The art of microRNA research.

abstract：:Atherosclerosis is considered to be an inflammatory disease. Tissue factor (TF), a prothrombotic molecule expressed by various cell types within atherosclerotic plaques, is thought to play an essential role in thrombus formation after atherosclerotic plaque rupture. Recent studies suggest that the antiinflammatory cyt...

journal_title：Circulation research

authors： Kamimura M,Viedt C,Dalpke A,Rosenfeld ME,Mackman N,Cohen DM,Blessing E,Preusch M,Weber CM,Kreuzer J,Katus HA,Bea F

更新日期：2005-08-19 00:00:00

abstract：:Increasing evidence indicates that the control of cell proliferation and apoptosis are linked. The c-myc proto-oncogene is induced early after cell-cycle entry in vascular smooth muscle cells (VSMCs) in vitro and after arterial injury and regulates both cell proliferation and apoptosis. Although both proliferation and...

journal_title：Circulation research

authors： Macdonald K,Bennett MR

更新日期：1999-04-16 00:00:00

abstract：:During myocardial ischemia, electrical uncoupling and contracture herald irreversible damage. In the present study, we tested the hypothesis that an increase of intracellular Ca2+ is an important factor initiating these events. Therefore, we simultaneously determined tissue resistance, mechanical activity, pH(0), and ...

journal_title：Circulation research

authors： Dekker LR,Fiolet JW,VanBavel E,Coronel R,Opthof T,Spaan JA,Janse MJ

更新日期：1996-08-01 00:00:00

abstract：RATIONALE:Inhibition of glycogen synthase kinase-3 (GSK-3) protects the heart during ischemia/reperfusion (I/R), yet the underlying mechanisms of cardioprotection afforded by beta isoform-specific inhibition GSK-3 remain to be elucidated. OBJECTIVE:We studied the molecular mechanism mediating the effect of GSK-3β acti...

journal_title：Circulation research

authors： Zhai P,Sciarretta S,Galeotti J,Volpe M,Sadoshima J

更新日期：2011-08-19 00:00:00

abstract：:alpha-Adrenergic stimulation (alpha-AS) and beta-adrenergic stimulation (beta-AS) of the myocardium are associated respectively with an increase and a decrease in myofilament responsiveness to Ca2+. We hypothesized that changes in cytosolic pH (pH(i)) may modulate these opposite actions of alpha-AS and beta-AS. The ef...

journal_title：Circulation research

authors： Gambassi G,Spurgeon HA,Lakatta EG,Blank PS,Capogrossi MC

更新日期：1992-10-01 00:00:00

abstract：RATIONALE:The ventricular conduction system (VCS) rapidly propagates electrical impulses through the working myocardium of the ventricles to coordinate chamber contraction. GWAS (Genome-wide association studies) have associated nucleotide polymorphisms, most are located within regulatory intergenic or intronic sequence...

journal_title：Circulation research

authors： Vincentz JW,Firulli BA,Toolan KP,Arking DE,Sotoodehnia N,Wan J,Chen PS,de Gier-de Vries C,Christoffels VM,Rubart-von der Lohe M,Firulli AB

更新日期：2019-08-30 00:00:00

abstract：RATIONALE:We previously reported that vascular endothelial growth factor (VEGF)-induced binding of VEGF receptor 2 (VEGFR2) to epsins 1 and 2 triggers VEGFR2 degradation and attenuates VEGF signaling. The epsin ubiquitin interacting motif (UIM) was shown to be required for the interaction with VEGFR2. However, the mole...

journal_title：Circulation research

authors： Rahman HNA,Wu H,Dong Y,Pasula S,Wen A,Sun Y,Brophy ML,Tessneer KL,Cai X,McManus J,Chang B,Kwak S,Rahman NS,Xu W,Fernandes C,Mcdaniel JM,Xia L,Smith L,Srinivasan RS,Chen H

更新日期：2016-03-18 00:00:00

abstract：:We have measured the apparent Ca2+ sensitivities of force development in skinned cardiac trabeculae at different sarcome lengths together with shifts in troponin (Tn) T subunits on specimens from the same hearts and drawn insights into the pathogenesis of myocardial dysfunction in the diabetic rat. The Ca(2+)-force re...

journal_title：Circulation research

authors： Akella AB,Ding XL,Cheng R,Gulati J

更新日期：1995-04-01 00:00:00

abstract：:We tested the hypothesis that accumulation of H+ or inorganic phosphate (Pi) is responsible for the early contractile failure of hypoxia by measuring maximal Ca2+-activated pressure and 31P nuclear magnetic resonance spectra in Langendorff-perfused ferret hearts at 30 degrees C. Maximal Ca2+-activated pressure was ide...

journal_title：Circulation research

authors： Kusuoka H,Weisfeldt ML,Zweier JL,Jacobus WE,Marban E

更新日期：1986-09-01 00:00:00

abstract：:Fetal ventricular performance has been considered limited because ventricular output does not increase with rapid volume expansion above mean left atrial pressures (mLAPs) of 5-7 mm Hg. To explore relations between preload, afterload, and stroke volume (SV) in the fetal left ventricle, we instrumented 126-129 days ges...

journal_title：Circulation research

authors： Hawkins J,Van Hare GF,Schmidt KG,Rudolph AM

更新日期：1989-07-01 00:00:00

abstract：:Tropomyosin (TM) is an integral component of the thin filament in muscle fibers and is involved in regulating actin-myosin interactions. TM is encoded by a family of four alternatively spliced genes that display highly conserved nucleotide and amino acid sequences. To assess the functional and developmental significan...

journal_title：Circulation research

authors： Rethinasamy P,Muthuchamy M,Hewett T,Boivin G,Wolska BM,Evans C,Solaro RJ,Wieczorek DF

更新日期：1998-01-09 00:00:00

abstract：:The hypothesis that alpha-adrenergic coronary vasoconstriction helps maintain a uniform transmural distribution of myocardial blood flow during exercise was tested in dogs. Carotid artery loops were surgically constructed and a splenectomy performed three weeks prior to study. On the day of study, the dog was anesthet...

journal_title：Circulation research

authors： Huang AH,Feigl EO

更新日期：1988-02-01 00:00:00

abstract：:Accumulation of plasminogen activator inhibitor type 1 (PAI-1) in the arterial wall may accelerate atherogenesis by inhibiting fibrinolysis, diminishing proteolysis of extracellular matrix proteins, or modifying migration of vascular smooth muscle cells. Increased intramural expression of the PAI-1 gene is induced by ...

journal_title：Circulation research

authors： Sawa H,Sobel BE,Fujii S

更新日期：1993-10-01 00:00:00

abstract：:This study investigated the possible roles of strongly binding myosin crossbridges in determining loaded shortening and power output in cardiac myocytes. Single skinned cardiac myocytes were attached between a force transducer and position motor, and shortening velocities were measured over a range of loads during var...

journal_title：Circulation research

authors： McDonald KS,Moss RL

更新日期：2000-10-27 00:00:00

abstract：:Mammalian cardiomyocytes irreversibly lose their capacity to proliferate soon after birth, yet the underlying mechanisms have been unclear. Cyclin D1 and its partner, cyclin-dependent kinase 4 (CDK4), are important for promoting the G1-to-S phase progression via phosphorylation of the retinoblastoma (Rb) protein. Mito...

journal_title：Circulation research

authors： Tamamori-Adachi M,Ito H,Sumrejkanchanakij P,Adachi S,Hiroe M,Shimizu M,Kawauchi J,Sunamori M,Marumo F,Kitajima S,Ikeda MA

更新日期：2003-01-10 00:00:00

abstract：:Recent studies have demonstrated that vascular smooth muscle cells are responsive to changes in their local hemodynamic environment. The effects of shear stress on the expression of human protease activated receptor-1 (PAR-1) and tissue plasminogen activator (tPA) mRNA and protein were investigated in human aortic smo...

journal_title：Circulation research

authors： Papadaki M,Ruef J,Nguyen KT,Li F,Patterson C,Eskin SG,McIntire LV,Runge MS

更新日期：1998-11-16 00:00:00

abstract：:Endothelins exert potent excitatory cardiac effects by acting on specific receptors on myocytes. In this study, we have examined the signal transduction mechanism for the chronotropic effect of endothelins in guinea pig atria. A competition binding of [125I]endothelin 1 ([125I]ET-1) using the recently developed ETA re...

journal_title：Circulation research

authors： Ono K,Eto K,Sakamoto A,Masaki T,Shibata K,Sada T,Hashimoto K,Tsujimoto G

更新日期：1995-02-01 00:00:00

abstract：:The present series of experiments used gas chromatography to identify vapor-phase photoproducts liberated during excimer laser irradiation of cardiovascular tissues in air and blood. In air, laser beams produced from ArF (193 nm) and XeF (351 nm) excimer laser gas mixtures were delivered to samples of myocardium and a...

journal_title：Circulation research

authors： Clarke RH,Isner JM,Donaldson RF,Jones G 2nd

更新日期：1987-03-01 00:00:00

abstract：:This study was performed to examine, first, the protective effects and responses of collateral vessels of the hind limb in normal and atherosclerotic monkeys and, second, the effects of chronic arterial occlusion on the development of atherosclerosis. The iliac artery was ligated on one side in cynomolgus monkeys. Six...

journal_title：Circulation research

authors： Lopez JA,Armstrong ML,Harrison DG,Piegors DJ,Heistad DD

更新日期：1988-12-01 00:00:00

abstract：:Reductions in fluid shear stress produce endothelium-dependent vasoconstriction and promote neointimal hyperplasia, but the intracellular signaling mechanisms involved in these processes are poorly understood. To examine whether decreases in fluid shear stress affect endothelial cytosolic pH, carboxy-seminaphthorhodaf...

journal_title：Circulation research

authors： Ziegelstein RC,Blank PS,Cheng L,Capogrossi MC

更新日期：1998-04-20 00:00:00

abstract：:Electrical field stimulation (EFS) of phenylephrine-contracted bovine mesenteric arteries pretreated with guanethidine elicited a relaxation that amounted to roughly 40%. This relaxation was sensitive to tetrodotoxin pretreatment, suggesting a neurogenic origin. The EFS-induced relaxation was correlated to an increase...

journal_title：Circulation research

authors： Ahlner J,Ljusegren ME,Grundström N,Axelsson KL

更新日期：1991-03-01 00:00:00

abstract：:Recent studies from our laboratory involving syncytial preparations have delineated electrophysiological distinctions between epicardium, endocardium, and a unique population of cells in the deep subepicardial to midmyocardial layers (M region) of the canine ventricle. In the present study, we used standard microelect...

journal_title：Circulation research

authors： Liu DW,Gintant GA,Antzelevitch C

更新日期：1993-03-01 00:00:00

abstract：:Vascular calcification is a common finding in atherosclerosis and a serious problem in diabetic and uremic patients. Because of the correlation of hyperphosphatemia and vascular calcification, the ability of extracellular inorganic phosphate levels to regulate human aortic smooth muscle cell (HSMC) culture mineralizat...

journal_title：Circulation research

authors： Jono S,McKee MD,Murry CE,Shioi A,Nishizawa Y,Mori K,Morii H,Giachelli CM

更新日期：2000-09-29 00:00:00

abstract：RATIONALE:Voltage-gated sodium channels initiate action potentials in excitable tissues. Mice in which Scn5A (the predominant sodium channel gene in heart) has been knocked out die early in development with cardiac malformations by mechanisms which have yet to be determined. OBJECTIVE:Here we addressed this question b...

journal_title：Circulation research

authors： Chopra SS,Stroud DM,Watanabe H,Bennett JS,Burns CG,Wells KS,Yang T,Zhong TP,Roden DM

更新日期：2010-04-30 00:00:00

abstract：:We discuss the recent finding by Mizishima's group regarding the role of the autophagy-related conjugation system in mediating the closure of autophagosomes and its implication in the study of autophagy in mammalian cells. The study not only shows a novel function of the autophagy-related conjugation system but also i...

journal_title：Circulation research

authors： Saito T,Sadoshima J

更新日期：2017-02-17 00:00:00

abstract：:cAMP-dependent protein kinase is anchored to discrete cellular compartments by a family of proteins, the A-kinase anchor proteins (AKAPs). We have investigated in vivo and in vitro the biological effects of the expression of a prototypic member of the family, AKAP75, on smooth muscle cells. In vitro expression of AKAP...

journal_title：Circulation research

authors： Indolfi C,Stabile E,Coppola C,Gallo A,Perrino C,Allevato G,Cavuto L,Torella D,Di Lorenzo E,Troncone G,Feliciello A,Avvedimento E,Chiariello M

更新日期：2001-02-16 00:00:00

abstract：:Desmosomes and gap junctions are distinct structural components of the cardiac intercalated disc. Here, we asked whether the presence of plakophilin (PKP)2, a component of the desmosome, is essential for the proper function and distribution of the gap junction protein connexin (Cx)43. We used RNA silencing technology ...

journal_title：Circulation research

authors： Oxford EM,Musa H,Maass K,Coombs W,Taffet SM,Delmar M

更新日期：2007-09-28 00:00:00

abstract：:Atherosclerotic lesion development seems to be inflammatory in nature and involves the recruitment of monocytes to the vessel wall. In this study, we investigated the role of vascular cell adhesion molecule-1 (VCAM-1) and fibronectin (FN) connecting segment-1 containing the amino acid sequence ILDV as functional ligan...

journal_title：Circulation research

authors： Huo Y,Hafezi-Moghadam A,Ley K

更新日期：2000-07-21 00:00:00

abstract：RATIONALE:Prospective cohort studies question the value of HDL-C (high-density lipoprotein cholesterol) for stroke risk prediction. OBJECTIVE:Investigate the relationship between long-term functional recovery and HDL proteome and function. METHODS AND RESULTS:Changes in HDL protein composition and function (cholester...

journal_title：Circulation research

authors： Plubell DL,Fenton AM,Rosario S,Bergstrom P,Wilmarth PA,Clark WM,Zakai NA,Quinn JF,Minnier J,Alkayed NJ,Fazio S,Pamir N

更新日期：2020-10-23 00:00:00

abstract：:Because current therapy to treat abdominal aortic aneurysm (AAA), and particularly to manage small AAA, is limited to elective surgical repair, we explored less invasive molecular therapy by simultaneous inhibition of the transcription factors nuclear factor (NF)kappaB and ets using a decoy strategy. Both NFkappaB and...

journal_title：Circulation research

authors： Miyake T,Aoki M,Masaki H,Kawasaki T,Oishi M,Kataoka K,Ogihara T,Kaneda Y,Morishita R

更新日期：2007-11-26 00:00:00