Activation of natural killer T cells ameliorates postinfarct cardiac remodeling and failure in mice.

abstract：:During cardiac development, the epicardium is the source of multipotent mesenchymal cells, which give rise to endothelial and smooth muscle cells in coronary vessels and also, possibly, to cardiomyocytes. The aim of the present study was to determine whether stem cells are retained in the adult human and murine epicar...

journal_title：Circulation research

authors： Limana F,Zacheo A,Mocini D,Mangoni A,Borsellino G,Diamantini A,De Mori R,Battistini L,Vigna E,Santini M,Loiaconi V,Pompilio G,Germani A,Capogrossi MC

更新日期：2007-12-07 00:00:00

abstract：:The aging population is increasing in developed countries. Because the incidence of cardiac disease increases dramatically with age, it is important to understand the molecular mechanisms through which the heart becomes either more or less susceptible to stress. Cardiac aging is characterized by the presence of hypert...

journal_title：Circulation research

authors： Shirakabe A,Ikeda Y,Sciarretta S,Zablocki DK,Sadoshima J

更新日期：2016-05-13 00:00:00

abstract：RATIONALE:Studies have demonstrated that exosomes can repair cardiac tissue post-myocardial infarction and recapitulate the benefits of cellular therapy. OBJECTIVE:We evaluated the role of donor age and hypoxia of human pediatric cardiac progenitor cell (CPC)-derived exosomes in a rat model of ischemia-reperfusion inj...

journal_title：Circulation research

authors： Agarwal U,George A,Bhutani S,Ghosh-Choudhary S,Maxwell JT,Brown ME,Mehta Y,Platt MO,Liang Y,Sahoo S,Davis ME

更新日期：2017-02-17 00:00:00

abstract：:Troponin is essential for the regulation of cardiac contraction. Troponin is a sarcomeric molecular switch, directly regulating the contractile event in concert with intracellular calcium signals. Troponin isoform switching, missense mutations, proteolytic cleavage, and posttranslational modifications are known to dir...

journal_title：Circulation research

authors： Metzger JM,Westfall MV

更新日期：2004-02-06 00:00:00

abstract：:We determined whether local bradykinin production modulates cardiac adrenergic activity. Depolarization of guinea pig heart sympathetic nerve endings (synaptosomes) with 1 to 100 mmol/L K+ caused the release of endogenous norepinephrine (10% to 50% above basal level). This release was exocytotic, because it depended o...

journal_title：Circulation research

authors： Seyedi N,Win T,Lander HM,Levi R

更新日期：1997-11-01 00:00:00

abstract：RATIONALE:The ventricular conduction system (VCS) rapidly propagates electrical impulses through the working myocardium of the ventricles to coordinate chamber contraction. GWAS (Genome-wide association studies) have associated nucleotide polymorphisms, most are located within regulatory intergenic or intronic sequence...

journal_title：Circulation research

authors： Vincentz JW,Firulli BA,Toolan KP,Arking DE,Sotoodehnia N,Wan J,Chen PS,de Gier-de Vries C,Christoffels VM,Rubart-von der Lohe M,Firulli AB

更新日期：2019-08-30 00:00:00

abstract：:Three different isoforms of the inhibitory guanine nucleotide-binding protein alpha-subunit (Gi alpha) have been cloned. However, little information on the cardiac-specific expression of these isoforms is available. The deduced amino acid sequence of a full-length Gi alpha 2 complementary DNA from a canine ventricular...

journal_title：Circulation research

authors： Holmer SR,Stevens S,Homcy CJ

更新日期：1989-10-01 00:00:00

abstract：:We developed a mouse myocardial preparation to study cellular dysfunction in acute coxsackievirus myocarditis. Thin right ventricular papillary muscles from normal mice (n = 8) were compared with muscles from mice 7 days after coxsackievirus infection (n = 7). Sarcomere shortening was studied with laser diffraction (H...

journal_title：Circulation research

authors： Hamrell BB,Huber SA,Leslie KO

更新日期：1994-09-01 00:00:00

abstract：:Fetal ventricular performance has been considered limited because ventricular output does not increase with rapid volume expansion above mean left atrial pressures (mLAPs) of 5-7 mm Hg. To explore relations between preload, afterload, and stroke volume (SV) in the fetal left ventricle, we instrumented 126-129 days ges...

journal_title：Circulation research

authors： Hawkins J,Van Hare GF,Schmidt KG,Rudolph AM

更新日期：1989-07-01 00:00:00

abstract：:Mitochondria are an important source of reactive oxygen species (ROS), implicated in ischemia/reperfusion injury. When isolated from ischemic myocardium, mitochondria demonstrate increased ROS production as a result of damage to electron transport complexes. To investigate the mechanisms, we studied effects of hypoxia...

journal_title：Circulation research

authors： Korge P,Ping P,Weiss JN

更新日期：2008-10-10 00:00:00

abstract：RATIONALE:We have recently shown that the bone morphogenetic protein (BMP) antagonist Gremlin 2 (Grem2) is required for early cardiac development and cardiomyocyte differentiation. Our initial studies discovered that Grem2 is strongly induced in the adult heart after experimental myocardial infarction (MI). However, th...

journal_title：Circulation research

authors： Sanders LN,Schoenhard JA,Saleh MA,Mukherjee A,Ryzhov S,McMaster WG Jr,Nolan K,Gumina RJ,Thompson TB,Magnuson MA,Harrison DG,Hatzopoulos AK

更新日期：2016-07-22 00:00:00

abstract：:In isolated right atria of the rabbit heart, we studied the activation pattern within the sinus node, using the microelectrode technique. After the electrophysiological experiments, the preparations were subjected to a correlative morphological investigation, using light or electron microscopy. Different criteria for ...

journal_title：Circulation research

authors： Bleeker WK,Mackaay AJ,Masson-Pévet M,Bouman LN,Becker AE

更新日期：1980-01-01 00:00:00

abstract：:Platelet hyperactivity associated with hyperlipidemia may contribute to development of a prothrombotic state. We previously showed that oxidized low-density lipoprotein (oxLDL) formed in the setting of hyperlipidemia and atherosclerosis activated platelets in a CD36-dependent manner. We now show that mitogen-activated...

journal_title：Circulation research

authors： Chen K,Febbraio M,Li W,Silverstein RL

更新日期：2008-06-20 00:00:00

abstract：:To see how serotonin affects filtration from lung vessels, we measured vascular pressures, lung lymph flow, lung lymph and blood plasma protein concentrations, arterial blood gases, cardiac output, and lung water content in unanesthetized sheep before and during intravenous serotonin infusions and compared serotonin e...

journal_title：Circulation research

authors： Brigham KL,Owen PJ

更新日期：1975-06-01 00:00:00

abstract：RATIONALE:Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor-β super family of secreted factors. A recent study showed that reduced GDF11 blood levels with aging was associated with pathological cardiac hypertrophy (PCH) and restoring GDF11 to normal levels in old mice rescued PCH. ...

journal_title：Circulation research

authors： Smith SC,Zhang X,Zhang X,Gross P,Starosta T,Mohsin S,Franti M,Gupta P,Hayes D,Myzithras M,Kahn J,Tanner J,Weldon SM,Khalil A,Guo X,Sabri A,Chen X,MacDonnell S,Houser SR

更新日期：2015-11-06 00:00:00

abstract：:Matrix metalloproteinases (MMPs) include most major constituents of the arterial wall as substrates. A common promotor polymorphism (5A/6A) is associated with differences in MMP-3 (stromelysin-1) activity, and associations with certain forms of vascular disease have been shown. This study investigated whether the MMP-...

journal_title：Circulation research

authors： Medley TL,Kingwell BA,Gatzka CD,Pillay P,Cole TJ

更新日期：2003-06-13 00:00:00

abstract：:The red cell membrane is a permeability barrier that limits the equilibration of a variety of solutes between red cell and plasma water. We utilized the multiple indicator dilution technique to investigate the effect of this barrier on the exchange in the liver of a group of tracer substances that are not removed in n...

journal_title：Circulation research

authors： Goresky CA,Bach GG,Nadeau BE

更新日期：1975-02-01 00:00:00

abstract：:The localization patterns of human plasma lipoproteins and their respective apoproteins and of neutral lipid were determined in normal and atherosclerotic arteries. Specific antisera were prepared against plasma low-density lipoproteins(LDL) and their apoproteins (apoB), high-density lipoproteins(HDL) and one of their...

journal_title：Circulation research

authors： Hoff HF,Heideman CL,Jackson RL,Bayardo RJ,Kim HS,Gotto AM Jr

更新日期：1975-07-01 00:00:00

abstract：:Mammalian cardiomyocytes irreversibly lose their capacity to proliferate soon after birth, yet the underlying mechanisms have been unclear. Cyclin D1 and its partner, cyclin-dependent kinase 4 (CDK4), are important for promoting the G1-to-S phase progression via phosphorylation of the retinoblastoma (Rb) protein. Mito...

journal_title：Circulation research

authors： Tamamori-Adachi M,Ito H,Sumrejkanchanakij P,Adachi S,Hiroe M,Shimizu M,Kawauchi J,Sunamori M,Marumo F,Kitajima S,Ikeda MA

更新日期：2003-01-10 00:00:00

abstract：:The cardiac high molecular weight proteins/ryanodine receptors were purified to homogeneity from junctional sarcoplasmic reticulum membranes and shown to exhibit large conductance calcium channel activity. High molecular weight proteins were solubilized from junctional sarcoplasmic reticulum in zwitterionic detergent ...

journal_title：Circulation research

authors： Rardon DP,Cefali DC,Mitchell RD,Seiler SM,Jones LR

更新日期：1989-04-01 00:00:00

abstract：:Cultured quail myocytes were much more resistant to H2O2 toxicity than cultured mouse myocytes. The intracellular concentration of glutathione ([GSH]i) and the activity of gamma-glutamylcysteine synthetase (gamma-GCS) in quail heart cells were about five and three times higher, respectively, than in mouse heart cells,...

journal_title：Circulation research

authors： Nakamura TY,Yamamoto I,Kanno Y,Shiba Y,Goshima K

更新日期：1994-05-01 00:00:00

abstract：:Mitochondria play a key role in determining cell fate during exposure to stress. Their role during ischemia/reperfusion is particularly critical because of the conditions that promote both apoptosis by the mitochondrial pathway and necrosis by irreversible damage to mitochondria in association with mitochondrial perme...

journal_title：Circulation research

authors： Weiss JN,Korge P,Honda HM,Ping P

更新日期：2003-08-22 00:00:00

abstract：:The present study was undertaken to determine the mechanism of neointima formation in rabbit arteries subjected to extensive endothelial desquamation. Endothelial cells were selectively removed from the abdominal aorta by passing an inflated balloon catheter through the vessel. The healing response was then studied se...

journal_title：Circulation research

authors： Spaet TH,Stemerman MB,Veith FJ,Lejnieks I

更新日期：1975-01-01 00:00:00

abstract：:We have previously demonstrated pressure-dependent membrane depolarization and action potential generation in cat cerebral arteries. It was the purpose of this study to examine and compare the membrane electrical responses to increasing transmural pressure in spontaneously hypertensive rats with those of their normote...

journal_title：Circulation research

authors： Harder DR,Smeda J,Lombard J

更新日期：1985-08-01 00:00:00

abstract：:Lipid rafts are discrete membrane subdomains rich in sphingolipids and cholesterol. In ventricular myocytes a function of caveolae, a type of lipid rafts, is to concentrate in close proximity several proteins of the beta-adrenergic transduction pathway. We have investigated the subcellular localization of HCN4 channel...

journal_title：Circulation research

authors： Barbuti A,Gravante B,Riolfo M,Milanesi R,Terragni B,DiFrancesco D

更新日期：2004-05-28 00:00:00

abstract：:Fibrinopeptide A (FPA) levels were measured in a group of 130 controls and patients with various types of primary hyperlipidemia to investigate whether an increased steady state level of thrombin activity is present in hyperlipidemic patients. In a subset of 56 subjects, levels of clotting factors II, VII, and X were ...

journal_title：Circulation research

authors： Nossel HL,Smith FR,Seplowitz AH,Dell RB,Sciacca RR,Merskey C,Goodman DS

更新日期：1979-09-01 00:00:00

abstract：:To determine whether coronary vasodilator reserve that persists during myocardial ischemia is present in all left ventricular regions, we measured regional blood flow in 192 left ventricular pieces (mean weight, 201 mg) in each of eight dogs by using radioactive microspheres while perfusing the left main coronary arte...

journal_title：Circulation research

authors： Coggins DL,Flynn AE,Austin RE Jr,Aldea GS,Muehrcke D,Goto M,Hoffman JI

更新日期：1990-08-01 00:00:00

abstract：:-ATP-sensitive potassium (K(ATP)) channels were discovered in ventricular cells, but their roles in the heart remain mysterious. K(ATP) channels have also been found in numerous other tissues, including vascular smooth muscle. Two pore-forming subunits, Kir6.1 and Kir6.2, contribute to the diversity of K(ATP) channels...

journal_title：Circulation research

authors： Suzuki M,Li RA,Miki T,Uemura H,Sakamoto N,Ohmoto-Sekine Y,Tamagawa M,Ogura T,Seino S,Marbán E,Nakaya H

更新日期：2001-03-30 00:00:00

abstract：:The relationship of P-wave polarity and morphology in leads II, III, and aVF to the sequence of atrial activation was studied in the canine heart when the atria were paced from the region of the sinus node or the posterior-inferior left atrium and when retrograde activation of the atria occurred with right ventricular...

journal_title：Circulation research

authors： Waldo AL,Vitikainen KJ,Hoffman BF

更新日期：1975-08-01 00:00:00

abstract：:Muscle ring finger (MuRF) proteins have been implicated in transmitting mechanical forces to cell signaling pathways through their interactions with the giant protein titin. Recent evidence has linked mechanically-induced stimuli with the control of serum response factor activity and localization through MuRF2. This o...

journal_title：Circulation research

authors： Willis MS,Ike C,Li L,Wang DZ,Glass DJ,Patterson C

更新日期：2007-03-02 00:00:00