Differential sensitivity of canine cardiac sarcolemmal and microsomal enzymes to inhibition by free radical-induced lipid peroxidation.

abstract：:Although estradiol (E(2)) has been recognized to exert several vasculoprotective effects in several species, its effects in mouse vasomotion are unknown, and consequently, so is the estrogen receptor subtype mediating these effects. We investigated the effect of E(2) (80 microg/kg/day for 15 days) on NO production in ...

journal_title：Circulation research

authors： Darblade B,Pendaries C,Krust A,Dupont S,Fouque MJ,Rami J,Chambon P,Bayard F,Arnal JF

更新日期：2002-03-08 00:00:00

abstract：:Glibenclamide, one of the antidiabetic sulfonylureas, is known to block ATP-dependent K+ channels. We used this drug to determine to what extent K+ loss from acutely ischemic myocardium is mediated via these channels. We also investigated whether glibenclamide would influence ischemic arrhythmias. Isolated rat hearts ...

journal_title：Circulation research

authors： Kantor PF,Coetzee WA,Carmeliet EE,Dennis SC,Opie LH

更新日期：1990-02-01 00:00:00

abstract：:This review considers critically the evidence for the involvement of mediators of innate and acquired immunity in various stages of atherosclerosis. Rapidly mobilized arms of innate immunity, including phagocytic leukocytes, complement, and proinflammatory cytokines, contribute to atherogenesis. In addition, adaptive ...

journal_title：Circulation research

authors： Hansson GK,Libby P,Schönbeck U,Yan ZQ

更新日期：2002-08-23 00:00:00

abstract：:Clonidine and related drugs cause a specific pattern of cardiovascular depression by an agonistic effect on alpha-adrenoceptors within the central nervous system (CNS). For further characterization of the central adrenoceptors, the actions of three substances of the "clonidine-type" derived from two different chemical...

journal_title：Circulation research

authors： Kobinger W,Lillie C,Pichler L

更新日期：1980-06-01 00:00:00

abstract：:Ischemia and simulated ischemic conditions induce enhanced release of norepinephrine (NE) in the brain and the heart. Although studies with neuronal preparations demonstrated a rise in [Ca2+]i under energy-depleted conditions, such release of NE in the heart appears to be predominantly Ca2+ independent. Since Ca2+ ove...

journal_title：Circulation research

authors： Du XJ,Bobik A,Little PJ,Esler MD,Dart AM

更新日期：1997-02-01 00:00:00

abstract：:Autoregulatory responses to alterations in arterial or venous perfusion pressure were determined for individual arterioles within the rat cremaster muscle. The cremaster muscle of pentobarbital anesthetized rats (50 mg/kg, ip) was surgically exposed and maintained in a controlled tissue bath for visualization by in vi...

journal_title：Circulation research

authors： Morff RJ,Granger HJ

更新日期：1982-07-01 00:00:00

abstract：:The release of acetylcholine from autonomic nerves in those tissues that receive a cholinergic innervation is widely believed to dilate blood vessels. Exogenously administered acetylcholine in vivo does dilate vascular beds and produce hypotension; however, this latter effect is indirect and probably the result of lib...

journal_title：Circulation research

authors： Kalsner S

更新日期：1989-08-01 00:00:00

abstract：:Previous studies have demonstrated that low shear rates promote leukocyte adherence to microvascular endothelium in postcapillary venules. The objective of this study was to determine whether an accumulation of inflammatory mediators such as platelet activating factor and leukotriene B4 is responsible for shear rate-d...

journal_title：Circulation research

authors： Bienvenu K,Russell J,Granger DN

更新日期：1992-10-01 00:00:00

abstract：:The fat-derived hormone adiponectin has been shown to have a protective role in macrovascular disorders. However, nothing is known about the function of adiponectin in retinal microvessel disease. Here, we investigated the causal role of adiponectin in retinal vessel formation and inflammation under conditions of hypo...

journal_title：Circulation research

authors： Higuchi A,Ohashi K,Kihara S,Walsh K,Ouchi N

更新日期：2009-05-08 00:00:00

abstract：RATIONALE:Long noncoding RNAs (lncRNAs) constitute a novel class of noncoding RNAs that regulate gene expression. Although recent data suggest that lncRNAs may be associated with cardiac disease, little is known about lncRNAs in the setting of myocardial ischemia. OBJECTIVE:To measure lncRNAs in patients with myocardi...

journal_title：Circulation research

authors： Vausort M,Wagner DR,Devaux Y

更新日期：2014-09-12 00:00:00

abstract：:The hallmark of most cardiac diseases is the progressive loss of cardiomyocytes. In the perinatal period, cardiomyocytes still proliferate, and the heart shows the capacity to regenerate upon injury. In the adult heart, however, the actual rate of cardiomyocyte renewal is too low to efficiently counteract substantial ...

journal_title：Circulation research

authors： Derks W,Bergmann O

更新日期：2020-02-14 00:00:00

abstract：:Protein kinase C (PKC) is a key mediator of many diverse physiological and pathological responses. Although little is known about the specific in vivo roles of the various cardiac PKC isozymes, activation-induced translocation of PKC is believed to be the primary determinant of isozyme-specific functions. Recently, we...

journal_title：Circulation research

authors： Mochly-Rosen D,Wu G,Hahn H,Osinska H,Liron T,Lorenz JN,Yatani A,Robbins J,Dorn GW 2nd

更新日期：2000-06-09 00:00:00

abstract：:Transformer splicing regulatory proteins determine the sexually dimorphic traits of Drosophila. The role of the vertebrate homologs of Tra-2 in phenotypic specification is undefined. We are using the alternative splicing of the MYPT1 E23 exon as a model for the study of smooth muscle diversification into fast and slow...

journal_title：Circulation research

authors： Shukla S,Fisher SA

更新日期：2008-08-29 00:00:00

abstract：:The cellular basis of reactive oxygen intermediate-induced arrhythmias was investigated in isolated rabbit ventricular cells using the whole-cell voltage- and current-clamp techniques. Singlet oxygen and superoxide were generated by the photoactivation of rose bengal. Single ventricular cells exposed to rose bengal (1...

journal_title：Circulation research

authors： Matsuura H,Shattock MJ

更新日期：1991-02-01 00:00:00

abstract：:Hearts from rabbits with 8-16 weeks of alloxan-diabetes were compared with hearts from normal rabbits to determine whether diabetic myocardium is more sensitive to ischemic injury. In isolated buffer-perfused hearts, left ventricular developed pressure, diastolic pressure, time to peak pressure (TTPP), time to half-ma...

journal_title：Circulation research

authors： Vogel WM,Apstein CS

更新日期：1988-05-01 00:00:00

abstract：:Increasing attention is currently devoted to the multiple roles that pericytes (also defined as mural, Rouget, or perivascular cells) may play during angiogenesis, vascular homeostasis, and pathology. Many recent excellent reviews thoroughly address these topics (see below); hence, we will not discuss them in detail h...

journal_title：Circulation research

authors： Cappellari O,Cossu G

更新日期：2013-07-19 00:00:00

abstract：:We tested a number of hypotheses concerning the mechanism of K+-induced vasodilation of the coronary vascular bed. Blood flow in the circumflex artery was measured in pentobarbital-anesthetized, open-chest dogs. Intracircumflex artery bolus injections of 40 mumol of isomotic KCl produced decreases in coronary vascular...

journal_title：Circulation research

authors： Murray PA,Sparks HV

更新日期：1978-01-01 00:00:00

abstract：:An animal model was used to test the hypothesis that in heart failure the decrease in the ability to resynthesize ATP through the creatine kinase (CK) reaction (which we call energy reserve) contributes to the inability of the heart to maintain its normal function and contractile reserve. One-week-old turkey poults we...

journal_title：Circulation research

authors： Liao R,Nascimben L,Friedrich J,Gwathmey JK,Ingwall JS

更新日期：1996-05-01 00:00:00

abstract：RATIONALE:Anti-inflammatory and vascular protective actions of adiponectin are well recognized. However, many fundamental questions remain unanswered. OBJECTIVE:The current study attempted to identify the adiponectin receptor subtype responsible for adiponectin's vascular protective action and investigate the role of ...

journal_title：Circulation research

authors： Wang Y,Wang X,Lau WB,Yuan Y,Booth D,Li JJ,Scalia R,Preston K,Gao E,Koch W,Ma XL

更新日期：2014-02-28 00:00:00

abstract：:Electrical field stimulation (EFS) of phenylephrine-contracted bovine mesenteric arteries pretreated with guanethidine elicited a relaxation that amounted to roughly 40%. This relaxation was sensitive to tetrodotoxin pretreatment, suggesting a neurogenic origin. The EFS-induced relaxation was correlated to an increase...

journal_title：Circulation research

authors： Ahlner J,Ljusegren ME,Grundström N,Axelsson KL

更新日期：1991-03-01 00:00:00

abstract：:Diadenosine triphosphate is present in platelet-dense granules and released quantitatively on platelet aggregation. We have found that intact porcine aortic endothelial cells can efficiently hydrolyze extracellular diadenosine triphosphate. The products of diadenosine triphosphate hydrolysis are adenosine monophosphat...

journal_title：Circulation research

authors： Goldman SJ,Gordon EL,Slakey LL

更新日期：1986-09-01 00:00:00

abstract：RATIONALE:Obesity leads to increased ischemic heart disease (IHD) risk, but the risk is thought to be mediated through intermediate variables and may not be caused by increased weight per se. OBJECTIVE:To test the hypothesis that the increased IHD risk because of obesity is mediated through lipoproteins, blood pressur...

journal_title：Circulation research

authors： Varbo A,Benn M,Smith GD,Timpson NJ,Tybjaerg-Hansen A,Nordestgaard BG

更新日期：2015-02-13 00:00:00

abstract：:During cardiac development, the epicardium is the source of multipotent mesenchymal cells, which give rise to endothelial and smooth muscle cells in coronary vessels and also, possibly, to cardiomyocytes. The aim of the present study was to determine whether stem cells are retained in the adult human and murine epicar...

journal_title：Circulation research

authors： Limana F,Zacheo A,Mocini D,Mangoni A,Borsellino G,Diamantini A,De Mori R,Battistini L,Vigna E,Santini M,Loiaconi V,Pompilio G,Germani A,Capogrossi MC

更新日期：2007-12-07 00:00:00

abstract：:Several time- and voltage-dependent ionic currents have been identified in cardiac pacemaker cells, including Na(+) current, L- and T-type Ca(2+) currents, hyperpolarization-activated cation current, and various types of delayed rectifier K(+) currents. Mathematical models have demonstrated that spontaneous action pot...

journal_title：Circulation research

authors： Mitsuiye T,Shinagawa Y,Noma A

更新日期：2000-07-21 00:00:00

abstract：:Current management of ventricular septal defect (VSD) after myocardial infarction (MI) is aimed at improving left ventricular (LV) performance by afterload reduction as a means of hemodynamic stabilization or shunt control. The current investigation was undertaken to determine whether primary manipulation of right ven...

journal_title：Circulation research

authors： Babb JD,Waldhausen JA,Zelis R

更新日期：1977-04-01 00:00:00

abstract：:We have shown that the cellular contractile dysfunction characteristic of pressure-overload cardiac hypertrophy results not from an abnormality intrinsic to the myofilament portion of the cardiocyte cytoskeleton but rather from an increased density of the microtubule component of the extramyofilament portion of the ca...

journal_title：Circulation research

authors： Tagawa H,Wang N,Narishige T,Ingber DE,Zile MR,Cooper G 4th

更新日期：1997-02-01 00:00:00

abstract：:Calcineurin, a calcium/calmodulin-regulated protein phosphatase, modulates gene expression in cardiac and skeletal muscles during development and in remodeling responses such as cardiac hypertrophy that are evoked by environmental stresses or disease. Recently, we identified two genes encoding proteins (MCIP1 and MCIP...

journal_title：Circulation research

authors： Yang J,Rothermel B,Vega RB,Frey N,McKinsey TA,Olson EN,Bassel-Duby R,Williams RS

更新日期：2000-12-08 00:00:00

abstract：:It has been reported that immunization against tonin normalizes blood pressure, and that sialoadenectomy, during which the tonin-rich salivary glands are removed, decreases blood pressure in one-kidney, one-clip hypertension. To investigate the role of tonin on this form of hypertension further, we actively immunized ...

journal_title：Circulation research

authors： Seto S,Rabito SF,Scicli AG,Carretero OA

更新日期：1984-11-01 00:00:00

abstract：RATIONALE:Smooth muscle precursor cells have previously been reported to reside in bone marrow and in the circulation, but little is currently known regarding the proximate stimuli for smooth muscle cell differentiation of these putative progenitors. OBJECTIVE:Because local thrombin generation occurs as an initial res...

journal_title：Circulation research

authors： Martin K,Weiss S,Metharom P,Schmeckpeper J,Hynes B,O'Sullivan J,Caplice N

更新日期：2009-07-31 00:00:00

abstract：RATIONALE:Sustained cardiac hypertrophy is often accompanied by maladaptive cardiac remodeling leading to decreased compliance and increased risk for heart failure. Maladaptive hypertrophy is considered to be a therapeutic target for heart failure. MicroRNAs (miRNAs) and long noncoding RNAs (lncRNAs) have various biolo...

journal_title：Circulation research

authors： Wang K,Liu F,Zhou LY,Long B,Yuan SM,Wang Y,Liu CY,Sun T,Zhang XJ,Li PF

更新日期：2014-04-25 00:00:00