Intermittent hypoxia in rats increases myogenic tone through loss of hydrogen sulfide activation of large-conductance Ca(2+)-activated potassium channels.

abstract：:The cellular basis of reactive oxygen intermediate-induced arrhythmias was investigated in isolated rabbit ventricular cells using the whole-cell voltage- and current-clamp techniques. Singlet oxygen and superoxide were generated by the photoactivation of rose bengal. Single ventricular cells exposed to rose bengal (1...

journal_title：Circulation research

authors： Matsuura H,Shattock MJ

更新日期：1991-02-01 00:00:00

abstract：:Increased levels of C-peptide, a cleavage product of proinsulin, circulate in patients with insulin resistance and early type 2 diabetes mellitus. Recent data suggest a potential causal role of C-peptide in atherogenesis by promoting monocyte and T-lymphocyte recruitment into the vessel wall. The present study examine...

journal_title：Circulation research

authors： Walcher D,Babiak C,Poletek P,Rosenkranz S,Bach H,Betz S,Durst R,Grüb M,Hombach V,Strong J,Marx N

更新日期：2006-11-24 00:00:00

abstract：RATIONALE:Hypoxia promotes renal damage and progression of chronic kidney disease (CKD). The erythrocyte is the only cell type for oxygen (O2) delivery. Sphingosine 1-phosphate (S1P)-a highly enriched biolipid in erythrocytes-is recently reported to be induced under high altitude in normal humans to enhance O2 delivery...

journal_title：Circulation research

authors： Xie T,Chen C,Peng Z,Brown BC,Reisz JA,Xu P,Zhou Z,Song A,Zhang Y,Bogdanov MV,Kellems RE,D'Alessandro A,Zhang W,Xia Y

更新日期：2020-07-17 00:00:00

abstract：:To determine the relative importance of protein degradation in the development of starvation-induced cardiac atrophy, in vivo fractional synthetic rates of total cardiac protein, myosin heavy chain, actin, light chain 1, and light chain 2 were measured in fed and fasted rabbits by continuous infusion of [3H] leucine. ...

journal_title：Circulation research

authors： Samarel AM,Parmacek MS,Magid NM,Decker RS,Lesch M

更新日期：1987-06-01 00:00:00

abstract：RATIONALE:Peroxisome proliferator-activated receptor (PPAR)γ agonists attenuate atherosclerosis and abdominal aortic aneurysms (AAAs). PPARγ, a nuclear receptor, is expressed on many cell types including smooth muscle cells (SMCs). OBJECTIVE:To determine whether a PPARγ agonist reduces angiotensin II (Ang II)-induced ...

journal_title：Circulation research

authors： Subramanian V,Golledge J,Ijaz T,Bruemmer D,Daugherty A

更新日期：2010-10-15 00:00:00

abstract：:To clarify the physiological role of calcium-activated neutral protease (CANP) in human platelets, we loaded the platelets with a Ca2+ -sensitive fluorescent dye, fura-2, and measured the degree of aggregation, cytosolic calcium ion concentration [( Ca2+]i), and proteolysis by sodium dodecyl sulfate-polyacrylamide gel...

journal_title：Circulation research

authors： Toyo-oka T,Shin WS,Okai Y,Dan Y,Morita M,Iizuka M,Sugimoto T

更新日期：1989-02-01 00:00:00

abstract：:Tissue factor (TF) is a low-molecular-weight glycoprotein that initiates the extrinsic clotting cascade and is considered a major regulator of arterial thrombogenicity. TF pathway inhibitor (TFPI) is a major physiological inhibitor of TF-initiated coagulation. The aim of this study was to define the complex interplay ...

journal_title：Circulation research

authors： Singh R,Pan S,Mueske CS,Witt T,Kleppe LS,Peterson TE,Slobodova A,Chang JY,Caplice NM,Simari RD

更新日期：2001-07-06 00:00:00

abstract：:Endocardial endothelium and endothelium of coronary vessels produce NO. Histochemical methods have suggested that coronary arterial endothelial cells contain more endothelial constitutive NO synthase (ecNOS) than does coronary venous endothelium. We have further investigated the distribution of ecNOS in cardiac endoth...

journal_title：Circulation research

authors： Andries LJ,Brutsaert DL,Sys SU

更新日期：1998-02-09 00:00:00

abstract：:The arterial pressure of rabbits with chronic one-kidney hypertension can be lowered to normotensive levels by direct immunization with preparations made from the cortex of hog kidneys. Hypertensive rabbits that are immunized with large amounts of renin may develop high plasma antirenin titers without affecting their ...

journal_title：Circulation research

authors： Skeggs LT,Kahn JR,Levine M,Dorer FE,Lentz KE

更新日期：1976-09-01 00:00:00

abstract：:Inflammation is an important driver of atherosclerosis, the underlying pathology of cardiovascular diseases. Therefore, therapeutic targeting of inflammatory pathways is suggested to improve cardiovascular outcomes in patients with cardiovascular diseases. This concept was recently proven by CANTOS (Canakinumab Anti-I...

journal_title：Circulation research

authors： Grebe A,Hoss F,Latz E

更新日期：2018-06-08 00:00:00

abstract：:Although functional coupling between protein kinase Cepsilon (PKCepsilon) and mitochondria has been implicated in the genesis of cardioprotection, the signal transduction mechanisms that enable this link and the identities of the mitochondrial proteins modulated by PKCepsilon remain unknown. Based on recent evidence t...

journal_title：Circulation research

authors： Baines CP,Song CX,Zheng YT,Wang GW,Zhang J,Wang OL,Guo Y,Bolli R,Cardwell EM,Ping P

更新日期：2003-05-02 00:00:00

abstract：:Intracellular recordings were made from eustachian ridge of cat right atrium to determine mechanisms responsible for subsidiary pacemaker automaticity. Pacemaker action potentials exhibited two phases of diastolic depolarization: an initial steeper slope (D1) followed by a more gradual slope (D2). Cesium (1 mM) decrea...

journal_title：Circulation research

authors： Rubenstein DS,Lipsius SL

更新日期：1989-04-01 00:00:00

abstract：:Shear stress caused by the frictional forces of a fluid moving over a cell monolayer is an important regulator of gene expression. In this study, we investigated the effect of shear stress on angiotensin-converting enzyme (ACE) expression and promoter activity in vitro and on local vascular ACE activity in vivo. ACE a...

journal_title：Circulation research

authors： Rieder MJ,Carmona R,Krieger JE,Pritchard KA Jr,Greene AS

更新日期：1997-03-01 00:00:00

abstract：:Blockade of angiotensin type 1 (AT1) receptors induces smooth muscle cell (SMC) death and regression of aortic hypertrophy in spontaneously hypertensive rats (SHR). We postulated that SMC death and vascular remodeling in this model may be attenuated by z-Val-Ala-Asp(OMe)-CH2F (z-VAD-fmk), a tripeptide inhibitor of cas...

journal_title：Circulation research

authors： Marchand EL,Der Sarkissian S,Hamet P,deBlois D

更新日期：2003-04-18 00:00:00

abstract：:Neuropeptide Y (NPY) is stored with norepinephrine in sympathetic nerves throughout the cardiovascular system and is released during activation of the sympathetic nervous system in humans and other animals. After stimulation of the cardiac sympathetic nerves in anesthetized dogs, the action of the vagus nerve on heart...

journal_title：Circulation research

authors： Hall GT,Gardner TD,Potter EK

更新日期：1990-07-01 00:00:00

abstract：:Vascular remodeling, rather than vasoconstriction, is believed to account for high vascular resistance in severe pulmonary arterial hypertension (PAH). We have found previously that acute Rho kinase inhibition nearly normalizes PAH in chronically hypoxic rats that have no occlusive neointimal lesions. Here we examined...

journal_title：Circulation research

authors： Oka M,Homma N,Taraseviciene-Stewart L,Morris KG,Kraskauskas D,Burns N,Voelkel NF,McMurtry IF

更新日期：2007-03-30 00:00:00

abstract：:Studies were performed to characterize the morphology and vascular reactivity of the allografted cerebral microcirculation. Cerebral cortical tissue was allografted into the cheek pouch of the hamster so that cerebral parenchymal vessels could be studied. The vascular morphology was characterized by a large number of ...

journal_title：Circulation research

authors： Joyner WL,Young R,Blank D,Eccleston-Joyner CA,Gilmore JP

更新日期：1988-10-01 00:00:00

abstract：:The transverse tubular system (t-system) of cardiac muscle is a structure that allows rapid propagation of excitation into the cell interior. Using 2-photon molecular excitation microscopy and digital image-processing methods, we have obtained a comprehensive overview of the t-system of rat ventricular myocytes in liv...

journal_title：Circulation research

authors： Soeller C,Cannell MB

更新日期：1999-02-19 00:00:00

abstract：:It has been proposed that lipopolysaccharide (LPS) bound to the 60-kD LPS binding protein (LBP) forms an LPS/LBP complex that, in turn, binds to the CD14 receptor on monocytes/macrophages and stimulates the release of cytokines. We examined the role of LBP and CD14 in tumor necrosis factor-alpha (TNF-alpha) production...

journal_title：Circulation research

authors： Ishii Y,Wang Y,Haziot A,del Vecchio PJ,Goyert SM,Malik AB

更新日期：1993-07-01 00:00:00

abstract：:This study was performed to examine, first, the protective effects and responses of collateral vessels of the hind limb in normal and atherosclerotic monkeys and, second, the effects of chronic arterial occlusion on the development of atherosclerosis. The iliac artery was ligated on one side in cynomolgus monkeys. Six...

journal_title：Circulation research

authors： Lopez JA,Armstrong ML,Harrison DG,Piegors DJ,Heistad DD

更新日期：1988-12-01 00:00:00

abstract：RATIONALE:Activin receptor-like kinase-1 (ALK1) is an endothelial transforming growth factor β receptor involved in angiogenesis. ALK1 expression is high in the embryo vasculature, becoming less detectable in the quiescent endothelium of adult stages. However, ALK1 expression becomes rapidly increased after angiogenic ...

journal_title：Circulation research

authors： Garrido-Martín EM,Blanco FJ,Roquè M,Novensà L,Tarocchi M,Lang UE,Suzuki T,Friedman SL,Botella LM,Bernabéu C

更新日期：2013-01-04 00:00:00

abstract：:C-reactive protein (CRP), a characteristic inflammatory marker, is a powerful predictor of cardiovascular events. Recent data suggest that CRP may also promote atherogenesis through inducing endothelial dysfunction. Lectin-like oxidized low-density lipoprotein (oxLDL) receptor-1 (LOX-1) is a newly identified endotheli...

journal_title：Circulation research

authors： Li L,Roumeliotis N,Sawamura T,Renier G

更新日期：2004-10-29 00:00:00

abstract：:A series of new phenylethanolamines with 2-methoxy and/or 4-methyl, 4-chloro, or 4-bromo ring substituents and either N-isopropyl or N-tert butyl substituents have been synthesized and tested for beta 1- and beta 2-adrenoceptor blocking activity using isolated guinea pig atrial and tracheal preparations. Each of the d...

journal_title：Circulation research

authors： Letts LG,Temple DM,Williams LR

更新日期：1980-06-01 00:00:00

abstract：:Spatial electrical heterogeneity has a profound effect on normal cardiac electrophysiology and genesis of cardiac arrhythmias in diseased hearts. The Na+-Ca2+ exchanger (NCX) is a key linker, through Ca2+ signaling, between contractility and arrhythmias. Here we characterize the differential transmural expression of N...

journal_title：Circulation research

authors： Xiong W,Tian Y,DiSilvestre D,Tomaselli GF

更新日期：2005-08-05 00:00:00

abstract：:Choline acetyltransferase is the enzyme that catalyzes the biosynthesis of acetylcholine, the neurotransmitter of the pre- and postganglionic parasympathetic system. To assess the extent of parasympathetic innervation, enzyme activity was measured in specialized and contractile regions throughout the guinea pig heart....

journal_title：Circulation research

authors： Schmid PG,Greif BJ,Lund DD,Roskoski R Jr

更新日期：1978-05-01 00:00:00

abstract：:Previous work has shown that neutrophils isolated from whole blood adhere to cardiac-myocytes via CD18 (beta 2 integrin) to cause injury to the heart cells. In vitro, we have found that upon endothelial transmigration, neutrophils can also express alpha 4 beta 1; however, whether this contributes to neutrophil adhesio...

journal_title：Circulation research

authors： Reinhardt PH,Ward CA,Giles WR,Kubes P

更新日期：1997-08-01 00:00:00

abstract：:Genome-wide association studies have provided a rich collection of ≈ 58 coronary artery disease (CAD) loci that suggest the existence of previously unsuspected new biology relevant to atherosclerosis. However, these studies only identify genomic loci associated with CAD, and many questions remain even after a genomic ...

journal_title：Circulation research

authors： Nurnberg ST,Zhang H,Hand NJ,Bauer RC,Saleheen D,Reilly MP,Rader DJ

更新日期：2016-02-19 00:00:00

abstract：:Diabetes mellitus has profound adverse effects on vascular and, in particular, endothelial function. Although pressure-induced constriction ("myogenic tone") is a major contributor to the regulation of blood flow, little is known about the effects of diabetes on this response. Diabetes has been shown to diminish the d...

journal_title：Circulation research

authors： Zimmermann PA,Knot HJ,Stevenson AS,Nelson MT

更新日期：1997-12-01 00:00:00

abstract：:A period of prolonged vasodilation follows flow-restricted exercise of skeletal muscle. We tested the hypothesis that adenosine participates in mediating this vascular response. Vascularly isolated, anterior calf muscles of anesthetized dogs were stimulated to contract at a rate of 4 twitches/sec. Blood flow was held ...

journal_title：Circulation research

authors： Belloni FL,Phair RD,Sparks HV

更新日期：1979-06-01 00:00:00

abstract：:In 26 Wistar rats with surface glomeruli, the determinants of glomerular ultrafiltration and peritubular capillary uptake of proximal reabsorbate were studied before and during intravenous infusions of norepinephrine or angiotensin II. Regardless of whether renal perfusion pressure (AP) was permitted to increase, both...

journal_title：Circulation research

authors： Myers BD,Deen WM,Brenner BM

更新日期：1975-07-01 00:00:00