Abstract:
:The relations between atrial natriuretic peptide (ANP) binding sites in the renal medulla, plasma ANP concentration, and ventricular dysfunction have been studied in rats 4 weeks after myocardial infarction induced by left coronary artery ligation. Plasma ANP concentration was measured by radioimmunoassay, and quantitation of receptors was performed by computerized in vitro autoradiography with 125I-labeled alpha-rat ANP (1-28) as the radioligand. When compared with controls, rats with myocardial infarction had markedly elevated plasma immunoreactive ANP concentrations (462 +/- 82 versus 124 +/- pg/ml, p less than 0.01) and reduced densities of ANP binding in the inner renal medulla (2.93 +/- 0.19 versus 3.53 +/- 0.22 fmol/mg protein, p less than 0.01). Extensive myocardial infarction was associated with a significant decrease in receptor numbers in the inner medulla (33.6 +/- 5.7 versus 95.6 +/- 9.6 fmol/mg protein, p less than 0.01) without significantly altering the affinity constant (1.76 +/- 0.51 versus 1.03 +/- 0.15 x 10(9) M-1, p greater than 0.05). Right ventricular weight increased in proportion to infarct size (r = 0.71, p less than 0.01), and both were correlated with plasma immunoreactive ANP levels (r = 0.74, p less than 0.01 and r = 0.75, p less than 0.01, respectively). Binding densities in the inner medulla of rats with infarcts were negatively correlated with right ventricular weight, plasma immunoreactive ANP concentrations, and also with infarct size (r = -0.92, p less than 0.001; r = -0.78, p less than 0.001; r = -0.77, p less than 0.01, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Circ Resjournal_title
Circulation researchauthors
Tsunoda K,Mendelsohn FA,Sexton PM,Chai SY,Hodsman GP,Johnston CIdoi
10.1161/01.res.62.1.155subject
Has Abstractpub_date
1988-01-01 00:00:00pages
155-61issue
1eissn
0009-7330issn
1524-4571journal_volume
62pub_type
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更新日期:1999-09-03 00:00:00
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更新日期:1992-01-01 00:00:00
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更新日期:1995-11-01 00:00:00
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更新日期:2003-03-21 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-04-29 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.46.1.11
更新日期:1980-01-01 00:00:00
abstract::Ultrarapid freezing has been applied to monitor the structure of the freeze-fractured myocardial sarcolemma. Our two goals were to demonstrate that large areas of membrane can be preserved free of visible ice crystal damage and, thus, be amenable to quantitative analysis and to compare the structure of directly frozen...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.61.1.141
更新日期:1987-07-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.62.6.1111
更新日期:1988-06-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:
更新日期:1987-10-01 00:00:00
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更新日期:2000-03-31 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.75.6.1006
更新日期:1994-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2002-12-13 00:00:00
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doi:10.1161/01.res.76.2.199
更新日期:1995-02-01 00:00:00
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更新日期:2015-01-30 00:00:00
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更新日期:1994-08-01 00:00:00
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更新日期:2007-08-17 00:00:00
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更新日期:1999-06-11 00:00:00
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更新日期:2004-02-06 00:00:00