Abstract:
:A period of prolonged vasodilation follows flow-restricted exercise of skeletal muscle. We tested the hypothesis that adenosine participates in mediating this vascular response. Vascularly isolated, anterior calf muscles of anesthetized dogs were stimulated to contract at a rate of 4 twitches/sec. Blood flow was held constant at 12.5 +/- 1.3 ml/min per 100 g which was about 14% of the expected free flow for this exercise level. Skeletal muscle tissue adenosine was measured with the an enzymatic, spectophotometric assay of trichloroacetic acid extracts of congruent to 50 mg biopsy samples. Tissue adenosine rose from 2.30 +/- 0.90 nmol/g in resting muscle to 22.5 +/- 5.8 nmol/g by the end of the 22-minute exercise. Following exercise, tissue adenosine fell toward its baseline value with a time course very similar to the early portion of the return of skeletal muscle vascular resistance to its control level. Thus, skeletal muscle adenosine content (1) increases to a sufficient magnitude and (2) falls with an appropriate time course to be at least partly responsible for the early portion of prolonged vasodilation seen after flow-restricted exercise of skeletal muscle.
journal_name
Circ Resjournal_title
Circulation researchauthors
Belloni FL,Phair RD,Sparks HVdoi
10.1161/01.res.44.6.759subject
Has Abstractpub_date
1979-06-01 00:00:00pages
759-66issue
6eissn
0009-7330issn
1524-4571journal_volume
44pub_type
杂志文章abstract::The mechanism of propranolol-inhibited sarcolemmal membrane lipid peroxidation was investigated by electron spin resonance spin-trapping technique using 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) and 2-methyl-2-nitrosopropane (MNP). Highly purified canine myocytic sarcolemma were peroxidized by a superoxide-driven (from ...
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更新日期:2000-02-04 00:00:00
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更新日期:2010-10-15 00:00:00
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更新日期:1994-04-01 00:00:00
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更新日期:2010-04-02 00:00:00
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更新日期:2001-04-13 00:00:00
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pub_type: 杂志文章
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更新日期:1983-06-01 00:00:00
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更新日期:2003-05-02 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.45.3.347
更新日期:1979-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.80.2.179
更新日期:1997-02-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.117.306712
更新日期:2015-07-03 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1996-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:1979-08-01 00:00:00
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更新日期:1988-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-09-15 00:00:00
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pub_type: 杂志文章
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更新日期:2006-09-29 00:00:00
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更新日期:2009-12-04 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.45.3.404
更新日期:1979-09-01 00:00:00
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更新日期:2018-02-02 00:00:00
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更新日期:2011-10-14 00:00:00
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journal_title:Circulation research
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更新日期:2006-09-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.42.2.263
更新日期:1978-02-01 00:00:00