p63RhoGEF couples Gα(q/11)-mediated signaling to Ca2+ sensitization of vascular smooth muscle contractility.

abstract：:Vascular endothelial cells respond to laminar shear stress by aligning in the direction of flow, a process which may contribute to atheroprotection. Here we report that localized alpha4 integrin phosphorylation is a mechanism for establishing the directionality of shear stress-induced alignment in microvascular endoth...

journal_title：Circulation research

authors： Goldfinger LE,Tzima E,Stockton R,Kiosses WB,Kinbara K,Tkachenko E,Gutierrez E,Groisman A,Nguyen P,Chien S,Ginsberg MH

更新日期：2008-07-18 00:00:00

abstract：:The consequences of endothelin receptor activation were examined in atrial tumor myocytes derived from transgenic mice (AT-1 cells). Endothelin-1 (endothelin) stimulates phosphoinositide hydrolysis in a dose-dependent manner. Endothelin also induces the rapid and transient translocation of protein kinase C (PKC)-epsil...

journal_title：Circulation research

authors： Jiang T,Pak E,Zhang HL,Kline RP,Steinberg SF

更新日期：1996-04-01 00:00:00

abstract：:The aging population is increasing in developed countries. Because the incidence of cardiac disease increases dramatically with age, it is important to understand the molecular mechanisms through which the heart becomes either more or less susceptible to stress. Cardiac aging is characterized by the presence of hypert...

journal_title：Circulation research

authors： Shirakabe A,Ikeda Y,Sciarretta S,Zablocki DK,Sadoshima J

更新日期：2016-05-13 00:00:00

abstract：:Previous studies have demonstrated a role for voltage-gated K+ (Kv) channel alpha subunits of the Kv4 subfamily in the generation of rapidly inactivating/recovering cardiac transient outward K+ current, I(to,f), channels. Biochemical studies suggest that mouse ventricular I(to,f) channels reflect the heteromeric assem...

journal_title：Circulation research

authors： Guo W,Jung WE,Marionneau C,Aimond F,Xu H,Yamada KA,Schwarz TL,Demolombe S,Nerbonne JM

更新日期：2005-12-09 00:00:00

abstract：:Previous studies have suggested that intravenous infusion of arginine vasopressin (AVP) inhibits sympathetic nerve activity (SNA) in rabbits by its action at the brainstem. This study aimed to determine, first, whether this action of AVP depended on functioning baroreflex mechanisms. The second aim was to determine th...

journal_title：Circulation research

authors： Suzuki S,Takeshita A,Imaizumi T,Hirooka Y,Yoshida M,Ando S,Nakamura M

更新日期：1989-11-01 00:00:00

abstract：:The relations between atrial natriuretic peptide (ANP) binding sites in the renal medulla, plasma ANP concentration, and ventricular dysfunction have been studied in rats 4 weeks after myocardial infarction induced by left coronary artery ligation. Plasma ANP concentration was measured by radioimmunoassay, and quantit...

journal_title：Circulation research

authors： Tsunoda K,Mendelsohn FA,Sexton PM,Chai SY,Hodsman GP,Johnston CI

更新日期：1988-01-01 00:00:00

abstract：:Changes in cardiac filling pressure (central venous pressure) were measured following carotid occlusion and infusions of catecholamines in awake dogs while cardiac output was held constant. After carotid occlusion in dogs with vagi blocked, central venous pressure increased about 0.8 mm Hg (an estimated decrease in va...

journal_title：Circulation research

authors： Bennett TD,Wyss CR,Scher AM

更新日期：1984-10-01 00:00:00

abstract：:We have measured the apparent Ca2+ sensitivities of force development in skinned cardiac trabeculae at different sarcome lengths together with shifts in troponin (Tn) T subunits on specimens from the same hearts and drawn insights into the pathogenesis of myocardial dysfunction in the diabetic rat. The Ca(2+)-force re...

journal_title：Circulation research

authors： Akella AB,Ding XL,Cheng R,Gulati J

更新日期：1995-04-01 00:00:00

abstract：RATIONALE:Clinical benefits of reperfusion after myocardial infarction are offset by maladaptive innate immune cell function, and therapeutic interventions are lacking. OBJECTIVE:We sought to test the significance of phagocytic clearance by resident and recruited phagocytes after myocardial ischemia reperfusion. METH...

journal_title：Circulation research

authors： DeBerge M,Yeap XY,Dehn S,Zhang S,Grigoryeva L,Misener S,Procissi D,Zhou X,Lee DC,Muller WA,Luo X,Rothlin C,Tabas I,Thorp EB

更新日期：2017-09-29 00:00:00

abstract：:Age-related diastolic dysfunction is a major factor in the epidemic of heart failure. In patients hospitalized with heart failure, HFpEF is now as common as heart failure with reduced ejection fraction. We now have many successful treatments for heart failure with reduced ejection fraction, while specific treatment op...

journal_title：Circulation research

authors： Loffredo FS,Nikolova AP,Pancoast JR,Lee RT

更新日期：2014-06-20 00:00:00

abstract：:Gene therapy, aimed at the correction of key pathologies being out of reach for conventional drugs, bears the potential to alter the treatment of cardiovascular diseases radically and thereby of heart failure. Heart failure gene therapy refers to a therapeutic system of targeted drug delivery to the heart that uses fo...

journal_title：Circulation research

authors： Pleger ST,Brinks H,Ritterhoff J,Raake P,Koch WJ,Katus HA,Most P

更新日期：2013-08-30 00:00:00

abstract：:In a complex system of interrelated reactions, the heart converts chemical energy to mechanical energy. Energy transfer is achieved through coordinated activation of enzymes, ion channels, and contractile elements, as well as structural and membrane proteins. The heart's needs for energy are difficult to overestimate....

journal_title：Circulation research

authors： Taegtmeyer H,Young ME,Lopaschuk GD,Abel ED,Brunengraber H,Darley-Usmar V,Des Rosiers C,Gerszten R,Glatz JF,Griffin JL,Gropler RJ,Holzhuetter HG,Kizer JR,Lewandowski ED,Malloy CR,Neubauer S,Peterson LR,Portman MA,Recch

更新日期：2016-05-13 00:00:00

abstract：:The relationship of P-wave polarity and morphology in leads II, III, and aVF to the sequence of atrial activation was studied in the canine heart when the atria were paced from the region of the sinus node or the posterior-inferior left atrium and when retrograde activation of the atria occurred with right ventricular...

journal_title：Circulation research

authors： Waldo AL,Vitikainen KJ,Hoffman BF

更新日期：1975-08-01 00:00:00

abstract：:The hypothesis that neurally mediated coronary vasodilation occurs as part of the carotid baroreceptor reflex was investigated. The left main coronary artery was cannulated and perfused at constant pressure (100 mm Hg) in closed-chest, chloralose-anesthetized dogs. The heart was paced at a constant rate between 60 and...

journal_title：Circulation research

authors： Ito BR,Feigl EO

更新日期：1985-04-01 00:00:00

abstract：BACKGROUND:Myocyte contractile dysfunction occurs in pathological remodeling in association with abnormalities in calcium regulation. Mice with cardiac myocyte-specific overexpression of Galphaq develop progressive left ventricular failure associated with myocyte contractile dysfunction and calcium dysregulation. OBJE...

journal_title：Circulation research

authors： Lancel S,Qin F,Lennon SL,Zhang J,Tong X,Mazzini MJ,Kang YJ,Siwik DA,Cohen RA,Colucci WS

更新日期：2010-07-23 00:00:00

abstract：:We determined whether cerebral arterioles in vitro adjust their diameters in response to changes in intraluminal flow rate and pressure. Intracerebral arterioles (38- to 55-microns diameter) were isolated from Sprague-Dawley rats and cannulated with a perfusion system that permitted separate control of intraluminal pr...

journal_title：Circulation research

authors： Ngai AC,Winn HR

更新日期：1995-10-01 00:00:00

abstract：:Large conductance Ca(2+)-activated K(+) channels (BK(Ca)) play a critical role in blood pressure regulation by tuning the vascular smooth muscle tone, and hyposensitivity of BK(Ca) to Ca(2+) sparks resulting from its altered beta1 subunit stoichiometry underlies vasoconstriction in animal models of hypertension. Here ...

journal_title：Circulation research

authors： Zhao G,Zhao Y,Pan B,Liu J,Huang X,Zhang X,Cao C,Hou N,Wu C,Zhao KS,Cheng H

更新日期：2007-08-31 00:00:00

abstract：RATIONALE:Our insights into physiological and pathophysiological cardiac excitation-contraction coupling has greatly benefited from significant advancement in optical technologies such as high-speed confocal microscopy. This has pushed pixel dwell times into the time domain of nanoseconds, resulting in low signal-to-no...

journal_title：Circulation research

authors： Tian Q,Kaestner L,Lipp P

更新日期：2012-06-22 00:00:00

abstract：:Vascular disease in diabetics could arise in part from altered vessel wall catebolism. Specific activities of hydrolases in aortic smooth muscle cells from rats with streptozotocin-induced diabetes were measured. Enyzmes included: neutral alpha-glucosidase, alpha-mannosidase, and lysosomal N-acetyl beta-glucosaminidas...

journal_title：Circulation research

authors： Wolinsky H,Goldfischer S,Capron L,Capron F,Coltoff-Schiller B,Kasak L

更新日期：1978-06-01 00:00:00

abstract：:Vascular endothelial growth factors (VEGFs) and their receptors have emerged as central regulators of the angiogenic process. However, involvement of VEGF-B, one of these factors, in angiogenesis remains obscure. Mice received subcutaneous injection of Matrigel alone or Matrigel with human recombinant protein rhVEGF-B...

journal_title：Circulation research

authors： Silvestre JS,Tamarat R,Ebrahimian TG,Le-Roux A,Clergue M,Emmanuel F,Duriez M,Schwartz B,Branellec D,Lévy BI

更新日期：2003-07-25 00:00:00

abstract：:We have recently shown that adult canine ventricular myocytes express three distinct gap junction channel proteins, connexin40 (Cx40), connexin43 (Cx43), and connexin45 (Cx45). These proteins have unique cytoplasmic domains that likely confer connexin-specific physiological properties. To determine whether the three d...

journal_title：Circulation research

authors： Kanter HL,Laing JG,Beyer EC,Green KG,Saffitz JE

更新日期：1993-08-01 00:00:00

abstract：RATIONALE:Atherosclerosis proceeds through a multistep reaction that begins with endothelial injury caused by a host of stress signals, among which oxidized low-density lipoprotein (oxLDL) plays a critical role. OxLDL disrupts normal functionality of the endothelium by upregulating adhesion molecules (eg, ICAM-1) and c...

journal_title：Circulation research

authors： Fang F,Yang Y,Yuan Z,Gao Y,Zhou J,Chen Q,Xu Y

更新日期：2011-04-01 00:00:00

abstract：:Sarcolemmal and microsomal membranes prepared from adult canine cardiac myocytes (sarcolemmal Na+, K+-ATPase = 71.8 mumol/mg per hr and microsomal rotenone-insensitive NADH cytochrome c reductase = 114 mumol/mg per hr) were each preincubated at 37 degrees C in the presence of a free radical generating system consistin...

journal_title：Circulation research

authors： Kramer JH,Mak IT,Weglicki WB

更新日期：1984-07-01 00:00:00

abstract：:We determined the effects of indomethacin and meclofenamate, two inhibitors of prostaglandin synthesis, on renal vascular resistance and on renal responses to nerve stimulation, pressor and depressor hormones in the in situ feline kidney under conditions of controlled blood flow. Both inhibitors produced a gradual ris...

journal_title：Circulation research

authors： Chapnick BM,Paustian PW,Feigen LP,Joiner PD,Hyman AL,Kadowitz PJ

更新日期：1977-04-01 00:00:00

abstract：:Beta(1)- and beta(2)-adrenergic receptors (betaARs) are known to differentially regulate cardiomyocyte contraction and growth. We tested the hypothesis that these differences are attributable to spatial compartmentation of the second messenger cAMP. Using a fluorescent resonance energy transfer (FRET)-based approach, ...

journal_title：Circulation research

authors： Nikolaev VO,Bünemann M,Schmitteckert E,Lohse MJ,Engelhardt S

更新日期：2006-11-10 00:00:00

abstract：:Canine cardiac Purkinje cells contain both L- and T-type calcium currents, yet the single Ca2+ channels have not been characterized from these cells. Additionally, previous studies have shown an overlap between the steady-state inactivation and activations curves for L-type Ca2+ currents, suggesting the presence of L-...

journal_title：Circulation research

authors： Shorofsky SR,January CT

更新日期：1992-03-01 00:00:00

abstract：RATIONALE:Increased sympathetic nerve activity has been linked to the pathogenesis of hypertension in humans and animal models. Enhanced peripheral chemoreceptor sensitivity which increases sympathetic nerve activity has been observed in established hypertension but has not been identified as a possible mechanism for i...

journal_title：Circulation research

authors： Tan ZY,Lu Y,Whiteis CA,Simms AE,Paton JF,Chapleau MW,Abboud FM

更新日期：2010-02-19 00:00:00

abstract：:Since the first description of the anatomical atrioventricular nodes (AVNs), a large number of studies have provided insights into the heterogeneity of the structure as well as a repertoire of ion channel proteins that govern this complex conduction pathway between the atria and ventricles. These studies have revealed...

journal_title：Circulation research

authors： Zhang Q,Timofeyev V,Lu L,Li N,Singapuri A,Long MK,Bond CT,Adelman JP,Chiamvimonvat N

更新日期：2008-02-29 00:00:00

abstract：RATIONALE:Accurate knowledge of the cellular composition of the heart is essential to fully understand the changes that occur during pathogenesis and to devise strategies for tissue engineering and regeneration. OBJECTIVE:To examine the relative frequency of cardiac endothelial cells, hematopoietic-derived cells, and ...

journal_title：Circulation research

authors： Pinto AR,Ilinykh A,Ivey MJ,Kuwabara JT,D'Antoni ML,Debuque R,Chandran A,Wang L,Arora K,Rosenthal NA,Tallquist MD

更新日期：2016-02-05 00:00:00

abstract：RATIONALE:Mammalian cardiomyocytes withdraw from the cell cycle during early postnatal development, which significantly limits the capacity of the adult mammalian heart to regenerate after injury. The regulatory mechanisms that govern cardiomyocyte cell cycle withdrawal and binucleation are poorly understood. OBJECTIV...

journal_title：Circulation research

authors： Porrello ER,Johnson BA,Aurora AB,Simpson E,Nam YJ,Matkovich SJ,Dorn GW 2nd,van Rooij E,Olson EN

更新日期：2011-09-02 00:00:00