Integrin-mediated transcriptional activation of inhibitor of apoptosis proteins protects smooth muscle cells against apoptosis induced by degraded collagen.

abstract：:The focal pattern of atherosclerotic lesions in arterial vessels suggests that local blood flow patterns are important factors in atherosclerosis. Although disturbed flows in the branches and curved regions are proatherogenic, laminar flows in the straight parts are atheroprotective. Results from in vitro studies on c...

journal_title：Circulation research

authors： Shyy JY,Chien S

更新日期：2002-11-01 00:00:00

abstract：RATIONALE:Chronic rejection, accelerated coronary atherosclerosis, myocardial infarction, and ischemic heart failure determine the unfavorable evolution of the transplanted heart in humans. OBJECTIVE:Here we tested whether the pathological manifestations of the transplanted heart can be corrected partly by a strategy ...

journal_title：Circulation research

authors： D'Alessandro DA,Kajstura J,Hosoda T,Gatti A,Bello R,Mosna F,Bardelli S,Zheng H,D'Amario D,Padin-Iruegas ME,Carvalho AB,Rota M,Zembala MO,Stern D,Rimoldi O,Urbanek K,Michler RE,Leri A,Anversa P

更新日期：2009-11-20 00:00:00

abstract：:Rationale: The overuse of antibiotics has been an important clinical issue, and antibiotic exposure is linked to alterations in gut microbiota, which has been related to risks of various chronic diseases such as cardiovascular disease and cancer. Also, duration of antibiotic exposure may be a risk factor of premature ...

journal_title：Circulation research

authors： Heianza Y,Ma W,Li X,Cao Y,Chan AT,Rimm EB,Hu FB,Rexrode KM,Manson JE,Qi L

更新日期：2020-01-31 00:00:00

abstract：RATIONALE:The vascular adventitia is a complex layer of the vessel wall consisting of vasa vasorum microvessels, nerves, fibroblasts, immune cells, and resident progenitor cells. Adventitial progenitors express the stem cell markers, Sca1 and CD34 (adventitial sca1-positive progenitor cells [AdvSca1]), have the potenti...

journal_title：Circulation research

authors： Majesky MW,Horita H,Ostriker A,Lu S,Regan JN,Bagchi A,Dong XR,Poczobutt J,Nemenoff RA,Weiser-Evans MC

更新日期：2017-01-20 00:00:00

abstract：:We report the hemodynamic parameters of stage 18, 21, 24, and 27 chick embryos (from 3 to 5 days of incubation). Dorsal aortic blood velocity and mean vitelline artery blood pressure are measured with a 20 MHz pulsed-Doppler meter and servo-null pressure system respectively. We also measure heart rate, dorsal aortic d...

journal_title：Circulation research

authors： Clark EB,Hu N

更新日期：1982-12-01 00:00:00

abstract：:The goal of this study was to test the hypothesis that the cardioprotective effects of the late phase of ischemic preconditioning (PC) can be mimicked by treatment with NO donors. In phase I (studies of myocardial stunning), conscious rabbits underwent a sequence of six 4-minute coronary occlusion/4-minute reperfusion...

journal_title：Circulation research

authors： Takano H,Tang XL,Qiu Y,Guo Y,French BA,Bolli R

更新日期：1998-07-13 00:00:00

abstract：:The effect of transmural pressure on the responsiveness of vascular smooth muscle was studied using rats with chronic occlusion of one external iliac artery. The arterial pressure in the occluded leg was reduced to approximately half of that in the contralateral unoccluded leg. Helical strips from the low- and high-pr...

journal_title：Circulation research

authors： Hansen TR,Bohr DF

更新日期：1975-05-01 00:00:00

abstract：:Endothelial cells, either in vivo or freshly isolated, respond when exposed to muscarinic agonists with an increase in cytosolic free calcium concentration ([Ca2+]i) and release of endothelium-derived relaxing factor (EDRF). When placed in culture, however, endothelial cells rapidly lose these responses, which may be ...

journal_title：Circulation research

authors： Tracey WR,Peach MJ

更新日期：1992-02-01 00:00:00

abstract：:Baroreceptor reflexes can be demonstrated during fetal life, but whether baroreceptors normally regulate fetal arterial pressure is unknown. This problem was addressed directly by measuring arterial pressure and analyzing its variation in eight unanesthetized fetal lambs throughout the last third of gestation, and com...

journal_title：Circulation research

authors： Yardley RW,Bowes G,Wilkinson M,Cannata JP,Maloney JE,Ritchie BC,Walker AM

更新日期：1983-05-01 00:00:00

abstract：RATIONALE:Myogenic tone, an important regulator of vascular resistance, is dependent on vascular smooth muscle (VSM) depolarization, can be modulated by endothelial factors, and is increased in several models of hypertension. Intermittent hypoxia (IH) elevates blood pressure and causes endothelial dysfunction. Hydrogen...

journal_title：Circulation research

authors： Jackson-Weaver O,Paredes DA,Gonzalez Bosc LV,Walker BR,Kanagy NL

更新日期：2011-06-10 00:00:00

abstract：:Whole-cell voltage-clamp experiments were performed on enzymatically dissociated single ventricular myocytes harvested from feline endocardial and epicardial surfaces. The studies were designed to test the hypothesis that the differences in the amplitude of transient outward current (Ito) contribute to the difference ...

journal_title：Circulation research

authors： Furukawa T,Myerburg RJ,Furukawa N,Bassett AL,Kimura S

更新日期：1990-11-01 00:00:00

abstract：:We have recently characterized the promoter region of the rabbit embryonic smooth muscle myosin heavy chain (SMemb/NMHC-B) gene and identified the 15-bp sequence, designated SE1, located at -105 from the transcriptional start site as an important regulatory element for its transcriptional activity in a smooth muscle c...

journal_title：Circulation research

authors： Watanabe N,Kurabayashi M,Shimomura Y,Kawai-Kowase K,Hoshino Y,Manabe I,Watanabe M,Aikawa M,Kuro-o M,Suzuki T,Yazaki Y,Nagai R

更新日期：1999-07-23 00:00:00

abstract：:Ultrarapid freezing has been applied to monitor the structure of the freeze-fractured myocardial sarcolemma. Our two goals were to demonstrate that large areas of membrane can be preserved free of visible ice crystal damage and, thus, be amenable to quantitative analysis and to compare the structure of directly frozen...

journal_title：Circulation research

authors： Frank JS,Beydler S,Mottino G

更新日期：1987-07-01 00:00:00

abstract：:Recent studies from our laboratory involving syncytial preparations have delineated electrophysiological distinctions between epicardium, endocardium, and a unique population of cells in the deep subepicardial to midmyocardial layers (M region) of the canine ventricle. In the present study, we used standard microelect...

journal_title：Circulation research

authors： Liu DW,Gintant GA,Antzelevitch C

更新日期：1993-03-01 00:00:00

abstract：:The recent discovery of neutral active choline and ethanolamine glycerophospholipid specific phospholipase C in myocardium (Wolf RA, Gross RW. J Biol Chem 1985;260:7295) has demonstrated a novel catabolic pathway that potentially contributes to the accumulation of amphiphilic metabolites during myocardial ischemia. To...

journal_title：Circulation research

authors： Ford DA,Gross RW

更新日期：1989-01-01 00:00:00

abstract：:The beta-adrenergic receptor system of the failing human heart is markedly desensitized. We have recently postulated that this desensitization may in part be caused by an increase in beta-adrenergic receptor kinase (beta ARK) expression. beta ARK is thought to effect desensitization by acting in concert with an inhibi...

journal_title：Circulation research

authors： Ungerer M,Parruti G,Böhm M,Puzicha M,DeBlasi A,Erdmann E,Lohse MJ

更新日期：1994-02-01 00:00:00

abstract：RATIONALE:Cardiac resynchronization therapy (CRT) is an effective clinical treatment for heart failure patients with conduction delay, impaired contraction, and energetics. Our recent studies have revealed that mitochondrial posttranslational modifications (PTM) may contribute to its benefits, motivating the present st...

journal_title：Circulation research

authors： Wang SB,Foster DB,Rucker J,O'Rourke B,Kass DA,Van Eyk JE

更新日期：2011-09-16 00:00:00

abstract：RATIONALE:The high morbidity/mortality of atherosclerosis is typically precipitated by plaque rupture and consequent thrombosis. However, research on underlying mechanisms and therapeutic approaches is limited by the lack of animal models that reproduce plaque instability observed in humans. OBJECTIVE:Development and ...

journal_title：Circulation research

authors： Chen YC,Bui AV,Diesch J,Manasseh R,Hausding C,Rivera J,Haviv I,Agrotis A,Htun NM,Jowett J,Hagemeyer CE,Hannan RD,Bobik A,Peter K

更新日期：2013-07-19 00:00:00

abstract：:Atrial fibrillation (AF) may result from stationary reentry in the left atrium (LA), with fibrillatory conduction toward the right atrium (RA). We hypothesize that periodic input to the RA at an exceedingly high frequency results in disorganized wave propagation, compatible with fibrillatory conduction. Simultaneous e...

journal_title：Circulation research

authors： Berenfeld O,Zaitsev AV,Mironov SF,Pertsov AM,Jalife J

更新日期：2002-06-14 00:00:00

abstract：:A surgical technique was developed to place sutures around the pulmonary arteries of young rats (about 1 month old and 100 g body weight). As the operated rats grew, the pulmonary arteries were gradually constricted, leading after 4-6 weeks to the development of severe right ventricular hypertrophy with free wall weig...

journal_title：Circulation research

authors： Julian FJ,Morgan DL,Moss RL,Gonzalez M,Dwivedi P

更新日期：1981-12-01 00:00:00

abstract：:p21ras is a potent regulator of myogenic cell growth and differentiation. It has been implicated as playing a major role in the genesis of cardiac hypertrophy. We examined the effect of Ras overexpression on human atrial natriuretic peptide (hANP) gene expression, a marker of hypertrophy, in neonatal rat ventricular m...

journal_title：Circulation research

authors： Kovacic-Milivojevic B,Zlock DW,Gardner DG

更新日期：1997-04-01 00:00:00

abstract：RATIONALE:During the transition from compensated hypertrophy to heart failure, the signaling between L-type Ca(2+) channels in the cell membrane/T-tubules and ryanodine receptors in the sarcoplasmic reticulum becomes defective, partially because of the decreased expression of a T-tubule-sarcoplasmic reticulum anchoring...

journal_title：Circulation research

authors： Li RC,Tao J,Guo YB,Wu HD,Liu RF,Bai Y,Lv ZZ,Luo GZ,Li LL,Wang M,Yang HQ,Gao W,Han QD,Zhang YY,Wang XJ,Xu M,Wang SQ

更新日期：2013-02-15 00:00:00

abstract：:After cervical aortic nerve section, mean arterial pressure in the unanesthetized dog increased by an average of 7.4 mm Hg. Following a more extensive denervation of aortic arch receptors by section of intrathoracic vagal branches, arterial pressure increased by 16.7 mm Hg. The above changes were seen in the stable st...

journal_title：Circulation research

authors： Ito CS,Scher AM

更新日期：1979-07-01 00:00:00

abstract：:Proliferation of vascular smooth muscle cells (VSMC) is a primary cause of vascular disorders and is associated with major alterations in Ca2+ handling supported by loss of the sarco/endoplasmic reticulum calcium ATPase, SERCA2a. To determine the importance of SERCA2a in neointima formation, we have prevented loss of ...

journal_title：Circulation research

authors： Lipskaia L,del Monte F,Capiod T,Yacoubi S,Hadri L,Hours M,Hajjar RJ,Lompré AM

更新日期：2005-09-02 00:00:00

abstract：:This study examines the cellular basis and specificity of the effects of adenosine on early afterdepolarizations (EADs), delayed afterdepolarizations (DADs), and triggered activity (TA) induced by various drugs with different mechanisms of action. Membrane potential and currents were measured in isolated guinea pig ve...

journal_title：Circulation research

authors： Song Y,Thedford S,Lerman BB,Belardinelli L

更新日期：1992-04-01 00:00:00

abstract：:The impact of vanadate on the Na,K-ATPase system in the vascular smooth muscle cell is poorly understood. The present study describes the kinetics of the effect of vanadate on Na,K-ATPase and the Na-K pump in in vitro grown rat VSMC's. Vanadate interaction with the Na,K-ATPase system in vascular smooth muscle cells wa...

journal_title：Circulation research

authors： Searle BM,Higashino H,Khalil F,Bogden JD,Tokushige A,Tamura H,Kino M,Aviv A

更新日期：1983-08-01 00:00:00

abstract：:Cardiac hypertrophy induced by thyrotoxic stress leads to an increase in the rate of force development, velocity of shortening, tension-dependent heat generation, and myosin ATPase activity. We did studies to see whether alterations in covalent phosphorylation of myofibrillar proteins correlate with these changes. The...

journal_title：Circulation research

authors： Litten RZ 3rd,Martin BJ,Howe ER,Alpert NR,Solaro RJ

更新日期：1981-04-01 00:00:00

abstract：:Patients with severe heart failure are at high risk of sudden cardiac death. In the majority of these patients, sudden cardiac death is thought to be due to ventricular tachyarrhythmias. Alterations of the electric properties of single myocytes in heart failure may favor the occurrence of ventricular arrhythmias in th...

journal_title：Circulation research

authors： Priebe L,Beuckelmann DJ

更新日期：1998-06-15 00:00:00

abstract：:The patch-clamp technique was used to examine the inhibition of delayed rectifier K+ channels by agents that release intracellular Ca2+. During voltage-clamp experiments on isolated myocytes with 4-aminopyridine (4-AP, 10 mmol/L) and niflumic acid (100 mumol/L) present to inhibit delayed rectifier K+ current (IK(dr)) ...

journal_title：Circulation research

authors： Gelband CH,Hume JR

更新日期：1995-07-01 00:00:00

abstract：:We have recently demonstrated that endogenous erythropoietin (Epo)/Epo receptor (EpoR) system plays an important protective role in hypoxia-induced pulmonary hypertension. However, it remains to be examined whether vascular EpoR system contributes to angiogenesis in response to ischemia. We examined angiogenesis in Ep...

journal_title：Circulation research

authors： Nakano M,Satoh K,Fukumoto Y,Ito Y,Kagaya Y,Ishii N,Sugamura K,Shimokawa H

更新日期：2007-03-16 00:00:00