Relationship between changes in left ventricular bipolar electrograms and regional myocardial blood flow during acute coronary artery occlusion in the dog.

abstract：:Urea transporters have been cloned from kidney medulla (UT-A) and erythrocytes (UT-B). We determined whether UT-A proteins could be detected in heart and whether their abundance was altered by uremia or hypertension or in human heart failure. In normal rat heart, bands were detected at 56, 51, and 39 kDa. In uremic ra...

journal_title：Circulation research

authors： Duchesne R,Klein JD,Velotta JB,Doran JJ,Rouillard P,Roberts BR,McDonough AA,Sands JM

更新日期：2001-07-20 00:00:00

abstract：:In isolated right atria of the rabbit heart, we studied the activation pattern within the sinus node, using the microelectrode technique. After the electrophysiological experiments, the preparations were subjected to a correlative morphological investigation, using light or electron microscopy. Different criteria for ...

journal_title：Circulation research

authors： Bleeker WK,Mackaay AJ,Masson-Pévet M,Bouman LN,Becker AE

更新日期：1980-01-01 00:00:00

abstract：:The fluorescent dye 2',7'-bis(carboxyethyl)-5,6-carboxyfluorescein (BCECF) was used to measure pHi in the spontaneously hypertensive rat (SHR) and in normal rat cardiac myocytes under nominally HCO3-free (20 mmol/L HEPES-buffered) conditions. When only the Na-H exchanger was blocked, the intrinsic buffering power (bet...

journal_title：Circulation research

authors： Wu ML,Tsai ML,Tseng YZ

更新日期：1994-07-01 00:00:00

abstract：:Different myosin isoenzymes of pig and human atrium and ventricle and rat ventricle were characterized by two approaches: pyrophosphate polyacrylamide gel electrophoresis (PP-PAGE) and analysis of the myosin P light chains by two-dimensional polyacrylamide gel electrophoresis (2D-PAGE). We further investigated the rel...

journal_title：Circulation research

authors： Morano I,Arndt H,Gärtner C,Rüegg JC

更新日期：1988-03-01 00:00:00

abstract：:We studied the time-dependent changes in the response of heart rate (sinus cycle length) to 30-second trains of vagal stimulation (8 Hz), repeated every 2 minutes, in canine neonates aged 7.1 +/- 2.5 (mean +/- SD) days. The first vagal train prolonged the sinus cycle length by 58 +/- 35%, but the response was attenuat...

journal_title：Circulation research

authors： Yamasaki S,Stolfi A,Mas MS,Fox LS,Pickoff AS

更新日期：1991-08-01 00:00:00

abstract：:To study whether atrial fibrillation might produce local changes in the atrium which could facilitate the tendency of this arrhythmia to become chronic and self-perpetuating, we compared the effect of atrial fibrillation, atrial pacing, and acute volume loading on the perfusion and oxygen consumption of the atrium in ...

journal_title：Circulation research

authors： White CW,Kerber RE,Weiss HR,Marcus ML

更新日期：1982-08-01 00:00:00

abstract：:The cardiac muscarinic potassium channel (IK.ACh) is activated by a G protein upon receptor stimulation with acetylcholine. The G protein subunit responsible for activation (G alpha versus G beta gamma) has been disputed. We used G beta gamma inhibitors derived from the beta-adrenergic kinase 1 (beta ARK1) to assess t...

journal_title：Circulation research

authors： Nair LA,Inglese J,Stoffel R,Koch WJ,Lefkowitz RJ,Kwatra MM,Grant AO

更新日期：1995-05-01 00:00:00

abstract：:We have previously demonstrated pressure-dependent membrane depolarization and action potential generation in cat cerebral arteries. It was the purpose of this study to examine and compare the membrane electrical responses to increasing transmural pressure in spontaneously hypertensive rats with those of their normote...

journal_title：Circulation research

authors： Harder DR,Smeda J,Lombard J

更新日期：1985-08-01 00:00:00

abstract：:Extracellular ATP plays an important role in the regulation of prostacyclin and nitric oxide release from vascular endothelial cells. These cellular responses to ATP are generally attributed to the stimulation of the P2y subtype of P2 purinergic receptors. However, it has recently been suggested that two types of ATP ...

journal_title：Circulation research

authors： Motte S,Pirotton S,Boeynaems JM

更新日期：1993-03-01 00:00:00

abstract：:Understanding molecular mechanisms regulating angiogenesis may lead to novel therapies for ischemic disorders. Hypoxia-inducible factor 1 (HIF-1) activates vascular endothelial growth factor (VEGF) gene expression in hypoxic/ischemic tissue. In this study we demonstrate that exposure of primary cultures of cardiac and...

journal_title：Circulation research

authors： Kelly BD,Hackett SF,Hirota K,Oshima Y,Cai Z,Berg-Dixon S,Rowan A,Yan Z,Campochiaro PA,Semenza GL

更新日期：2003-11-28 00:00:00

abstract：:Body surface electrocardiograms and electrograms recorded from the surfaces of the heart are the basis for diagnosis and treatment of cardiac electrophysiological disorders and arrhythmias. Given recent advances in understanding the molecular mechanisms of arrhythmia, it is important to relate these electrocardiograph...

journal_title：Circulation research

authors： Gima K,Rudy Y

更新日期：2002-05-03 00:00:00

abstract：:Calcific aortic valve sclerosis involves inflammatory processes and occurs preferentially on the aortic side of endothelialized valve leaflets. Although the endothelium is recognized to play critical roles in focal vascular sclerosis, the contributions of valvular endothelial phenotypes to aortic valve sclerosis and s...

journal_title：Circulation research

authors： Simmons CA,Grant GR,Manduchi E,Davies PF

更新日期：2005-04-15 00:00:00

abstract：RATIONALE:Disruption of endothelial barrier function and neutrophil-mediated injury are two major mechanisms underlying the pathophysiology of sepsis-induced acute lung injury (ALI). Recently we reported that endotoxin induced activation of RhoA in mice lungs that led to the disruption of endothelial barrier and lung e...

journal_title：Circulation research

authors： Gorovoy M,Han J,Pan H,Welch E,Neamu R,Jia Z,Predescu D,Vogel S,Minshall RD,Ye RD,Malik AB,Voyno-Yasenetskaya T

更新日期：2009-09-11 00:00:00

abstract：:Heterozygous familial hypercholesterolemia (FH) is a highly atherogenic genetic disorder leading to premature coronary heart disease (CHD), usually before 60 years of age. We studied an extended multigenerational kindred with FH linked to chromosome 1p32 in which atherosclerotic complications were either delayed or pr...

journal_title：Circulation research

authors： Canizales-Quinteros S,Aguilar-Salinas CA,Reyes-Rodríguez E,Riba L,Rodríguez-Torres M,Ramírez-Jiménez S,Huertas-Vázquez A,Fragoso-Ontiveros V,Zentella-Dehesa A,Ventura-Gallegos JL,Vega-Hernández G,López-Estrada A,Aurón-Gómez M,G

更新日期：2003-03-21 00:00:00

abstract：:In urethane-anesthetized rats, electrophysiological recordings of spontaneously active neurons in the vasopressor area of the rostral ventrolateral medulla were analyzed for participation in cardiovascular regulation. A total of 138 units were found which were inhibited by transient increases in mean arterial pressure...

journal_title：Circulation research

authors： Brown DL,Guyenet PG

更新日期：1985-03-01 00:00:00

abstract：:We have shown that the cellular contractile dysfunction characteristic of pressure-overload cardiac hypertrophy results not from an abnormality intrinsic to the myofilament portion of the cardiocyte cytoskeleton but rather from an increased density of the microtubule component of the extramyofilament portion of the ca...

journal_title：Circulation research

authors： Tagawa H,Wang N,Narishige T,Ingber DE,Zile MR,Cooper G 4th

更新日期：1997-02-01 00:00:00

abstract：:Effects of blood flow on the production of prostacyclin (PGI2) were examined in the canine femoral artery perfused ex vivo. Each artery was perfused in situ with medium 199, under conditions of simulated blood flow. To simulate the normal and abnormal blood flow waveforms at the same mean flow rate, we developed a flo...

journal_title：Circulation research

authors： Onohara T,Okadome K,Yamamura S,Mii S,Sugimachi K

更新日期：1991-04-01 00:00:00

abstract：:Genome-wide association studies have uncovered over a 100 genetic loci associated with atrial fibrillation (AF), the most common arrhythmia. Many of the top AF-associated loci harbor key cardiac transcription factors, including PITX2, TBX5, PRRX1, and ZFHX3. Moreover, the vast majority of the AF-associated variants li...

journal_title：Circulation research

authors： van Ouwerkerk AF,Hall AW,Kadow ZA,Lazarevic S,Reyat JS,Tucker NR,Nadadur RD,Bosada FM,Bianchi V,Ellinor PT,Fabritz L,Martin JF,de Laat W,Kirchhof P,Moskowitz IP,Christoffels VM

更新日期：2020-06-19 00:00:00

abstract：:In the first 4 hours after occlusion of the anterior septal coronary artery, 18 dogs developed bundle branch block, heart block, or both. The hearts were then excised, and preparations were dissected to expose the His bundle and the bundle branches, which were superfused with modified Tyrode's solution at 37 degrees C...

journal_title：Circulation research

authors： Lazzara R,El-Sherif N,Scherlag BJ

更新日期：1975-03-01 00:00:00

abstract：RATIONALE:Cardiac resynchronization therapy (CRT) is an effective clinical treatment for heart failure patients with conduction delay, impaired contraction, and energetics. Our recent studies have revealed that mitochondrial posttranslational modifications (PTM) may contribute to its benefits, motivating the present st...

journal_title：Circulation research

authors： Wang SB,Foster DB,Rucker J,O'Rourke B,Kass DA,Van Eyk JE

更新日期：2011-09-16 00:00:00

abstract：:Rationale: The overuse of antibiotics has been an important clinical issue, and antibiotic exposure is linked to alterations in gut microbiota, which has been related to risks of various chronic diseases such as cardiovascular disease and cancer. Also, duration of antibiotic exposure may be a risk factor of premature ...

journal_title：Circulation research

authors： Heianza Y,Ma W,Li X,Cao Y,Chan AT,Rimm EB,Hu FB,Rexrode KM,Manson JE,Qi L

更新日期：2020-01-31 00:00:00

abstract：:Nitroglycerin dilates large (greater than or equal to 100 microns) but not small coronary arterial microvessels, and a putative metabolite of nitroglycerin, S-nitroso-L-cysteine, has been shown in vitro to dilate both large and small coronary microvessels. Based on this evidence, we tested the hypothesis that the lack...

journal_title：Circulation research

authors： Kurz MA,Lamping KG,Bates JN,Eastham CL,Marcus ML,Harrison DG

更新日期：1991-03-01 00:00:00

abstract：:We examined the late coronary vascular response to carotid chemoreceptor reflex activation in normal, conscious dogs instrumented for the measurement of right main and left circumflex coronary artery blood flows, arterial and right ventricular pressures, and arterial and coronary sinus blood gases and O2 contents. Wit...

journal_title：Circulation research

authors： Murray PA,Lavallee M,Vatner SF

更新日期：1984-01-01 00:00:00

abstract：:Vascular endothelial cells are constantly exposed to mechanical forces resulting from blood flow and transmural pressure. The goal of this study was to determine whether mechanical stimulation alters the properties of endothelial voltage-gated K+ channels. Cardiac microvascular endothelial cells (CMECs) were isolated ...

journal_title：Circulation research

authors： Fan J,Walsh KB

更新日期：1999-03-05 00:00:00

abstract：RATIONALE:Deep vein thrombosis (DVT) and its complication pulmonary embolism have high morbidity reducing quality of life and leading to death. Cellular mechanisms of DVT initiation remain poorly understood. OBJECTIVE:We sought to determine the role of mast cells (MCs) in DVT initiation and validate MCs as a potential...

journal_title：Circulation research

authors： Ponomaryov T,Payne H,Fabritz L,Wagner DD,Brill A

更新日期：2017-09-29 00:00:00

abstract：:Angiotensin II (Ang II) increases renal sympathetic nerve activity in anesthetized mice before and after ganglionic blockade, suggesting that Ang II may directly activate postganglionic sympathetic neurons. The present study directly tested this hypothesis in vitro. Neurons were dissociated from aortic-renal and celia...

journal_title：Circulation research

authors： Ma X,Chapleau MW,Whiteis CA,Abboud FM,Bielefeldt K

更新日期：2001-04-27 00:00:00

abstract：:Reactive oxygen species and reactive nitrogen species are biological molecules that play important roles in cardiovascular physiology and contribute to disease initiation, progression, and severity. Because of their ephemeral nature and rapid reactivity, these species are difficult to measure directly with high accura...

journal_title：Circulation research

authors： Griendling KK,Touyz RM,Zweier JL,Dikalov S,Chilian W,Chen YR,Harrison DG,Bhatnagar A,American Heart Association Council on Basic Cardiovascular Sciences.

更新日期：2016-08-19 00:00:00

abstract：RATIONALE:Congestive heart failure (CHF) frequently results in remodeling and increased tone of pulmonary resistance vessels. This adaptive response, which aggravates pulmonary hypertension and thus, promotes right ventricular failure, has been attributed to lung endothelial dysfunction. OBJECTIVE:We applied real-time...

journal_title：Circulation research

authors： Kerem A,Yin J,Kaestle SM,Hoffmann J,Schoene AM,Singh B,Kuppe H,Borst MM,Kuebler WM

更新日期：2010-04-02 00:00:00

abstract：:This study investigations the phenomenon of sustained mechanical alternans (SMA) through the use of quantitative criteria. Discrete analysis is used to demonstrate that the hemodynamic variables during SMA are governed by a simple mathematical relation. The analysis shows that the value of the slope created by the two...

journal_title：Circulation research

authors： Adler D,Nikolic S,Sonnenblick EH,Yellin EL

更新日期：1991-07-01 00:00:00

abstract：:Previous studies have shown that integrin activation and fluid shear stress can modulate the activity of sterol regulatory element binding proteins (SREBPs) in vascular endothelial cells. We investigated the role of small GTPase Rho-mediated signal transduction pathway in this mode of SREBP activation. Fluid shear str...

journal_title：Circulation research

authors： Lin T,Zeng L,Liu Y,DeFea K,Schwartz MA,Chien S,Shyy JY

更新日期：2003-06-27 00:00:00