Innate and adaptive immunity in the pathogenesis of atherosclerosis.

Abstract:

:This review considers critically the evidence for the involvement of mediators of innate and acquired immunity in various stages of atherosclerosis. Rapidly mobilized arms of innate immunity, including phagocytic leukocytes, complement, and proinflammatory cytokines, contribute to atherogenesis. In addition, adaptive immunity, with its T cells, antibodies, and immunoregulatory cytokines, powerfully modulates disease activity and progression. Atherogenesis involves cross talk between and shared pathways involved in adaptive and innate immunity. Immune processes can influence the balance between cell proliferation and death, between synthetic and degradative processes, and between pro- and antithrombotic processes. Various established and emerging risk factors for atherosclerosis modulate aspects of immune responses, including lipoproteins and their modified products, vasoactive peptides, and infectious agents. As we fill in the molecular details, new potential targets for therapies will doubtless emerge.

journal_name

Circ Res

journal_title

Circulation research

authors

Hansson GK,Libby P,Schönbeck U,Yan ZQ

doi

10.1161/01.res.0000029784.15893.10

subject

Has Abstract

pub_date

2002-08-23 00:00:00

pages

281-91

issue

4

eissn

0009-7330

issn

1524-4571

journal_volume

91

pub_type

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