Abstract:
RATIONALE:GlycA, an emerging inflammatory biomarker, predicted cardiovascular events in population-based studies. Psoriasis, an inflammatory disease associated with increased cardiovascular risk, provides a model to study inflammatory biomarkers in cardiovascular disease (CVD). Whether GlycA associates with psoriasis and how it predicts subclinical CVD beyond high-sensitivity C-reactive protein in psoriasis is unknown. OBJECTIVE:To investigate the relationships between GlycA and psoriasis and between GlycA and subclinical CVD. METHODS AND RESULTS:Patients with psoriasis and controls (n=412) participated in a 2-stage study. We measured GlycA by nuclear magnetic resonance spectroscopy. National Institutes of Health (NIH) participants underwent 18-F Fluorodeoxyglucose Positron Emission Tomography Computed Tomography (18-FDG PET/CT) scans to assess vascular inflammation (VI) and coronary computed tomographic angiography to quantify coronary artery disease burden. Psoriasis cohorts were young (mean age=47.9), with low cardiovascular risk and moderate skin disease. high-sensitivity C-reactive protein and GlycA were increased in psoriasis compared with controls (GlycA: [PENN: 408.8±75.4 versus 289.4±60.2, P<0.0001; NIH: 415.8±63.2 versus 346.2±46, P<0.0001]) and demonstrated a dose-response with psoriasis severity. In stage 2, VI (β=0.36, P<0.001) and coronary artery disease (β=0.29, P=0.004) associated with GlycA beyond CV risk factors in psoriasis. In receiver operating characteristic analysis, GlycA added value in predicting VI (P=0.01) and coronary artery disease (P<0.01). Finally, initiating anti-tumor necrosis factor therapy (n=16) reduced psoriasis severity (P<0.001), GlycA (463.7±92.5 versus 370.1±78.5, P<0.001) and VI (1.93±0.36 versus 1.76±0.19, P<0.001), whereas GlycA remained associated with VI (β=0.56, P<0.001) post treatment. CONCLUSIONS:GlycA associated with psoriasis severity and subclinical CVD beyond traditional CV risk and high-sensitivity C-reactive protein. Moreover, psoriasis treatment reduced GlycA and VI. These findings support the potential use of GlycA in subclinical CVD risk assessment in psoriasis and potentially other inflammatory diseases.
journal_name
Circ Resjournal_title
Circulation researchauthors
Joshi AA,Lerman JB,Aberra TM,Afshar M,Teague HL,Rodante JA,Krishnamoorthy P,Ng Q,Aridi TZ,Salahuddin T,Natarajan B,Lockshin BN,Ahlman MA,Chen MY,Rader DJ,Reilly MP,Remaley AT,Bluemke DA,Playford MP,Gelfand JM,Mehtdoi
10.1161/CIRCRESAHA.116.309637subject
Has Abstractpub_date
2016-11-11 00:00:00pages
1242-1253issue
11eissn
0009-7330issn
1524-4571pii
CIRCRESAHA.116.309637journal_volume
119pub_type
杂志文章abstract::Na(v)1.5, the cardiac isoform of the voltage-gated Na+ channel, is critical to heart excitability and conduction. However, the mechanisms regulating its expression at the cell membrane are poorly understood. The Na(v)1.5 C-terminus contains a PY-motif (xPPxY) that is known to act as binding site for Nedd4/Nedd4-like u...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.RES.0000136816.05109.89
更新日期:2004-08-06 00:00:00
abstract::We have previously shown that VEGF165 gene delivery into ischemic skeletal muscle exerts not only proangiogenic, but also remarkable antiapoptotic and proregenerative activity. The aim of this study was to determine whether recombinant adeno-associated virus (rAAV)-mediated gene delivery of VEGF165 into cardiac muscle...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.RES.0000217342.83731.89
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abstract::A new protocol has been developed for selective removal of the endothelium from the arteries of the perfused rat hind-limb preparation. The hind limb was perfused with oxygenated Krebs-Ringer bicarbonate solution with a combination of high flow and timed air bubbles (2 minutes at high flow followed by 5 minutes of air...
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pub_type: 杂志文章
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更新日期:2005-11-11 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1976-06-01 00:00:00
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journal_title:Circulation research
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doi:10.1161/hh1701.095642
更新日期:2001-08-31 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,评审
doi:10.1161/CIRCRESAHA.108.192872
更新日期:2009-03-27 00:00:00
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doi:10.1161/01.res.62.1.81
更新日期:1988-01-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.82.1.116
更新日期:1998-01-09 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,评审
doi:10.1161/RES.0000000000000110
更新日期:2016-08-19 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.RES.0000080536.06932.E3
更新日期:2003-07-11 00:00:00
abstract::Myocardial stunning is a form of reversible myocardial ischemia/reperfusion injury associated with systolic and diastolic contractile dysfunction. In the isolated rat heart model, myocardial stunning is characterized by specific C-terminal proteolysis of the myofilament protein, troponin I (cTnI) that yields cTnI1-193...
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更新日期:2003-11-14 00:00:00
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更新日期:2000-02-04 00:00:00
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doi:10.1161/01.res.78.4.724
更新日期:1996-04-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.117.311327
更新日期:2017-09-29 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-02-05 00:00:00
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更新日期:2006-11-24 00:00:00
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更新日期:1990-02-01 00:00:00
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更新日期:1995-02-01 00:00:00
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更新日期:1991-12-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1994-05-01 00:00:00
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journal_title:Circulation research
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更新日期:2009-07-02 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/hh0901.090926
更新日期:2001-05-11 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.118.313409
更新日期:2018-12-07 00:00:00
abstract:RATIONALE:The embryonic epicardium is a crucial cell source of the cardiac fibrous skeleton as well as of the coronary system. Genetic lineage tracing systems based on Wt1 regulatory sequences provided evidence that epicardium-derived cells also adopt a myocardial fate in the mouse. OBJECTIVE:To define the adequacy of...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.112.273946
更新日期:2012-07-06 00:00:00