Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association.

abstract：:Increases in free Mg2+ from 0.04 to 10.0 mM with constant pH 7.0 TO 0.10 M ionic strength, and 2 mM MgATP2- caused a rightward shift of the free Ca-relative ATPase relation for both cardiac skeletal myofibrils. The specific activity of cardiac myofibrillar ATPase over a wide range of free Ca2+ was, however, depressed ...

journal_title：Circulation research

authors： Solaro RJ,Shiner JS

更新日期：1976-07-01 00:00:00

abstract：:In this review current hypotheses for the regulation of filtration rate and the subsequent reabsorption of that filtrate by the proximal tubule are discussed. In the rat the filtration rate is highly plasma flow dependent because of the phenomenon of filtration equilibrium. On the other hand, in man and dog filtration...

journal_title：Circulation research

authors： Knox FG,Cuche J-L,Ott CE,Diaz-Buxo JA,Marchand G

更新日期：1975-06-01 00:00:00

abstract：RATIONALE:Although tyrosine kinases (TKs) are important for cardiac function, their relevant downstream targets in the adult heart are unknown. The ShcA docking protein binds specific phosphotyrosine (pTyr) sites on activated TKs through its N-terminal pTyr-binding (PTB) and C-terminal SH2 domains and stimulates downst...

journal_title：Circulation research

authors： Vanderlaan RD,Hardy WR,Kabir MG,Pasculescu A,Jones N,deTombe PP,Backx PH,Pawson T

更新日期：2011-01-21 00:00:00

abstract：:The transverse tubular system (t-system) of cardiac muscle is a structure that allows rapid propagation of excitation into the cell interior. Using 2-photon molecular excitation microscopy and digital image-processing methods, we have obtained a comprehensive overview of the t-system of rat ventricular myocytes in liv...

journal_title：Circulation research

authors： Soeller C,Cannell MB

更新日期：1999-02-19 00:00:00

abstract：:Protein kinase C (PKC) is a key mediator of many diverse physiological and pathological responses. Although little is known about the specific in vivo roles of the various cardiac PKC isozymes, activation-induced translocation of PKC is believed to be the primary determinant of isozyme-specific functions. Recently, we...

journal_title：Circulation research

authors： Mochly-Rosen D,Wu G,Hahn H,Osinska H,Liron T,Lorenz JN,Yatani A,Robbins J,Dorn GW 2nd

更新日期：2000-06-09 00:00:00

abstract：:To assess whether coronary spasm affects the progression of atherosclerosis and results in evolution of myocardial infarction, the role of coronary spasm on the fine structure of conduit coronary arteries was studied morphologically. Göttingen miniature pigs were fed a semisynthetic diet containing 2% cholesterol and ...

journal_title：Circulation research

authors： Nagasawa K,Tomoike H,Hayashi Y,Yamada A,Yamamoto T,Nakamura M

更新日期：1989-08-01 00:00:00

abstract：RATIONALE:Diabetes mellitus increases cardiovascular disease risk in humans and remains elevated despite cholesterol-lowering therapy with statins. Consistent with this, in mouse models, diabetes mellitus impairs atherosclerosis plaque regression after aggressive cholesterol lowering. MicroRNA 33 (miR33) is a key negat...

journal_title：Circulation research

authors： Distel E,Barrett TJ,Chung K,Girgis NM,Parathath S,Essau CC,Murphy AJ,Moore KJ,Fisher EA

更新日期：2014-10-10 00:00:00

abstract：RATIONALE:Lymphatic vasculature plays important roles in tissue fluid homeostasis maintenance and in the pathology of human diseases. Yet, the molecular mechanisms that control lymphatic vessel maturation remain largely unknown. OBJECTIVE:We analyzed the gene expression profiles of ex vivo isolated lymphatic endotheli...

journal_title：Circulation research

authors： Jurisic G,Maby-El Hajjami H,Karaman S,Ochsenbein AM,Alitalo A,Siddiqui SS,Ochoa Pereira C,Petrova TV,Detmar M

更新日期：2012-08-03 00:00:00

abstract：:We tested the hypothesis that TNF-alpha induces early-onset endothelial adhesivity toward PMN by activating the constitutive endothelial cell surface ICAM-1, the beta2-integrin (CD11/CD18) counter-receptor. Stimulation of human pulmonary artery endothelial cells with TNF-alpha resulted in phosphorylation of ICAM-1 wit...

journal_title：Circulation research

authors： Javaid K,Rahman A,Anwar KN,Frey RS,Minshall RD,Malik AB

更新日期：2003-05-30 00:00:00

abstract：RATIONALE:Disruption of endothelial barrier function and neutrophil-mediated injury are two major mechanisms underlying the pathophysiology of sepsis-induced acute lung injury (ALI). Recently we reported that endotoxin induced activation of RhoA in mice lungs that led to the disruption of endothelial barrier and lung e...

journal_title：Circulation research

authors： Gorovoy M,Han J,Pan H,Welch E,Neamu R,Jia Z,Predescu D,Vogel S,Minshall RD,Ye RD,Malik AB,Voyno-Yasenetskaya T

更新日期：2009-09-11 00:00:00

abstract：:The effects of acute hypoxemia and hypercapnic acidosis were examined in five unanesthetized dogs in which sodium intake was controlled at 80 mEq/24 hours for 4 days prior to study. Each animal was studied during combined acute hypoxemia and hypercapnic acidosis (Pao2 = 36 +/- 1 mm Hg, Paco2 = 52 +/- 1 mm Hg, pH = 7.1...

journal_title：Circulation research

authors： Rose CE Jr,Kimmel DP,Godine RL Jr,Kaiser DL,Carey RM

更新日期：1983-08-01 00:00:00

abstract：:Vasoactive drugs are known to affect impedance (pressure/flow) and vessel wall motion in arteries. The nonlinear theory of oscillatory flow in straight elastic vessels indicates that wall shear rate is affected by changes in impedance phase angle and wall motion. To test whether wall shear rate depends on impedance ph...

journal_title：Circulation research

authors： White KC,Kavanaugh JF,Wang DM,Tarbell JM

更新日期：1994-10-01 00:00:00

abstract：:A rapidly emerging body of literature implicates a pivotal role for the Ca2+-calmodulin-dependent phosphatase calcineurin as a cellular target for a variety of Ca2+-dependent signaling pathways culminating in left ventricular hypertrophy (LVH). Most of the recent experimental support for this hypothesis is derived fro...

journal_title：Circulation research

authors： Zhang W,Kowal RC,Rusnak F,Sikkink RA,Olson EN,Victor RG

更新日期：1999-04-02 00:00:00

abstract：:In intact porcine aorta, endothelium-derived nitric oxide released on thrombin stimulation inhibits the concomitant production of endothelin. Experiments were designed to examine the effect of hirudin (which inactivates thrombin) and the nitrovasodilators nitroglycerin and 3-morpholinosydnonimine on the spontaneous an...

journal_title：Circulation research

authors： Boulanger CM,Lüscher TF

更新日期：1991-06-01 00:00:00

abstract：RATIONALE:Thioredoxin (Trx)1 inhibits pathological cardiac hypertrophy. MicroRNAs (miRNAs) are small noncoding RNAs that downregulate posttranscriptional expression of target molecules. OBJECTIVES:We investigated the role of miRNAs in mediating the antihypertrophic effect of Trx1 on angiotensin II (Ang II)-induced car...

journal_title：Circulation research

authors： Yang Y,Ago T,Zhai P,Abdellatif M,Sadoshima J

更新日期：2011-02-04 00:00:00

abstract：RATIONALE:It has been reported that epicardial adipose tissue (EAT) may affect myocardial autonomic function. OBJECTIVE:The aim of this study was to explore the relationship between EAT and cardiac sympathetic nerve activity in patients with heart failure. METHODS AND RESULTS:In 110 patients with systolic heart failu...

journal_title：Circulation research

authors： Parisi V,Rengo G,Perrone-Filardi P,Pagano G,Femminella GD,Paolillo S,Petraglia L,Gambino G,Caruso A,Grimaldi MG,Baldascino F,Nolano M,Elia A,Cannavo A,De Bellis A,Coscioni E,Pellegrino T,Cuocolo A,Ferrara N,Leosco D

更新日期：2016-04-15 00:00:00

abstract：:The aims of the current study were to examine the efficacy of acetylcholine (ACh) to mimic ischemic preconditioning in dogs and to determine the role of nitric oxide (NO), muscarinic receptors, and ATP-sensitive K+ (KATP) channels in mediating its effects. Barbital-anesthetized open-chest dogs were subjected to 60 min...

journal_title：Circulation research

authors： Yao Z,Gross GJ

更新日期：1993-12-01 00:00:00

abstract：:Oxidative stress through the production of oxygen metabolites such as hydrogen peroxide (H2O2) increases vascular endothelial permeability. H2O2 stimulates ADP-ribose formation, which in turn opens transient receptor potential melastatin (TRPM)2 channels. Here, in endothelial cells, we demonstrate transcript and prote...

journal_title：Circulation research

authors： Hecquet CM,Ahmmed GU,Vogel SM,Malik AB

更新日期：2008-02-15 00:00:00

abstract：:We have investigated the requirement for c-myc downregulation in the growth arrest of vascular smooth muscle cells (VSMCs). Rat VSMCs were infected with a retrovirus vector directing constitutive expression of either the complete human c-Myc protein (VSM-myc cells) or the c-Myc deletion mutant D106-143, which is inact...

journal_title：Circulation research

authors： Bennett MR,Evan GI,Newby AC

更新日期：1994-03-01 00:00:00

abstract：:Electrical activity of enzymatically isolated, smooth muscle cells from hog carotid arteries was recorded under current clamp and voltage clamp. Under the experimental conditions, membrane potential usually was not stable, and spontaneous hyperpolarizing transients of approximately 100-msec duration were recorded. The...

journal_title：Circulation research

authors： Désilets M,Driska SP,Baumgarten CM

更新日期：1989-09-01 00:00:00

abstract：:Three different isoforms of the inhibitory guanine nucleotide-binding protein alpha-subunit (Gi alpha) have been cloned. However, little information on the cardiac-specific expression of these isoforms is available. The deduced amino acid sequence of a full-length Gi alpha 2 complementary DNA from a canine ventricular...

journal_title：Circulation research

authors： Holmer SR,Stevens S,Homcy CJ

更新日期：1989-10-01 00:00:00

abstract：:It is believed that inotropic agents exert their effects in cardiac muscle via a modulation of Ca2+ cycling; however, the involvement of phospholipase activation and the biochemical pathways participating in inotropic responsiveness remain unclear. The aim of the current study was to determine whether arachidonic acid...

journal_title：Circulation research

authors： Damron DS,Bond M

更新日期：1993-02-01 00:00:00

abstract：RATIONALE:Carriers of the most common prothrombotic mutations FVL (factor V Leiden) and FII (prothrombin) 20210G>A show a highly variable clinical phenotype. Using standardized in vivo coagulation activation followed by activity pattern analysis we have recently shown, that the FVL mutation accelerates thrombin and APC...

journal_title：Circulation research

authors： Rühl H,Berens C,Winterhagen FI,Reda S,Müller J,Oldenburg J,Pötzsch B

更新日期：2019-08-16 00:00:00

abstract：:We examined whether albumin-derived advanced glycosylation end products (AGEs) downregulate the expression of endothelial nitric oxide synthase (NOS). Significant reductions in NOS activity and cGMP levels in bovine aortic endothelial cells were observed when exposed to different concentrations of albumin-derived AGEs...

journal_title：Circulation research

authors： Rojas A,Romay S,González D,Herrera B,Delgado R,Otero K

更新日期：2000-02-18 00:00:00

abstract：:We examined the mechanism(s) of hypotensive action of platelet-activating factor (PAF) in anesthetized dogs. PAF (0.5 micrograms/kg i.v.) caused a biphasic hypotension; the first phase was transient and was accompanied by a decrease in systemic vascular resistance and an increase in cardiac output. Aspirin-DL-lysine, ...

journal_title：Circulation research

authors： Yamanaka S,Miura K,Yukimura T,Okumura M,Yamamoto K

更新日期：1992-05-01 00:00:00

abstract：:We have cloned from cultured vascular smooth muscle cells a protein tyrosine phosphatase, rat density-enhanced phosphatase-1 (rDEP-1), which is a probable rat homologue of DEP-1/HPTP eta. rDEP-1 is encoded by an 8.7-kb transcript and is expressed as a 180- to 220-kD protein. The rDEP-1 gene is located on human chromos...

journal_title：Circulation research

authors： Borges LG,Seifert RA,Grant FJ,Hart CE,Disteche CM,Edelhoff S,Solca FF,Lieberman MA,Lindner V,Fischer EH,Lok S,Bowen-Pope DF

更新日期：1996-09-01 00:00:00

abstract：RATIONALE:Circumstantial evidence links the development of heart failure to posttranslational modifications of mitochondrial proteins, including lysine acetylation (Kac). Nonetheless, direct evidence that Kac compromises mitochondrial performance remains sparse. OBJECTIVE:This study sought to explore the premise that ...

journal_title：Circulation research

authors： Davidson MT,Grimsrud PA,Lai L,Draper JA,Fisher-Wellman KH,Narowski TM,Abraham DM,Koves TR,Kelly DP,Muoio DM

更新日期：2020-09-25 00:00:00

abstract：RATIONALE:Transcatheter, intramyocardial injections of bone marrow-derived cell therapy produces reverse remodeling in large animal models of ischemic cardiomyopathy. OBJECTIVE:We used cardiac MRI (CMR) in patients with left ventricular (LV) dysfunction related to remote myocardial infarction (MI) to test the hypothes...

journal_title：Circulation research

authors： Williams AR,Trachtenberg B,Velazquez DL,McNiece I,Altman P,Rouy D,Mendizabal AM,Pattany PM,Lopera GA,Fishman J,Zambrano JP,Heldman AW,Hare JM

更新日期：2011-04-01 00:00:00

abstract：:This article examines the role of innervation in regulating expression of acetylcholinesterase (AchE), butyrylcholinesterase (BuchE), and the muscarinic acetylcholine receptor (mAchR) in avian heart. Two distinct approaches are taken. The first approach examines the relation between the onsets of parasympathetic and s...

journal_title：Circulation research

authors： Jo SA,Higgins DM,Berman HA

更新日期：1992-04-01 00:00:00

abstract：:Phenotypic switching of vascular smooth muscle cells (VSMCs) is known to play a critical role in the development of atherosclerosis. However, the factors present within lesions that mediate VSMC phenotypic switching are unclear. Oxidized phospholipids (OxPLs), including 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosp...

journal_title：Circulation research

authors： Cherepanova OA,Pidkovka NA,Sarmento OF,Yoshida T,Gan Q,Adiguzel E,Bendeck MP,Berliner J,Leitinger N,Owens GK

更新日期：2009-03-13 00:00:00