The identification of nitric oxide as endothelium-derived relaxing factor.

abstract：:Different myosin isoenzymes of pig and human atrium and ventricle and rat ventricle were characterized by two approaches: pyrophosphate polyacrylamide gel electrophoresis (PP-PAGE) and analysis of the myosin P light chains by two-dimensional polyacrylamide gel electrophoresis (2D-PAGE). We further investigated the rel...

journal_title：Circulation research

authors： Morano I,Arndt H,Gärtner C,Rüegg JC

更新日期：1988-03-01 00:00:00

abstract：:Nitrite has recently emerged as an important bioactive molecule, capable of conferring cardioprotection and a variety of other benefits in the cardiovascular system and elsewhere. The mechanisms by which it accomplishes these functions remain largely unclear. To characterize the dose response and corresponding cardiac...

journal_title：Circulation research

authors： Perlman DH,Bauer SM,Ashrafian H,Bryan NS,Garcia-Saura MF,Lim CC,Fernandez BO,Infusini G,McComb ME,Costello CE,Feelisch M

更新日期：2009-03-27 00:00:00

abstract：:The effects of prostaglandin E2 (PGE2) indomethacin, and reserpine were evaluated in the rabbit renal vascular bed in situ under conditions of controlled blood flow. Intrarenal infusion of PGE2, 0.03 and 0.3 microgram/min, decreased responses to renal nerve stimulation, intra-arterial norepinephrine, and angiotensin. ...

journal_title：Circulation research

authors： Fink GD,Chapnick BM,Goldberg MR,Paustian PW,Kadowitz PJ

更新日期：1977-08-01 00:00:00

abstract：:Elevated plasma levels of plasminogen activator inhibitor type I (PAI-1), a significant risk factor of ischemic heart disease, are associated with insulin resistance in which insulin and transforming growth factor (TGF)-beta play a pivotal role in regulating PAI-1 production. Forkhead transcription factor FOXC2 is an ...

journal_title：Circulation research

authors： Fujita H,Kang M,Eren M,Gleaves LA,Vaughan DE,Kume T

更新日期：2006-03-17 00:00:00

abstract：:Recent advances in cardiac physiology identify the integrin-linked kinase (ILK) as an essential molecule regulating cardiac growth, contractility, and repair. A key transducer of biochemical signals initiated at the plasma membrane by cell-matrix interactions, ILK now emerges as a crucial player in mechanotransduction...

journal_title：Circulation research

authors： Hannigan GE,Coles JG,Dedhar S

更新日期：2007-05-25 00:00:00

abstract：RATIONALE:Post-myocardial infarction ventricular remodeling is associated with the expression of a variety of factors including S100B that can potentially modulate myocyte apoptosis. OBJECTIVE:This study was undertaken to investigate the expression and function of S100B and its receptor, the receptor for advanced glyc...

journal_title：Circulation research

authors： Tsoporis JN,Izhar S,Leong-Poi H,Desjardins JF,Huttunen HJ,Parker TG

更新日期：2010-01-08 00:00:00

abstract：:We have investigated the requirement for c-myc downregulation in the growth arrest of vascular smooth muscle cells (VSMCs). Rat VSMCs were infected with a retrovirus vector directing constitutive expression of either the complete human c-Myc protein (VSM-myc cells) or the c-Myc deletion mutant D106-143, which is inact...

journal_title：Circulation research

authors： Bennett MR,Evan GI,Newby AC

更新日期：1994-03-01 00:00:00

abstract：:Body surface electrocardiograms and electrograms recorded from the surfaces of the heart are the basis for diagnosis and treatment of cardiac electrophysiological disorders and arrhythmias. Given recent advances in understanding the molecular mechanisms of arrhythmia, it is important to relate these electrocardiograph...

journal_title：Circulation research

authors： Gima K,Rudy Y

更新日期：2002-05-03 00:00:00

abstract：:Ventricular repolarization was analyzed by measuring epicardial potential distributions in intact dogs with single or multiple ectopic foci and a minimum at the terminal site(s) of excitation. During the latter half of the T wave the distributions became more complex, and two maxima evolved from the initial one at eac...

journal_title：Circulation research

authors： Spach MS,Barr RC

更新日期：1976-10-01 00:00:00

abstract：:Increasing evidence suggests that endogenous NO inhibits sympathetic outflow in anesthetized animals. However, in a recent study from this laboratory, we were unable to find any evidence of increased renal sympathetic nerve activity (RSNA) in response to blockade of NO synthesis in conscious rabbits. Because angiotens...

journal_title：Circulation research

authors： Liu JL,Murakami H,Zucker IH

更新日期：1998-03-09 00:00:00

abstract：:Whole-cell Ca2+ channel currents were recorded from isolated single canine Purkinje and ventricular cells to determine whether there were multiple types of Ca2+ channels in these two cell types, as in many other excitable tissues. The experimental conditions were such that currents other than Ca2+ channel currents wer...

journal_title：Circulation research

authors： Tseng GN,Boyden PA

更新日期：1989-12-01 00:00:00

abstract：RATIONALE:Carriers of the most common prothrombotic mutations FVL (factor V Leiden) and FII (prothrombin) 20210G>A show a highly variable clinical phenotype. Using standardized in vivo coagulation activation followed by activity pattern analysis we have recently shown, that the FVL mutation accelerates thrombin and APC...

journal_title：Circulation research

authors： Rühl H,Berens C,Winterhagen FI,Reda S,Müller J,Oldenburg J,Pötzsch B

更新日期：2019-08-16 00:00:00

abstract：:We studied the mechanisms underlying the increase in automaticity induced by alpha 1-adrenergic stimulation of normal and "ischemic" canine Purkinje fibers. Fibers were superfused with a control Tyrode's solution, followed by an ischemic superfusate that included 10 mM KCl, 5 mM NaHCO3, Po2 of 10-25 mm Hg, and pH 6.7....

journal_title：Circulation research

authors： Anyukhovsky EP,Rybin VO,Nikashin AV,Budanova OP,Rosen MR

更新日期：1992-09-01 00:00:00

abstract：:Autoregulatory responses to alterations in arterial or venous perfusion pressure were determined for individual arterioles within the rat cremaster muscle. The cremaster muscle of pentobarbital anesthetized rats (50 mg/kg, ip) was surgically exposed and maintained in a controlled tissue bath for visualization by in vi...

journal_title：Circulation research

authors： Morff RJ,Granger HJ

更新日期：1982-07-01 00:00:00

abstract：:We performed morphological studies of myocardial contracture to define its nature and relationship to mechanical changes occurring during metabolic blockade. Isolated rat papillary and trabecular muscles were stretched to the apices of their length-tension curves and stimulated to contract isometrically 12 times a min...

journal_title：Circulation research

authors： Bing OH,Fishbein MC

更新日期：1979-08-01 00:00:00

abstract：RATIONALE:Myocardial ischemia-reperfusion (I/R) results in the generation of oxygen-derived free radicals and the accumulation of lipid peroxidation-derived unsaturated aldehydes. However, the contribution of aldehydes to myocardial I/R injury has not been assessed. OBJECTIVE:We tested the hypothesis that removal of a...

journal_title：Circulation research

authors： Conklin DJ,Guo Y,Jagatheesan G,Kilfoil PJ,Haberzettl P,Hill BG,Baba SP,Guo L,Wetzelberger K,Obal D,Rokosh DG,Prough RA,Prabhu SD,Velayutham M,Zweier JL,Hoetker JD,Riggs DW,Srivastava S,Bolli R,Bhatnagar A

更新日期：2015-08-14 00:00:00

abstract：:Platelet hyperactivity associated with hyperlipidemia may contribute to development of a prothrombotic state. We previously showed that oxidized low-density lipoprotein (oxLDL) formed in the setting of hyperlipidemia and atherosclerosis activated platelets in a CD36-dependent manner. We now show that mitogen-activated...

journal_title：Circulation research

authors： Chen K,Febbraio M,Li W,Silverstein RL

更新日期：2008-06-20 00:00:00

abstract：:The impact of vanadate on the Na,K-ATPase system in the vascular smooth muscle cell is poorly understood. The present study describes the kinetics of the effect of vanadate on Na,K-ATPase and the Na-K pump in in vitro grown rat VSMC's. Vanadate interaction with the Na,K-ATPase system in vascular smooth muscle cells wa...

journal_title：Circulation research

authors： Searle BM,Higashino H,Khalil F,Bogden JD,Tokushige A,Tamura H,Kino M,Aviv A

更新日期：1983-08-01 00:00:00

abstract：RATIONALE:Although PSA (prostate-specific antigen)-a tumor marker for prostate cancer-has been reported to be associated with cardiovascular disease (CVD) risk factors, studies on the association of PSA with subclinical and clinical CVD remain limited. OBJECTIVE:We examined the association of total serum PSA within th...

journal_title：Circulation research

authors： Chang Y,Kim JH,Noh JW,Cho YS,Park HJ,Joo KJ,Ryu S

更新日期：2019-05-10 00:00:00

abstract：:We determined the effects of changing the spatial dispersion of acetylcholine release on the phase-dependent chronotropic responses to vagal stimulation in anesthetized dogs. We stimulated the vagus nerves with one brief burst of electrical pulses each cardiac cycle, and we changed the timing of the stimulus by a smal...

journal_title：Circulation research

authors： Yang TE,Cheng J,Levy MN

更新日期：1990-10-01 00:00:00

abstract：:Propagation in cardiac muscle is faster in the longitudinal than in the transverse axis of the cells. Yet, as a result of the larger upstroke velocity of action potentials propagating transversely, it has been suggested that longitudinal propagation is more vulnerable to block. To study the relation between conduction...

journal_title：Circulation research

authors： Delmar M,Michaels DC,Johnson T,Jalife J

更新日期：1987-05-01 00:00:00

abstract：:In addition to its role in reverse cholesterol transport, high-density lipoprotein (HDL) cholesterol has direct action on numerous cell types that influence cardiovascular and metabolic health. Cellular responses to HDL entail its capacity to invoke cholesterol efflux that causes signal initiation via scavenger recept...

journal_title：Circulation research

authors： Mineo C,Shaul PW

更新日期：2012-09-28 00:00:00

abstract：:In intact porcine aorta, endothelium-derived nitric oxide released on thrombin stimulation inhibits the concomitant production of endothelin. Experiments were designed to examine the effect of hirudin (which inactivates thrombin) and the nitrovasodilators nitroglycerin and 3-morpholinosydnonimine on the spontaneous an...

journal_title：Circulation research

authors： Boulanger CM,Lüscher TF

更新日期：1991-06-01 00:00:00

abstract：RATIONALE:Significant progress has revealed transcriptional inputs that underlie regulation of artery and vein endothelial cell fates. However, little is known concerning genome-wide regulation of this process. Therefore, such studies are warranted to address this gap. OBJECTIVE:To identify and characterize artery- an...

journal_title：Circulation research

authors： Sissaoui S,Yu J,Yan A,Li R,Yukselen O,Kucukural A,Zhu LJ,Lawson ND

更新日期：2020-03-27 00:00:00

abstract：:In vitro and in vivo evidence indicates that hemodynamic wall shear stress evokes a diversity of biological responses in vascular endothelial cells, ranging from cell shape changes to alterations in low density lipoprotein receptor expression. The signal transduction mechanisms by which the level of fluid mechanical s...

journal_title：Circulation research

authors： Prasad AR,Logan SA,Nerem RM,Schwartz CJ,Sprague EA

更新日期：1993-04-01 00:00:00

abstract：:Isovolumic relaxation abnormalities have been noted in the ischemic left ventricle, but altered end-diastolic distensibility, as well as the role of right ventricular distention, is debated. Accordingly, left ventricular end-diastolic pressure and myocardial segment length were studied in the open-chest dogs with crit...

journal_title：Circulation research

authors： Momomura S,Bradley AB,Grossman W

更新日期：1984-08-01 00:00:00

abstract：RATIONALE:Cardiac resynchronization therapy (CRT) is an effective clinical treatment for heart failure patients with conduction delay, impaired contraction, and energetics. Our recent studies have revealed that mitochondrial posttranslational modifications (PTM) may contribute to its benefits, motivating the present st...

journal_title：Circulation research

authors： Wang SB,Foster DB,Rucker J,O'Rourke B,Kass DA,Van Eyk JE

更新日期：2011-09-16 00:00:00

abstract：:Magnesium modulates vascular smooth muscle cell (VSMC) function. However, molecular mechanisms regulating VSMC Mg2+ remain unknown. Using biochemical, pharmacological, and genetic tools, the role of transient receptor potential membrane melastatin 7 (TRPM7) cation channel in VSMC Mg2+ homeostasis was evaluated. Rat, m...

journal_title：Circulation research

authors： He Y,Yao G,Savoia C,Touyz RM

更新日期：2005-02-04 00:00:00

abstract：:The sarcolemmal Na+-Ca2+ exchanger (NCX) is the main Ca2+ extrusion mechanism in cardiac myocytes and is thus essential for the regulation of Ca2+ homeostasis and contractile function. A cytosolic region (f-loop) of the protein mediates regulation of NCX function by intracellular factors including inhibition by exchan...

journal_title：Circulation research

authors： Maack C,Ganesan A,Sidor A,O'Rourke B

更新日期：2005-01-07 00:00:00

abstract：:Whole-cell voltage-clamp experiments were performed on enzymatically dissociated single ventricular myocytes harvested from feline endocardial and epicardial surfaces. The studies were designed to test the hypothesis that the differences in the amplitude of transient outward current (Ito) contribute to the difference ...

journal_title：Circulation research

authors： Furukawa T,Myerburg RJ,Furukawa N,Bassett AL,Kimura S

更新日期：1990-11-01 00:00:00