Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival.

abstract：:Alternans in heart is important as pulsus alternans in cardiac failure and electrophysiological alternans in myocardial ischemia. The explanation of this phenomenon is still unclear. We attempted to investigate the cellular mechanisms of alternans by measuring intracellular free calcium concentration [( Ca2+]i) with t...

journal_title：Circulation research

authors： Lab MJ,Lee JA

更新日期：1990-03-01 00:00:00

abstract：:Fibrinopeptide A (FPA) levels were measured in a group of 130 controls and patients with various types of primary hyperlipidemia to investigate whether an increased steady state level of thrombin activity is present in hyperlipidemic patients. In a subset of 56 subjects, levels of clotting factors II, VII, and X were ...

journal_title：Circulation research

authors： Nossel HL,Smith FR,Seplowitz AH,Dell RB,Sciacca RR,Merskey C,Goodman DS

更新日期：1979-09-01 00:00:00

abstract：RATIONALE:It has been reported that epicardial adipose tissue (EAT) may affect myocardial autonomic function. OBJECTIVE:The aim of this study was to explore the relationship between EAT and cardiac sympathetic nerve activity in patients with heart failure. METHODS AND RESULTS:In 110 patients with systolic heart failu...

journal_title：Circulation research

authors： Parisi V,Rengo G,Perrone-Filardi P,Pagano G,Femminella GD,Paolillo S,Petraglia L,Gambino G,Caruso A,Grimaldi MG,Baldascino F,Nolano M,Elia A,Cannavo A,De Bellis A,Coscioni E,Pellegrino T,Cuocolo A,Ferrara N,Leosco D

更新日期：2016-04-15 00:00:00

abstract：:Ischemia/reperfusion (I/R) affects the integrity of the endoplasmic reticulum (ER), the site of synthesis and folding of numerous proteins. Therefore, I/R may activate the unfolded protein response (UPR), resulting in the induction of a collection of ER stress proteins, many of which are protective and function to res...

journal_title：Circulation research

authors： Martindale JJ,Fernandez R,Thuerauf D,Whittaker R,Gude N,Sussman MA,Glembotski CC

更新日期：2006-05-12 00:00:00

abstract：:Inflammatory processes underlie a broad spectrum of conditions that injure the heart muscle and cause both structural and functional deficits. In this article, we address current knowledge regarding 4 common forms of myocardial inflammation: myocardial ischemia and reperfusion, sepsis, viral myocarditis, and immune re...

journal_title：Circulation research

authors： Marchant DJ,Boyd JH,Lin DC,Granville DJ,Garmaroudi FS,McManus BM

更新日期：2012-01-06 00:00:00

abstract：:Existing evidence led us to hypothesize that increases in p85alpha, a regulatory subunit of PI3-kinase, in presympathetic brain areas contribute to hypertension. PI3-kinase p85alpha, p110alpha, and p110delta mRNA was 1.5- to 2-fold higher in the paraventricular nucleus (PVN) of spontaneously hypertensive rats (SHR) co...

journal_title：Circulation research

authors： Veerasingham SJ,Yamazato M,Berecek KH,Wyss JM,Raizada MK

更新日期：2005-02-18 00:00:00

abstract：:We have shown previously that tyrosine 319 in a conserved YIPP motif in the C terminus of angiotensin II (Ang II) type 1 receptors (AT(1)Rs) is essential for transactivation of epidermal growth factor receptor (EGFR) in vitro. We hypothesized that the signaling mechanism mediated through the specific amino acid sequen...

journal_title：Circulation research

authors： Zhai P,Galeotti J,Liu J,Holle E,Yu X,Wagner T,Sadoshima J

更新日期：2006-09-01 00:00:00

abstract：:Ventricular repolarization was analyzed by measuring epicardial potential distributions in intact dogs with single or multiple ectopic foci and a minimum at the terminal site(s) of excitation. During the latter half of the T wave the distributions became more complex, and two maxima evolved from the initial one at eac...

journal_title：Circulation research

authors： Spach MS,Barr RC

更新日期：1976-10-01 00:00:00

abstract：:CD40 is a 48-kDa phosphorylated transmembrane glycoprotein belonging to the TNF receptor superfamily. CD40 has been demonstrated on a range of cell types, and it has an important role in adaptive immunity and inflammation. CD40 has recently been described on platelets but platelet activation by CD40 has not been descr...

journal_title：Circulation research

authors： Inwald DP,McDowall A,Peters MJ,Callard RE,Klein NJ

更新日期：2003-05-16 00:00:00

abstract：:To investigate the effect of lactate, pyruvate, and glucose on the endogenous levels of lipids in the normoxic, ischemic, and reperfused myocardium, isolated working rat hearts were exposed to various grades of ischemic insult (15, 30, or 45 minutes). Glucose was present as the basal substrate in the perfusion medium,...

journal_title：Circulation research

authors： de Groot MJ,Coumans WA,Willemsen PH,van der Vusse GJ

更新日期：1993-01-01 00:00:00

abstract：RATIONALE:Mechanical stress plays an important role in proliferation of venous smooth muscle cells (SMCs) in neointima, a process of formation that contributes to failure of vein grafts. However, it is unknown what intracellular growth signal leads to proliferation of venous SMCs. OBJECTIVE:The objective of this study...

journal_title：Circulation research

authors： Cheng J,Wang Y,Ma Y,Chan BT,Yang M,Liang A,Zhang L,Li H,Du J

更新日期：2010-11-12 00:00:00

abstract：:We determined the extent of convergence of preganglionic fibers from the right and left vagus nerves on postganglionic neurons that supply the sinoatrial node in chloralose-anesthetized dogs. We administered hemicholinium-3 and stimulated the right vagus nerve at a high frequency to deplete acetylcholine from the post...

journal_title：Circulation research

authors： Lang SA,Zieske H,Levy MN

更新日期：1990-09-01 00:00:00

abstract：:Electrical responses induced by perivasascular nerve stimulation were recorded intracellularly from the smooth muscle of dog middle cerebral artery. With nerve stimulation, the muscle membrane produced excitatory junction potential and then a slow hyperpolarization. The excitatory junction potential showed facilitatio...

journal_title：Circulation research

authors： Suzuki H,Fujiwara S

更新日期：1982-12-01 00:00:00

abstract：:The aims of the current study were to examine the efficacy of acetylcholine (ACh) to mimic ischemic preconditioning in dogs and to determine the role of nitric oxide (NO), muscarinic receptors, and ATP-sensitive K+ (KATP) channels in mediating its effects. Barbital-anesthetized open-chest dogs were subjected to 60 min...

journal_title：Circulation research

authors： Yao Z,Gross GJ

更新日期：1993-12-01 00:00:00

abstract：:In response to hypoxia and reoxygenation, mammalian cells are known to express a variety of genes to adapt to these external stresses or lead to further cell damage. We investigated the intracellular signaling cascades in cultured rat cardiac myocytes subjected to hypoxia followed by reoxygenation (hypoxia/reoxygenati...

journal_title：Circulation research

authors： Seko Y,Tobe K,Ueki K,Kadowaki T,Yazaki Y

更新日期：1996-01-01 00:00:00

abstract：RATIONALE:Chronic inflammation in the myocardium is involved in the development of left ventricular (LV) remodeling and failure after myocardial infarction (MI). Invariant natural killer T (iNKT) cells have been shown to produce inflammatory cytokines and orchestrate tissue inflammation. However, no previous studies ha...

journal_title：Circulation research

authors： Sobirin MA,Kinugawa S,Takahashi M,Fukushima A,Homma T,Ono T,Hirabayashi K,Suga T,Azalia P,Takada S,Taniguchi M,Nakayama T,Ishimori N,Iwabuchi K,Tsutsui H

更新日期：2012-09-28 00:00:00

abstract：:Notch signaling is critically important for proper architecture of the vascular system, and mutations in NOTCH3 are associated with CADASIL, a stroke and dementia syndrome with vascular smooth muscle cell (VSMC) dysfunction. In this report, we link Notch signaling to platelet-derived growth factor (PDGF) signaling, a ...

journal_title：Circulation research

authors： Jin S,Hansson EM,Tikka S,Lanner F,Sahlgren C,Farnebo F,Baumann M,Kalimo H,Lendahl U

更新日期：2008-06-20 00:00:00

abstract：:We have recently demonstrated that endogenous erythropoietin (Epo)/Epo receptor (EpoR) system plays an important protective role in hypoxia-induced pulmonary hypertension. However, it remains to be examined whether vascular EpoR system contributes to angiogenesis in response to ischemia. We examined angiogenesis in Ep...

journal_title：Circulation research

authors： Nakano M,Satoh K,Fukumoto Y,Ito Y,Kagaya Y,Ishii N,Sugamura K,Shimokawa H

更新日期：2007-03-16 00:00:00

abstract：RATIONALE:The mutation A341V in the S6 transmembrane segment of KCNQ1, the α-subunit of the slowly activating delayed-rectifier K(+) (I(Ks)) channel, predisposes to a severe long-QT1 syndrome with sympathetic-triggered ventricular tachyarrhythmias and sudden cardiac death. OBJECTIVE:Several genetic risk modifiers have...

journal_title：Circulation research

authors： Heijman J,Spätjens RL,Seyen SR,Lentink V,Kuijpers HJ,Boulet IR,de Windt LJ,David M,Volders PG

更新日期：2012-01-20 00:00:00

abstract：:A plasma membrane preparation purified from guinea pig ventricles without the use of high concentrations of detergents or structure-disrupting salts was used to compare the mechanisms of controlling sodium, potassium-activated adenosinetriphosphatase (Na, K-ATPase) and adenylate cyclase activities. The basal ATPase ac...

journal_title：Circulation research

authors： Tada M,Kirchberger MA,Iorio JM,Katz AM

更新日期：1975-01-01 00:00:00

abstract：:It has been postulated that cardiopulmonary baroreceptor unloading in humans results in nonuniform activation of the sympathetic nervous system. We reasoned that simultaneous measurements of arterial and venous norepinephrine (NE) spillover and clearance (using NE kinetics), muscle sympathetic neural activity (using m...

journal_title：Circulation research

authors： Baily RG,Prophet SA,Shenberger JS,Zelis R,Sinoway LI

更新日期：1990-06-01 00:00:00

abstract：:Patients with severe heart failure are at high risk of sudden cardiac death. In the majority of these patients, sudden cardiac death is thought to be due to ventricular tachyarrhythmias. Alterations of the electric properties of single myocytes in heart failure may favor the occurrence of ventricular arrhythmias in th...

journal_title：Circulation research

authors： Priebe L,Beuckelmann DJ

更新日期：1998-06-15 00:00:00

abstract：:Twenty-one dogs were studied under conditions of normal oxygenation and hypoxia with the microsphere distribution method to determine the effect of arterial oxygen saturation on the regional distribution of cardiac output. The dogs were anesthetized and artifically ventilated. Cannulas were placed in the left ventricl...

journal_title：Circulation research

authors： Adachi H,Strauss W,Ochi H,Wagner HN Jr

更新日期：1976-09-01 00:00:00

abstract：:The daily rate of cell replication in the aortic endothelium of the normal rat falls from a maximum of 13% at birth to 0.1-0.3% at age 5-6 months. This residual rate of replication largely represents the turnover rate of the endothelium in normal animals. After renal hypertension of 2-3 weeks duration, however, the ra...

journal_title：Circulation research

authors： Schwartz SM,Benditt EP

更新日期：1977-08-01 00:00:00

abstract：:Cation channels activated by Ca(2+) store depletion have been proposed to mediate Ca(2+) influx in vascular smooth muscle cells. The aim of this study was to determine if store-operated channels have a functional role in pulmonary artery smooth muscle cells (PASMCs). In intact rat pulmonary artery rings, cyclopiazonic...

journal_title：Circulation research

authors： Ng LC,Gurney AM

更新日期：2001-11-09 00:00:00

abstract：RATIONALE:Cardiac myocyte-specific deletion of either glycogen synthase kinase (GSK)-3α and GSK-3β leads to cardiac protection after myocardial infarction, suggesting that deletion of both isoforms may provide synergistic protection. This is an important consideration because of the fact that all GSK-3-targeted drugs, ...

journal_title：Circulation research

authors： Zhou J,Ahmad F,Parikh S,Hoffman NE,Rajan S,Verma VK,Song J,Yuan A,Shanmughapriya S,Guo Y,Gao E,Koch W,Woodgett JR,Madesh M,Kishore R,Lal H,Force T

更新日期：2016-04-15 00:00:00

abstract：:A specific difference-spectrophotometric method was used to measure nitric oxide (NO) release into the coronary effluent perfusate of isolated, constant-flow-perfused guinea pig hearts. Authentic NO applied into the coronary circulation decreased vascular resistance dose dependently and enhanced coronary release of cy...

journal_title：Circulation research

authors： Kelm M,Schrader J

更新日期：1990-06-01 00:00:00

abstract：:The objectives of this study were to measure action potential parameters in enzyme-dissociated, adult rat ventricular myocytes stimulated at 1 Hz, to compare these measurements with those obtained from intact ventricular tissue, and to determine myocyte and tissue responses at stimulus frequencies between 0.1 and 5 Hz...

journal_title：Circulation research

authors： Watanabe T,Delbridge LM,Bustamante JO,McDonald TF

更新日期：1983-03-01 00:00:00

abstract：RATIONALE:Long noncoding RNAs (lncRNAs) constitute a novel class of noncoding RNAs that regulate gene expression. Although recent data suggest that lncRNAs may be associated with cardiac disease, little is known about lncRNAs in the setting of myocardial ischemia. OBJECTIVE:To measure lncRNAs in patients with myocardi...

journal_title：Circulation research

authors： Vausort M,Wagner DR,Devaux Y

更新日期：2014-09-12 00:00:00

abstract：:The responses of cardiac mitochondria to anoxia may be evaluated in terms of the oxidation-reduction state of the electron carriers and the ability of the mitochondria to function in energy-linked reactions. The previous detailed evaluation of the oxygen requirements for electron transfer in mitochondria is here exten...

journal_title：Circulation research

authors： Chance B

更新日期：1976-05-01 00:00:00