology and motility. However, the functional role of Rho on the signaling pathway in myocardial cells (MCs) is unknown. In the present study, we attempted to explore the mode of Rho action for c-fos gene expression in MCs. Expression of the c-fos promoter/enhanc...

journal_title：Circulation research

authors： Ueyama T,Sakoda T,Kawashima S,Hiraoka E,Hirata K,Akita H,Yokoyama M

更新日期：1997-11-01 00:00:00

abstract：:True propagation coefficients of pulse wave harmonics in an artery can be determined in vivo by measuring pulsatile blood pressure and flow at each of two points along the length of the vessel. These coefficients, which are complex numbers that describe the attenuation and the phase shift imposed on a traveling wave, ...

journal_title：Circulation research

authors： Milnor WR,Nichols WW

更新日期：1975-05-01 00:00:00

abstract：:The cardiac troponin T (TnT) I79N mutation has been linked to familial hypertrophic cardiomyopathy and high incidence of sudden death, despite causing little or no cardiac hypertrophy in patients. Transgenic mice expressing mutant human TnT (I79N-Tg) have increased cardiac contractility, but no ventricular hypertrophy...

journal_title：Circulation research

authors： Knollmann BC,Kirchhof P,Sirenko SG,Degen H,Greene AE,Schober T,Mackow JC,Fabritz L,Potter JD,Morad M

更新日期：2003-03-07 00:00:00

abstract：:To study the effects of stretch on the function of rat left atrium, we recorded contraction force, calcium transients, and intracellular action potentials (APs) during stretch manipulations. The stretch of the atrium was controlled by intra-atrial pressure. The Frank-Starling behavior of the atrium was manifested as a...

journal_title：Circulation research

authors： Tavi P,Han C,Weckström M

更新日期：1998-11-30 00:00:00

abstract：:The major goal of this study was to determine the interactions of VLDL surface and core lipids with the artery wall. We first demonstrated in vitro that surface lipid in VLDL could be traced using the phospholipid-like fluorescent probe 1,1'-dioctadecyl-3,3, 3',3'-tetramethyl-indocarbocyanine (DiI). The core of VLDL p...

journal_title：Circulation research

authors： Rutledge JC,Mullick AE,Gardner G,Goldberg IJ

更新日期：2000-04-14 00:00:00

abstract：:Glibenclamide, one of the antidiabetic sulfonylureas, is known to block ATP-dependent K+ channels. We used this drug to determine to what extent K+ loss from acutely ischemic myocardium is mediated via these channels. We also investigated whether glibenclamide would influence ischemic arrhythmias. Isolated rat hearts ...

journal_title：Circulation research

authors： Kantor PF,Coetzee WA,Carmeliet EE,Dennis SC,Opie LH

更新日期：1990-02-01 00:00:00

abstract：RATIONALE:Gamma aminobutyric acid (GABA), a neurotransmitter of the central nervous system, is found in the systemic circulation of humans at a concentration between 0.5 and 3 μmol/L. However, the potential source of circulating GABA and its significance on the vascular system remains unknown. We hypothesized that endo...

journal_title：Circulation research

authors： Sen S,Roy S,Bandyopadhyay G,Scott B,Xiao D,Ramadoss S,Mahata SK,Chaudhuri G

更新日期：2016-08-19 00:00:00

abstract：:Autoregulatory responses to alterations in arterial or venous perfusion pressure were determined for individual arterioles within the rat cremaster muscle. The cremaster muscle of pentobarbital anesthetized rats (50 mg/kg, ip) was surgically exposed and maintained in a controlled tissue bath for visualization by in vi...

journal_title：Circulation research

authors： Morff RJ,Granger HJ

更新日期：1982-07-01 00:00:00

abstract：:It has been demonstrated by other investigators that endothelium-dependent vasodilators are more effective on arterial tissue than on venous tissue. The purpose of this study was to determine if this was due to a difference in the sensitivity of arterial and venous smooth muscle to the endothelial dilator (EDRF) or to...

journal_title：Circulation research

authors： Seidel CL,LaRochelle J

更新日期：1987-04-01 00:00:00

abstract：:Membrane current abnormalities have been described in human heart failure. To determine whether similar current changes are observed in a large animal model of heart failure, we studied dogs with pacing-induced cardiomyopathy. Myocytes isolated from the midmyocardium of 13 dogs with heart failure induced by 3 to 4 wee...

journal_title：Circulation research

authors： Kääb S,Nuss HB,Chiamvimonvat N,O'Rourke B,Pak PH,Kass DA,Marban E,Tomaselli GF

更新日期：1996-02-01 00:00:00

abstract：:The effects of acute hypoxemia and hypercapnic acidosis were examined in five unanesthetized dogs in which sodium intake was controlled at 80 mEq/24 hours for 4 days prior to study. Each animal was studied during combined acute hypoxemia and hypercapnic acidosis (Pao2 = 36 +/- 1 mm Hg, Paco2 = 52 +/- 1 mm Hg, pH = 7.1...

journal_title：Circulation research

authors： Rose CE Jr,Kimmel DP,Godine RL Jr,Kaiser DL,Carey RM

更新日期：1983-08-01 00:00:00

abstract：:Apoptosis of smooth muscle cells (SMC) and degradation of the extracellular matrix (ECM) have both been implicated in atherosclerotic plaque rupture. We have previously reported that degraded type I collagen fragments induce a rapid but transient apoptotic burst initiated by calpains in SMC. The aim of the current stu...

journal_title：Circulation research

authors： von Wnuck Lipinski K,Keul P,Ferri N,Lucke S,Heusch G,Fischer JW,Levkau B

更新日期：2006-06-23 00:00:00

abstract：:Although clinical trials of cell-based approaches to cardiovascular disease have yielded some promising results, no cell-based therapy has achieved regulatory approval for a cardiovascular indication. To broadly assess the challenges to regulatory approval and identify strategies to facilitate this goal, the Cardiac S...

journal_title：Circulation research

authors： Fanaroff AC,Morrow V,Krucoff MW,Seltzer JH,Perin EC,Taylor DA,Miller LW,Zeiher AM,Fernández-Avilés F,Losordo DW,Henry TD,Povsic TJ

更新日期：2018-08-03 00:00:00

abstract：:Transforming growth factor (TGF)-beta plays a major role in the development of vascular diseases. Despite the pleiotropic effects of TGF-ss on vascular smooth muscle cells (VSMCs), only a few genes have been characterized as direct targets of TGF-beta in VSMCs. Cardiac ankyrin repeat protein (CARP) has been thought to...

journal_title：Circulation research

authors： Kanai H,Tanaka T,Aihara Y,Takeda S,Kawabata M,Miyazono K,Nagai R,Kurabayashi M

更新日期：2001-01-19 00:00:00

abstract：:The purpose of this study was to determine whether a quantitative relationship existed between a reduction in regional myocardial blood flow, measured by radiolabeled microspheres, and the degree and type of changes in myocardial activation recorded in bipolar left ventricular subepicardial and subendocardial electrog...

journal_title：Circulation research

authors： Ruffy R,Lovelace DE,Mueller TM,Knoebel SB,Zipes DP

更新日期：1979-12-01 00:00:00

abstract：:We investigated the combined effectiveness of intra-aortic balloon counterpulsation and hyperosmotic mannitol (25%) on regional myocardial blood flow during acute coronary insufficiency. Cardiac output and paced heart rate were held constant in chloralose-anesthetized dogs during right heart bypass. Acute coronary ins...

journal_title：Circulation research

authors： Watson JT,Fixler DE,Platt MR,Nall BB,Jett GK,Willerson JT

更新日期：1976-06-01 00:00:00

abstract：:Isolated, cultured arterial endothelial cells express an acetylcholine (ACh)-activated K+ current in addition to an inward rectifier current whose conductance is unaffected by ACh. The cholinergic K+ current is specifically blocked by atropine (1 microM) and shows single saturation kinetics with ACh (half-maximal stim...

journal_title：Circulation research

authors： Olesen SP,Davies PF,Clapham DE

更新日期：1988-06-01 00:00:00

abstract：:Nitrite has recently emerged as an important bioactive molecule, capable of conferring cardioprotection and a variety of other benefits in the cardiovascular system and elsewhere. The mechanisms by which it accomplishes these functions remain largely unclear. To characterize the dose response and corresponding cardiac...

journal_title：Circulation research

authors： Perlman DH,Bauer SM,Ashrafian H,Bryan NS,Garcia-Saura MF,Lim CC,Fernandez BO,Infusini G,McComb ME,Costello CE,Feelisch M

更新日期：2009-03-27 00:00:00