Abstract:
:Age-related diastolic dysfunction is a major factor in the epidemic of heart failure. In patients hospitalized with heart failure, HFpEF is now as common as heart failure with reduced ejection fraction. We now have many successful treatments for heart failure with reduced ejection fraction, while specific treatment options for HFpEF patients remain elusive. The lack of treatments for HFpEF reflects our very incomplete understanding of this constellation of diseases. There are many pathophysiological factors in HFpEF, but aging appears to play an important role. Here, we propose that aging of the myocardium is itself a specific pathophysiological process. New insights into the aging heart, including hormonal controls and specific molecular pathways, such as microRNAs, are pointing to myocardial aging as a potentially reversible process. While the overall process of aging remains mysterious, understanding the molecular pathways of myocardial aging has never been more important. Unraveling these pathways could lead to new therapies for the enormous and growing problem of HFpEF.
journal_name
Circ Resjournal_title
Circulation researchauthors
Loffredo FS,Nikolova AP,Pancoast JR,Lee RTdoi
10.1161/CIRCRESAHA.115.302929subject
Has Abstractpub_date
2014-06-20 00:00:00pages
97-107issue
1eissn
0009-7330issn
1524-4571pii
CIRCRESAHA.115.302929journal_volume
115pub_type
杂志文章,评审abstract::Endothelial cells release nitric oxide (NO) more potently in response to increased shear stress than to agonists which elevate intracellular free calcium concentration ([Ca2+]i). To determine mechanistic differences in the regulation of endothelial constitutive NO synthase (ecNOS), we measured NO production by bovine ...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.79.5.984
更新日期:1996-11-01 00:00:00
abstract::We studied the individual and combined effects of extracellular acidosis and increases in extracellular potassium on action potential characteristics and conduction in order to gain a better understanding of the effects of acute ischemia. At each level of potassium between 2.7 and 17 mm, acidosis induced by increasing...
journal_title:Circulation research
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Circulation research
pub_type: 杂志文章,评审
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更新日期:2013-07-05 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.0000027529.37429.38
更新日期:2002-07-26 00:00:00
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pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.115.304267
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.51.2.216
更新日期:1982-08-01 00:00:00
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doi:10.1161/01.res.72.4.827
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pub_type: 杂志文章
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更新日期:1996-03-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:2016-11-11 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.85.3.272
更新日期:1999-08-06 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.64.6.1190
更新日期:1989-06-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.107.150755
更新日期:2007-12-07 00:00:00
abstract::Myocardial damage due to reperfusion of ischemic tissue is caused primarily by infiltrating neutrophils. Although leukocyte beta2 integrins (CD18) play a critical role, significant neutrophil emigration persists when CD18 is neutralized or absent. This study examined the role of leukocyte beta1 integrin (alpha4) and i...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.0000013835.53611.97
更新日期:2002-03-22 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1987-04-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.115.304457
更新日期:2015-01-02 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.0000052313.23087.3f
更新日期:2003-02-07 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,评审
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更新日期:2011-01-21 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.116.308700
更新日期:2016-07-22 00:00:00
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pub_type: 杂志文章
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更新日期:2007-05-25 00:00:00
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更新日期:1978-11-01 00:00:00
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journal_title:Circulation research
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更新日期:1989-05-01 00:00:00
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更新日期:2007-03-16 00:00:00
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doi:10.1161/01.res.50.5.671
更新日期:1982-05-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,评审
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更新日期:2016-06-24 00:00:00
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pub_type: 杂志文章
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更新日期:2013-10-25 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1987-09-01 00:00:00